ライフサイエンスコーパス: metazoan

1 ritical ER-mitochondria tethering protein in metazoans.

2 ases (POMTs) are evolutionarily conserved in metazoans.

3 ng the evolution of the IKKgamma proteins in metazoans.

4 role in the development of various organs in metazoans.

5 for any ERMES protein has been identified in metazoans.

6 uggested to play several biological roles in metazoans.

7 innate immune responses is necessary in all metazoans.

8 as been associated with long lifespan across metazoans.

9 signaling pathway regulates cell fate in all metazoans.

10 onship between spindle size and cell size in metazoans.

11 ion of a myriad of genes in humans and other metazoans.

12 ms with more complex pathways reminiscent of metazoans.

13 ells is a powerful antimicrobial strategy in metazoans.

14 nuclear periphery and in the nucleoplasm in metazoans.

15 ate immune defence predates the emergence of metazoans.

16 vel mechanisms of lineage differentiation in Metazoans.

17 play a role in sister-chromatid cohesion in metazoans.

18 a brevicollis, a unicellular relative to the metazoans.

19 a universal modulator of Notch signaling in metazoans.

20 4 and resembles promoter-proximal pausing in metazoans.

21 mentary to the sexual mode, are found across metazoans.

22 vidence for a similar mechanism operating in metazoans.

23 is conserved in proliferating tissues among metazoans.

24 interactions in stem cell regulation across metazoans.

25 gnaling pathway that specifies cell fates in metazoans.

26 llagen plays a fundamental role in all known metazoans.

27 s and cryptochromes) have been discovered in metazoans.

28 icipated complex translational landscapes in metazoans.

29 lecular structures in the early evolution of metazoans.

30 ilencing activities are shared among diverse metazoans.

31 es have genomic bases shared with many other metazoans.

32 protease SPRTN as the DPC protease acting in metazoans.

33 major components of regulatory machinery of metazoans.

34 ns that specify cell lineages and tissues in metazoans.

35 tions of newly emerging genes, especially in metazoans.

36 paves the way for analyzing this process in metazoans.

37 diversity of transcriptomes and proteomes in metazoans.

38 to ensure faithful chromosome segregation in metazoans.

39 cytial architectures in the germline of most metazoans.

40 , such Pi sensing has not been documented in metazoans.

41 s and stimulates transcription elongation in metazoans.

42 CENPB) in Schizosaccharomyces, as well as in metazoans.

43 ancient oxygen-monitoring machinery used by metazoans.

44 is a key regulator of cell fate decisions in metazoans [5-7].

45 The metazoan actin cytoskeleton supports a wide range of con

46 duced by voltage depolarizations, similar to metazoan action potentials.

47 enosine deamination mechanisms distinct from metazoan ADARs.

48 Contrary to the fast radiation of most metazoans after the end-Permian mass extinction, it is b

49 t network to mediate adhesion signals in the metazoan ancestor.

50 The earliest metazoan ancestors of humans include the ctenophore Mnem

51 and Pleurobrachia bachei, among our earliest metazoan ancestors.

52 y natural environments, especially among non-metazoan and non-fungal opisthokonts.

53 functional compatibility expands between the metazoan and plant kingdoms, illustrating striking conse

54 e 3' RNA uridylation across protists, fungi, metazoan and plant species.

55 conserved histone H3 replacement variant in metazoans and has been implicated in many important biol

56 in polarization underlies differentiation in metazoans and in bacteria.

57 signalling via Notch is highly conserved in metazoans and is required for many processes in vascular

58 lucosamine transferase (OGT) is found in all metazoans and plays an important role in development but

59 ow Ca(2+) is taken up by these organelles in metazoans and the physiological relevance for migration

60 error rates: negligible (yeast), tolerable (metazoan), and high (some plants), with the human genome

61 the molecular evolution of the KANK genes in metazoan, and found that KANK1, KANK2, KANK3 and KANK4 e

62 rotein O-mannosylation is found in yeast and metazoans, and a family of conserved orthologous protein

63 building of a functional digestive system in metazoans, and genetic conditions involving these genes

64 tion has played in controlling the timing of metazoan (animal) emergence and diversification, if any,

65 thelial sheets are crucial components of all metazoan animals, enclosing organs and protecting the an

66 on of stem cells underpins the physiology of metazoan animals.

67 nisms that control expression of RP genes in metazoans are poorly understood.

68 ty of this DNA-binding domain exclusively in metazoans are, however, mostly unknown.

69 , and the potential of Hydra and other basal metazoans as a model system for neural circuit studies.

70 Although BCAR1 orthologs exist only in metazoans as identified by an N-terminal SH3 domain, Yxx

71 iquitous immune gene expression mechanism in metazoans, as a way to promote long-term parasitism.

72 Wnt signals were pivotal in constructing the metazoan body by generating cellular diversity and spati

73 d mechanism propelling the generation of the metazoan body plan.

74 is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eu

75 ome dosage compensation is essential in most metazoans, but the developmental timing and underlying m

76 ins are required for germline development in metazoans, but the underlying mechanisms remain poorly u

77 uring germ layer specification in bilaterian metazoans, but there has been no direct experimental evi

78 gers irreversible S-phase entry in yeast and metazoans, but why this occurs at a given cell size is n

79 o be under cell nonautonomous control in the metazoan C. elegans.

80 challenges the view that the only identified metazoan CDK-activating kinase, cyclin H-CDK7-Mat1 (CAK)

81 Apoptosis is a prominent metazoan cell death form.

82 ddle of the bipolar spindle is a hallmark of metazoan cell divisions.

83 In metazoan cell nuclei, hundreds of large chromatin domain

84 ransduction pathway found in most if not all metazoan cell types characterized to date.

85 es are small vesicles that are secreted from metazoan cells and may convey selected membrane proteins

86 romoters of primary response genes (PRGs) in metazoan cells is controlled by inducible transcription

87 The genome of metazoan cells is organized into topologically associati

88 Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses e

89 d late endosomes with lysosomes in yeast and metazoan cells, acting together with its effector, the t

90 form of physical asymmetry occurs in several metazoan cells, but the underlying mechanisms and functi

91 or constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the developme

92 re major constituents of the cytoskeleton of metazoan cells.

93 Ago) proteins and inhibit gene expression in metazoan cells.

94 Complete duplication of large metazoan chromosomes requires thousands of potential ini

95 s quickly became important members of marine metazoan communities [6].

96 , which are observed in a great diversity of metazoans, control neurogenesis in the sea star larva by

97 We suggest key structural aspects of metazoan Ctr1 and Ctr2 that discriminate between their b

98 cal, genetic, and phylogenetic comparison of metazoan Ctr1 and Ctr2, suggesting that Ctr2 arose over

99 Metazoan cytoplasmic dynein moves processively along mic

100 In metazoans, delineation of the role of PP2A B' in meiosis

101 nalling directs fundamental processes during metazoan development and can be aberrantly activated in

102 repair and consequences of DNA crosslinks in metazoan development and in adult post-mitotic and proli

103 Wnt/beta-catenin signal transduction directs metazoan development and is deregulated in numerous huma

104 Metazoan development involves the successive activation

105 Metazoan development is regulated by transcriptional net

106 essing) regulation across multiple stages of metazoan development, using 80 inbred Drosophila wild is

107 lia and flagella and play important roles in metazoan development.

108 l transduction pathway that is essential for metazoan development.

109 amental yet diverse morphogenetic process of metazoan development.

110 ling pathway is one of the key regulators of metazoan development.

111 thresholds governing cell fate decisions in metazoan development.

112 cilia play central roles in signaling during metazoan development.

113 HSF is also required for metazoan development; however, its function and regulati

114 Metazoans display a tremendous diversity of developmenta

115 the key evolutionary innovation that enabled metazoan diversification, leading to the formation of di

116 Plants and basal metazoans do not have a germline but generate gametes fr

117 on experiments with any sexually-reproducing metazoan, Drosophila melanogaster.

118 Most metazoan E3 ligases contain a signature RING domain that

119 single canonical alpha-helical motif, while metazoan eIF4E-binding proteins (m4E-BPs) advantageously

120 onical and noncanonical motifs, similarly to metazoan eIF4E-eIF4G complexes.

121 As in the case of metazoan eIF4E-eIF4G, this may have very important pract

122 Metazoan eIF4Gs share this extended binding interface wi

123 rplus, damaged, and transformed cells during metazoan embryonic development and adult tissue homeosta

124 The early cell divisions of many metazoan embryos are rapid and occur in the near absence

125 Circadian rhythms in metazoan eukaryotes are controlled by an endogenous mole

126 cription factor is well conserved throughout metazoan evolution and serves as a central regulator of

127 erstanding of the linkage of oxygenation and metazoan evolution in Early Cambrian time.

128 An important group for understanding early metazoan evolution is Ctenophora (comb jellies), which d

129 imals, therefore often being associated with metazoan evolution, where the emergence of an ancestral

130 anisms of complex vision at the beginning of metazoan evolution.

131 niotes by H3K4me3/H3K27me3 poising, early in metazoan evolution.

132 active carnivores has been a major driver of metazoan evolution.

133 eoglycan-mediated functions evolved early in metazoan evolution.

134 Here, we compile inventories for aquatic metazoans extant in or threatening to invade the Laurent

135 which evolved to accommodate Bag6, a unique metazoan factor.

136 metabolites have been detected in different metazoan families, there is limited information about wh

137 chemosynthetic production supplementing the metazoan food web both at vent sites and elsewhere in th

138 This pause is a key component of metazoan gene expression regulation.

139 eplication-dependent H3K36 in the control of metazoan gene expression.

140 some conformation is an important feature of metazoan gene regulation; however, enhancer-promoter con

141 Our dataset outperforms previous metazoan gene superalignments in terms of data quality a

142 (Pol II) plays a critical role in regulating metazoan gene transcription.

143 ing insights into the 3D architecture of the metazoan genome and the roles it may play in regulating

144 ightly wrapping the DNA that constitutes the metazoan genome.

145 Metazoan genomes are spatially organized at multiple sca

146 Developmental genes in metazoan genomes are surrounded by dense clusters of con

147 conserved over hundreds of millions of years.Metazoan genomes contain many clusters of conserved nonc

148 the prevalence of Pol II pausing across the metazoan genomes, little is known about the in vivo effe

149 have undergone drastic expansions in higher metazoan genomes.

150 ve evolved to accomplish unique tasks within metazoan genomes.

151 its conserved property in 3D organization of metazoan genomes.

152 de) non-protein-coding RNAs expressed in the metazoan germline.

153 The metazoan gut harbours complex communities of commensal a

154 Early metazoans had to evolve the first cell adhesion mechanis

155 Whereas metazoans have detoxifying organs to cope with toxic met

156 thetic genetic analysis with null-alleles in metazoans have not been feasible.

157 In metazoans, histone mRNAs are not polyadenylated but end

158 Like other metazoan homologs, Drosophila anillin contains a conserv

159 However, Hsp104 has no metazoan homologue.

160 fluences many physiological processes in the metazoan host, including development and intestinal home

161 Protozoan parasites colonize numerous metazoan hosts and insect vectors through their life cyc

162 ur models are tested against observations of metazoan hosts and their parasites in littoral zones of

163 the range of protein aggregates targeted by metazoan Hsp70 for disaggregation.

164 Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensin

165 ial transcriptional activators mediating the metazoan hypoxic response.

166 rubra and A. ylvae sequences are typical for metazoans in size and gene content.

167 alanoid copepods are among the most abundant metazoans in the ocean and constitute a vital trophic li

168 in silico evidence of RIP encoding genes in metazoans, in two closely related species of insects: Ae

169 urs in unicellular ciliates and a variety of metazoans, including invertebrates and vertebrates.

170 as a key mechanism of antiviral immunity in metazoans, including the selective elimination of viral

171 recent experiments from bacteria, yeast and metazoans indicating that the stability of most mRNAs is

172 The metazoan Integrator complex (INT) has important function

173 at future studies will establish a model for metazoan interorgan communication network (ICN) and how

174 blood cells), lower than those reported for metazoan invertebrates.

175 family of RNA-binding proteins that modulate metazoan iron metabolism.

176 Gene activation in metazoans is accompanied by the presence of histone vari

177 Epigenetic regulation of gene expression in metazoans is central for establishing cellular diversity

178 zation of the gastrointestinal (GI) tract of metazoans is critical for health.

179 Here, we show that the C2H2-ZF expansion in metazoans is facilitated by contribution of non-base-con

180 Gene expression in metazoans is regulated by RNA polymerase II (Pol II) pro

181 ed with zygotic gene activation and, in most metazoans, is dependent upon maternal factors.

182 Taf14 is not conserved as a TFIID subunit in metazoans, it is conserved through its chromatin-binding

183 key events that occur during M-phase exit in metazoans: kinetochore disassembly and nuclear reassembl

184 xes on microtubules suggests a mechanism for metazoan kinetochores to couple the depolymerization of

185 the mechanism diverge between the plant and metazoan kingdoms.

186 challenging evolutionary landscape for early metazoan life.

187 oring billion" years before the emergence of metazoan life.

188 and is thus an essential aspect of complex, metazoan life.

189 ins, and that subsequent duplications in the metazoan lineage produced its functional homolog Myo10.

190 the hypothesis that sleep arose early in the metazoan lineage, prior to the emergence of a centralize

191 sent in Cnidaria [6-8], an earlier-branching metazoan lineage.

192 The rate of divergence varies in different metazoan lineages but has not been widely studied in pla

193 of gut evolution assumes that non-bilaterian metazoan lineages either lack a gut (Porifera and Placoz

194 ther sponges, one of the most ancient extant metazoan lineages, possess an MBD2/3 capable of recogniz

195 s evolutionarily highly conserved across the metazoan lineages, the observation of striking differenc

196 Metazoan linker histones are essential for development a

197 Metazoan linker histones have a conserved tripartite str

198 ia-induced metamorphosis is widespread among metazoans, little is known about the molecular changes t

199 ies, and only approximately 16% of the 7,095 metazoan miRBase entries, are robustly supported as miRN

200 However, unlike metazoan miRNA where target site utilization localizes m

201 Here, we study evolutionary patterns of metazoan miRNAs, focusing on the targeting preferences o

202 ex (Mtw1, Nnf1, Nsl1, Dsn1), ortholog of the metazoan Mis12 complex, joins the centromere-proximal co

203 e genome organisation in comparison to other metazoan mitochondrial genomes.

204 two predicted transmembrane domains, whereas metazoan Mitofusins contain only a single transmembrane

205 also present examples of nonstandard marine metazoan model species that have made important contribu

206 Studies in metazoan models ranging from Caenorhabditis elegans to m

207 Metazoan molecular chaperones assist native folding and

208 ysis, to our knowledge, of changes in marine metazoans (Mollusca, Echinodermata, Arthropoda, and Anne

209 esoderm specification in the early branching metazoan Nematostella vectensis (an anthozoan cnidarian)

210 Increasing evidence indicates that the metazoan nervous system, which responds to stimuli origi

211 re provides insight into its contribution to metazoan nuclear stiffness.

212 clear lamina is a fundamental constituent of metazoan nuclei.

213 yet what regulatory steps are controlled by metazoan Nups remains unclear.

214 Transcription regulation in metazoans often involves promoter-proximal pausing of RN

215 ocrustaceans and represent the most abundant metazoans on Earth, outnumbering insects and nematode wo

216 type-1 repeat (TSR) domain proteins in basal metazoans or their potential role in regulation of cnida

217 Cellular identity in metazoan organisms is frequently established through lin

218 In metazoan organisms, the STT3A isoform of the oligosaccha

219 POMT genes are evolutionarily conserved in metazoan organisms.

220 face ocean O2 levels on the ecology of early metazoan organisms.

221 nts of connective tissues in essentially all metazoan organisms.

222 transcripts in diverse human cell lines and metazoan organisms.

223 organizer and suggest similarity with other metazoan organizers.

224 were strongly up-regulated, whereas genes of metazoan origin were primarily inactivated.

225 Since the tyrosine kinase SRC also has a pre-metazoan origin, co-option of BCAR1-related sequences ma

226 ta comprises 8%-10% of genes of putative non-metazoan origin, indicating that horizontal gene transfe

227 iggered similar evolutionary dynamics in the metazoan orthologues.

228 n of an important degree of immunity against metazoan parasites (helminths and arthropods) in mammali

229 Metazoan parasites have to survive in many different nic

230 Host responses against metazoan parasites or an array of environmental substanc

231 2 immunity is a primary host defence against metazoan pathogens and two of the important cytokines in

232 d that this method could accommodate various metazoan phenotypes with performances comparable to thos

233 The position of Chaetognatha among metazoan phyla remains equivocal-neither morphological n

234 Cnidaria and Ctenophora are the first metazoan phyla to evolve tissue-level organization and d

235 Like metazoans, plants use small regulatory RNAs (sRNAs) to d

236 Developmental signals in metazoans play critical roles in inducing cell different

237 We conclude that, like microbes, metazoans possess robust homology-dependent repair mecha

238 Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and com

239 The metazoan protein BCL2-associated athanogene cochaperone

240 d protein, is the founding member of a large metazoan protein family.

241 Thus, in metazoans, Rab1 activation requires TRAPP subunits not f

242 imals that diverged close to the base of the metazoan radiation, are structurally simple and thus hav

243 ocean redox state during the Early Cambrian metazoan radiation.

244 ene architecture patterns resembling ancient metazoans rather than pancrustaceans.

245 y the transmembrane Na(+) gradient common to metazoans, regulates Smoothened by shielding its heptahe

246 ere, we report on our reconstruction of deep metazoan relationships using a 1,719-gene dataset with d

247 in signaling cascades are one of the primary metazoan sensing mechanisms linking a cell to environmen

248 Neuropeptides are conserved metazoan signaling molecules, and represent useful marke

249 or rationalizing the high levels of noise in metazoan signaling networks and have implications for th

250 s the extent of cross-talk between the major metazoan signaling pathways, we characterized immediate

251 Metazoan signalling networks are complex, with extensive

252 ing and information processing in non-neural metazoan somatic cell networks.

253 Evolutionary theory explains why metazoan species are largely protected against the negat

254 In most metazoan species studied so far, linker histones are hig

255 Seven of 12 collected metazoan species were new to science, and four belonged

256 e for these proteins across a broad range of metazoan species.

257 ared by TRAPPII and an unrelated GEF that is metazoan specific.

258 The metazoan-specific approximately 800-kD ROD-Zwilch-ZW10 (

259 del substrate, we demonstrated that Grp94, a metazoan-specific Hsp90 in the ER lumen, uses its middle

260 kingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that t

261 s, we discover the presence of ufmylation, a metazoan-specific post-translational modification (PTM),

262 e we show that SZT2 (seizure threshold 2), a metazoan-specific protein mutated in epilepsy, recruits

263 Furthermore, the metazoan-specific SESN proteins function as guanine nucl

264 re, we identify Tim29 (C19orf52) as a novel, metazoan-specific subunit of the human TIM22 complex.

265 across evolutionarily distant members of the metazoan StART-like PITP family.

266 Metazoans start embryogenesis with a relatively naive ge

267 We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chla

268 muscle cells, either evolved once along the metazoan stem lineage and were then lost in sponges and

269 hrough-gut has its origins very early in the metazoan stem lineage or (2) the ctenophore lineage has

270 levels thereafter accumulated giving rise to metazoan success known as the Cambrian explosion commenc

271 BORIS resolves 16 size classes of metazoans, successively doubling in mass from approximat

272 conds to hours in bacteria and up to days in metazoans), suggesting a significant role for stability

273 ck of vital core pathway components in basal metazoans suggests that the core planar polarity pathway

274 Metazoan synaptotagmins are Ca(2+) sensors that regulate

275 significantly limited compared with that in metazoan systems.

276 functional implications of the five largest metazoan TF families.

277 re endogenous molecules found throughout the metazoan, the functions of which remain poorly understoo

278 of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) clade, which contains la

279 of somatic gametogenesis in plants and basal metazoans, the evolution of oogamy in all plants and ani

280 ed by reporter systems in which, at least in metazoans, the observed repression vastly exceeds that t

281 In metazoans, the pausing of RNA polymerase II at the promo

282 In metazoans, their rotors contain a ring of eight c-subuni

283 In metazoans, these are preferentially active in the germli

284 ated interpretation for the evolution of the metazoan through-gut.

285 of the cellular microenvironment in enabling metazoan tissue genesis remains obscure.

286 lly long executioner caspase 3' UTRs in many metazoans, translational control of executioner caspases

287 , and a C-terminal FAT-like domain, some pre-metazoan transmembrane proteins include several YxxP rep

288 potential cross-linking sites throughout the metazoan tree of life.

289 family expansions dominate across the whole metazoan tree; however, some branches experience excepti

290 Most metazoans undergo dynamic, circadian-regulated changes i

291 Embryos of most metazoans undergo rapid and synchronous cell cycles foll

292 ndant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in a

293 ts suggest that the evolution of C2H2-ZFs in metazoans was expedited by the interaction of non-base-c

294 To investigate TRAPP function in metazoans, we show that Drosophila melanogaster have two

295 In metazoans, WGD occurred before the last common ancestor

296 homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes

297 ip between spindle size and cell size across metazoans, which indicates a conserved principle of spin

298 During M-phase entry in metazoans with open mitosis, the concerted action of mit

299 Hormonal signaling provides metazoans with the ability to regulate development, grow

300 ing sponges as the sister-group to all other metazoans, with ctenophores emerging as the second-earli