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1 n and reduced survival time of patients with metastatic colorectal cancer.
2 ividual patients during initial treatment of metastatic colorectal cancer.
3 ith capecitabine to target chemoradiation to metastatic colorectal cancer.
4 actor), is standard first-line treatment for metastatic colorectal cancer.
5 id cultures of patient-derived xenografts of metastatic colorectal cancer.
6 ubjected to PVE before major hepatectomy for metastatic colorectal cancer.
7 ed widely for cancer treatment, particularly metastatic colorectal cancer.
8 for diagnostic and therapeutic assessment of metastatic colorectal cancer.
9 ften under-represented in clinical trials of metastatic colorectal cancer.
10  capecitabine alone in elderly patients with metastatic colorectal cancer.
11 -tolerated regimen for elderly patients with metastatic colorectal cancer.
12 embolization for unresectable liver-dominant metastatic colorectal cancer.
13 nts who received anti-EGFR-based therapy for metastatic colorectal cancer.
14 l of treatment strategies for liver-confined metastatic colorectal cancer.
15 motherapy after resection of liver- confined metastatic colorectal cancer.
16 rial of patients with relapsed or refractory metastatic colorectal cancer.
17 (PS) is a prognostic factor in patients with metastatic colorectal cancer.
18 th head and neck squamous cell carcinoma and metastatic colorectal cancer.
19 ad experienced treatment failure with FU for metastatic colorectal cancer.
20 ent predictor of PFS and OS in patients with metastatic colorectal cancer.
21 ed of actively enrolling treatment trials in metastatic colorectal cancer.
22 ative" have been adopted in trial designs in metastatic colorectal cancer.
23 lus leucovorin (LV) in first-line therapy of metastatic colorectal cancer.
24 n invaluable in the staging of patients with metastatic colorectal cancer.
25 erred irinotecan-based regimen in first-line metastatic colorectal cancer.
26  cetuximab and bevacizumab, in patients with metastatic colorectal cancer.
27 during colon carcinogenesis and particularly metastatic colorectal cancer.
28 otherapy in patients with previously treated metastatic colorectal cancer.
29 dy in combination with standard regimens for metastatic colorectal cancer.
30 been approved for treatment of patients with metastatic colorectal cancer.
31 can that predicts prognosis in patients with metastatic colorectal cancer.
32 py improves survival in previously untreated metastatic colorectal cancer.
33  plus oxaliplatin in patients with untreated metastatic colorectal cancer.
34 ents (78%) who received prior irinotecan for metastatic colorectal cancer.
35  FU/LV as the standard systemic approach for metastatic colorectal cancer.
36  underwent multidetector CT of the liver for metastatic colorectal cancer.
37 bination with chemotherapy for patients with metastatic colorectal cancer.
38  plus leucovorin as first-line treatment for metastatic colorectal cancer.
39 enefit to patients with previously untreated metastatic colorectal cancer.
40  improvement in survival among patients with metastatic colorectal cancer.
41 c lesions, and skin from three patients with metastatic colorectal cancer.
42  vector, with E1b deleted, for patients with metastatic colorectal cancer.
43 lity of life in patients with FU-refractory, metastatic colorectal cancer.
44 primary tumor samples from 219 patients with metastatic colorectal cancer.
45 or anti-permeability agent for patients with metastatic colorectal cancer.
46 rgeted prevention and therapy of primary and metastatic colorectal cancer.
47 fluorouracil (FU) treatment in patients with metastatic colorectal cancer.
48 rin (LV) versus FU/LV alone in patients with metastatic colorectal cancer.
49  plus chemotherapy as first-line therapy for metastatic colorectal cancer.
50  by either LV or interferon in patients with metastatic colorectal cancer.
51 vant role for patients with resected hepatic metastatic colorectal cancer.
52 n combination chemotherapy in 5-FU-resistant metastatic colorectal cancer.
53  mononuclear cells from all 24 patients with metastatic colorectal cancer.
54 cil and leucovorin as first-line therapy for metastatic colorectal cancer.
55 has until recently been standard therapy for metastatic colorectal cancer.
56 s who may benefit from hepatic resection for metastatic colorectal cancer.
57 , recently approved for use in patients with metastatic colorectal cancer.
58 ffective first-line chemotherapy regimen for metastatic colorectal cancer.
59 e chromosomal regions is a critical step for metastatic colorectal cancer.
60 trexate with 5FU and leucovorin is active in metastatic colorectal cancer.
61 his trial, 9-AC lacked antitumor activity in metastatic colorectal cancer.
62 ts the only potentially curative therapy for metastatic colorectal cancer.
63 s activity in the treatment of patients with metastatic colorectal cancer.
64 testinal mucosa and universally expressed by metastatic colorectal cancer.
65 point inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer.
66 ment, results in prognostic heterogeneity of metastatic colorectal cancer.
67 herapy in patients with previously untreated metastatic colorectal cancer.
68 sites than in those with isolated peritoneal metastatic colorectal cancer.
69 ing lymphocytes obtained from a patient with metastatic colorectal cancer.
70 ave established efficacy in the treatment of metastatic colorectal cancer.
71  discerned potentially druggable targets for metastatic colorectal cancer.
72 se of placebo in the third-line treatment of metastatic colorectal cancer.
73  bevacizumab in the second-line treatment of metastatic colorectal cancer.
74  a standard of care for previously untreated metastatic colorectal cancer.
75 ab [arm B]) for patients with KRAS wild-type metastatic colorectal cancer.
76 ost per QALY in the third-line management of metastatic colorectal cancer.
77 ailable addressing the use of bevacizumab in metastatic colorectal cancer.
78 ct on future directions for the treatment of metastatic colorectal cancer.
79 hemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer.
80   Tumors were obtained from 19 patients with metastatic colorectal cancer (12 hepatic and seven pulmo
81       We studied 25 patients with primary or metastatic colorectal cancer; 19 patients had surgical e
82 , compared with patients with non-peritoneal metastatic colorectal cancer (194 [9%] of 2230; p=0.028
83 (63 months), gallbladder cancer (47 months), metastatic colorectal cancer (40 months), and hepatocell
84  (87%) of 10 553 patients had non-peritoneal metastatic colorectal cancer (4385 with one site of meta
85 ne were studied independently: patients with metastatic colorectal cancer (72 lesions), non-small cel
86 nosis (1,642 patients, 91%); of these cases, metastatic colorectal cancer accounted for 62% (n = 1,02
87                    Eight patients of 21 with metastatic colorectal cancer achieved responses (one com
88              Eligibility included measurable metastatic colorectal cancer, adequate hematologic and b
89 y and efficacy of sunitinib in patients with metastatic colorectal cancer after failure of standard t
90 been available for patients with progressive metastatic colorectal cancer after front-line treatment
91 activity in heavily pretreated patients with metastatic colorectal cancer, all with prior irinotecan
92    Apart from colon adenomas and primary and metastatic colorectal cancers, ALX4 is frequently methyl
93  years or older with chemotherapy-refractory metastatic colorectal cancer, an Eastern Cooperative Onc
94 pproved for the treatment of EGFR-expressing metastatic colorectal cancer and advanced head and neck
95 ementioned polymorphisms in 73 patients with metastatic colorectal cancer and determined their outcom
96 ts support a role for Akt2 overexpression in metastatic colorectal cancer and establish a mechanistic
97 zumab, improved the outcome in patients with metastatic colorectal cancer and increased the incidence
98 gress in prolonging life among patients with metastatic colorectal cancer and increasing cure rates a
99 at led to approval of bevacizumab for use in metastatic colorectal cancer and metastatic lung cancer
100 rectal cancer, and 1181 (11%) had peritoneal metastatic colorectal cancer and other organ involvement
101 ts with unresectable chemotherapy-refractory metastatic colorectal cancer and primary hepatobiliary t
102                     Patients with documented metastatic colorectal cancer and progression during or w
103 didate lipid mediator of apoptosis, in human metastatic colorectal cancer and tested in vitro and in
104 is is a common presentation in patients with metastatic colorectal cancer and the overall survival is
105 survival and response rates in patients with metastatic colorectal cancer and thus, validate VEGF pat
106 ), 194 (2%) patients had isolated peritoneal metastatic colorectal cancer, and 1181 (11%) had periton
107 uracil, and irinotecan were investigated for metastatic colorectal cancer, and 979254, in which survi
108 phase III trial of chemotherapy regimens for metastatic colorectal cancer, and compared the power of
109 trol in pre-treated patients with dMMR/MSI-H metastatic colorectal cancer, and could be a new treatme
110 side-effects of treatment, patients who have metastatic colorectal cancer, and for whom fluorouracil
111  FOLFOX6 in Patients With Previously Treated Metastatic Colorectal Cancer] and HORIZON III [Cediranib
112                  Current clinical trials for metastatic colorectal cancer are deficient in the invest
113 y mortality after initiation of treatment of metastatic colorectal cancer are poorly understood.
114 FR are currently approved for the therapy of metastatic colorectal cancer (as well as other tumors),
115 Plus Chemotherapy in Patients With Untreated Metastatic Colorectal Cancer] assessed infusional fluoro
116 inical trials demonstrate that patients with metastatic colorectal cancer benefit from therapy with m
117 tive patients undergoing liver resection for metastatic colorectal cancer between July 1985 and Octob
118                          In 24 patients with metastatic colorectal cancer, biodistribution (liver, lu
119 linical benefit to patients with advanced or metastatic colorectal cancer, but the optimal choice of
120 In phase II studies, irinotecan is active in metastatic colorectal cancer, but the overall benefit ha
121 ith chemotherapy in unselected patients with metastatic colorectal cancer cannot be recommended.
122        To further define the role of SIRT in metastatic colorectal cancer, careful patient selection
123          Autocrine secretion of cytokines by metastatic colorectal cancer cells and their role during
124  analyze the secretomes of poorly and highly metastatic colorectal cancer cells.
125 ient focus group (11 patients with early and metastatic colorectal cancer convened during a teleconfe
126 0 years and older with a recent diagnosis of metastatic colorectal cancer (CRC) about their preferenc
127 utation is seen in 5% to 8% of patients with metastatic colorectal cancer (CRC) and is associated wit
128                                 Unresectable metastatic colorectal cancer (CRC) can be rendered resec
129  a complex process affecting the outcomes of metastatic colorectal cancer (CRC) patients treated with
130 uperior to irinotecan alone in patients with metastatic colorectal cancer (CRC) previously treated wi
131 orouracil/leucovorin as the sole therapy for metastatic colorectal cancer (CRC) provides an overall s
132 with chemotherapy (CTX) in patients who have metastatic colorectal cancer (CRC), an increase in wound
133 FU) and oxaliplatin are standard therapy for metastatic colorectal cancer (CRC), but the development
134 , has shown efficacy in 10% of patients with metastatic colorectal cancer (CRC).
135 one in first-line treatment of patients with metastatic colorectal cancer (CRC).
136 ased chemotherapy in first-line treatment of metastatic colorectal cancer (CRC).
137 gral part of the evaluation of patients with metastatic colorectal cancer (CRC).
138 ve through a set of defined mutations toward metastatic colorectal cancer (CRC).
139 ed With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL) trial and FOLFIRI
140 ed With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL) trial and FOLFIRI
141  patients with liver-only and liver-dominant metastatic colorectal cancer did not improve overall sur
142 n patients with liver-dominant or liver-only metastatic colorectal cancer did not improve PFS at any
143 scape of systemic therapies for unresectable metastatic colorectal cancer during the current era of t
144 ab as First-Line Treatment For Patients With Metastatic Colorectal Cancer (FIRE-3) trial.
145 ab as First-Line Treatment For Patients With Metastatic Colorectal Cancer (FIRE-3) trial.
146    For patients with surgically unresectable metastatic colorectal cancer, FOLFOXIRI-Bev is associate
147  has doubled the median overall survival for metastatic colorectal cancer from 10 to 20 months, and t
148 ng median overall survival for patients with metastatic colorectal cancer from less than 9 months wit
149  retrospective analysis patients with RAS wt metastatic colorectal cancer from the CRYSTAL and FIRE-3
150  retrospective analysis patients with RAS wt metastatic colorectal cancer from the CRYSTAL and FIRE-3
151  in the third-line setting for patients with metastatic colorectal cancer from the US payer perspecti
152                        Resection of isolated metastatic colorectal cancer, gastrointestinal stromal t
153 IRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in pat
154 ival of patients diagnosed with unresectable metastatic colorectal cancer has increased from approxim
155 on of risk scoring systems for patients with metastatic colorectal cancer has limited clinical value
156 uation for resection of locally recurrent or metastatic colorectal cancer has not been established, e
157 h was recently approved for the treatment of metastatic colorectal cancer, has antiangiogenic propert
158 motherapy for the treatment of patients with metastatic colorectal cancer, has provided proof of prin
159                     Patients with peritoneal metastatic colorectal cancer have reduced overall surviv
160                     Patients with peritoneal metastatic colorectal cancer have significantly shorter
161 biopsies were obtained from 14 patients with metastatic colorectal cancer (i) to test the feasibility
162  for the treatment of initially unresectable metastatic colorectal cancer in humans were included.
163 nib seems to have promising activity against metastatic colorectal cancer in patients who received pr
164 eucovorin, fluorouracil, and irinotecan) for metastatic colorectal cancer in patients with disease pr
165 d regimen of fluorouracil and leucovorin for metastatic colorectal cancer in terms of progression-fre
166                       Molecular profiling of metastatic colorectal cancer (including mutational analy
167 ning regimens in the first-line treatment of metastatic colorectal cancer: irinotecan plus infusional
168                                              Metastatic colorectal cancer is a prevalent disease for
169  the peripheral circulation of patients with metastatic colorectal cancer is associated with a shorte
170 n the basis of these data, tumor response in metastatic colorectal cancer is not a necessary factor f
171 ed phase II trials of cytotoxic therapies in metastatic colorectal cancer; it was either comparable o
172 d regimens in the treatment of patients with metastatic colorectal cancer led to several multicenter
173 ) with histologically confirmed recurrent or metastatic colorectal cancer locally assessed as dMMR/MS
174 ients), hepatocellular carcinoma (HCC) (14), metastatic colorectal cancer (MCRC) (26), and benign bil
175 resent in approximately 40% of patients with metastatic colorectal cancer (mCRC) and may be associate
176 o comparing capecitabine with bolus FU/LV in metastatic colorectal cancer (MCRC) and one comparing ca
177 ients with chemorefractory KRAS G13D-mutated metastatic colorectal cancer (mCRC) benefit from cetuxim
178                                Treatment for metastatic colorectal cancer (mCRC) commonly involves a
179                Symptoms and complications of metastatic colorectal cancer (mCRC) differ by metastatic
180 rvival (PFS) in patients with wild-type KRAS metastatic colorectal cancer (mCRC) in studies 20050203
181                                              Metastatic colorectal cancer (mCRC) is heterogeneous, an
182                                  Importance: Metastatic colorectal cancer (mCRC) is heterogeneous, an
183           Earlier detection of patients with metastatic colorectal cancer (mCRC) might improve their
184 esults of prospective immunomonitoring of 25 metastatic colorectal cancer (mCRC) patients treated wit
185 erm outcome in patients with chemorefractory metastatic colorectal cancer (mCRC) receiving cetuximab.
186 d RAS gene mutation testing in patients with metastatic colorectal cancer (mCRC) to detect resistance
187 esection is the most effective treatment for metastatic colorectal cancer (MCRC) to the liver.
188 tometry in peripheral blood of patients with metastatic colorectal cancer (mCRC) treated with bevaciz
189 mes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treated with bevaciz
190   Elderly patients with previously untreated metastatic colorectal cancer (mCRC) were randomly assign
191 ebo plus capecitabine (CAP) in patients with metastatic colorectal cancer (mCRC) who had progressed a
192 have witnessed progress in the management of metastatic colorectal cancer (mCRC) with more effective
193              As treatment options expand for metastatic colorectal cancer (mCRC), a blood marker with
194                      In the pivotal trial in metastatic colorectal cancer (mCRC), addition of bevaciz
195 I trial in patients previously untreated for metastatic colorectal cancer (mCRC), and changes during
196 monoclonal antibody therapy in patients with metastatic colorectal cancer (mCRC), but preclinical stu
197  recent advances in the medical treatment of metastatic colorectal cancer (mCRC), which include irino
198 ression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC).
199 placebo plus FOLFIRI in previously untreated metastatic colorectal cancer (mCRC).
200 y or intermittently, in previously untreated metastatic colorectal cancer (mCRC).
201 iranib in patients with previously untreated metastatic colorectal cancer (mCRC).
202 he combination of cetuximab and erlotinib in metastatic colorectal cancer (mCRC).
203 ker for resistance to cetuximab (Erbitux) in metastatic colorectal cancer (mCRC).
204 s and Europe for the treatment of refractory metastatic colorectal cancer (mCRC).
205 a survival benefit in first- and second-line metastatic colorectal cancer (mCRC).
206  factor receptor, is active in patients with metastatic colorectal cancer (mCRC).
207 rouracil, and leucovorin (IFL) in first-line metastatic colorectal cancer (mCRC).
208 ), has activity in a subset of patients with metastatic colorectal cancer (mCRC).
209 ed high efficacy as first-line treatment for metastatic colorectal cancer (MCRC).
210 T4 is expressed in more than 90% of cases of metastatic colorectal cancer (mCRC).
211 nts with KRAS codon 12/13 (exon 2) wild-type metastatic colorectal cancer (mCRC).
212 ate for overall survival (OS) for first-line metastatic colorectal cancer (mCRC).
213 lder represent the majority of patients with metastatic colorectal cancer (mCRC).
214  dissemination to the liver in a KRAS-mutant metastatic colorectal cancer model.
215 I clinical trials for detecting recurrent or metastatic colorectal cancer, most patients received a s
216                     Patients with measurable metastatic colorectal cancer; no previous therapy for ad
217 those determined previously in patients with metastatic colorectal cancer not receiving antiepileptic
218 ts disease-free 10 years after resection for metastatic colorectal cancer or gallbladder cancer were
219 ovements have been made in the management of metastatic colorectal cancer over the last two decades.
220 ng preclinical and clinical activity against metastatic colorectal cancer, particularly in combinatio
221 ipheral blood samples were collected from 62 metastatic colorectal cancer patients and 30 metastatic
222                                              Metastatic colorectal cancer patients preparing to initi
223                    Eight hundred twenty-nine metastatic colorectal cancer patients previously treated
224          A total of 430 previously untreated metastatic colorectal cancer patients were randomly assi
225 that irinotecan (CPT-11) extends survival in metastatic colorectal cancer patients when administered
226  this paper, we review the published work on metastatic colorectal cancer, pertaining to the role of
227 0.86-1.25, p=0.69) and those with peritoneal metastatic colorectal cancer plus one other site of meta
228                                Patients with metastatic colorectal cancer previously treated with com
229 in a separate population of 63 patients with metastatic colorectal cancer receiving fluoropyrimidine
230 n an independent cohort of 339 patients with metastatic colorectal cancer receiving FOLFOX4 in the Fe
231       Predictors of outcome in patients with metastatic colorectal cancer remain inconsistent.
232                                              Metastatic colorectal cancer remains largely incurable,
233 ts show that proteomic sequencing of matched metastatic colorectal cancer samples is feasible, with h
234                            For patients with metastatic colorectal cancer, second-line treatment with
235 ecreased expression of TFAP2E in primary and metastatic colorectal-cancer specimens and cell lines.
236  and in increased proportions of primary and metastatic colorectal cancers suggest that Fhit plays a
237 l was to evaluate gefitinib in patients with metastatic colorectal cancer that had progressed despite
238                                Patients with metastatic colorectal cancer that harbors KRAS mutations
239 tandard-care option for treatment-refractory metastatic colorectal cancer that increases median overa
240           Patients were eligible if they had metastatic colorectal cancer that progressed, were intol
241 ment options are available for patients with metastatic colorectal cancer that progresses after all a
242 h irinotecan with that of cetuximab alone in metastatic colorectal cancer that was refractory to trea
243                             In patients with metastatic colorectal cancer, the predictive value of KR
244 umab Plus FOLFOX6 in Patients With Untreated Metastatic Colorectal Cancer]), the 20-mg dose met the p
245                           For a patient with metastatic colorectal cancer there are limited clinical
246  patients with KRAS wt untreated advanced or metastatic colorectal cancer, there was no significant d
247 e more likely than those with non-peritoneal metastatic colorectal cancer to be women (565 [41%] of 1
248 of a protocol that assigns all patients with metastatic colorectal cancer to one of a number of paral
249 andomly assigned 508 patients with untreated metastatic colorectal cancer to receive either FOLFIRI p
250  an important determinant of the response of metastatic colorectal cancer to targeted treatments.
251 r intraarterial (90)Y-glass microspheres for metastatic colorectal cancer to the liver by comparing v
252 en, 12 women; age, 68 +/- 12 y [+/-SD]) with metastatic colorectal cancer to the liver, and tumor pro
253 est and a potentially curative treatment for metastatic colorectal cancer to the liver.
254 ST) for response evaluation of patients with metastatic colorectal cancer treated with a combination
255  both the first- and second-line settings of metastatic colorectal cancer treatment.
256               When serum from a patient with metastatic colorectal cancer was chromatographed on Supe
257 tive patients undergoing liver resection for metastatic colorectal cancer was performed.
258    Of 813 patients with previously untreated metastatic colorectal cancer, we randomly assigned 402 t
259                One hundred ten patients with metastatic colorectal cancer were enrolled onto a cetuxi
260                      Seventeen patients with metastatic colorectal cancer were entered onto this tria
261                     Patients with peritoneal metastatic colorectal cancer were more likely than those
262             From 2006 to 2009, patients with metastatic colorectal cancer were prospectively included
263 reviously untreated patients with measurable metastatic colorectal cancer were randomly assigned to o
264                    Forty-three patients with metastatic colorectal cancer were referred for hepatic r
265  with chemotherapy-refractory liver-dominant metastatic colorectal cancer were treated with (90)Y rad
266  chemotherapy-naive patients with measurable metastatic colorectal cancer were treated with a 90-minu
267 enefit in patients with previously untreated metastatic colorectal cancer when combined with irinotec
268 of survival and progression in patients with metastatic colorectal cancer, whereas p53 and EGFR are n
269 tikinase inhibitor with survival benefits in metastatic colorectal cancer which has progressed after
270 tikinase inhibitor with survival benefits in metastatic colorectal cancer which has progressed after
271                         Patients with proven metastatic colorectal cancer, which had progressed withi
272 omes among patients with locally advanced or metastatic colorectal cancer who achieve a complete resp
273 btained from the plasma of 503 patients with metastatic colorectal cancer who enrolled in the CORRECT
274 ation in patients with irinotecan-refractory metastatic colorectal cancer who had developed no or mil
275 erent two-drug combinations in patients with metastatic colorectal cancer who had not been treated pr
276                                Patients with metastatic colorectal cancer who progressed after IFL th
277          The 9.8% 5-year OS in patients with metastatic colorectal cancer who were treated with first
278             Chemotherapy-naive patients with metastatic colorectal cancer (WHO performance status 0 o
279 der with previously untreated, unresectable, metastatic colorectal cancer, who were not deemed to be
280 es in patients with unpretreated advanced or metastatic colorectal cancer, who were regarded as not p
281  2012) with previously untreated advanced or metastatic colorectal cancer whose tumors were KRAS wt c
282 s in the UK with newly diagnosed advanced or metastatic colorectal cancer whose tumour was wild-type
283 blished from tumor biopsies of patients with metastatic colorectal cancer with a success rate of 71%.
284 trium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases.
285 patients with available data) and peritoneal metastatic colorectal cancer with other sites of metasta
286 ss the prognostic associations of peritoneal metastatic colorectal cancer with overall survival and p
287 mpared the global gene expression profile of metastatic colorectal cancer with that of primary cancer
288 patients with Dukes' stage D disease died of metastatic colorectal cancer within 4 to 14 months of su
289              A total of 639 patients who had metastatic colorectal cancer without KRAS mutations in e
290 overall survival compared with patients with metastatic colorectal cancer without peritoneal involvem
291                          In patients who had metastatic colorectal cancer without RAS mutations, impr

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