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1 des and for remethylation of homocysteine to methionine.
2 nzyme to conditionally charge tRNA(Leu) with methionine.
3 a methyl group originating from S-adenosyl-l-methionine.
4 n of S-adenosylmethionine (SAM) from ATP and methionine.
5 , 0.57); betaine, 0.29 (95% CI: 0.01, 0.58); methionine, 0.31 (95% CI: 0.03, 0.60); docosahexaenoic a
6 known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred
10 nced asymmetric synthesis of D-[methyl-(11)C]methionine ([(11)C] D-Met), and showed that it can rapid
11 s procedure to that used for L-[methyl-(11)C]methionine ([(11)C] L-Met), we developed an enhanced asy
12 nerate formate and the ketoacid precursor of methionine, 2-keto-4-methylthiobutyrate, whereas the Ni(
13 terozygous mutation replacing lysine-36 with methionine-36 (K36M) in the histone H3 variant H3.3.
16 methionine to S-adenosylmethionine in mESCs, methionine adenosyltransferase 2a (MAT2a), is under cont
19 four S-adenosylmethionine synthetase genes, METHIONINE ADENOSYLTRANSFERASE3 (MAT3), is highly expres
22 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have shown that 3',
23 catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homo
25 initiation of translation from unformylated methionine, also activates specifically translation of A
29 at very low levels and is unable to reverse methionine and adenine auxotrophy of Ppmet6 Thus, nuclea
30 me involved in utilization of the substrates methionine and adenosine and in formation of the product
32 lant protein (PP), which differ in levels of methionine and BCAAs, in patients with type 2 diabetes a
35 with endotoxin (lipopolysaccharide) or fed a methionine and choline-deficient (MCD) diet to induce ex
37 ne lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier protein (ACP
38 o acid-derived radiotracers, such as l-(11)C-methionine and l-1-(11)C-5-hydroxytryptophan, demonstrat
39 idine were low, while values for citrulline, methionine and lysine were borderline low, all attribute
41 e molecular-level geometry of (13)C-enriched methionine and natural abundance poly(vinyl alcohol) ads
43 he strategy involves partially oxidizing the methionine and quantifying the oxidation level by both N
44 ene expression related to purine catabolism, methionine and S-adenosylmethionine biosynthesis and met
46 y mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linking them toget
49 characterized the effects of both valine-to-methionine and valine-to-leucine substitutions at this p
50 between alpha-amino acids (phenylalanine or methionine) and either gallic acid, caffeic acid or (+)-
51 enylalanine, isoleucine, serine, tryptophan, methionine, and cysteine were successfully employed, as
52 ing site contains an unusual, but conserved, methionine, and its sulfur coordinates transition metal
56 ne group such as arginine, cysteine, lysine, methionine, and tryptophan had the strongest antioxidant
58 probe captured proteins involved in folate, methionine, and ubiquinone metabolism, suggesting that i
60 fed either a standard chow for 4 weeks or a methionine- and choline-deficient diet for 1, 4, 8, or 1
61 ose), mice on a Western-type diet, mice on a methionine- and choline-deficient diet, mice on a high-f
62 ein and a truncated form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain,
63 subtilis speD mutant uncovered a nitrogen-, methionine-, and S-adenosylmethionine-sufficiency respon
64 g variant, H50Q; an oxidized aS in which all methionines are sulfoxides (aS4ox); a fully lysine-alkyl
65 ion into E. coli in culture, we identified D-methionine as a probe with outstanding radiopharmaceutic
67 the MET6 gene encoding MS (Ppmet6) exhibits methionine as well as adenine auxotrophy indicating that
74 alization of PpMS and its ability to reverse methionine auxotrophy of Ppmet6 Thus, association of two
75 ere, we report a strategy for chemoselective methionine bioconjugation through redox reactivity, usin
76 itated by the misacylation of tRNA(Leu) with methionine by the methionyl-tRNA synthetase (MetRS).
77 to the promoter region of genes involved in methionine catabolism and that this binding affects hist
78 encing of kappaOR in the LHA attenuated both methionine choline-deficient, diet-induced and choline-d
79 In animal models of NASH, particularly the methionine-choline deficient (MCD) model, profound chang
80 Upon chronic liver damage induced by CCl4 or methionine-choline-deficient (MCD) diet, liver injury an
84 C) causes a missense change of the initiator methionine codon (minor-allele frequency = 0.43) to thre
85 ith the EZH2 inhibitor, selective S-adenosyl-methionine-competitive small-molecule (GSK126), or the D
86 liver plays a significant role in regulating methionine concentrations by altering its flux through t
88 established the importance of histidine and methionine containing motifs for Ag(+) -binding, and ide
89 rategy for the detection and quantitation of methionine-containing peptides in SPROX experiments.
90 r the targeted detection and quantitation of methionine-containing peptides in SPROX using selective
93 in human patients (OMIM:614300) disrupts the methionine cycle and triggers hypermethioninemia, hepati
94 se DNA methylation can be predicted from the methionine cycle exhibited improved survival over cases
95 pectedly, we found that serine supported the methionine cycle in the presence and absence of methioni
97 e that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamically controlle
98 a causal relationship between EC signaling, methionine deficiency and impaired liver development.
99 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is trapped at nuc
101 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that N-methylates
102 While we observed this contribution under methionine-depleted conditions, unexpectedly, we found t
104 need with a mouse strain that incorporates a methionine derivate into proteins, allowing for their de
106 thylglycine, retinol, essential fatty acids, methionine, dimethylamine (DMA), trimethylamine, and tri
108 t inducible mistranslation specifically with methionine engendered at the tRNA charging level occurs
113 o the production of aroma compounds, such as methionine forming methional and benzothiazole while orn
114 phosphate-buffered saline (PBS) and cysteine/methionine-free Dulbecco's Modified Eagle Medium (DMEM).
116 plants overexpressing Brevibacterium linens methionine-gamma-lyase (BlMGL) produced the sulfur volat
119 t (protein valine at residue 804 replaced by methionine) genetic mutation, with 2 of the relatives pr
120 Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation
121 In a frying study with potato cubes, 5.5mM l-methionine had significantly stronger antioxidant activi
122 n to the other sulfur-containing amino acid, methionine, has been precluded by its intrinsically weak
123 accept analogues of the cofactor S-adenosyl methionine have been widely deployed for alkyl-diversifi
126 the mechanism of inhibition as reduction of methionine import, leading to decreased immediate-early
129 ifferences due to oxidation at the conserved methionine in position 254 were significantly verifiable
133 men with the highest NO2 exposure and lowest methionine intake had the greatest odds of offspring wit
134 women with the lowest NO2 exposure and high methionine intake, women with the highest NO2 exposure a
135 selectively blocked in incorporating [(35)S]methionine into Atp8p at nonpermissive but not at the pe
138 , we show that, surprisingly, this conserved methionine is dispensable for transport of the physiolog
139 The NMR assignment of methyl resonances of methionine is made by correlating the quantitative resul
141 hionine, an S-ethyl analog of the amino acid methionine, is known to induce steatosis and pancreatiti
142 r the biosynthesis of serine, histidine, and methionine; (iv) catabolic end products of lignin (pyruv
145 topic expression of histone H3.3 lysine 4-to-methionine (K4M) mutant, which reduces endogenous H3K4 m
147 ides l-Lys, recombinant ALD1 transaminates l-methionine, l-leucine, diaminopimelate, and several othe
148 achieve highly selective, rapid, and robust methionine labeling under a range of biocompatible react
149 pressure to maintain the Nramp metal-binding methionine likely exists because it-more effectively tha
150 suggested potential correlations between the methionine loss with the relative amount of the deamidat
151 ncluding those for alanine, valine, leucine, methionine, lysine, phenylalanine, tyrosine, and tryptop
152 n amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3
154 used by a D178N mutation in combination with methionine (Met) at codon 129 in the mutated allele of P
158 n two case studies to evaluate the impact of methionine (Met) oxidation on the biological functions o
160 a also produce DMSP, probably using the same methionine (Met) transamination pathway as macroalgae an
161 jasmonate (MeJA), jasmonic acid (JA) and DL-methionine (MET), in order to find a successful and feas
164 gluconeogenesis, suggesting that influencing methionine metabolic flux has the potential to be therap
165 n of Sin3A directly alters the expression of methionine metabolic genes to increase SAM, which in tur
166 ngs uncover a novel regulatory mechanism for methionine metabolism and highlight the importance of me
168 se results highlight a communication between methionine metabolism and PGC-1alpha-mediated hepatic gl
169 ce as a model for schizophrenia, and uncover methionine metabolism as a potential preventive and/or t
170 aster at different ages, we demonstrate that methionine metabolism changes strikingly during aging.
171 e metabolism and highlight the importance of methionine metabolism in SIRT1-mediated mESC maintenance
173 A comprehensive understanding of how hepatic methionine metabolism intersects with other regulatory n
177 omic approaches to explore the potential for methionine metabolism to influence signal transduction a
178 tylase, is critically involved in modulating methionine metabolism, thereby impacting maintenance of
179 ne, isoleucine, kynurenine, leucine, lysine, methionine, methylmalonic acid, ornithine, phenylalanine
180 A. pernix undergoes constitutive leucine to methionine mistranslation at low growth temperatures.
182 fferent cofactors, primarily SAM (S-adenosyl methionine), NAD (nicotinamide adenine dinucleotide), an
184 e vicinity of Ser-938, with alanine, lysine, methionine, or serine resulted in wild type-like Na(+) a
185 chnique to monitor structural changes due to methionine oxidation at sensitivity levels realistic to
187 We present the molecular features in the methionine permease Mup1 that are required for Art1-Rsp5
188 urally variant amino acids, glycine, valine, methionine, phenylalanine and cysteine were examined as
190 thereforepi-bonded radical cation due to the methionine-phenylalanine interaction, which is consisten
191 gned to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transferase allow
192 hyzoites, translation initiates at the third methionine, producing the 25 kDa form that is conserved
194 arvation increased the methionine/S-adenosyl methionine ratio, decreasing the transfer of methyl grou
195 ich is essential for purine biosynthesis and methionine recycling and affects methylation of DNA, his
196 ed that H. rubrisubalbicans up-regulates the methionine recycling pathway as well as phyto-siderophor
197 the active site of the SET domain, with the methionine residue located in the pocket that normally a
200 at alpha-Tyr-42, and oxidation at the three methionine residues are significantly higher in diabetic
201 at alpha-Tyr-42, and oxidation at the three methionine residues are significantly higher in the nons
202 e two complementary determining region (CDR) methionine residues had little or no impact on antigen b
206 Post-translational redox modification of methionine residues often triggers a change in protein f
207 gG monoclonal antibodies (mAbs) contains two methionine residues which are susceptible to oxidation.
210 ne methylation and are sensitive to maternal methionine restriction-induced lethality, whereas matern
211 SIRT1-deficient mESCs are hypersensitive to methionine restriction/depletion-induced differentiation
212 us cellular processes involving S-adenosyl-l-methionine result in the formation of the toxic by-produ
213 ies are strongly modulated by mutations in a methionine-rich loop that is predicted to lie at the inn
215 of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which catalyzes t
218 Acireductone dioxygenase (ARD) from the methionine salvage pathway (MSP) is a unique enzyme that
221 ne and S-adenosylmethionine biosynthesis and methionine salvage, and signs of altered membrane status
223 e the structures of RlmH bound to S-adenosyl-methionine (SAM) and the methyltransferase inhibitor sin
224 the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value in the convers
225 diesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of free fatty aci
226 of the (endogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylation and IEG
227 ophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation of
228 ng enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically es
229 in is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown whether viper
231 effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 monomethylatio
232 balamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identified
233 hich encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BChl
234 NifB utilizes two equivalents of S-adenosyl methionine (SAM) to insert a carbide atom and fuse two s
235 ionine generates the methyl donor S-adenosyl-methionine (SAM), which is converted via methylation to
237 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can cataly
238 methyltransferase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferase responsib
243 sferase G9a and SAM, which reveales that the methionine side chain had enhanced van der Waals interac
244 upuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perforatum]), exe
249 Mutants with phenylalanine, tyrosine, and methionine substitutions were phenotypically indistingui
251 odifications included lysine formylation and methionine sulfoxidation both of which occur with nearly
252 e oxygen species (ROS) oxidize methionine to methionine sulfoxide (MetSO) and thereby inactivate prot
257 ecies signaling by targeting the antioxidant methionine sulfoxide reductase A to modulate liposarcoma
258 dants superoxide dismutase (SOD2), catalase, methionine sulfoxide reductase A, and the 20S proteasome
261 rx2) and the intracellular and extracellular methionine sulfoxide reductases (SpMsrAB1 and SpMsrAB2,
262 markers of oxidative stress such as urinary methionine sulfoxide were observed in Hhip (+/-) but not
263 and GS-knockout/muscle) and pharmacological (methionine sulfoximine and dexamethasone) approaches to
264 hesis and increases from approximately 7% in methionine sulfoximine-treated mice to approximately 500
267 triction-induced lethality, whereas maternal methionine supplementation increases the survival of SIR
269 metRS, which preferentially incorporates the methionine surrogate azido-nor-leucine (ANL) into newly
272 inactive in vivo in microbial bioassays for methionine synthase and acted as an in vitro inhibitor o
273 ed for the function of the essential enzymes methionine synthase and methylmalonyl-CoA mutase, respec
276 that ubiquitously expresses a modified tRNA methionine synthase, metRS, which preferentially incorpo
277 e novo dTMP biosynthesis was investigated in methionine synthase-null human fibroblast and nitrous ox
278 As a consequence of MeHg detoxification, Se-methionine, the selenium pool in the system is depleted
279 Five essential amino acids (leucine, lysine, methionine, threonine, tryptophan) in pasta digesta incr
281 CS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxylic acid (ACC
282 SSAGE: Reactive oxygen species (ROS) oxidize methionine to methionine sulfoxide (MetSO) and thereby i
284 ally, we discover that the enzyme converting methionine to S-adenosylmethionine in mESCs, methionine
287 etabolic pathway intermediates revealed that methionine transamination, and not the transmethylation
289 treptococcus agalactiae (MtaR) that regulate methionine transport, amino acid metabolism, resistance
291 methylate the adenosine 58 of the initiator methionine tRNA (tRNAi(Met)), a nuclear post-transcripti
292 entified between the expression of initiator methionine tRNA and cancer progression, whereby elevated
293 that both WT and W321F KatG produce the same methionine-tyrosine-tryptophan (MYW) cofactor radical in
298 steine, the last step in the biosynthesis of methionine, which is essential for the regeneration of t
299 ions in the remethylation of homocysteine to methionine, which regenerates THF from 5-methylTHF.
300 uppress PGC-1alpha acetylation stimulated by methionine, which was accompanied by predicted alteratio
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