ライフサイエンスコーパス: methodological

1 s two key challenges, one biological and one methodological.

2 purification method represents an important methodological advance likely to facilitate robust and r

3 rbidity and mortality represent an important methodological advance, but they generally assign undue

4 This methodological advancement enables determination of endo

5 MALDI mechanisms and could assist in further methodological advancement of the technique.

6 A, and then explore how some of these recent methodological advancements have enabled the discovery o

7 Since its inception, a variety of methodological advances are opening new avenues of inves

8 Recellularization was achieved, though methodological advances are required regarding cell seed

9 Recent methodological advances have advanced the identification

10 Numerous methodological advances have also occurred, though inert

11 the state of the art, a recent explosion of methodological advances in exogenous labelling and singl

12 Recent research using methodological advances in molecular genetics has improv

13 work sets the basis for new theoretical and methodological advances in movement ecology.

14 ddress these challenges and to transform the methodological advances in predicting deleterious noncod

15 Specifically, we (1) review methodological advances that are important for dissociat

16 Despite many methodological advances that have facilitated investigat

17 By using the methodological advantages of three species (of either se

18 mor progression through the development of a methodological analysis of gene expression.

19 ethod to assess global gene translation, but methodological and analytical challenges often lead to i

20 Here we present such a unifying methodological and conceptual framework which detects as

21 We conclude with methodological and conceptual suggestions for future pro

22 s yielded conflicting results, partly due to methodological and data limitations.

23 ater than previous estimates, as a result of methodological and data source differences.

24 and evolutionary psychology contributes both methodological and empirical insights, with broad implic

25 cell-based therapies present several unique methodological and ethical issues.

26 and elaborate on how they raise outstanding methodological and philosophical questions for the appro

27 Whilst methodological and reporting limitations in the included

28 Limitation: Methodological and technical heterogeneity among studies

29 light questions being addressed using recent methodological and technological developments in those f

30 uestions and challenges that require further methodological and theoretical discussion.

31 ed PTSD literature, we highlight conceptual, methodological, and diagnostic issues, and identify clin

32 udy, we explore observational, experimental, methodological, and practical aspects of the flux quanti

33 In this paper, we discuss this methodological approach and conclude that further work i

34 Second, the choice of methodological approach has implications, thus we recomm

35 This methodological approach illuminates how miniaturized com

36 Our methodological approach is of general utility for analyz

37 This multi-methodological approach revealed the attention-related c

38 ic variation in schizophrenia, introducing a methodological approach that can be used to inform epige

39 The methodological approach that combines Phenotype MicroArr

40 says, specifically lytic IFAs, were the best methodological approach to identify HHV8-infected SOT do

41 A standardized methodological approach to quality improvement and elect

42 ies depending on tissue, experimental model, methodological approach, and features of mitochondrial f

43 A methodological approach, based on bulk etch length, is p

44 We used two methodological approaches (ecological niche modeling [EN

45 For phenology change, methodological approaches accounted for 4% of the variat

46 There was variability in methodological approaches across settings and disease co

47 ecological traits of the responding taxa and methodological approaches for quantifying biological res

48 Supporting these advances is a host of methodological approaches from chemical biology, proteom

49 These data and the methodological approaches provide a way to track the glo

50 ent results across a variety of datasets and methodological approaches provide reassurance that phylo

51 We reviewed the disparate methodological approaches taken and evaluated the progno

52 We also suggest methodological approaches to clarify this issue.

53 cardiovascular imaging and to propose novel methodological approaches to inform the demonstration of

54 ions that may be impacted by theoretical and methodological approaches used.

55 We stress the importance of using multiple methodological approaches when testing prediction of com

56 rigorous research methods, clearly identify methodological approaches, and consider employing or dev

57 ntroduced the seminal terminology, concepts, methodological approaches, and initial data pertaining t

58 l heterogeneity in the reported results, the methodological approaches, and the clinical characterist

59 egans, which in part may be due to different methodological approaches, including use of either pepti

60 an unprecedented diversity of complementary methodological approaches, the results of which suggest

61 We apply and compare four methodological approaches: first passage time (FPT), Bay

62 t studies be limited to studies with similar methodological approaches; (3) meta-analyses of climate

63 ed as a robust alternative yet because their methodological aspects are not sufficiently developed wi

64 m surgery clinical trials (CTs), focusing on methodological aspects, as a result of the lack of this

65 idemiology studies, with particular focus on methodological aspects, study design, and analytical cha

66 p analyses of depression characteristics and methodological aspects.

67 ) meta-analyses of climate responses include methodological attributes as covariates; and (4) that ne

68 Most studies were at high risk of methodological bias.

69 A major methodological breakthrough is described that couples th

70 Methodological breakthroughs are accelerating knowledge

71 Methodological breakthroughs over the past four decades

72 onomy and birth outcomes, in part due to the methodological challenge of distinguishing effects of ec

73 Common methodological challenges among glioma studies include s

74 The presented workflow addresses many of the methodological challenges current exposomics research is

75 We addressed methodological challenges for assessing change in the ab

76 ractices to these outcomes and discusses the methodological challenges inherent in reaching causal co

77 des addressing some important conceptual and methodological challenges related to study design and ap

78 has experienced rapid growth, conceptual and methodological challenges remain.

79 n specificity provides both intellectual and methodological challenges, lacking a robust model system

80 actions to lipid surfaces poses considerable methodological challenges.

81 We then review the methodological changes that psychologists have proposed

82 en after statistically adjusting for several methodological characteristics (e.g., statistical power,

83 ers and proportion of remitted patients, and methodological characteristics did not significantly mod

84 10 highway drainage projects to evaluate LCA methodological choices by characterizing environmental a

85 ubject to various types of bias, among which methodological choices have received particular attentio

86 pleted in 1 week, but determining definitive methodological choices will typically take up to 1 month

87 om 18 to 28%, respectively, depending on the methodological choices-with favorable economic condition

88 Because of the methodological complexity of network meta-analyses (NMAs

89 ersal consensus regarding the most important methodological components of FMT and inability to assess

90 aracteristics and the reporting of important methodological components of the FMT intervention.

91 Important methodological components that were not reported in publ

92 We begin by discussing two major unresolved methodological concerns facing wealth research: how to a

93 When adjusted for surgical contamination and methodological confounders, secondary assessment was ass

94 This deficit was not influenced by methodological confounds or schizophrenia-associated com

95 iated with vaccination status and to explore methodological considerations for linked survey implemen

96 couched in this perspective, we focus on the methodological considerations that are necessary to cond

97 nvironment interactions and discuss specific methodological considerations with each approach.

98 humans has been slow in large measure by the methodological constraint of generating and manipulating

99 Methodological constraints of measuring SOM decompositio

100 ed these evaluations due to limited data and methodological constraints.

101 urate interpretation within a biological and methodological context.

102 eriority trials and then explore some common methodological criticism by analyzing a sample of contem

103 tive - such as means or extremes - can guide methodological decisions for projections of ecological i

104 he application of high shear stress is a key methodological determinant accelerating the process of t

105 I conclude that methodological development and training should go beyond

106 Besides the methodological development for a high throughput routine

107 Further methodological development is needed to illuminate wheth

108 LC-MS/MS methodological development was performed using 4 represe

109 need to be overcome in the next phase of WE methodological development.

110 hopping approaches are discussed and recent methodological developments analyzed.

111 presents particular challenges, and further methodological developments are needed.

112 Rapid methodological developments in DNA sequencing, macroevol

113 Despite the recent methodological developments in LCA, most LCO application

114 nges that remain and the need for additional methodological developments necessary to further strengt

115 le, we introduce and review the foundational methodological developments of social psychophysics, pre

116 Here we report on new methodological developments that make it possible to inv

117 Here we use recent analytical and methodological developments to generate a new high-fidel

118 Progress in cognitive neuroscience relies on methodological developments to increase the specificity

119 a, there is an opportunity to foster further methodological developments, particularly focused on par

120 g juncture, it is timely to review these new methodological developments.

121 from the published values, likely because of methodological differences between laboratories and impr

122 Methodological differences between the studies mean that

123 Methodological differences explained 22% of the variatio

124 lant failure and to explore the influence of methodological differences in study design.

125 Comparability of studies is difficult due to methodological differences including variability in timi

126 hods differ in their results and whether the methodological differences, in particular the high bleac

127 ith previous estimates is not ideal owing to methodological differences, our results are consistent w

128 y in published palmitoyl proteomes is due to methodological differences.

129 ements are poorly understood, largely due to methodological difficulties in analyzing specific replic

130 uct of executive functions itself and/or the methodological difficulties related to its evaluation.

131 There were 28 methodological evaluations that met the inclusion criter

132 ematic Reviews and Meta-Analyses) and MECIR (Methodological Expectations of Cochrane Intervention Rev

133 We provide a short account of different methodological factors (size-effects, truncation procedu

134 , case-control vs longitudinal study design, methodological factors, age and smoking significantly af

135 ychology and other fields stems from various methodological factors, including low statistical power,

136 , are sensitive to sampling and a variety of methodological factors.

137 However, several key methodological flaws that are hindering progress in the

138 We formulate a new methodological framework encapsulating cognitive and gen

139 ibitor for Torsin processing, we provide the methodological framework for interfering with Torsin pro

140 We propose a methodological framework for interpretation focusing on

141 y approach presented here could be used as a methodological framework for more holistic food systems

142 We aim to present a methodological framework for oil and gas development pro

143 mmal ancestors after the PTME and provides a methodological framework for quantifying survival strate

144 l May 2017 for publications that presented a methodological framework for research impact.

145 The conceptual and methodological framework we describe should enable the c

146 We extend a methodological framework, initially proposed and validat

147 arised the common concepts and themes across methodological frameworks and identified the metrics use

148 ew provides a collective summary of existing methodological frameworks for research impact, which fun

149 We aimed to identify the existing methodological frameworks used to measure healthcare res

150 Twenty-four unique methodological frameworks were identified, addressing 5

151 On the methodological front, these results demonstrate that BOL

152 We contribute to close this important methodological gap between the two models by providing t

153 lopment is critically needed to address this methodological gap.

154 The findings reported had methodological gaps and inconsistencies.

155 cancer has been critiqued on conceptual and methodological grounds, and important differential diagn

156 following megathrust earthquakes, providing methodological guidelines for this relatively inexpensiv

157 Limitations included the quantity and methodological heterogeneity of direct ARI data, and lim

158 Findings were limited by the clinical and methodological heterogeneity of the included studies.

159 -analyses, namely inadequate sample size and methodological heterogeneity.

160 th have shown mixed results, probably due to methodological heterogeneity.

161 uantitatively pooled because of clinical and methodological heterogeneity.

162 It also provides a methodological high-throughput approach to studying mult

163 d with somatic mutation in neurons; however, methodological hurdles have prevented testing this hypot

164 ng VR in the experimental study of awe, with methodological implications for the study of other emoti

165 ian modulation of reward and underscores the methodological importance of accounting for time of day

166 hese mapping approaches provide an essential methodological improvement applicable to mountain peatla

167 While there was methodological improvement between CAFA1 and CAFA2, the

168 We highlight key methodological innovations and results describing effect

169 uman ecology, coupled with computational and methodological innovations, is amplifying the power of m

170 These results provide unique mechanistic and methodological insights into characterization of complex

171 l resolution is currently limited because of methodological intricacy.

172 If this methodological issue can be successfully addressed, thei

173 e role of social interaction in infancy, the methodological issues about imitation experiments, and t

174 ry are increasing in frequency, but specific methodological issues and weaknesses in reporting exist.

175 The present commentary examines three key methodological issues arising from the literature on the

176 This review focuses on conceptual and methodological issues as well as the approaches to answe

177 We consider methodological issues central to the study of neurocogni

178 w, we discuss the theoretical, clinical, and methodological issues in light of the development of mor

179 Methodological issues in OHRQoL research are discussed,

180 These results show that methodological issues must be carefully addressed to tac

181 The study also highlights methodological issues related to the analysis of gene ex

182 iating clinical aspects of LLD and examining methodological issues show that this relationship is not

183 ion to the original statement that addressed methodological issues specific to trials of nonpharmacol

184 We show that potential methodological issues with the WCS do not corrupt inform

185 The risk of bias assessment revealed several methodological issues, but the overall direction of bias

186 e for school-based prevention is affected by methodological issues; interventions that incorporate sk

187 Methodological limitations across studies limited the ge

188 Methodological limitations and caveats, and results of t

189 Methodological limitations have led to gaps in our under

190 Several technological and methodological limitations in obesity and microbiome res

191 zed organs, are under debate, largely due to methodological limitations in the evaluation of embolism

192 evious research suggests an association, but methodological limitations included retrospective data c

193 All the included papers had methodological limitations including insufficient sample

194 on asthma, but data are inconsistent due to methodological limitations of previous studies.

195 In view of the relatively scarce data and methodological limitations of the available studies, we

196 Despite some methodological limitations of the reviewed studies it wa

197 However, because of methodological limitations of the studies the prevalence

198 The methodological limitations of this trial are the suscept

199 Significant methodological limitations were present, including incom

200 ssion is inconclusive, and many studies have methodological limitations.

201 tic accuracy and concordance had significant methodological limitations.

202 e fair-quality ecologic study with important methodological limitations.

203 the trials had small sample sizes and other methodological limitations.

204 ls included in these systematic reviews have methodological limitations.

205 o unmeasured confounding and measurement and methodological limitations.

206 AD brain has been elusive, primarily due to methodological limitations.

207 Small, diverse body of evidence with many methodological limitations; possible publication bias.

208 igible studies, all of which had significant methodological limitations; these suggested that SLIT, w

209 ticle, the author reviews and integrates the methodological literature concerning dealing with covari

210 tructural priming has now reached sufficient methodological maturity to provide substantial evidence

211 for assessing NTP's effectiveness, including methodological needs for more thorough and efficient imp

212 iority or how they reconciled differences in methodological paradigms.

213 Common misconceptions and methodological pitfalls are highlighted.

214 These methodological pitfalls need to be avoided if the opport

215 on visual perception, pointing out possible methodological "pitfalls." Results generated in multiple

216 These results provide a new methodological platform to study Aer function along with

217 e conclude with a roadmap of the conceptual, methodological, practical, and numerical challenges that

218 of a "reference case" and a set of standard methodological practices that all cost-effectiveness ana

219 This meta-analysis reviews the methodological preferences and results for energy consum

220 in measuring pollen exposure and associated methodological problems and limitations were considered

221 onstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any c

222 uable information and can disguise potential methodological problems.

223 rches for eligible studies, (3) assessed the methodological quality (risk of bias) of the included st

224 Methodological quality according to the revised tool for

225 A further two reviewers assessed the methodological quality against agreed criteria.

226 cohort studies (1833 patients) with moderate methodological quality and 2 original registry studies (

227 We rated methodological quality and conducted random-effects meta

228 differing statistical methods, and variable methodological quality and quality of data abstraction.

229 Methodological quality and reporting of statistical anal

230 cteristics, conduction of literature search, methodological quality and reporting of statistical anal

231 e research question, studies were subject to methodological quality appraisal.

232 All included articles had high methodological Quality Assessment of Diagnostic Accuracy

233 1 studies (15 two-by-two tables) of moderate methodological quality enrolling 820 participants (range

234 sess Systematic Reviews) checklist to assess methodological quality of each review.

235 e and assess consistency of recommendations, methodological quality of guidelines, and the quality of

236 aisal showed a low-moderate level of overall methodological quality of included studies.

237 Although methodological quality of studies has improved over time

238 Methodological quality of studies including randomizatio

239 The methodological quality of studies was assessed based on

240 Additionally, the methodological quality of studies was assessed using the

241 The methodological quality of studies was poor, with studies

242 Three authors independently appraised the methodological quality of the included studies using a c

243 In conclusion, although limited by the methodological quality of the included studies, our meta

244 All authors assessed the methodological quality of the studies and consensus was

245 The overall methodological quality of the studies was intermediate (

246 The risk of bias and the methodological quality of these articles were assessed u

247 Studies in Education Guideline and evaluated methodological quality using the Weight of Evidence Fram

248 Methodological quality was examined using the Downs and

249 Information on funding source, outcome, and methodological quality was extracted.

250 No difference in methodological quality was found.

251 However, overall methodological quality was low with most studies (n=16)

252 Methodological quality was rated using a modified versio

253 equacy of the measurement properties and the methodological quality with the COnsensus-based Standard

254 t-effectiveness of AIT is limited and of low methodological quality, but suggests that AIT may be cos

255 f interventions for refractive error are low methodological quality.

256 dependently abstracted raw data and assessed methodological quality.

257 s, who must interpret the findings and gauge methodological quality.

258 The QUADAS 2 tool was used to assess methodological quality.

259 20 cross-sectional studies were assessed for methodological quality.

260 Here we present an essential methodological refinement to correct [CO3(2-)]spec absor

261 framework for assessing future tractography methodological refinements objectively.

262 This sparked a period of methodological reflection that we review here and call P

263 f this observation, we propose an agenda for methodological research and steps required to improve on

264 Previously methodological research in connectivity mapping mainly f

265 r selecting studies (5; 13%), did not assess methodological rigor (10; 26%), did not conduct comprehe

266 Methodological rigor was assessed using the relevant Cri

267 ely demonstrated significant improvements in methodological rigor.

268 t care, special attention should be given to methodological rigor.

269 tervention proves difficult in light of poor methodological rigour, lack of validated tools and compl

270 lyses (NMAs), NMAs may be more vulnerable to methodological risks than conventional pair-wise meta-an

271 Only those methodological settings that exacerbated long-branch att

272 Methodological shortcomings are prevalent in preclinical

273 hat discrepant inferences are neither due to methodological shortcomings of specific measurements nor

274 tudy designs and clinical heterogeneity, and methodological shortcomings of studies.

275 erization factors, eventually embody several methodological shortcomings, such as the lack of time-de

276 age studies were included, many of which had methodological shortcomings.

277 have underestimated the impact of SCM due to methodological shortcomings.

278 These data also have methodological significance, suggesting that there may b

279 random effects) on the basis of clinical and methodological similarities among studies to be included

280 RATIONALE: Methodological sources of bias and suboptimal reporting

281 o, and Los Angeles-to develop hypotheses and methodological strategies for assessing how the multidim

282 ealth (NIMH) (N=2) are characterized by many methodological strengths, lower placebo response rates (

283 mprising qualitative, quantitative and other methodological studies about a range of genetic and chro

284 A methodological study was needed to identify suitable rea

285 To complete this methodological study, a "sequential" oxidation/SNAr proc

286 In this methodological study, we propose to use the distribution

287 Methodological suggestions are made for future experimen

288 In this methodological systematic review, we identified all PubM

289 The experiments we review span a range of methodological techniques, including neuroimaging, psych

290 biomarker for wheat and rye bran and offer a methodological template for future investigations of wid

291 mechanisms can be achieved by expanding the methodological toolbox, applying ethologically relevant

292 anotechnology applications, and are valuable methodological tools for understanding DNA quadruplex fo

293 for the problem of abuse of statistics, but methodological training needs to cover cognitive biases

294 Various post methodological transformations were performed to explore

295 Methodological validation was performed by using cold va

296 The implications of this methodological variation for inference and comparability

297 ped from established theory, to quantify the methodological variation in characterizing risk using ca

298 To circumvent PET studies' methodological variation, we generated and used 'fold ch

299 a (OSCC) remain inconclusive, largely due to methodological variations/limitations.

300 chromosomes under tension was likely due to methodological weakness in early chromatin immunoprecipi