ライフサイエンスコーパス: methanandamide

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1 produced by the stable CB1 agonist AM356 (R-methanandamide).

2 also observed in wild-type mice treated with methanandamide.

3 sive role in the thermoregulatory effects of methanandamide.

4 ivity as the rate of hydrolysis of (R)-alpha-methanandamide (2.4%) (anandamide = 100%) was about 10-f

5 We also show that methanandamide, a synthetic long-lasting anandamide anal

6 Our results demonstrate that methanandamide activates cannabinoid CB1 receptors to at

7 Methanandamide administration (5 mg/kg, four times/wk i.

8 Methanandamide also attenuated the hyperthermia caused b

9 rent-clamp studies neither R(+)-WIN nor R(+)-methanandamide altered the membrane response to NMDA or

10 Methanandamide (an analog of an endogenous cannabinoid,

11 (+)-WIN 55,212, delta9-tetrahydrocannabinol, methanandamide and JWH-133 quantitatively ameliorated bo

12 l, HU-210, CP55,940, 2-arachidonoylglycerol, methanandamide, and cannabidiol.

13 abinoids (Delta(9)THC, the anandamide analog methanandamide, and JWH015) increases intracellular calc

14 uction of AQP5 was blocked by ruthenium red, methanandamide, and miconazole, agents that inhibit the

15 e reinforcing effects of both anandamide and methanandamide are blocked by pretreatment with the cann

16 For combined administration, methanandamide attenuated the hyperthermia, but not hype

17 These results suggest that methanandamide augments tumor growth by a cannabinoid re

18 2), N-arachidonoylethanolamine (anandamide), methanandamide, CP55940 [2-[(1R,2R,5R)-5-hydroxy-2-(3-hy

19 Notably, anandamide and (R)-methanandamide demonstrated high selectivity for the CB1

20 -2 (EC(50) of 0.6 microM) and 41 +/- 5% with methanandamide (EC(50) of 1 microM).

21 tion of PGE2 production in vitro and blocked methanandamide-enhanced tumor growth in vivo.

22 Consistent with these results, methanandamide increased PGE2 and COX-2 levels in murine

23 COX-2-specific inhibitor, SC58236, abrogated methanandamide induction of PGE2 production in vitro and

24 A uses the specific interactions of [3H]R(+)-methanandamide (MAEA) and FAAH expressing microsomes to

25 ts, SR141716 and SR144528, did not block the methanandamide-mediated increase in tumor growth.

26 , and the p42/44 inhibitor, PD98059, blocked methanandamide-mediated induction of PGE2 and COX-2.

27 We evaluated the impact of methanandamide on COX-2 expression, PGE2 production, and

28 rfusion of the cannabimimetics WIN55212-2 or methanandamide onto CA1 neurons elicited an inward stead

29 on of the cannabinoid receptor agonists R(+)-methanandamide, R(+)-WIN, and HU-210 (1-50 nM) dose-depe

30 Methanandamide reduced the activity of all three TASKs b

31 nnabinoid anandamide and its stable analogue methanandamide relax rings of rabbit superior mesenteric

32 The thio analogs of both anandamide and (R)-methanandamide showed very weak affinity for CB1.

33 In vivo, methanandamide treatment increased the production of PGE

34 In contrast, (R)-beta-methanandamide was 6-times more susceptible (121%) than

35 The effect of methanandamide was abolished by pretreatment with a cann

36 duced hyperthermia and hyperactivity whereas methanandamide was ineffective.

37 Kinetic constants obtained for (S)-methanandamide were an apparent Km of 8.6 +/- 1.3 microM

38 elium-denuded preparations to anandamide and methanandamide were unaffected by 43Gap 27 peptide, 18al

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