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4 with 2,2-dimethyl-6-t-butyl-dimethyl-silyoxy-methyl-1-cyclo-hexanone to give a vinyl cyclohexanol der
5 Yb; L(1): 1,4,7-tris[(6-carboxypyridin-2-yl)methyl]-1,4,7-triazacyclononane), taking into account th
7 ructurally related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate [bardoxo
9 en-28-oate [bardoxolone-methyl (Bar-Me)] and methyl 2-trifluoromethyl-3,11-dioxoolean-1,12-dien-30-oa
10 nes [1-((2'-lithiochloromethyldimethylsilyl)-methyl)-2-(methoxymethyl)-pyrrolidine], thus enabling th
11 t CYP11B1 inhibitor 5-((5-methylpyridin-3-yl)methyl)-2-phenylpyridine Ref 7 (IC50= 2 nM) exhibited pr
12 sis, cooked fruit notes were identified as 3-methyl-2,4-nonanedione, gamma-nonalactone and gamma-deca
13 the preparation of the regioisomer (S)-N(1)-methyl-2-[2'-(3''-methoxy-4''-hydroxyphenyl)ethyl]-1,2,3
14 ctural revision of (-)-galipeine to (S)-N(1)-methyl-2-[2'-(3''-methoxy-4''-hydroxyphenyl)ethyl]-1,2,3
15 fied from the headspace of infected hosts, 3-Methyl-2-buten-1-ol (prenol) and 3-Hydroxy-2-butanone (A
16 methoxy-poly (ethylene glycol)-block-poly (2-methyl-2-carboxyl-propylene carbonate-graft-SMART-graft-
17 y vinylogous aldol reaction between methyl-5-methyl-2-furoate and aldehydes or ketones is described.
18 Thus, we introduced the enantiopure (R)-2-methyl-2-isocyano-3-(tritylthio)propanoate as a novel cl
20 des fragilis, Sutterella, Lachnospiraceae, 4-methyl-2-pentanone, 1-butanol, and 2-butanone could disc
22 igorously with the standard slurry solvent N-methyl-2-pyrrolidinone (NMP), indicating it is not compa
23 clization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a hig
24 (0.86%), pregan,20-one-2hydroxy,5,6,epox-15-methyl (3.45%), hexa-decanoicacid (8.19%), 9,O-ctadeceno
27 crobial strains that produce either chiral 2-methyl-3-hydroxy acids (1.1 +/- 0.2 g L(-1)) or branched
28 her KR(0) domains is, as predicted, a (2R)-2-methyl-3-ketoacyl-ACP intermediate, came from a newly de
31 ty changes were confirmed using biotinylated methyl-3-nitro-4-(piperidin-1-ylsulfonyl) benzoate (NPSB
32 t hit compound, N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide (3, IC50 = 3 muM)
33 r of the roasted meat aroma, i.e., (2S,3R)-2-methyl-3-thioacetate tetrahydrofuran, is reported as wel
35 on of ethyl 3-(trimethylsilyl)propiolate and methyl 4-formylbenzoate shows first-order dependence on
36 and evaluation of N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (27, VU0424238)
38 ic spine morphology, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) to N-methyl-D-a
41 e compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and mam
42 Ac spine density and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediat
43 , lysosomes regulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor levels at the
44 elated with synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor
45 n primary dopaminergic neurons potentiated 1-methyl-4-phenyl pyrinidium (MPP(+))-induced neuronal dea
46 d, monkeys were rendered parkinsonian with n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and dy
49 ine dinucleotide, methylnicotinamide, and N1-methyl-4-pyridone-5-carboxamide, that can be used as val
53 , alpha-citral, hexanal, 3-hexen-1-ol, and 6-methyl-5-hepten-2-one; Fraction 2 was described as a "fr
54 tch induced by acidic citrate, but not alpha-methyl-5-hydroxytryptamine, chloroquine, compound 48/80,
55 the doubly vinylogous aldol reaction between methyl-5-methyl-2-furoate and aldehydes or ketones is de
58 we review the pro- and anti-viral effects of methyl-6-adenosine in distinct viral life cycles, the ro
59 e B. cereus sensu lato group produce CDP-3-C-methyl-6-deoxy sugars for the formation of cereose-conta
60 d confirmed the highly potent antiandrogen 4-methyl-7-diethylaminocoumarin (C47) and two derivatives
61 [h]chromen-4-yl)-2-methylpropyl benzoate and methyl 8-(2-(benzoyloxy)-ethyl)-hexahydro-4-((E)-pent-2-
62 -Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyri do[4',3':4,5]thieno[3,2
63 g synthetic pathways for production of alpha-methyl acids in Escherichia coli using these enzymes all
66 generated in ca. 90% yield on metathesis of methyl acrylate, styrene, or ethylene in the presence of
70 pretreated with non-AFXL (median, 2898 AU), methyl aminolevulinate-treated controls (median, 2254 AU
74 it of detection) to 7.3 ng/m(3) for azinphos-methyl, and < LOD to 0.8 ng/m(3) for azinphos-methyl-oxo
75 outdoor exposures to chlorpyrifos, azinphos-methyl, and oxygen analogs in a rural agricultural commu
76 hosphorus pesticides: chlorpyrifos, azinphos-methyl, and their oxygen analogs at 14 farmworker and 9
77 nternal and external double bonds, number of methyl- and ethyl- functional groups, molecular weight,
78 of 44 Michael acceptors and their calculated methyl anion affinities, particularly when solvation by
79 odel allowed us to show unambiguously that a methyl appears bigger than a chlorine and gave the follo
80 inol amide, and were completely prevented by methyl-arachidonoyl-fluorophosphate and palmostatin B, a
85 ,12-dioxoolean-1,9-dien-28-oate [bardoxolone-methyl (Bar-Me)] and methyl 2-trifluoromethyl-3,11-dioxo
86 Based on laboratory studies, we report that methyl benzoate (MB), a naturally-occurring compound in
87 Treatment of HSV-1-infected Vero cells with methyl beta-cyclodextrin from 2 to 9 h postentry reduced
88 and increased to approximately 79 pN/mum by methyl-beta-cyclodextrin treatment to sequester membrane
89 chromium (VI) and organic pollutants (using methyl blue (MB) as an example) removal, and the removal
93 hed and abandoning gas fumigation containing methyl bromide resulted in the recurrence of an almost f
94 This is related to a different gas product (methyl bromide, MeBr) removal mechanism, changing from c
95 renoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), are ligands of th
96 vitamin C from day 0 to day 6 of storage (3-methyl butane nitrile) and temperature (limonene) are id
97 hosphate (N(2) -alkyl-dGTP) derivatives with methyl, butyl, benzyl, or 4-ethynylbenzyl substituents w
99 d with a second peripheral (4-chlorobiphenyl)methyl (CBP) addition to the vancomycin disaccharide to
101 ifferent ingredients (guar, xanthan, carboxy methyl cellulose, locust bean gums, potato fiber, milk,
102 using ground-based measurements of methane, methyl chloroform, and the C(13)/C(12) ratio in atmosphe
104 NMR correlations, we have identified novel N-methyl-containing amines and amides, primary amides, and
105 der caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) that occur sporadic
112 Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex plays
113 Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome
114 isorder caused primarily by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes
117 The TET enzymes catalyze conversion of 5-methyl cytosine (5mC) to 5-hydroxymethyl cytosine (5hmC)
118 Here, we examine the genome-wide, C(5) -Methyl-cytosine (m5C) methylome and its correlation to g
123 vel glutamatergic compound that acts as an N-methyl-D-aspartate (NMDA) modulator with glycine-like pa
124 ethyl-4-isoxazole propionic acid (AMPA) to N-methyl-D-aspartate (NMDA) ratios, and matrix metalloprot
125 ne) has been used successfully to quantify N-methyl-d-aspartate (NMDA) receptor binding in humans.
126 nic motoneuron expression of glutamatergic N-methyl-D-aspartate (NMDA) receptors and decreased expres
129 netic approaches, we find that ablation of N-methyl-D-aspartate (NMDA) receptors during postnatal dev
131 totoxicity, mediated by overstimulation of N-methyl-D-aspartate (NMDA) receptors, is a mechanism that
132 aocular) unimNPs with the glutamate analog N-methyl-d-aspartate (NMDA), which is excito-toxic and ind
133 subset of antibody-positive patients, anti-N-methyl-d-aspartate receptor (5 patients), had normal MRI
134 nd are linked to underlying dysfunction of N-methyl-D-aspartate receptor (NMDAR)-mediated neurotransm
135 tibodies-especially antibodies against the N-methyl-D-aspartate receptor (NMDAR)-more commonly than d
137 ggests a single sub-anesthetic dose of the N-methyl-D-aspartate receptor antagonist ketamine may work
139 ations for understanding D-serine-mediated N-methyl-D-aspartate receptor plasticity in the amygdala a
141 st common and was predicted best when both N-methyl-D-aspartate receptor-IgG and aquaporin-4-IgG coex
142 ferences in the pharmacological profile of N-methyl-d-aspartate receptors (NMDAR) in the NAc core, TL
143 interaction between synaptic activation of N-methyl-D-aspartate receptors (NMDARs) and intrinsic osci
144 synaptic accumulation of GluN2B-containing N-methyl-D-aspartate receptors (NMDARs) and pathological p
148 ent firing of 'Delay cells' is mediated by N-methyl-d-aspartate receptors and weakened by cAMP-PKA-po
151 ited by MK-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and th
155 were the 6-methoxy, 6-methylsulfanyl, and 6-methyl derivatives, which were highly active to cancer c
158 tion with S-adenosylmethionine, the reactive methyl donor, and by reaction with alkylating agents.
159 urthermore, bacterially induced reduction of methyl-donor availability influenced global DNA methylat
161 yl-thiophene) (P3HT)-phenyl-C61-butyric acid methyl ester (PCBM) mixture, and found to predict morpho
162 matic polyketide natural product zincophorin methyl ester has attracted significant attention from sy
164 400 admixture combinations for the oxidative methyl esterification of 1-octanol at 60 degrees C in me
165 ethane" ((13)C-TrEnDi), which results in the methyl esterification of all acidic sites and the conver
167 L/h and a process yield of 0.27 g-fatty acid methyl esters/g-glucose, which constitutes a 25% improve
168 er 3-(1H-imidazol-4-yl)propyl-(4-iodophenyl)-methyl ether (iodoproxyfan), which are strongly consiste
169 a blend formation with poly(ethylene glycol) methyl ether (mPEG) to prevent its leaching out from the
170 ortho-, meta- and para-Hydroxymethylaniline methyl ethers 3-5-OMe and acetyl derivatives 3-5-OAc wer
171 solvent free strategy to functionalize aryl methyl ethers through direct nucleophilic substitution o
172 ludes the use of benzyl methyl ethers, vinyl methyl ethers, and unbiased anisole derivatives, thus re
173 wide scope, which includes the use of benzyl methyl ethers, vinyl methyl ethers, and unbiased anisole
174 phenone-3, bisphenol A, the sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol,
176 methyl farnesoate, and that the presence of methyl farnesoate stimulates dissociation of Met multime
177 highly dynamic in controlling the action of methyl farnesoate through temporal variation in its expr
178 et proteins self-associate in the absence of methyl farnesoate, and that the presence of methyl farne
181 mpounds, carotenoids, organic acids, hydroxy methyl furfural (HMF) and other quality parameters of to
182 tigated in the presence of gallic acid (GA), methyl gallate (MG), MG/GA combinations (75:25, 50:50, a
183 zylglutathione cyclopentyl diester (pBBG) or methyl-gerfelin (MeGFN)) reduced immobility in the TST a
184 bone H-bond impairing modifications (alpha)N-methyl Gln or l-Pro at key positions within betaHP.
186 cence and excellent photostability, (b) an N-methyl group at each end of the squaraine core that ensu
187 hat results from the enzymatic addition of a methyl group at the fifth carbon of the cytosine base.
190 the KMT family catalyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine r
192 isotope effect), whereas deuteration of the methyl group induces a normal secondary isotope effect.
196 y to overcome this obstacle is to remove the methyl group on these modified bases prior to cDNA synth
197 ed set of genes encoding the upper branch of methyl group oxidation to CO2 as well as membrane-bound
198 substitution at a bridgehead position with a methyl group produced a quadricyclane that thermally rev
199 rsible synthesis of acetyl-CoA from CO and a methyl group through a series of nickel-based organometa
201 only catalyzes sequential methylations of a methyl group to form ethyl and isopropyl groups but rema
202 cterized protein that oxidizes the pyocyanin methyl group to formaldehyde and reduces the pyrazine ri
205 lex regulatory feedback network between free methyl groups and genomic imprinting at birth.-Tserga, A
207 The nitroxides are designed to have the methyl groups further away from the N-O spin site to dec
208 possesses four mPEG-3 groups replacing four methyl groups in the tert-butyl groups at the 3- and 6-p
209 he distance between the nitroxide moiety and methyl groups is effective in lengthening Tm at T > 70 K
210 acking motif with the electron-poor ammonium methyl groups occupying the electron-rich cavity of the
213 m (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, which facilitated (1)H/(13)C methyl TROSY
215 the fast and reversible deuteration of the 2-methyl H of the imidazolium cation followed by D transfe
216 ard selective monohalogenation of methane to methyl halides or their in situ oligomerization to highe
218 xytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as homovanillyl alcoho
219 tions with methane that result in a discrete methyl intermediate where the formal oxidation state (FO
223 des along with their (omega)-linked or alpha-methyl isomers and ethanolamide derivatives, as well as
224 oliar applications of phenylalanine (Phe) or methyl jasmonate (MeJ) could improve the synthesis of se
227 on whitebark pine needles demonstrated that methyl jasmonate (MeJA)-triggered transcriptome re-progr
228 ichomes under normal conditions, addition of methyl jasmonate, a biotic stress hormone, induced expre
229 neral process that involved a 12,13-olefinic methyl ketone as a starting material obtained by ozonoly
233 nt cysLT) or the selective CysLT2R agonist N-methyl LTC4 to allergen sensitized wild-type mice marked
234 os, pups and dams were collected for choline/methyl metabolite measurements, immunoblotting or gene e
236 ased monomers and the photopolymerization of methyl methacrylate and made it possible to determine th
237 ulk polymerization using methacrylic acid or methyl methacrylate as monomer and ethylene glycol dimet
239 ces, i.e., nitrocellulose, polystyrene, poly(methyl methacrylate), and poly(butyl methacrylate), poly
240 noethyl methacrylate, butyl methacrylate and methyl methacrylate, E) to enhance vancomycin encapsulat
241 e determined the mutation spectrum caused by methyl methanesulfonate (MMS), and showed that MMS also
242 oped in this study, the reactivity between S-methyl methanethiosulfonate (MMTS) with persulfide was u
244 el human mitochondrial KMT that introduces a methyl modification into a metabolic enzyme and whose ac
245 distinct viral life cycles, the role of 2' O-methyl modifications in RNA stability and innate immune
246 N)2Cu(II)2(O2(2-))](2+) ((S)P(MeAN), MeAN: N-methyl-N,N-bis[3-(dimethylamino)propyl]amine) that featu
249 an active component of Cassia seed, in an N-methyl-N-nitrosourea (MNU)-induced mouse model of RP.
255 s sp. based optical microplate biosensor for methyl parathion (MP) was good as it detected multiple s
257 d 21 healthy individuals (HC) received alpha-methyl-paratyrosine (AMPT) over 24 h to achieve catechol
258 )F-fluoronicotinamid o)butanamido)butanamido)methyl)phenyl)-3-(naphthalen-2-ylmethyl)-1,4,12-trioxo-2
259 In nitrogen, protonated forms of dimethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MP
260 ile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxi
261 ms of dimethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MPA) exhibit the reduced mobilit
262 is worldwide, produces a CPS with a unique O-methyl phosphoramidate (MeOPN) modification on specific
263 hin in the muscle of mdx mouse through a 2'O-methyl phosphorothioate-mediated splicing modulation.
264 bPs, [3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methylphosphonic acid, exhibited Ki value
265 nt couplings of the unpaired electron to the methyl protons that shorten Tm at T > 70 K in currently
266 sence of six odour-active compounds, being 2-methyl pyrazine the key aroma compound of this beverage.
267 rded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]pyridin-3-amine, VA012), which exhibited dose-dep
268 and (R)-2-(1-((2,3-dihydro-1H-imidazol-2-yl)methyl)pyrrolidin-3-yl)-5-fluoro-1H-benzo [d]imidazole (
271 rometry (MS)-assisted strategy to assign the methyl resonances of methionine residues is presented.
274 idual components elicited varying responses; Methyl salicylate (MeSA) elicited the highest positive c
275 Exposure to methyl jasmonate (MeJA) and methyl salicylate (MeSA) vapours at 10 and 100micromoll(
279 e genome-wide DNA methylation analysis using methyl-sequencing to measure changes between normal and
280 iloxane (D5, C10H30O5Si5), a cyclic volatile methyl siloxane (cVMS) found in consumer products, was s
284 of which JJC8-016 (N-(2-((bis(4-fluorophenyl)methyl)thio)ethyl)-3-phenylpropan-1-amine) was selected
285 , but lengthening the amine substituent from methyl to ethyl, propyl, and butyl produced a stepwise d
286 o catalyze unconventional reactions, such as methyl transfer to electrophilic carbon atoms, sulfur to
287 ue of VTE4 (which encodes a gamma-tocopherol methyl transferase converting gamma-tocopherol into alph
288 an et al. found that mutation of the histone methyl transferase SEDT2 affects alternative splicing fa
289 ed that copy number elevations of catechol-O-methyl-transferase (COMT) or Tbx1, two genes encoded in
291 millions of years, driven by CG-specific DNA methyl transferases and spontaneous methyl-cytosine deam
292 ), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl
294 midate salt protecting strategy that employs methyl trifluoromethanesulfonate as a reversible alkylat
295 methyl groups, which facilitated (1)H/(13)C methyl TROSY NMR measurements with opposing ligands.
300 rein are the naturally occurring benzofurans methyl wutaifuranate, wutaifuranol, wutaifuranal, their
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