ライフサイエンスコーパス: metastatic potential

1 tiation, transformation, tumorigenicity, and metastatic potential.

2 form secondary tumors, and possess increased metastatic potential.

3 in terms of predictability, complexity, and metastatic potential.

4 histopathology, cytogenetic complexity, and metastatic potential.

5 , CTC clusters have 23- to 50-fold increased metastatic potential.

6 portant biomarkers of cancer progression and metastatic potential.

7 ial depletion of Dicer, can promote enhanced metastatic potential.

8 as possible markers for disease relapse and metastatic potential.

9 witch that confers cancer cells an increased metastatic potential.

10 AC cells and Suit2 derivatives with enhanced metastatic potential.

11 ells with stem-cell-like properties and high metastatic potential.

12 fer aberrant proliferative, survival, and/or metastatic potential.

13 kers or differentiation is the best guide to metastatic potential.

14 ungs of nude mice, suggesting an increase in metastatic potential.

15 ssor whose loss is associated with increased metastatic potential.

16 ns may dysregulate miRNAs, in turn affecting metastatic potential.

17 ndependent growth in soft agar, and enhanced metastatic potential.

18 he adrenal gland, suggesting their increased metastatic potential.

19 erivative of MCF10a cells selected for their metastatic potential.

20 n vimentin is observed, indicating increased metastatic potential.

21 r samples and its expression correlated with metastatic potential.

22 aster entry velocities than cells with lower metastatic potential.

23 as a potential factor that influences brain metastatic potential.

24 n be mechanistically coupled to greater bone metastatic potential.

25 umour adaptation, therapeutic resistance and metastatic potential.

26 s, a property that correlates with increased metastatic potential.

27 ers and suggested to serve as a barometer of metastatic potential.

28 ligand (FasL) and show high malignancy with metastatic potential.

29 tumor might serve as a prognostic marker for metastatic potential.

30 susceptibility to anoikis and impairs their metastatic potential.

31 significant effect on both tumor growth and metastatic potential.

32 rade tumors from high-grade tumors with high metastatic potential.

33 wth, it had a dramatic effect on spontaneous metastatic potential.

34 ansport barriers, and the tumor invasive and metastatic potential.

35 y enhance chemotaxis to HRGbeta1 and overall metastatic potential.

36 STAT1 in STS cells, thereby increasing their metastatic potential.

37 smaller tumors that exhibited an attenuated metastatic potential.

38 aling, neovascularization, invasiveness, and metastatic potential.

39 thelial cells and potentially reducing their metastatic potential.

40 elate with prostate tumor aggressiveness and metastatic potential.

41 hyme (EMT) transition and possible increased metastatic potential.

42 olon cancer, whereas PRL-3 knockdown reduced metastatic potential.

43 of detached breast tumor cells and enhances metastatic potential.

44 A shape its genetic landscape and define its metastatic potential.

45 f deregulated growth, survival and increased metastatic potential.

46 ammary tumor cell lines that differ in their metastatic potential.

47 hology of cancer cells associated with their metastatic potential.

48 did not correlate with either tumor size or metastatic potential.

49 expression, in close agreement with observed metastatic potential.

50 which selects for tumor cells with increased metastatic potential.

51 tumor progression to malignancy and increase metastatic potential.

52 he behaviors of cancer cells associated with metastatic potential.

53 vels could be used as a predictive marker of metastatic potential.

54 umor phenotype, particularly with respect to metastatic potential.

55 astasis and provides potential biomarkers of metastatic potential.

56 ion of biologically indolent tumors with low metastatic potential.

57 ations to promote their growth, survival and metastatic potential.

58 mechanism whereby cancer stem cells acquire metastatic potential.

59 omic instability and aggressive disease with metastatic potential.

60 lls profoundly inhibited their migratory and metastatic potential.

61 sis we show that knockdown of Kdm3a enhances metastatic potential.

62 av1 in HCC cells enhances their invasive and metastatic potential.

63 tumors with shorter latency and have higher metastatic potential.

64 nal consequences on tumor cell signaling and metastatic potential.

65 gression from benign to invasive stages with metastatic potential.

66 elerated mammary tumorigenesis with enhanced metastatic potential.

67 s quantified by a key parameter of intrinsic metastatic potential.

68 oor prognosis due to its highly invasive and metastatic potential.

69 (MCC), an aggressive skin cancer with a high metastatic potential.

70 ells with increased stem cell properties and metastatic potential.

71 conventional anticancer treatments and high metastatic potential.

72 through multiple passages, and tumors retain metastatic potential.

73 tion and invasion in cancer cells to promote metastatic potential.

74 the most prevalent invasive malignancy with metastatic potential.

75 a major biological correlate of breast tumor metastatic potential.

76 tumor growth, apoptotic resistance and high metastatic potential.

77 endow rare cells within a primary tumor with metastatic potential.

78 lines induced AnR and dramatically increased metastatic potential.

79 ntributing to acquisition and maintenance of metastatic potential.

80 where its expression correlated with reduced metastatic potential.

81 from the immune system, and facilitate their metastatic potential.

82 t, histological appearance, invasiveness and metastatic potential.

83 development or abnormal cells as they evolve metastatic potential.

84 of mammary tumor cell lines with increasing metastatic potentials.

85 p63 led to both rapid tumour development and metastatic potential, although the incidence of metastas

86 tant lung adenocarcinoma cell line with high metastatic potential and an orthotopic syngeneic mouse m

87 he most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a commo

88 progression and poor prognosis by increasing metastatic potential and drug resistance in breast cance

89 nt neoplasm of melanocytes with considerable metastatic potential and drug resistance, explaining the

90 cells and is often associated with increased metastatic potential and drug resistance.

91 No correlation between metastatic potential and expression of the other Id fami

92 ed in pancreatic cancer cell lines with high metastatic potential and human pancreatic tumors compare

93 d isogenic tumor cells, cells with different metastatic potential and malignant vs normal cells can b

94 nt models to assess the impact of surgery on metastatic potential and may guide optimal timing of tre

95 ssion may serve as an important biomarker of metastatic potential and patient survival.

96 pression and transcriptional activities with metastatic potential and poor prognosis in cancer, altho

97 pressure has been associated with increased metastatic potential and poor prognosis in some tumors.

98 sine kinase ErbB-2 are characterized by high metastatic potential and poor prognosis, but the signali

99 on of Phip in melanoma cell lines suppressed metastatic potential and prolonged the survival of tumor

100 proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy.

101 Cancer cells with high metastatic potential and stem cell-like characteristics

102 en procoagulant function strongly influences metastatic potential and suggest that endothelial cell-a

103 t when activated in cancer endows cells with metastatic potential and the properties of stem cells.

104 er Notch signaling correlates with increased metastatic potential and worse disease survival rates.

105 ategorizes melanoma specimens based on their metastatic potential and, importantly, is capable of str

106 espect to their infiltrative growth pattern, metastatic potential, and altered cell differentiation b

107 renewability, multipotency, drug resistance, metastatic potential, and enrichment of a metastasis-ass

108 ors positively correlate with cell motility, metastatic potential, and grade, including bladder, mela

109 rcinomas (SCC) is characterized by increased metastatic potential, and SCC progression is associated

110 and MCF-7) with distinct deformabilities and metastatic potentials, and (ii) a heterogeneous breast c

111 motherapy and the acquisition of invasive or metastatic potential, arose within detectable subclones

112 the lowlands, in order to assess cancer cell metastatic potential as they invade the highlands.

113 evidence in line with autopsy data that the metastatic potential, as shown by the incidence of CUP,

114 novel integrated perspective on the enhanced metastatic potential associated with MUC16 overexpressio

115 d L-selectin ligand may explain the enhanced metastatic potential associated with tumor cell CEA over

116 to a group of benign fibrous growths without metastatic potential but with a significant risk of loca

117 only a surface marker for cells with higher metastatic potential, but also functionally involved in

118 er stem cells (CSC) appear to have increased metastatic potential, but mechanisms underlying this are

119 trol of cytoplasmic and extracellular pH and metastatic potential, but the isoforms involved and the

120 ased proliferation, decreased apoptosis, and metastatic potential by conservation of proteins like ep

121 ogram to promote survival, proliferation and metastatic potential by mechanisms that remain largely u

122 We demonstrate that miR-22 exerts its metastatic potential by silencing antimetastatic miR-200

123 To test the metastatic potential conferred by increased Dyn2 express

124 ts and show that primary tumors of differing metastatic potential differ in ECM composition.

125 elopment of specific inhibitors for reducing metastatic potential during radiotherapy.

126 d with longer glycopolymers showed increased metastatic potential, enhanced cell cycle progression, a

127 t mass, we find that cells possessing higher metastatic potential exhibit faster entry velocities tha

128 onally find that some cell types with higher metastatic potential exhibit greater than expected chang

129 teosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modif

130 but aggressive cutaneous neoplasm with high metastatic potential, has a poor prognosis at late stage

131 correlated with poor prognosis and increased metastatic potential in a number of cancers.

132 n in vitro and significantly reduced in vivo metastatic potential in a preclinical model of experimen

133 fter arterial injury and markedly diminished metastatic potential in a setting of experimental tumor

134 D49f(-) cells in tissue culture and enhanced metastatic potential in allograft-nude mice.

135 ubulin acetylation are a sufficient cause of metastatic potential in breast cancer.

136 eby enhances the invasive, proliferative and metastatic potential in cancer.

137 s have highlighted the implications of their metastatic potential in cancers.

138 ti-cellular aggregates (MCAs), of increasing metastatic potential in different elastic moduli of hydr

139 nd CD44 contribute to early pathogenesis and metastatic potential in established lung cancer.

140 tivation may contribute to tumorigenesis and metastatic potential in human cancers via a similar mech

141 apeutic resistance also correlates with high metastatic potential in human cancers, including breast

142 reased tumor growth, tumor angiogenesis, and metastatic potential in many malignancies, including pan

143 ong correlation between NFAT1 expression and metastatic potential in melanoma cell lines and tumor sp

144 that syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an imp

145 we grafted human RCC cells with varying lung metastatic potential in mice.

146 ibited carcinoma cell migration in vitro and metastatic potential in mice.

147 3b/27b/24 cluster is found to correlate with metastatic potential in mouse and human breast cancer ce

148 d in vivo as tumorigenicity and experimental metastatic potential in NOD/SCID mice.

149 cell invasion and increases tumor growth and metastatic potential in nude mice.

150 h the markers Sca1 and CD24 are enriched for metastatic potential in orthotopic transplantation assay

151 ial for identifying cell subpopulations with metastatic potential in primary tumors or with resistanc

152 sphere-forming ability, metabolic shift and metastatic potential in vitro and in vivo.

153 hymal transition with highly tumorigenic and metastatic potential in vivo compared to conventional tw

154 acity during reoxygenation in vitro and lung metastatic potential in vivo On a mechanistic level, we

155 ack PTPN12 exhibited reduced tumorigenic and metastatic potential in vivo that correlated with their

156 dulating Cnot2 expression changes tumor cell metastatic potential in vivo, supporting a functional ro

157 gration of melanoma cells in vitro and their metastatic potential in vivo, whereas miR-182 down-regul

158 endometrial cancer cells in vitro and their metastatic potential in vivo.

159 nges, and fully restored melanoma growth and metastatic potential in vivo.

160 asive properties of the cells, and decreased metastatic potential in vivo.

161 1 controls tumour differentiation and limits metastatic potential in vivo.

162 ession resulted in enhanced tumor growth and metastatic potential in vivo.

163 dance of cancer cells with tumor-forming and metastatic potential in vivo.

164 altering tumor growth, chemosensitivity and metastatic potential in vivo.

165 The effect of miR-200b on metastatic potential involved the expression regulation

166 The PSA-mediated enhancement of metastatic potential involved the induction of HDAC3, MC

167 Although difficult, imaging of metastatic potential is also arguably the most important

168 ed, and the impact of drug treatments on CTC metastatic potential is currently unclear.

169 The increased metastatic potential is dependent on IL-6 induction medi

170 haracterization of tumor cells with enhanced metastatic potential is highly desirable.

171 The impact of such diversification on metastatic potential is unknown.

172 ma xenografts that spanned the full range of metastatic potential measured by an in vivo lung colony

173 nd the induction of apoptosis; (b) decreased metastatic potential mediated by down-regulation of the

174 ificantly rescued the decreased invasive and metastatic potential mediated by RSK2 knockdown in vitro

175 o report that the oncogene RhoC, a driver of metastatic potential, modulates glutamine and N-acetylas

176 e tumor control for iris melanoma with a low metastatic potential of 1% at 7 years.

177 of its activity is associated with increased metastatic potential of A549 cells.

178 Finally, we found that the metastatic potential of breast cancer and melanoma cells

179 portant role in controlling invasiveness and metastatic potential of breast cancer cells and that its

180 DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repr

181 signatures, and their depletion impairs the metastatic potential of breast cancer cells.

182 between ErbB2 and Rac1/Cdc42 to modulate the metastatic potential of breast cancer cells.

183 eta-regulated "metastamir" that enhanced the metastatic potential of breast cancers by promoting epit

184 -MEA effectively attenuated the invasive and metastatic potential of cancer cells in vitro and in viv

185 in stem cell pluripotency and suppresses the metastatic potential of cancer cells through multiple me

186 The finding that folate modulates metastatic potential of cancer cells was confirmed in an

187 ted by MAPK, the increased cell motility and metastatic potential of cancer cells with PI3K and/or MA

188 had negative effects on the tumorigenic and metastatic potential of cancer cells.

189 nosuppression, and enhances the invasive and metastatic potential of cancer cells.

190 en implicated in increased cell invasion and metastatic potential of cancer cells.

191 ical to be able to assess quantitatively the metastatic potential of cancer cells.

192 carcinoembryonic antigen (CEA) enhances the metastatic potential of cancer cells.

193 In this study, we have investigated metastatic potential of cancer stem cells (CSCs) isolate

194 chanical phenotypes can be used to grade the metastatic potential of cell populations with the potent

195 of Dicer and miR-130b markedly affected the metastatic potential of cells lacking TAp63.

196 ted with functional cross-talk and increased metastatic potential of cells.

197 particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordin

198 ular mechanism of radioresistance-associated metastatic potential of cervical cancer cells.

199 ession of NFATc1 significantly increased the metastatic potential of colon cancer cells, whereas inhi

200 roRNA (miR)-192 is inversely correlated with metastatic potential of colon cancer cells.

201 nhanced intracellular oxygen contents on the metastatic potential of colon cancer.

202 mportance of clonal variation in determining metastatic potential of colorectal cancer cells using th

203 Tumorigenicity and metastatic potential of colorectal tumor cells over and

204 e cellular pathways influence the growth and metastatic potential of CRC.

205 present study, we aimed to evaluate the anti-metastatic potential of deguelin in vivo and in tumor gr

206 y been linked to cellular transformation and metastatic potential of epithelial cancers, our findings

207 ctopaxin expression also correlated with the metastatic potential of HCC cell lines.

208 RSK2 substantially reduced the invasive and metastatic potential of HNSCC cells in vitro and in vivo

209 rin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possi

210 nature derived from the subgroup can predict metastatic potential of human breast cancer.

211 channels (VGSC) have been implicated in the metastatic potential of human breast, prostate, and lung

212 11 depletion on the tumorigenic capacity and metastatic potential of human cancer cells and xenograft

213 sublethal dose of radiation can enhance the metastatic potential of human cervical cancer cells via

214 ealed that Hunk is sufficient to restore the metastatic potential of Hunk-deficient tumor cells, as w

215 on in tumors markedly reduces the number and metastatic potential of infiltrating tumor-associated ma

216 significantly abrogated the tumorigenic and metastatic potential of invasive breast cancer cells.

217 mpaired cell migration in vitro and also the metastatic potential of invasive lung cancer cells in vi

218 zygous mutation of Dpc4/Smad4 attenuates the metastatic potential of Kras(G12D/+);Trp53(R172H/+) panc

219 orated by in vitro experiments assessing the metastatic potential of LS174T cells.

220 markers of hyperactive PR-A may help predict metastatic potential of luminal breast tumors.

221 CD24 knockdown decreased the metastatic potential of lung cancer cell lines resemblin

222 f miR-487b targets, and decreased growth and metastatic potential of lung cancer cells in vivo.

223 Decreased metastatic potential of MDA-MB-231 cells by blueberry wa

224 migration/invasion capacity in vitro and the metastatic potential of MDA-MB-231 cells in immunodefici

225 f blueberry phytochemicals on the growth and metastatic potential of MDA-MB-231 cells through modulat

226 showing that interstitial flow increases the metastatic potential of MDA-MB-435S melanoma cells.

227 aminoglycan levels increased with increasing metastatic potential of melanoma cells.

228 pin RNA results in a loss of tumorigenic and metastatic potential of melanoma cells.

229 topaxin reverted the invasive phenotypes and metastatic potential of metastatic HCC cells through reg

230 PSA enhanced the tumorigenic and metastatic potential of mouse melanoma cells in HDAC3- a

231 The metastatic potential of NME2-depleted cells was remarkab

232 portant for maintaining the invasiveness and metastatic potential of non-epithelial sarcoma cells.

233 rgistically and is sufficient to promote the metastatic potential of nonmetastatic cells to that of n

234 on in osteosarcoma, thus contributing to the metastatic potential of osteosarcoma cells by altering t

235 sue samples and cell lines, and predicts the metastatic potential of pancreatic cancer.

236 oduction correlated with the increase in the metastatic potential of PC-3 and LNPCa prostate cancer m

237 regulating E-selectin-mediated adhesion and metastatic potential of PCa cells.

238 not total talin1 expression, correlates with metastatic potential of PCa cells.

239 tivation is a novel mechanism that increases metastatic potential of PCa cells.

240 n and messenger RNA were associated with the metastatic potential of PDAC cell lines and progression

241 syltransferase, which is associated with the metastatic potential of PDAC tumors in mice and progress

242 truncated PDGFRalpha is able to restore bone-metastatic potential of prostate cancer cells as effecti

243 The tumorigenic and metastatic potential of PTPN12-deficient TNBC cells is s

244 data suggest that SFRP1 plays a role in the metastatic potential of RCC.

245 these targets in isolation did not alter the metastatic potential of sarcoma cells injected orthotopi

246 tion identifies metastatic cells; rather the metastatic potential of several ROS-generating mutations

247 enewal, gene expression, tumorigenicity, and metastatic potential of spheres at generations G1-G5 wer

248 sion levels did not change with the invasive/metastatic potential of the cancer cells or tumors.

249 The metastatic potential of the cancer cells was reduced aft

250 a primary tumor may provide an index of the metastatic potential of the lesion.

251 rget for molecular imaging of metastases and metastatic potential of the primary tumor.

252 In addition, silencing of RSK1 enhanced the metastatic potential of these cells in vivo using a zebr

253 e resulted in a significant reduction of the metastatic potential of these cells.

254 coexist in SCC and that tumor initiation and metastatic potential of these populations can be uncoupl

255 anced the chemosensitivity and decreased the metastatic potential of this p53(null) claudin-low tumor

256 proliferation, migration, invasion, and the metastatic potential of tumor cells by promoting loss of

257 s been shown to enhance the invasiveness and metastatic potential of tumor cells by regulating the ge

258 of action by which kisspeptins suppress the metastatic potential of tumor cells lacking expression o

259 nt in the allergic inflammation-promotion of metastatic potential of tumor cells.

260 c inflammation has been known to enhance the metastatic potential of tumor cells.

261 helial-mesenchymal transition to enhance the metastatic potential of tumor cells.

262 y, which could be associated with increasing metastatic potential of tumor cells.

263 gly recognized as critical modulators of the metastatic potential of tumor cells.

264 cell adhesion and is thought to be linked to metastatic potential of tumor cells.

265 etastasis independent of origin or intrinsic metastatic potential of tumor cells.

266 Accurate prediction of metastatic potential of tumors has been elusive, and the

267 that hCDC14A may directly contribute to the metastatic potential of tumors.

268 blood vessels is important in the growth and metastatic potential of various cancers.

269 vascular remodeling, local tumor growth, and metastatic potential of various cancers.

270 In vivo metastatic potentials of both molecules were assessed.

271 associated with tumor cell invasiveness and metastatic potential, prominent characteristics of NPC.

272 dolent tumours with PTEN alterations acquire metastatic potential remains poorly understood.

273 Tumor cell lines of high metastatic potential show significantly increased extens

274 bpd null mammary tumours, which have reduced metastatic potential, show altered expression of inflamm

275 verexpressed specifically in cells with high metastatic potential, suggesting a role for this miRNA a

276 tumor that has a worse prognosis and higher metastatic potential than its adenocarcinoma counterpart

277 evalent, CTC clusters appear to have greater metastatic potential than single CTCs in the circulation

278 ds produced larger tumours and showed higher metastatic potential than WT cybrids.

279 pendymoma is a locally aggressive tumor with metastatic potential that arises in diverse locations th

280 fluidity as a necessary cellular feature of metastatic potential that can be controlled by many curr

281 motility, tissue invasion and acquisition of metastatic potential through the upregulation of epithel

282 een resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding o

283 erived exosomes have the ability to transfer metastatic potential to a recipient cell and cancer exos

284 n reduced primary tumor size and blocked the metastatic potential to the lungs.

285 This metastatic potential was dependent on Plexin D1 expressi

286 these functional domains in cancer biology, metastatic potential was evaluated in TM(Pro) mice expre

287 Radiation-associated metastatic potential was evaluated using a wound-healing

288 ressing phenotype were identified, and their metastatic potential was studied in nude mice.

289 By comparing cell lines with different metastatic potential, we have identified a tumor-secrete

290 ell viability, apoptosis, proliferation, and metastatic potential were analyzed.

291 bladder carcinoma cell lines with differing metastatic potential were uncoupled from binding to targ

292 n, Stat3 signaling, tumor proliferation, and metastatic potential when expressed in a murine RMS cell

293 mors appear to have had a biologic impact on metastatic potential, whereas mutations arising in the m

294 linked with the expansion of subclones with metastatic potential which we can detect in the blood.

295 r (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to

296 B-231 and BT-549 cancer cells stimulated the metastatic potential while it actually inhibited it in t

297 exhibited a slower growth rate and a reduced metastatic potential with a more differentiated epitheli

298 a malignancy characterized by high invasive/metastatic potential, with no efficient therapy after me

299 Melanomas are characterized by high metastatic potential, with regional lymph node represent

300 ve or minimally invasive prediction of tumor metastatic potential would facilitate individualized can