ライフサイエンスコーパス: methyl CpG binding domain

1 homology to MBD2 and MBD3, but it lacks the methyl-CpG binding domain.

2 MBD3 and 38% identical to MBD2 but lacks the methyl-CpG binding domain.

3 eins (MBD2, MBD3, and MBD4) that contain the methyl-CpG binding domain.

4 homology to MBD2 and MBD3, but it lacks the methyl-CpG-binding domain.

5 are closely related proteins with consensus methyl-CpG binding domains.

6 Methyl-CpG-binding domain 1 (MBD1) belongs to a family o

7 We show that methyl-CpG-binding domain 1 (MBD1), a DNA methylation "r

8 RNA expression of brain and liver Dnmt3a and methyl CpG-binding domain 2 (Mbd2) protein as well as ce

9 ort alternative mRNA splicing variant of the methyl-CpG binding domain 2 gene, isoform MBD2c.

10 sine-binding protein complex 1 that contains methyl-CpG-binding domain 2 protein (MBD2) in electropho

11 We demonstrate a key role for the protein methyl-CpG-binding domain-2 (Mbd2), which links DNA meth

12 Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex plays

13 nd G-U mismatches are also substrates of the methyl-CpG binding domain 4 (Mbd4) glycosylase.

14 Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair

15 ermore, analyses of incorporated FdUrd using methyl-CpG-binding domain 4 glycosylase indicated that t

16 We identified a single gene, methyl-CpG-binding domain 5 (MBD5), as the only locus th

17 The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove t

18 action sites for partner macromolecules: the methyl-CpG binding domain and the NCoR/SMRT interaction

19 are transcriptional repressors that contain methyl-CpG binding domains and are components of a CpG-m

20 MBD2 and MBD3 are two proteins that contain methyl-CpG binding domains and have a transcriptional re

21 unrelated mammalian protein that contains a methyl-CpG binding domain, can also efficiently remove t

22 A methyl-CpG binding domain column isolates methylated GC-

23 a library of mouse whole CpG islands using a methyl-CpG binding domain column.

24 tastasis-associated protein 1, MTA2, and the methyl-CpG-binding domain-containing protein, MBD3, were

25 MBD1, a member of the methyl-CpG-binding domain family of proteins, has been r

26 isordered MeCP2 protein is restricted to the methyl-CpG binding domain; however, at least four region

27 The mammalian repair protein MBD4 (methyl-CpG-binding domain IV) excises thymine from mutag

28 MeCP2 binds to chromocentric DNA through its methyl CpG-binding domain (MBD) to regulate gene express

29 s two DNA binding domains, an amino-proximal methyl-CpG binding domain (MBD) and a C-terminal mismatc

30 NA interactions is that only proteins with a methyl-CpG binding domain (MBD) can interact with methyl

31 lecting fragments with a high affinity for a methyl-CpG binding domain (MBD) column.

32 Since members of the methyl-CpG binding domain (MBD) family of proteins recru

33 syndrome mutations at known sites within the methyl-CpG binding domain (MBD) impair binding to methyl

34 odifications were assayed for binding to the methyl-CpG binding domain (MBD) of one member of the MBP

35 The methyl-CpG binding domain (MBD) of the transcriptional r

36 ng with a RTT-causing mutation in either the methyl-CpG binding domain (MBD) or the transcriptional r

37 Methyl-CpG binding domain (MBD) proteins play an essenti

38 It has been recognized that methyl-CpG binding domain (MBD) proteins play an importa

39 of chromatin remodeling complexes containing methyl-CpG binding domain (MBD) proteins.

40 hylation has been proposed to be mediated by methyl-CpG binding domain (MBD) proteins.

41 The gene for MeCP2 has been cloned and a methyl-CpG binding domain (MBD) within it has been defin

42 comprise a family of proteins that contain a methyl-CpG binding domain (MBD).

43 Proteins containing a methyl-CpG-binding domain (MBD) bind methylated DNA and

44 Like other members of the methyl-CpG-binding domain (MBD) family, MeCP2 functions

45 from DNMT1, CGBP (CFP1), and MBD1, or with a methyl-CpG-binding domain (MBD) from MBD1.

46 Transfection of a MED1 mutant lacking the methyl-CpG-binding domain (MBD) is associated with micro

47 Within MeCP2, the methyl-CpG-binding domain (MBD) is the primary determina

48 P1 transcription was mediated in part by the methyl-CpG-binding domain (MBD) protein MBD2.

49 but mediates the ubiquitination of MeCP2, a methyl-CpG-binding domain (MBD) protein.

50 Canonical Methyl-CpG-binding domain (MBD) proteins are important i

51 stable gene repression, mediated in part by methyl-CpG-binding domain (MBD) proteins that recruit co

52 e defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyl

53 the molecular basis of their recognition by methyl-CpG-binding domain (MBD) proteins.

54 d transcription levels occurs via binding of methyl-CpG-binding domain (MBD) proteins.

55 In the presence of the MeCP2 methyl-CpG-binding domain (MBD), however, DNA methylatio

56 , although a family of proteins containing a methyl-CpG-binding domain (MBD), of which MeCP2 is the b

57 yl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD).

58 hyl-CpGs exposed in the major groove via the methyl-CpG-binding domain (MBD).

59 he number and variety of proteins containing methyl-CpG binding domains (MBDs) that are encoded in an

60 reted by protein factors that contain shared methyl-CpG-binding domains (MBDs).

61 ected an association with a highly conserved methyl-CpG-binding domain missense variant, p.79Gly>Glu

62 homology domain of Dnmt3a interacts with the methyl CpG binding domain of Mbd3 and with both bromo an

63 We report that the methyl CpG binding domain of MeCP2 (MBD) greatly enhance

64 The MBD1-CAF-1 p150 interaction requires the methyl-CpG binding domain of MBD1, and the association o

65 ecipitation of methylated DNA by recombinant methyl-CpG binding domain of MBD2 protein and sequencing

66 Furthermore, the methyl-CpG binding domain of MBD4 binds preferentially t

67 We find that the methyl-CpG-binding domain of MBD1 binds more efficiently

68 Mellen et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydrox

69 issense mutations were located either in the methyl-CpG-binding domain or in the transcription repres

70 Helper T cells from methyl CpG-binding domain protein-2-deficient mice exhib

71 The methyl-CpG binding domain protein (MBD4) that is pivotal

72 DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.

73 We also observed occupancy of methyl-CpG binding domain protein 3 (MBD3), a subunit of

74 G modification and capable of binding to the methyl-CpG binding domain protein 4 (MBD4) are able to i

75 The BER enzyme methyl-CpG binding domain protein 4 (MBD4) has been link

76 Within the nucleus, FADD interacted with the methyl-CpG binding domain protein 4 (MBD4), which excise

77 The mammalian DNA glycosylase--methyl-CpG binding domain protein 4 (MBD4)--is involved

78 h-specific thymine-DNA glycosylase (Tdg) and methyl-CpG binding domain protein 4 can both excise urac

79 interactions between Dnmt3b and both Tdg and methyl-CpG binding domain protein 4.

80 The use of paramagnetic beads linked to methyl-CpG binding domain protein allowed separation of

81 target a specific sequence of dsDNA, while a methyl-CpG binding domain protein attached to the comple

82 LN promoter hypermethylation and reduces the methyl-CpG binding domain protein binding to RELN and GA

83 Here, we identified the methyl-CpG-binding domain protein 1 MBD1 as a physical a

84 ylation of the CpG island and the binding of methyl-CpG-binding domain protein 2 (MBD2) and DNA methy

85 a MeCP1-like protein complex that contained methyl-CpG-binding domain protein 2 (MBD2) and Sp3.

86 Methyl-CpG-binding domain protein 2 (MBD2) is a transcri

87 NA methyl-transferases (DNMTs) 3a and 3b and methyl-CpG-binding domain protein 2 (MBD2) to the Ankrd2

88 cing event is regulated by overexpression of methyl-CpG-binding domain protein 2 (MBD2), a key mediat

89 ry network with a possible contribution from methyl-CpG-binding domain protein 3 (MBD3).

90 chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spe

91 We used methyl-CpG-binding domain protein-enriched genome sequen

92 a CHD3 protein, a histone deacetylase, and a methyl-CpG-binding domain protein.

93 ylated one in UOK181, is associated with the methyl CpG binding domain proteins (MBDs), MBD2 and MeCP

94 tionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone de

95 tment to methylated cytosines of a family of methyl-CpG binding domain proteins (MBDs), which are dir

96 romoters express an increased recruitment of methyl-CpG binding domain proteins.

97 Methyl-CpG-binding domain proteins 2 and 3 (MBD2 and MBD

98 of novel DNA methyltransferase (SmDnmt2) and methyl-CpG-binding domain proteins mirrors the detection

99 family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-CpG-binding domain that has a specific affinity f

100 r acting at CpG sites depends largely on its methyl-CpG-binding domain, which binds preferably to G.T