ライフサイエンスコーパス: metastasis suppressor gene

1 quely acts by transcriptionally activating a metastasis suppressor gene.

2 with a potential oncogenic function of this metastasis suppressor gene.

3 ) kinase 4 (JNKK1/MKK4) as a prostate cancer metastasis suppressor gene.

4 e, is thought to be a tumor suppressor and a metastasis suppressor gene.

5 g cascade, has been identified recently as a metastasis-suppressor gene.

6 NAi screening strategy to identify candidate metastasis suppressor genes.

7 g strategy that enables the discovery of new metastasis suppressor genes.

8 dentifying therapeutic targets downstream of metastasis suppressor genes.

9 t has been demonstrated to repress tumor and metastasis suppressor genes.

10 l facilitate the identification of candidate metastasis-suppressor genes.

11 These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human

12 To define further the region harboring the metastasis suppressor gene, a truncated human chromosome

13 KiSS-1 has been shown to function as a tumor metastasis suppressor gene and reduce the number of meta

14 Metastasis-suppressor genes are attractive candidates fo

15 nctional characterization of prostate cancer metastasis-suppressor genes are discussed.

16 The mechanisms through which the metastasis suppressor gene BRMS1 functions are poorly un

17 tion and transcriptional repression of tumor metastasis suppressor gene BRMS1, highlights a new mecha

18 murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that alleli

19 Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions

20 entified a novel anti-tumor activity for the metastasis suppressor gene CC3.

21 NA-methyltransferase (MGMT) and the putative metastasis suppressor gene death-associated protein kina

22 the tumor suppressor gene p16, the putative metastasis suppressor gene death-associated protein kina

23 The tumor metastasis suppressor gene Drg-1 has been shown to suppr

24 These studies implicate MKK4/SEK1 as a metastasis suppressor gene encoded by human chromosome 1

25 Erk kinase 1 (MKK4/SEK1) gene as a candidate metastasis suppressor gene encoded by the approximately

26 uggesting that there are tumor suppressor or metastasis suppressor genes encoded by this chromosomal

27 city, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome

28 KAI1 is a metastasis suppressor gene for human prostate cancer and

29 s strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may s

30 Previous studies demonstrated that CD44 is a metastasis suppressor gene for prostate cancer and that

31 e human chromosome 8p21-p12 region encodes a metastasis suppressor gene for rat prostate cancer.

32 uman chromosome 8p21-p12 region contains the metastasis suppressor gene for the AT6.3 cells.

33 e also tested whether chromosome 6 harbors a metastasis-suppressor gene for breast cancer as observed

34 y also indicate that chromosome 11 encodes a metastasis-suppressor gene for human breast cancer.

35 Studies of metastasis suppressor gene function are providing a crit

36 are example demonstrating the relevance of a metastasis suppressor gene function utilized in a develo

37 Here we show that the metastasis suppressor gene homolog Nm23/awd is a negativ

38 tumor suppressor genes Tbx5 and Pten and the metastasis suppressor gene Hoxd10 are significantly upre

39 results show that KiSS-1 also functions as a metastasis suppressor gene in at least some human breast

40 tastasis suppressor 1 (BRMS1) functions as a metastasis suppressor gene in breast cancer and melanoma

41 ytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC.

42 d site markers, and this analysis placed the metastasis suppressor gene in the interval between D8S22

43 cancer patients and suggest that there is a metastasis suppressor gene in this region that may play

44 lls, similar to the overexpression of KiSS-1 metastasis suppressor gene in those cells.

45 However, the discovery of new metastasis suppressor genes in breast cancer using genom

46 We reveal these genes to be novel metastasis suppressor genes in breast cancer.

47 Expression of nm23-H1 (NME1), a known metastasis-suppressor gene in this breast cancer cell li

48 t regulate metastasis, and the importance of metastasis-suppressor genes in this process.

49 We hypothesize that metastasis suppressor gene inactivation or down-regulati

50 Metastasis suppressor genes inhibit one or more steps re

51 l four susceptibility loci: 11q23.3 CADM1, a metastasis suppressor gene involved in modifying tumour

52 Conventional dogma has regarded E-cad as a metastasis-suppressor gene involved in epithelial-mesenc

53 This suggests that an additional metastasis suppressor gene is located within the human c

54 The loss of function of metastasis suppressor genes is a major rate-limiting ste

55 Decreased expression of the human KAI1 metastasis-suppressor gene is involved in the progressio

56 s, combined with recent studies of the tumor metastasis suppressor gene KAI1 and plasminogen activato

57 The metastasis suppressor gene KAI1 was identified by its ab

58 Metastin, the gene product of metastasis suppressor gene KiSS-1, is the endogenous lig

59 Loss of the metastasis suppressor gene, KiSS-1 has been strongly cor

60 ether the recently discovered human melanoma metastasis suppressor gene, KiSS-1, which maps to chromo

61 The metastasis suppressor gene known as Nm23-H1 regulates tu

62 state cancer, which suggests that our target metastasis suppressor gene may also play an important ro

63 Twelve metastasis suppressor genes (MSGs) have been identified

64 Although >30 metastasis suppressor genes (MSGs) that negatively regul

65 on of the cell cycle inhibitor, p21, and the metastasis suppressor gene, NDRG1 (N-myc downstream-regu

66 t revealed a novel regulatory network of two metastasis suppressor genes, NDRG1 and KAI1, which toget

67 a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitiv

68 The expression levels of the metastasis suppressor gene Nm23 have been shown to corre

69 Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastati

70 was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2.

71 KAI1 is a metastasis suppressor gene on human chromosome 11p11.2 t

72 ocused on genetic mechanisms for the loss of metastasis suppressor genes, our results provide new evi

73 RMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene promoter via direct recruitme

74 static cancer cells to map the location of a metastasis suppressor gene(s).

75 rids, which suggests the presence of a novel metastasis-suppressor gene(s) or novel function of a kno

76 ic lineage for the identification of a novel metastasis suppressor gene, serum deprivation response (

77 The finding that DLC-1 can act as a metastasis-suppressor gene supports an influential role

78 pG island promoter methylation, invasion and metastasis suppressor genes, telomere shortening, and ge

79 ranscript (>300 kb) running antisense to the metastasis-suppressor gene TFPI-2.

80 KiSS1 is a metastasis suppressor gene that has been shown to inhibi

81 KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting

82 These findings define caspase-8 as a metastasis suppressor gene that, together with integrins

83 To discover novel metastasis suppressor genes that are clinically relevant

84 We conclude that RRM1 functions as a metastasis suppressor gene through induction of PTEN exp

85 SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby red

86 parental (C8161) metastatic cells, the KISS1 metastasis suppressor gene was isolated.

87 d symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published.

88 NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the disseminat

89 cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene whose mechanisms of action ar

90 We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is ass

91 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer pro