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1 lectronic effects of the fluorination at the methyl group.
2 acids that differ only by the position of a methyl group.
3 between the tryptophan and the hydroxamate's methyl group.
4 flexibility of the side chain imposed by the methyl group.
5 own the fatty acid chain toward the terminal methyl group.
6 2) an axial 4alpha-OMe group, and (3) a C-18 methyl group.
7 n arginine and a glutamate interact with the methyl group.
8 l core, and (d) the presence of a terminal N-methyl group.
9 together but when they are separated by one methyl group.
10 st likely be attributed to the exchange of a methyl group.
11 tional ZF interacts with a conserved thymine methyl group.
12 s, in which one of the substituents is not a methyl group.
13 hobic interactions with the methylcytosine 5-methyl group.
14 vital interactions through its beta-branched methyl group.
15 e trifluoromethyl group in comparison to the methyl group.
16 a 4-fluorophenyl moiety substitutes for the methyl group.
17 substrates in which the olefin bears a beta-methyl group.
18 ety that include either a trifluoromethyl or methyl group.
19 ffect favoring hydrogen abstraction from the methyl groups.
20 l toluene with all three H isotopes in their methyl groups.
21 sion of key genes to minimize loss of labile methyl groups.
22 ibly converted to betaine, a major source of methyl groups.
23 thyl group to mRNA while demethylases remove methyl groups.
24 stallation of radioactive and stable labeled methyl groups.
25 those of the alpha-methylene, beta- or gamma-methyl groups.
26 easuring of crucial distances between and to methyl groups.
27 " between the hypercoordinate carbon and its methyl groups.
28 ly measure the significance of the beta-face methyl groups.
29 Ms, including phospho, acetyl, ubiquityl and methyl groups.
30 near-depending on the stereochemistry of the methyl groups.
31 ain ten contiguous, stereochemically defined methyl groups.
32 lecule: the BCO, the C19 methoxy and the C18 methyl groups.
33 2-amino/hydroxy nitrobenzenes and activated methyl groups.
34 onds by main-group reagents occur at aryl or methyl groups.
35 tert-butyl substituents on the ligands with methyl groups.
36 m of transferring moieties other than simple methyl groups.
37 the C(sp(3))-H bonds of one of the prochiral methyl groups.
38 , resulting in the four spatially equivalent methyl groups.
39 ne interactions between the alpha- and gamma-methyl groups.
40 tution with a 2-fluoro-4-chloro-phenyl- or a methyl- group.
41 a,b), 3-methyl (6a,b), and both the 3- and 4-methyl group (7a,b) and compared their opioid receptor p
42 studies showed the two subtypes with an N-1 methyl group (9 and 10) inhibited RNase H in low micromo
43 mber and position of hydroxyl, glycosyl, and methyl groups about their aromatic core structure produc
45 including carboxyl, N-acetyl, fluorine, and methyl groups affect stacking interactions with aromatic
46 preclude Watson-Crick base pairing, the N(6)-methyl group alters the stability of RNA secondary struc
47 is the result of a steric clash between the methyl group and a highly ordered water network in the a
49 ify the amount of information stored by each methyl group and show that receptors consume energy in t
51 lex regulatory feedback network between free methyl groups and genomic imprinting at birth.-Tserga, A
52 choline-deficient (MCD) diet, which depletes methyl groups and results in a deleterious decrease in t
53 arent kinetic isotope effects related to the methyl group are more pronounced than for the methylene
54 ecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious st
56 (CH3)(Cl)Si(ONO(Q)), in which the phenyl and methyl groups are mutually trans, indicating that the ob
61 e metabolites [produced when choline-derived methyl groups are used by phosphatidylethanolamine N-met
65 ith heterocyclic aromatic rings and attached methyl groups (as on thymine) are particularly favorable
66 y analysis indicate that introduction of the methyl group at C-7 results in a significant deviation f
67 ween the methyl group at C3 in IPP and the Z-methyl group at C3 in DMAPP (3-OPP) and GPP (4-OPP), res
68 lic diphosphates with a C-C bond between the methyl group at C3 in IPP and the Z-methyl group at C3 i
69 cence and excellent photostability, (b) an N-methyl group at each end of the squaraine core that ensu
71 ed that the placement of a single side chain methyl group at specific positions in a traptamer determ
72 hat results from the enzymatic addition of a methyl group at the fifth carbon of the cytosine base.
74 t C1 and C1' or lack the naturally occurring methyl group at those positions were synthesized and eva
76 e, which displays C8-C6' coupling and four O-methyl groups at C6, C7, C3', and C4' as numbered on the
77 n of the pyrimidine, so each of them has two methyl groups at nucleotide positions 1 and 5 from the 5
78 dimethylallyl derivatives bearing deuterated methyl groups at the distal (C3) carbon atom in the doub
79 polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysa
82 bstitution patterns of organic compounds the methyl group attracts one of the phenyl sides to establi
85 AM and the abstraction of hydrogen from this methyl group by 5'-deoxyadenosyl radical that initiates
86 cytosine methylation, iterative oxidation of methyl group by TET dioxygenases, and restoration of unm
87 onbridging phosphate oxygens at A2662 with a methyl group by the introduction of a methylphosphonate
88 TMD interactions, demonstrate that a single methyl group can dictate specificity, and define the min
91 serve surface adsorbates, hydrogen atoms and methyl groups, chemisorbed to the nanowire sidewall and
94 analysis the extraterrestrial origin of the methyl group (delta(2)H +800 to +1100 per thousand, delt
95 , reactions with CdMe2 produce surface bound methyl groups (delta = 0.4 ppm, 0.04-0.22 nm(-2)) that p
101 diated by (1)H-(13)C cross-relaxation within methyl groups due to reorientation dynamics, and results
105 this pathway cleaves acetyl-CoA to donate a methyl group for production of methyl-tetrahydrofolate (
109 regnant women also used more choline-derived methyl groups for PC synthesis via phosphatidylethanolam
111 thymidylate synthesis, and the provision of methyl groups for synthetic, regulatory, and epigenetic
112 synthetic efficiency, deletion of one ortho-methyl group from o,o',o'',o'''-tetramethylbiaryl junctu
113 rase (HNMT) inactivates HA by transferring a methyl group from S-adenosyl-l-methionine to HA, and is
114 s aquaticus that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the N6 posi
115 the KMT family catalyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine r
116 Ma) and NifB(Mt) can catalyze the removal of methyl group from SAM and the abstraction of hydrogen fr
117 ow that PaMTH1 catalyzes the transfer of the methyl group from SAM to one hydroxyl group of the myric
118 ome substrates to catalyze the transfer of a methyl group from SAM to the epsilon-amino group of hist
119 rase 1 (NTMT1) catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine to the pro
120 The NirE enzyme catalyses the transfer of a methyl group from the SAM to uroporphyrinogen III and se
122 stone deacetylase 3 (HDAC3) gene by removing methyl groups from dimethylated H3K36 at the HDAC3 promo
123 These enzymes catalyze the transfer of donor methyl groups from the cofactor S-adenosylmethionine to
124 -ketoglutarate-dependent demethylases remove methyl groups from tri- and dimethylated lysine 4 of his
125 Polycomb-mediated gene silencing by removing methyl groups from trimethylated histone H3 lysine 27 (H
126 f-function (GOF)], apparently by placing its methyl group further inward and receiving stronger water
127 The nitroxides are designed to have the methyl groups further away from the N-O spin site to dec
128 tain a benzene ring and multiple side methyl methyl groups (galaxolide, 4-MBC) required high energy i
129 s of buprenorphine in which the standard C20-methyl group has been moved to the C7beta position, resu
132 ii) a similar cyclization with a loss of the methyl group; (iii) a tandem process of cyclization into
133 iguously to an electronic effect by the para-methyl group in 1b, which increases the contribution of
134 Several naphthalene compounds containing a methyl group in a 1,8-relationship to a metal-complexed
135 ands enables the sequential diarylation of a methyl group in an alanine derivative with two different
136 e that highlights the importance of a single methyl group in biasing the conformation in the acyclic
138 CH...O) hydrogen bonds coordinate the AdoMet methyl group in different methyltransferases irrespectiv
139 d benzylsulfanopyridinium amidates bearing a methyl group in position 6 with 2 equiv of diphenylketen
140 onal barrier of the phenyl ring nearby the N-methyl group in rac-2A was estimated to be >> 18.1 kcal/
141 enyl ring is slightly closer to the naphthyl methyl group in the complexes than in their metal-free c
142 w that a minor change, the introduction of a methyl group in the delta position, results in a signifi
143 e created new amino acids that incorporate a methyl group in the gamma-position of the stapling amino
145 labeling studies confirmed the origin of the methyl group in the methanol product is the iridium-meth
147 hat 5-methylcytosine and thymine both have a methyl group in the same position, 5-carbon of the pyrim
148 ular hydrogen atom abstraction from benzylic methyl groups in 3, followed by intermolecular hydrogen
149 e that is involved in the removal of two C-4 methyl groups in one of the later steps of cholesterol b
155 possesses four mPEG-3 groups replacing four methyl groups in the tert-butyl groups at the 3- and 6-p
158 isotope effect), whereas deuteration of the methyl group induces a normal secondary isotope effect.
160 voring the desired atropisomer in which this methyl group interacts with the S2 pocket of FVIIa.
161 enzo[g]indoles with [1,3] migration of the N-methyl group into the newly formed pyrrole ring; (ii) a
163 s an epigenetic modification of DNA, where a methyl group is added at the fifth carbon of the cytosin
165 urther experiments demonstrated that the C-7 methyl group is not derived from methionine and that met
167 f substituents on the signal of the naphthyl methyl group is small but discernible in the uncomplexed
168 al theory calculations indicate that the SAM methyl group is sterically constrained in complex with N
171 he distance between the nitroxide moiety and methyl groups is effective in lengthening Tm at T > 70 K
172 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholin
174 ding suggesting that hydrophobicity of the T-methyl group likely plays a minor role in protein bindin
175 ored by observing the (1)H NMR signal of the methyl group located in the shielding zone of the ring.
176 yldialkylamines show a strong preference for methyl group loss by displacement, as predicted by compu
178 anding of the contribution that the 3- and 4-methyl groups make to the pure antagonist properties of
179 eplacing the transferring hydrogen atom by a methyl group makes the substrate inactive and hence conf
182 Solvation of the fibrils does not affect methyl group motions within the hydrophobic core of indi
183 isms by which these unactivated atoms obtain methyl groups nor the actual methyl donors are conserved
184 acking motif with the electron-poor ammonium methyl groups occupying the electron-rich cavity of the
185 howed that inversion of configuration at the methyl group occurs when the chiral toluenes react with
189 side chain of Glu446 is known to contact the methyl group of 5-methylcytosine (5mC) or thymine (5-met
191 iD is a radical SAM enzyme that converts the methyl group of BChlide c or d into the formyl group of
194 and 2 equiv from C-H bond activation of one methyl group of each of the isopropyl groups at the 2- a
195 A methyltransferase responsible for the N(6)-methyl group of m(6)t(6)A in tRNA(Thr) specific for ACY
198 ynaphthalen-2-yl)butanoic acid (in which the methyl group of R-naproxen was replaced by an ethyl grou
200 e of SAM1 and the other two hydrogens of the methyl group of SAM2 appear in the methylated product.
201 show that a hydrogen is transferred from the methyl group of SAM2 to the 5'-deoxyadenosine of SAM1 an
204 addition to Sc horizontal lineNimide) with a methyl group of the NacNac(NMe2) ligand forming {MeC(NC6
206 for radical-mediated C-C bond formation; the methyl group of toluene is positioned between fumarate a
207 toluene metabolism by adding fumarate to the methyl group of toluene to yield (R)-benzylsuccinate.
208 tention or inversion of configuration at the methyl group of toluene, we synthesized both enantiomers
210 ith selective isotope labeling of the delta1 methyl groups of isoleucine side chains demonstrates tha
211 ally protonated amino acid moieties, such as methyl groups of isoleucines, valines, or leucines.
212 to probe the reorientation of the isopropyl methyl groups of l-leucine at the air-water interface.
213 en peroxide and ascorbic acid as reagents, S-methyl groups of organosulphur compounds are efficiently
214 is enforced by the steric clash between the methyl groups of the arene ligand and the phenyl rings o
216 MR relaxation dispersion measurements of the methyl groups of the Ile, Leu, and Val residues at two s
220 ffering only by the presence or absence of a methyl group on the alpha-carbon, (S)-2-amino-7-[(18)F]f
224 ate as the sole carbon source, the resulting methyl group on the pterin was predominantly labeled wit
225 y to overcome this obstacle is to remove the methyl group on these modified bases prior to cDNA synth
226 traints show that the interaction energy for methyl groups on homochiral molecules differs significan
228 The propargyl alcohol and the two terminal methyl groups on the olefinic unit shape the cyclization
230 s for tetrahydrofolate-linked oxidation of a methyl group originating from a methylated corrinoid pro
231 l cofactor that during catalysis transfers a methyl group originating from S-adenosyl-l-methionine.
233 n favors predominantly the C-H bonds of beta-methyl groups over the unactivated methylene C-H bonds.
234 lectivity by favoring the C-H bonds of alpha-methyl groups over those of the alpha-methylene, beta- o
236 ed set of genes encoding the upper branch of methyl group oxidation to CO2 as well as membrane-bound
238 adopts a rotated conformation in which the 5-methyl group points into the minor groove, rather than t
239 he rigid compounds also suggested that the 3-methyl group present in compound 1 type antagonists may
240 substitution at a bridgehead position with a methyl group produced a quadricyclane that thermally rev
242 by incorporation of P1' alkyl sulfone and P2 methyl groups provided a macrocycle with TF/FVIIa Ki = 1
244 According to IR and solid-state NMR, the methyl group remains intact, and does not evolve spontan
245 spectively), proceeds via oxidation of the N-methyl group, resulting in the release of formaldehyde.
246 In addition, while free rotation of the beta-methyl group results in a single, averaged gamma-H atom
247 (KDM4A-KDM4D), which selectively remove the methyl group(s) from tri/dimethylated lysine 9/36 of H3,
249 n of PAAs was related to the position of the methyl group, showing the same isomer specific preferenc
250 depend, as predicted by calculation, on its methyl group substitution pattern, making 3 by some way
251 phoethanolamine methyltransferases add three methyl groups successively to their substrate to produce
252 er, these results indicate that removal of a methyl group switches PK11195 from a potent antagonist o
253 ns 1 and 5 from the 5 end, resulting in four methyl groups symmetrically positioned in duplex DNA.
254 jos-Parrish ketone isomers with a transposed methyl group (termed "iso-Hajos-Parrish ketones") would
255 tion is predicted to be more in favor of the methyl group than the methylene of the pentyl chain, in
256 precursor and hydrogen abstraction from this methyl group that initiates the radical-based precursor
257 e leads to the selective transformation of a methyl group that is adjacent to an unprotected secondar
258 ing-tunneling microscopy showed well-ordered methyl groups that covered nearly all of the surface.
259 rexinoid, which induced hyperlipidemia, had methyl groups that interacted with helix 7 residues of t
261 rsible synthesis of acetyl-CoA from CO and a methyl group through a series of nickel-based organometa
262 at is involved in subsequent transfer of its methyl group to 5 or 8, H2O, and other nucleophilic comp
265 B12/rSAM enzyme, catalyses the transfer of a methyl group to an electrophilic carbon atom of tryptoph
266 nsecutive hydroxylation reactions of the C-7 methyl group to form a geminal diol intermediate, which
267 only catalyzes sequential methylations of a methyl group to form ethyl and isopropyl groups but rema
268 cterized protein that oxidizes the pyocyanin methyl group to formaldehyde and reduces the pyrazine ri
271 Subsequent steps entail conversion of the 1-methyl group to the 1-(dimethoxymethyl) unit and acid-ca
272 common mRNA modification, the addition of a methyl group to the N(6) position of adenosine (m(6)A),
273 mediates to drive hydrogen transfer from the methyl group to the terminal oxygen, followed by dissoci
275 novo DNA methyltransferases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated
280 ) kinetic isotope effects at the transferred methyl group, together with (1)H3/(3)H3 binding isotope
282 to form a methyl Pt(IV)-OOH species with the methyl group trans to the pyridine nitrogen, which then
285 asis of these studies, a mechanism involving methyl group transmetalation between Pd(II) and Pd(IV) i
287 redominant preference for sp(3) C-H bonds of methyl groups via a five-membered ring intermediate over
288 rence for activating sp(3) C-H bonds of beta-methyl groups, via a five-membered ring intermediate, ov
290 A derivative of HMPA in which one of the methyl groups was substituted by a CH2CH2OH unit was syn
291 eriments performed on selectively deuterated methyl groups, we probed the 3-fold symmetric and 2-fold
292 laxation performed on selectively deuterated methyl groups, we probed the dynamics in the threefold s
293 A total of 96 patients in the bardoxolone methyl group were hospitalized for heart failure or died
294 d baseline circulating glycoprotein N-acetyl methyl groups were associated with longitudinal risk of
296 e of the incident light, indicating that the methyl groups were bonded directly atop surface Ge atoms
298 ed to 1, possibly due to the presence of the methyl group, which allows favorable hydrophobic and van
299 m (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, which facilitated (1)H/(13)C methyl TROSY
300 e, we study how AP-1 and Zta recognize these methyl groups within their cognate response elements.
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