ライフサイエンスコーパス: metastasize

1 rker to predict high-risk tumors before they metastasize.

2 t converge biologically once they invade and metastasize.

3 pes, melanoma is one with great potential to metastasize.

4 ix is critical for tumor cells to invade and metastasize.

5 'miRNA sponge' promotes the cancer cells to metastasize.

6 ive for other cells to detach and ultimately metastasize.

7 ing PDX1+ cells with an inherent capacity to metastasize.

8 ite to be colonized by neoplastic cells that metastasize.

9 er Pfn1 expression levels with propensity to metastasize.

10 uction, and a failure of cells to invade and metastasize.

11 r cells strongly suppresses their ability to metastasize.

12 correlate to the ability of many cancers to metastasize.

13 otype and the propensity of these cancers to metastasize.

14 recurrences are not uncommon; a few may even metastasize.

15 s adhesion allows cancer cells to invade and metastasize.

16 of metastasis, some grew slowly and did not metastasize.

17 y tumor cells to invade other tissues and to metastasize.

18 ncer cell transit through the vasculature to metastasize.

19 ved in cancer cells to confer the ability to metastasize.

20 s thus critical to understanding how cancers metastasize.

21 tastasis, relative to control cells that did metastasize.

22 to develop uncontrolled proliferation and to metastasize.

23 at lead to melanomas that are more likely to metastasize.

24 omplex (TSC) 1 or 2 and have the capacity to metastasize.

25 ng epithelial tumor cells to disseminate and metastasize.

26 permitting them to both form tumours and to metastasize.

27 ist environmental stress, enter dormancy, or metastasize.

28 levance: Although rare, in situ melanoma may metastasize.

29 mmon in other models of prostate cancer that metastasize.

30 their precursors, with a high propensity to metastasize.

31 combined to maximize the cancer's ability to metastasize.

32 nces are maintained as the tumors invade and metastasize.

33 ollow-up, and whether the lesion recurred or metastasized.

34 None of the lesions metastasized.

35 primary colorectal cancer, of which half had metastasized.

36 g inflammatory breast cancer that frequently metastasized.

37 d average growth of 0.13 cm/year and only 1% metastasized.

38 gressive cancer often diagnosed after it has metastasized.

39 uided systemic therapy for cancers that have metastasized.

40 melanoma demonstrated local recurrence and 1 metastasized.

41 is known about how the cancer initiates and metastasizes.

42 ma, even when diagnosed early, nearly always metastasizes.

43 ) is an extremely lethal cancer that rapidly metastasizes.

44 l cancer cells within a tumor are capable of metastasizing.

45 d to assess patient prognosis and to prevent metastasizing.

46 Many human glandular cancers metastasize along nerve tracts, but the mechanisms invol

47 cells (CSCs) exhibit an intrinsic ability to metastasize and acquire drug resistance through distinct

48 Class 2 tumors were more likely to metastasize and cause death than class 1 tumors (DSS: P

49 al, drug sensitivity, and their potential to metastasize and cause relapse.

50 SRMs less than 3 cm are very unlikely to metastasize and deferring treatment has not been associa

51 promotes the ability of melanocytic cells to metastasize and engages actin dynamics via Rho-GTPases a

52 The "Metastasize and Infiltrate" theory may be the key mechan

53 of malignant melanoma are its propensity to metastasize and its resistance to treatment, giving pati

54 of CD200 impairs the ability of SCC cells to metastasize and seed secondary tumors, indicating that t

55 , the propensity for this disease to rapidly metastasize and the inability to improve patient outcome

56 The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this p

57 ith uveal melanoma (17 patients whose tumors metastasized and 40 patients whose tumors did not metast

58 exus required for the survival and growth of metastasizing and circulating tumor cells in vivo.

59 our screening study comparing mRNA levels in metastasizing and nonmetastasizing endometrial carcinoma

60 hether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was stil

61 tasized and 40 patients whose tumors did not metastasize), and 37 healthy donors.

62 or ablation, a subset of these tumors recur, metastasize, and cause death.

63 ected independent tumor lineage that did not metastasize, and early progenitor clones with the "first

64 own to be upregulated in primary tumors that metastasize, and we therefore investigated its role in p

65 fferentiated disease into a more aggressive, metastasizing, and fatal malignancy.

66 When cancer cells metastasize, angiogenesis is also required for metastati

67 ry thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis.

68 ear when in tumor progression the ability to metastasize arises and whether this ability is inherent

69 tually extravasate across the endothelium to metastasize at a secondary site.

70 oma is characterized by a high propensity to metastasize at low tumor volumes necessitating the need

71 tions, CD117(+)Stro-1(+ )cell-derived tumors metastasized at a high frequency.

72 Most notably, the metastasized B16F10 cells in UG-KO mouse lungs express M

73 aponeuroses, is uniformly fatal once it has metastasized because of its profound therapeutic resista

74 ells, while BMD cells were isolated from the metastasized bone.

75 We hypothesized that, to metastasize, breast cancers may escape their normative g

76 Lung cancer is notorious for its ability to metastasize, but the pathways regulating lung cancer met

77 e mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remai

78 Ovarian cancers metastasize by attaching to and invading through the mes

79 Pancreatic ductal adenocarcinoma (PDAC) metastasizes by neural, vascular, and local invasion rou

80 , 19 patients were alive, but their melanoma metastasized, by the end of the observation period (mean

81 nvironment induces complete reprogramming of metastasized cancer cells, resulting in a gain of neuron

82 onmental cues in the regulation of miRNAs in metastasizing cancer cells has not been studied.

83 ese results suggest that host B7x may enable metastasizing cancer cells to escape local antitumor imm

84 The reduction in miR-193b enabled the metastasizing cancer cells to invade and proliferate int

85 and even less is known about the identity of metastasizing cancer cells.

86 ick, adaptable switch to promote survival of metastasizing cancer cells.

87 potential therapeutic target for lung-tropic metastasizing cancers.

88 To metastasize, carcinoma cells must attenuate cell-cell ad

89 excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC

90 Collectively, this study demonstrates that metastasized cells are less migratory due in part to the

91 ived pancreatic cancer samples indicate that metastasized cells present significantly lower heterogen

92 the total number of cancer cells as well as metastasized cells.

93 After separating from a primary tumor, metastasizing cells enter the circulatory system and int

94 ove cancer therapy, it is critical to target metastasizing cells.

95 ell line, SW480, and its isogenic lymph node metastasized derivative, SW620.

96 salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known

97 on and LOH of genes on chromosome 3 occur in metastasizing disomy 3 UM and are detectable by aSNP ana

98 f chromosome 3 were seen in the remaining 17 metastasizing disomy 3 UMs by MLPA.

99 etastasizing monosomy 3 uveal melanoma; iii) metastasizing disomy 3 uveal melanoma; and iv) monosomy

100 servation (mean 0.32 cm/year), but only 1.4% metastasized during 32 months of follow-up (median).

101 play a dominant role by invading further and metastasizing earlier.

102 Melanomas can rapidly metastasize early in tumor progression, but the dependen

103 ells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting

104 ring epithelial-to-mesenchymal transition of metastasizing epithelial tumors, we generated citrullina

105 However, tumor cells grew and metastasized equally well in Fbln2-null and -wild-type l

106 f g-E and g-EAR delayed bioluminescence from metastasizing ES-2-luc cells for 2 and 3weeks, respectiv

107 ient renal cancers are highly aggressive and metastasize even when small, leading to a very poor clin

108 Pelvic tumors usually metastasize first to regional lymph nodes, which are spe

109 Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the

110 MDA-MB-231 cells because of their ability to metastasize from the breast fat pad to distant lymph nod

111 In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors

112 Our findings imply that the ability to metastasize-i.e., to colonize distant sites-is the direc

113 arcinoma cells and analyzed their ability to metastasize in 2 independent mouse models.

114 ls is necessary to maintain their ability to metastasize in a chick embryo model.

115 human prostate cancer gene expression, which metastasize in immune-competent mice, are a valuable new

116 breast cancer cells, which form tumors that metastasize in immunocompetent mice.

117 stories in patients and in their capacity to metastasize in NOD-SCID-Il2rg(-/-) (NSG) mice.

118 n-2 was required for tumor cells to grow and metastasize in syngeneic mice, a surprising finding give

119 nce of carcinomas that either did or did not metastasize in the same host animal suggests that there

120 ly, tumor cells that acquired the ability to metastasize in vivo constitutively downregulated SNPH an

121 cause of detachment (anoikis resistance) and metastasize in vivo To examine the mechanism by which CP

122 Rac3 regulates the ability of tumor cells to metastasize in vivo.

123 eases the ability of CRC cells to invade and metastasize in vivo.

124 The prostate cancer cell lines metastasized in FVB mice to brain and bone.

125 Of these 83 patients, 21 had melanoma that metastasized in the studied nodal basin for an in-basin

126 ancers, it inhibits primary lung tumors from metastasizing in a mouse model system.

127 tatic lesions to the oral mucosa; only cases metastasizing in the oral mucosa, gingiva, and periodont

128 The tumors metastasize inducibly and robustly to the liver.

129 However, the smooth muscle cell that metastasizes, infiltrates, and destroys the lung in LAM

130 cancer cells escape immune surveillance and metastasize into bone tissue by inducing osteoclastic bo

131 In the absence of tBregs, 4T1 tumors cannot metastasize into the lungs efficiently due to poor Treg

132 ggressive form of skin cancer, which further metastasizes into a deadly form of cancer.

133 brane of the surface epithelium, invade, and metastasize is essential to the development of novel tre

134 is typically diagnosed after the disease has metastasized; it is among the most lethal forms of cance

135 Benign metastasizing leiomyoma (BML) is a rare condition descri

136 ction with the diagnosis of pulmonary benign metastasizing leiomyoma being stated.

137 We present a case of pulmonary benign metastasizing leiomyoma in a female patient admitted to

138 Pulmonary benign metastasizing leiomyoma is a rare entity.

139 es confirmed the initial diagnosis of benign metastasizing leiomyoma with no evidence of neoplastic c

140 The tumors metastasize loco-regionally and are accompanied by high

141 However, in the B16-F10-metastasized lungs, ICOS-Fc also increased IL-17A/RORc a

142 is, thus, might hamper the identification of metastasized lymph nodes.

143 ty-six adults with histologically documented metastasized malignant melanoma received a single dose o

144 L-deficient (lal(-/-)) mouse model, melanoma metastasized massively in allogeneic lal(-/-) mice, whic

145 Successfully metastasizing melanomas underwent reversible metabolic c

146 plantation, particularly among inefficiently metastasizing melanomas.

147 uveal melanoma with long-term survival; ii) metastasizing monosomy 3 uveal melanoma; iii) metastasiz

148 We found that orthotopic tumors, which metastasized more easily, were characterized by higher v

149 tion of blood vessels and lymph vessels, and metastasized much less effectively to lymph nodes.

150 gene expression signature for distinguishing metastasizing (N+) from nonmetastasizing (N0) squamous c

151 ioleiomyomatosis (LAM) is a rare, low-grade, metastasizing neoplasm that arises from an unknown sourc

152 the view of LAM as a low-grade, destructive, metastasizing neoplasm.

153 y as those caused by low-grade or high-grade metastasizing neoplasms, polyclonal or monoclonal lympho

154 In a cohort study, patients with metastasized neuroendocrine cancer were treated with rep

155 tumors in syngeneic mice and reduced by 85% metastasizes of breast cancer cells from mammary fat to

156 r cells possess the ability to, for example, metastasize or to tolerate cytotoxic drugs.

157 hat in MM, CTCs may egress to PB to colonize/metastasize other sites in the BM during the patients' r

158 lymph nodes revealed the presence of grossly metastasized ovarian cancer cells within the lymphoid ti

159 on of a tumor suppressor miRNA, miR-193b, in metastasizing OvCa cells.

160 Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity.

161 performed for 24 lesions in 24 patients with metastasized pancreatic neuroendocrine tumors treated wi

162 Here, we show that tumor cells that metastasize predominantly to the lung, such as renal cel

163 t presentation, up to 25% of gastrinomas are metastasized, predominantly to the liver.

164 patients (mean age +/- SD, 64 +/- 8 y) with metastasized prostate cancer underwent two sets of (18)F

165 (PSMA) are under development for therapy of metastasized prostate cancer.

166 , from 8 patients with histologically proven metastasized prostate cancer.

167 ly unstable high-grade serous carcinoma that metastasizes rapidly (type II).

168 Melanoma is an aggressive cancer that metastasizes rapidly and is refractory to conventional c

169 ten lethal because it is highly invasive and metastasizes rapidly.

170 cer, but the mechanisms by which tumor cells metastasize remain incompletely understood.

171 ors exploit unique biophysical properties to metastasize remains unclear.

172 1)In-cG250 or (177)Lu-cG250 in patients with metastasized renal cell carcinoma were analyzed quantita

173 In patients with metastasized renal cell carcinoma, hematologic toxicity

174 se 14 patients, 11 had primary IOL and 3 had metastasized secondary lymphomas.

175 planted in liver, where colon tumors usually metastasize, SFV-IL-12 efficacy was significantly reduce

176 nesis in vivo remains poor, in particular in metastasizing solid cancers.

177 eatment of hematologic malignancies and bone-metastasizing solid tumors.

178 r, the mechanisms by which pancreatic cancer metastasizes still remain to be determined.

179 Higher levels of LRV-1 in metastasizing strains of L.V. guyanensis have been docum

180 array of cell membrane molecules on a liver-metastasizing subline of B16 melanoma versus the parenta

181 enges in the host tissue microenvironment to metastasize successfully to distant organs.

182 tissues at which breast cancer cells tend to metastasize such as the lungs and the brain.

183 docrine tumors (PNETs), although rare, often metastasize, such that surgery, the only potentially cur

184 Only a tiny proportion successfully metastasize, supporting the notion of metastasis-specifi

185 Cancer cells metastasize through the bloodstream either as single mig

186 ad to engulf the ovary and then aggressively metastasize throughout the abdominal cavity, causing asc

187 Malignant gliomas metastasize throughout the brain by infiltrative cell mi

188 Patients with tumors that metastasize to bone frequently suffer from debilitating

189 Prostate cancer (PCa) has a propensity to metastasize to bone, and cadherin-11, which is an osteob

190 A number of cancers predominantly metastasize to bone, due to its complex microenvironment

191 omotes survival of prostate TIC and CTC that metastasize to bone, whereas HER2 supports the growth of

192 tant talin1(S425D) restored their ability to metastasize to bone.

193 rfere with the capacity of melanoma cells to metastasize to bone.

194 nificantly suppressed the ability of CSCs to metastasize to brain but not to bone in our animal model

195 his model human breast cancer cells reliably metastasize to distant organs from primary tumors grown

196 Tumor cells metastasize to distant organs through genetic and epigen

197 ic ductal tumors invade local parenchyma and metastasize to distant organs.

198 to invade neighboring tissues and ultimately metastasize to distant organs.

199 the ability to invade basement membranes and metastasize to distant sites, establishing it as an appe

200 nsition (EMT) is co-opted by cancer cells to metastasize to distant sites.

201 oenvironments to survive in the circulation, metastasize to ectopic sites, and escape therapeutic int

202 neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node

203 HNSCCs often metastasize to locoregional lymph nodes, and lymph node

204 n receptor (AR)-positive ccRCC may prefer to metastasize to lung rather than to lymph nodes.

205 s of increasingly aggressive cell lines that metastasize to lung.

206 rt inhibitor brefeldin A (BFA) in cells that metastasize to lung.

207 resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes.

208 tumor cells migrate toward blood vessels and metastasize to lymph nodes.

209 led that these cells had a high potential to metastasize to sites such as the liver.

210 directional cues for breast cancer cells to metastasize to specific organs.

211 nsplanted onto the colonic mucosa invade and metastasize to specific target organs including the inte

212 g of primary cancer with a known tendency to metastasize to the bone marrow.

213 r is among the most common malignancies that metastasize to the brain, with 15% to 20% of patients wi

214 ly suppressed the ability of cancer cells to metastasize to the brain.

215 lp elucidate mechanisms by which tumor cells metastasize to the central nervous system.

216 These orthotopic tumors spontaneously metastasize to the cervical lymph nodes, where the prese

217 ssion of Fas L enables colon cancer cells to metastasize to the liver from local tumors as well as fr

218 It can metastasize to the liver or lung.

219 e propensity of RHAMM(B)-expressing cells to metastasize to the liver was confirmed using an experime

220 RC organoids engraft in the distal colon and metastasize to the liver.

221 t proteins to enable the two cancer types to metastasize to the lung.

222 xplain how they invade different tissues and metastasize to the lung.

223 4 expression correlated with a propensity to metastasize to the lung.

224 tion of large, well-vascularized tumors that metastasize to the lung.

225 es against osteosarcoma cell lines, known to metastasize to the lungs (CCH-OS-O and SJSA), similar to

226 B16F10 melanoma cells, which preferentially metastasize to the lungs, provide the components of a mo

227 on malignant bone tumor with a propensity to metastasize to the lungs.

228 ung women in which tuberin (TSC2)-null cells metastasize to the lungs.

229 ignant melanoma has an unusual propensity to metastasize to the small bowel; however, malignant melan

230 s in mice resulted in aggressive tumors that metastasized to distant organs with concurrent increases

231 , prostate tumor tissues and prostate cancer metastasized to lungs showed a higher expression of Pak1

232 2-month-old mice were highly aggressive, and metastasized to nearby and distant organs within the per

233 med tumors, and in one case, SKNBE(2)C iCSCs metastasized to the adrenal gland, suggesting their incr

234 tools, and available treatments for melanoma metastasized to the intestines.

235 Sprouty-2 tumors metastasized to the liver from cecal orthotopic implants

236 titis tissues and in pancreatic cancer cells metastasized to the liver.

237 te significantly reduced the number of cells metastasized to the lung without affecting the growth in

238 s markedly overexpressed in some tumors that metastasized to the lungs.

239 igh)iNOS(low) polarization only after tumors metastasized to the lungs.

240 2 in a subset of primary human sarcomas that metastasized to the lungs.

241 Advanced-stage prostate cancer usually metastasizes to bone and is untreatable due to poor biod

242 Breast tumor primarily metastasizes to bone to form osteolytic lesions, causing

243 Melanoma often metastasizes to bone where it is exposed to high concent

244 Human prostate cancer often metastasizes to bone, but the biological basis for such

245 Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells acr

246 Breast cancer frequently metastasizes to bone, in which tumor cells receive signa

247 arly detected cancers is high, once a cancer metastasizes to bone, it is incurable.

248 iculty of sampling as prostate cancer mainly metastasizes to bone.

249 Breast cancer preferentially metastasizes to bone.

250 gnant tumor that often invades the brain and metastasizes to distal organs through the blood stream.

251 ntratumoral heterogeneity as medulloblastoma metastasizes to leptomeninges and as it evolves in the f

252 Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disea

253 common types of human cancer and frequently metastasizes to LNs.

254 ve bone tumor with poor prognosis that often metastasizes to lung.

255 Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as

256 It commonly metastasizes to the bone marrow.

257 Melanoma frequently metastasizes to the brain, resulting in dismal survival.

258 Colorectal cancer primarily metastasizes to the liver and globally kills over 600,00

259 provide insights into how colorectal cancer metastasizes to the liver, the most common site of disse

260 BRCA1/2-deficient ovarian cancer frequently metastasizes to viscera.

261 The lowest T category tumor metastasizing to both regional nodes and distant locatio

262 fest distinct gene expression patterns after metastasizing to different organs.

263 was inhibited, and the number of tumor cells metastasizing to lung was reduced significantly by combi

264 c lesions to the gingiva compared with cases metastasizing to other oral mucosal sites.

265 ngiogenesis, which may influence the fate of metastasized tumor cells, was also COX-2/EP3-dependent.

266 cinoma transformation and expressed later in metastasized tumor cells.

267 nsive perspective on expression, we show how metastasized tumor samples localize in the vicinity of t

268 A mutual relationship exists between metastasizing tumor cells and components of the coagulat

269 Importantly, the omentum collects metastasizing tumor cells and supports tumor growth by i

270 Reduced recruitment of monocytes to metastasizing tumor cells in Fuc-TVII(-/-) mice correlat

271 Thus, the recruitment of monocytes to metastasizing tumor cells is facilitated by endogenous s

272 Metastasizing tumor cells migrate through the surroundin

273 rise from a multi-step process that requires metastasizing tumor cells to adapt to signaling input fr

274 , may enable a molecular mimicry that allows metastasizing tumor cells to downregulate MHC class I, t

275 As metastasizing tumor cells undergo epithelial to mesenchy

276 Metastasizing tumor cells use matrix metalloproteases, s

277 The recruitment of inflammatory monocytes to metastasizing tumor cells was dependent on the local end

278 s critically dependent on the interaction of metastasizing tumor cells with cells in the local microe

279 PMo established early interactions with metastasizing tumor cells, scavenged tumor material from

280 ns regulates migratory and invasive nexus of metastasizing tumor cells.

281 n vivo cancer cell tracking in spontaneously metastasizing tumor models still poses a challenge requi

282 To metastasize, tumor cells often need to migrate through a

283 emerging strategies for targeted imaging of metastasized tumors and metastasis-directed delivery of

284 Late detection of then nonresectable or metastasized tumors emphasizes the need for novel imagin

285 istinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96%

286 arcinoma differs from that of hematogenously metastasizing tumors because ovarian cancer cells primar

287 BAP1) on chromosome 3p21.1 in 26 of 31 (84%) metastasizing tumors, including 15 mutations causing pre

288 iated macrophages and their interaction with metastasizing tumour cells, is dependent on CCL2 synthes

289 16 genes showed LOH exclusively in disomy 3 metastasizing UM, suggesting a potential role for these

290 ozen tissue samples from four fatal disomy 3 metastasizing UMs and three disomy 3 tumors with >5 year

291 Two metastasizing UMs that had been classified as disomy 3 b

292 gosity (LOH) on chromosome 3 in the disomy 3 metastasizing UMs that were not deleted or showing LOH i

293 (FFPE) whole tumor sections from 19 disomy 3 metastasizing UMs.

294 sis that reflects the propensity of cells to metastasize via either lymphatic or hematogenous routes.

295 Unlike other cancers, gliomas do not metastasize via the vasculature but invade surrounding b

296 However, the capacity to metastasize was not modified.

297 nd propensity for biopsy-negative cancers to metastasize were both higher than expected or when the s

298 ike tissues are able to grow extensively and metastasize when transplanted into the abdomen of adult

299 SCLC) is extremely aggressive and frequently metastasizes widely in its early stage.

300 tumour cells' ability to migrate, invade and metastasize without affecting the cell survival and grow