ライフサイエンスコーパス: methylase

1 in" VI that clearly encodes a viral mRNA cap methylase.

2 to RNA polymerase and ectopic bacterial dam methylase.

3 t this region is necessary for binding PRMT1 methylase.

4 rm82, is the non-catalytic subunit of a tRNA methylase.

5 ly assayed DNA-modifying activity of hDNMT3a methylase.

6 d the unusual protective role of the LlaKR2I methylase.

7 a coli DNA despite the presence of the EcoRI methylase.

8 tially applying bisulfite PCR and SssI (CpG) methylase.

9 ion and is modulated by PapI and DNA adenine methylase.

10 st other SET proteins, is exclusively a mono-methylase.

11 a homologue of the mammalian SUV39H1 histone methylase.

12 s from BclI restriction endonuclease and dam methylase.

13 hion by the OxyR-DNA binding protein and Dam methylase.

14 ere methylated with the bacterial SssI (CpG) methylase.

15 ion of the endonuclease from the independent methylase.

16 lasmid vectors in the absence of the cognate methylase.

17 hal to E. coli in the absence of the cognate methylase.

18 from methylation by the Escherichia coli dam methylase.

19 y using cellular expression of a prokaryotic methylase.

20 aldococcus jannaschii is likely this missing methylase.

21 an open reading frame (ORF) encoding an rRNA methylase.

22 off early, preventing excessive synthesis of methylase.

23 gulated methylases that include Dam and CcrM methylases.

24 s the structural motifs usually required for methylases.

25 repressors such as histone deacetylases and methylases.

26 ne the DNA substrate preferences of cytosine methylases.

27 ily of predicted archaeal and bacterial rRNA methylases.

28 scribe a new class of recently discovered RS methylases.

29 during the life cycle and are candidate DNA methylases.

30 ins are likely to function as small-molecule methylases.

31 s217-mediated guanylyl transfer, and an open methylase-1 domain for SAM binding and methyl transfer.

32 n the egg cell depends on DOMAINS REARRANGED METHYLASE 2 (DRM2) and RNA polymerase V (Pol V), two mai

33 hionine (SAM) acts as a signal and binds the methylase-2 domain of TP to induce conformational change

34 ve been examined contain two classes of H3K4 methylases, a yeast (Saccharomyces cerevisiae) Set1 clas

35 e synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine s

36 nt of the transfected DNA fragments with CpG methylase abolished the promoter activity.

37 In addition, we show that the 2'-O and G-N-7 methylase activities act specifically on RNA substrates

38 c and biochemical evidence that its mRNA cap methylase activities are also unique.

39 s new mechanistic insights into the mRNA cap methylase activities of VSV L, demonstrates that 2'-O me

40 gmented negative-strand RNA viruses, the two methylase activities share a binding site for the methyl

41 tudies provide genetic evidence that the two methylase activities share an S-adenosyl-l-methionine-bi

42 sequence and length requirement for the two methylase activities.

43 only retain some sequence-specific activity; methylase activity can be detected on hemimethylated DNA

44 The mox gene is necessary for methylase activity in vivo, because an amber mutation in

45 mox gene is the only phage gene required for methylase activity in vivo, because ectopic expression o

46 This methylase activity is associated with Hox gene activatio

47 chemical analysis in S. pombe shows that the methylase activity of Clr4 is necessary for the correct

48 ignificantly increased the histone H3K27 tri-methylase activity of reconstituted PRC2 in vitro, and s

49 in the 762-Set1 strain are due to the rogue methylase activity of this mutant, resulting in the misl

50 acter pylori geographical origin and type II methylase activity, we examined 122 strains from various

51 e3 marks at the promoter, which involves its methylase activity.

52 otein, a putative RNA-binding protein, a DNA methylase, an ATPase-domain protein, and a protein of un

53 The NlaIII methylase and a portion of the NlaIII endonuclease gene

54 The absence of a cognate methylase and cleavage of modified DNA indicate that Sau

55 ich exhibit an unusual 13-codon overlap, the methylase and endonuclease genes are each separated by 1

56 M is composed of five genes, including a DNA methylase and four other genes annotated as a helicase d

57 ase and putative replicase components: RdRp, methylase and helicase.

58 ifications that require guide RNAs to direct methylase and pseudouridylase enzymes to the appropriate

59 Both the methylase and restriction subunits are encoded on a poly

60 the plasmid pUC19 were methylated with SssI methylase and subjected to damage by esperamicins A1 and

61 heterochromatin of an ectopic bacterial dam methylase and the decreased mobility of an HML heterochr

62 including MtbA, the methylamine-specific CoM methylase and the pyl operon required for co-translation

63 Metnase contains a SET histone methylase and transposase nuclease domain, and is a comp

64 nhancer-of-zeste and trithorax (SET) histone methylase and transposase nuclease domain.

65 tially involved in virulence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3.

66 e presence of the base-flipping enzymes HhaI methylase and uracil DNA glycosylase, as well as with TA

67 hose associated with chromatin modification (methylases and acetylases), transcription (RNA polymeras

68 gions within chromatin by recruiting histone methylases and deacetylases.

69 ery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mech

70 hylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, whic

71 The selectivity of the screen for several methylases and demethylases suggests that SUMO interacti

72 etic modifiers, specifically histone and DNA methylases and demethylases, drive hematopoietic cancer

73 ation of histone methylation by both histone methylases and demethylases.

74 factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured

75 e, Mox, and integrase, Int, related to other methylases and integrases.

76 nnose pathway genes and genes encoding sugar methylases and nucleotide sugar epimerase-dehydratase pr

77 e information about restriction enzymes, DNA methylases and related proteins such as nicking enzymes,

78 on (phosphatases and kinases) or protection (methylases), and scaffold or cofactor proteins.

79 undermethylation using Z-DNA sensitive SssI methylase, and by circular dichroism.

80 CbiF is the C-11 methylase, and CbiG, an enzyme which shows homology with

81 e used is the target sequence for the HaeIII methylase, and this partially flipped cytosine is the sa

82 se, with close evolutionary ties to type IIS methylases, and a trisubunit restriction complex.

83 he control of both Dam and GidA modification methylases, and Dam regulates Act production via GidA.

84 ruits histone deacetylase complexes, histone methylases, and heterochromatin proteins.

85 Enhancer-of-Zeste, which are H3K4 and H3K27 methylases, and Polycomb continuously associate with the

86 Therefore, both classes of H3K4 methylases appear to be required for proper regulation o

87 of RSVIgmyc methylation preimposed with SssI methylase appears to be specific to the early, undiffere

88 ocus tested, suggesting that the primary CpG methylases are encoded by the MET1 class of genes.

89 These studies show that the VSV methylases are inhibited by SIN, and they define new reg

90 In this study, we describe low-input methylase-assisted bisulfite sequencing (liMAB-seq ) and

91 We have recently developed a methylase-assisted bisulfite sequencing (MAB-seq) method

92 Here, we describe M.SssI methylase-assisted bisulfite sequencing (MAB-seq), a met

93 ssisted, chemical-modification assisted, and methylase-assisted bisulfite sequencing data.

94 Dot1, the H3-Lys79 methylase, associates with transcriptionally active gene

95 of hpnP, the gene encoding the C-2 hopanoid methylase, at the molecular level.

96 ycin resistance - the erythromycin ribosomal methylase B (ermB) gene - found in C. perfringens and C.

97 a reveals that Dnmt3a is predominantly a CpG methylase but also is able to induce methylation at CpA

98 protein, previously demonstrated to be a CoM methylase but otherwise of unknown physiological functio

99 ind the R subunit as effectively as the M2S1 methylase but possesses no activity; therefore, upon est

100 The methylase can function in either a monomeric or oligomer

101 ng increased expression of the histone H3R26-methylase CARM1 and is lowered following CARM1 inhibitio

102 In the NUMAC complex, the methylase, CARM1, acquires the ability to covalently mod

103 d class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the transfer of a C1 unit from

104 al of the D/anticodon arm modifications, but methylases catalyzing post-transcriptional m(2)G synthes

105 A related methylase, Cfr, modifies C8 of A2503 via a similar mecha

106 Removal of the H3K9 methylase Clr4 partially suppressed the slow growth phen

107 y unclassified fliB gene, encoding flagellin methylase, clustered as a class 2 gene, which was verifi

108 , including a previously uncharacterized CHH methylase, CMT2.

109 lation and alters the recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)

110 gh-molecular-weight DNA, and an endonuclease/methylase competition assay was employed to partially cl

111 thylation by knocking down components of the methylase complex and then examined 661 transcripts with

112 methylase Set1 and Ash2, a component of the methylase complex, are required for memory.

113 MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other poly

114 was demethylated by the purified 480-kDa CoM methylase, consuming 1 mol of CoM and producing 1 mol of

115 ic reaction was found to produce expected RS methylase coproducts S-adenosylhomocysteine and 5'-deoxy

116 model, whereas mutants that lack DNA adenine methylase (Dam(-)) are highly attenuated and elicit full

117 tains the target "GATC" site for DNA adenine methylase (Dam) and is present in both promoter proximal

118 tein Ag43 in E. coli requires deoxyadenosine methylase (Dam) and OxyR.

119 tions: error-prone polymerase IV (DinB), DNA methylase (Dam) and sigma S factor (RpoS).

120 serovar Typhimurium deficient in DNA adenine methylase (Dam) are attenuated for virulence in mice and

121 sis mutants that overproduce the DNA adenine methylase (Dam) are highly attenuated, confer fully prot

122 trains that lack and overproduce DNA adenine methylase (Dam) conferred cross-protective immunity to s

123 rovar Typhimurium that lacks the DNA adenine methylase (Dam) ectopically expresses multiple genes tha

124 strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to d

125 solates that lack or overproduce DNA adenine methylase (Dam) elicited a cross-protective immune respo

126 Salmonella DNA adenine methylase (Dam) mutants that lack or overproduce Dam are

127 hat altered levels of Salmonella DNA adenine methylase (Dam) resulted in acute defects in virulence-a

128 Salmonella typhimurium lacking DNA adenine methylase (Dam) were fully proficient in colonization of

129 ive regulatory protein (Lrp) and DNA adenine methylase (Dam) were required for pef transcription.

130 e DNA, which is essential for deoxyadenosine methylase (Dam)- and OxyR-dependent phase variation of a

131 ive regulatory protein (Lrp) and DNA adenine methylase (Dam).

132 ive regulatory protein (Lrp) and DNA adenine methylase (Dam).

133 onsive regulatory protein (Lrp), DNA adenine methylase (Dam)] and local regulators (PapI and PapB) co

134 sis mutants that overproduce the DNA adenine methylase (DamOP Yersinia) are attenuated, confer robust

135 reading frame potentially encoding cytosine methylase (dcm) was identified upstream of IS1469 in the

136 Expression of mutations at A1518/A1519 in a methylase deficient ksgA(-)strain had divergent effects

137 microg of circular vector prepared in a DNA methylase-deficient Escherichia coli (1.9 +/- 1.1 x 10(-

138 ence homologies suggest that the B. maritima methylase defines a new family of plant methyl transfera

139 romatin-modifying proteins tested, including methylases, demethylases, acetyltransferases and a deace

140 erved as the most abundant function with DNA methylase detected at levels 4.2-fold higher than other

141 restriction enzymes and their corresponding methylases, determination of the recognition sequence of

142 the two subunits comprising the 480-kDa CoM methylase) did not catalyze CoM methylation with methyla

143 he phage's damL gene, coding for DNA adenine methylase, did not make DNA cuttable.

144 ive pathogens suggest multiple roles for Dam methylase: directing post-replicative DNA mismatch repai

145 t be determined due to the presence of other methylases, DNA binding proteins, and chromatin structur

146 by stimulating lysine methylation of the DNA methylase DNMT1 and triggering its degradation via the u

147 This would be mediated by the DNA methylase, DNMT3A, which is down-regulated in cells lack

148 This led to the suggestion that a single methylase domain functions for both 2'-O and G-N-7 methy

149 a flexible "hinge" region separates the cap methylase domain of L proteins from upstream functions a

150 tnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and direct

151 iquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p.

152 ations in the Arabidopsis DOMAINS REARRANGED METHYLASE (DRM) genes and provide evidence that they enc

153 ecently reported that the DOMAINS REARRANGED METHYLASE (DRM) genes are required for de novo DNA methy

154 480-kDa corrinoid protein functions as a CoM methylase during methanogenesis from DMS or MMPA.

155 hylases (KDM1A inhibitor S2101), and histone methylases (EHMT2 inhibitor UNC0638 and EZH2 inhibitor G

156 s, we propose that this archaeal radical SAM methylase employs a previously uncharacterized mechanism

157 Here, we identify a radical SAM methylase encoded by the hpnP gene that is required for

158 f A1518/A1519 caused by mutation of the ksgA methylase enhanced the deleterious effect of many of the

159 sence of a functional erythromycin ribosomal methylase (erm) gene in most species of pathogenic rapid

160 Erm methylase (ermA and ermB) was the most common resistance

161 Molecular Cell, Sampath et al. show a lysine methylase exhibits substrate promiscuity and variability

162 from various locations around the world for methylase expression.

163 7 methylation owing to overexpression of the methylase EZH2 has been implicated in metastatic prostat

164 methyltransferases, the enzyme contains the methylase fold and has well-defined substrate binding po

165 acid sequence of PFC1 has identity with rRNA methylases found in bacteria and yeast that modify speci

166 oding the AatII restriction endonuclease and methylase from Acetobacter aceti have been cloned and ex

167 vious paper reports the purification of this methylase from Batis maritima and the isolation of a cDN

168 to the evolution of the cell cycle-regulated methylases from an existing R/M system.

169 A ParB-methylase fusion protein appears to nick DNA nonspecific

170 that physically bridges REST and the histone methylase G9a to repress transcription.

171 ere we report that NRSF recruits the histone methylase G9a to silence NRSF target genes in nonneurona

172 methylation site within p53 mediated by the methylases G9a and Glp and indicate that G9a is a potent

173 is encoded by three genes: the 2,739-bp BslI methylase gene (bslIM), the bslIRalpha gene, and the bsl

174 ribe the isolation of a genomic clone of the methylase gene and the expression of recombinant methyl

175 the chromosomally located erythromycin rRNA methylase gene ermA and the plasmid-borne ermC gene were

176 ranged in an operon and that it requires the methylase gene from the LlaKR2I R/M system.

177 conclude that promoters of the CATG-specific methylase gene hpyIM differ between iceA1 and iceA2 stra

178 No companion methylase gene was found near the SauUSI restriction gen

179 udied for the presence of ermAM (a ribosomal methylase gene), mefE (a macrolide efflux gene), and tet

180 f.I1, was found to be inserted into the bmhA methylase gene.

181 reading frame that includes the type I hsdM methylase gene.

182 ntibiotics by expressing two paralogous rRNA methylase genes pikR1 and pikR2 with seemingly redundant

183 ught about, for example, by knockouts of the methylase genes-result in embryo lethality or developmen

184 d plasmid harbored the gentamicin resistance methylase (grm), which has not previously been reported

185 be trapped in an inactive complex until the methylase has been able to modify and protect the host c

186 s the only mapped modification for which the methylase has not been assigned.

187 In fact, RS methylases have been grouped into three classes based on

188 Dam methylase (HI0209) in strain Rd KW20 was inactivated in

189 ific m6A-driven networks for 4 known m6A (de)methylases, i.e., FTO, METTL3, METTL14 and WTAP.

190 ASS was the first histone H3 lysine 4 (H3K4) methylase identified over 10 years ago.

191 In Escherichia coli, IE is methylated by Dam methylase (IE(ME)).

192 e Hsmar1 transposase downstream of a protein methylase in anthropoid primates.

193 A possible function for this novel methylase in halophytic plants is discussed.

194 es encoding a recently discovered coenzyme M methylase in Methanosarcina barkeri were analyzed.

195 By expressing a prokaryotic DNA methylase in P. falciparum, we directly assayed accessib

196 was the founding member and is the only H3K4 methylase in Saccharomyces cerevisiae; however, in mamma

197 stantiated the novel function of the LlaKR2I methylase in the AbiR system but also illustrated the ev

198 ators, nuclear pore components, and arginine methylases in mediating DPR toxicity.

199 t in mammalian cells there are multiple H3K4 methylases, including Set1A/B, forming human COMPASS com

200 out restriction enzymes and their associated methylases, including their recognition and cleavage sit

201 out restriction enzymes and their associated methylases, including their recognition and cleavage sit

202 out restriction enzymes and their associated methylases, including their recognition and cleavage sit

203 ferent pancreatic cancer cell lines with the methylase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR).

204 Treatment of cells with the methylase inhibitor 5-azacytidine restored CREB binding

205 The DNA methylase inhibitor, 5-aza-2'-deoxycytidine, induced KIR

206 When combined with histone methylase inhibitors, the extent of gene upregulation by

207 f Mox is related most closely to that of the methylase involved in the cell cycle control of Caulobac

208 r restriction activity; while an independent methylase is composed of HsdM and HsdS subunits.

209 in the globular domain of histone H3 by Dot1 methylase is important for transcriptional silencing and

210 We show that the methylase is not stable at the concentrations expected t

211 experimental evidence that inhibition of cap methylases is a potential strategy for development of an

212 The activity of DNA methylases is influenced by the differentiation status o

213 Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation machine

214 RELATED7 (ATXR7), a putative Set1 class H3K4 methylase, is required for proper FLC expression.

215 27 demethylase (UTX/KDM6A) or a H3 lysine 4 methylase (KMT2D).

216 of mouse and human Mettl3, one of the m(6)A methylases, led to m(6)A erasure on select target genes,

217 oup complexes together with histone arginine methylases like PRMT5 and lysine demethylases like JARID

218 , shuttle plasmids were treated with the CpG methylase M.SssI prior to the electroporation of a varie

219 convergently transcribed restriction (R) and methylase (M) genes of the Restriction-Modification syst

220 restriction endonuclease holoenzymes contain methylase (M), restriction (R) and specificity (S) subun

221 ependently in E. coli in the absence of BslI methylase (M.BslI) protection.

222 An orphan methylase, M.BceSV, was found to modify GCNGC, GGCC, CCG

223 This set the stage for Suv39H1 methylase-mediated di-methylation of H3.K9 and increased

224 with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and

225 Similarly, knockdown of histone methylases MLL2 and MLL3 decreased the E2-mediated activ

226 6 is an E2-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha a

227 such as mixed lineage leukemia (MLL) histone methylases (MLL2 and MLL3) and histone acetyltransferase

228 DNA and that the B. paralicheniformis DISARM methylase modifies host CCWGG motifs as a marker of self

229 with the loss of chromatin-associated H4K20 methylase, mono- and dimethyl H4K20, and a delay in the

230 Mx8 makes a DNA adenine methylase, Mox, and integrase, Int, related to other met

231 evelopment, Mx8 expresses a nonessential DNA methylase, Mox, which modifies adenine residues in occur

232 Dam methylase mutants were recovered in a screen for mutants

233 a M2S1 methylase or as a R2M2S1 bifunctional methylase/nuclease.

234 This new role for the LlaKR2I methylase offers a unique snapshot into the evolution of

235 on, Set1A but not Mll2 functions as the H3K4 methylase on bivalent genes and is required for their ex

236 cleavage), and can function solely as a M2S1 methylase or as a R2M2S1 bifunctional methylase/nuclease

237 d when the fungal DNA was treated with a CpG methylase or with CpG-specific endonucleases.

238 , which has histone demethylases but not DNA methylases or demethylases.

239 n ATX1, which encodes a Trithorax class H3K4 methylase, partially suppress the delayed flowering of w

240 ther nuclear RNA binding proteins suggests a methylase-preferred recognition sequence of Phe/Gly-Gly-

241 by in vitro artificial methylation with Sss1 methylase prior to transient transfections.

242 t A1518 in strains lacking a functional KsgA methylase produces a kasugamycin resistance phenotype.

243 cient when the PNA-binding site embodies the methylase-recognition site rather than overlaps it.

244 inhibited division gene (gidA) encoding tRNA methylase reduced Act levels, while overproduction of DN

245 Class B methylases require a cobalamin cofactor to methylate bot

246 Expression of the mutation-specific chimeric methylase resulted in the selective methylation of cytos

247 e Lactobacillus caseiTS mutant N229D, a dCMP methylase, revealed that there is a steric clash between

248 uclease gene were cloned into E. coli by the methylase selection method, and the remaining portion of

249 Metnase is a human protein with methylase (SET) and nuclease domains that is widely expr

250 n mutants demonstrated that the histone H3K4 methylase Set1 and Ash2, a component of the methylase co

251 ription elongation complex Paf1, the histone methylase Set1-COMPASS, and the translation-related Trm1

252 H3 lysine-4 by the trithorax-related histone methylase Set1.

253 siae; however, in mammals, at least six H3K4 methylases, Set1A and Set1B and MLL1 to MLL4, are found

254 Moreover, depletion of the H3K36 methylase Setd2 leads to upregulation of Xist, suggestin

255 Class C methylases share significant sequence homology with the

256 investigated how the uniquely clustered Dam methylase sites, GATCs, in the origin of Escherichia col

257 ted to 5-methylcytosines by the CpG-specific methylase SssI and the DNA was subsequently treated with

258 All of the methylases studied were present in all major human popul

259 us encodes an endonuclease subunit (HsdR), a methylase subunit (HsdM) and two DNA specificity subunit

260 requires the chromodomains (CDs) of the H3K9 methylase Suv39/Clr4 and the HP1/Swi6 protein.

261 In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein

262 for Sm and Lsm complexes as well as for the methylase Tgs1.

263 ermB gene, which encodes a 23S ribosomal RNA methylase that mediates resistance to macrolide, lincosa

264 RlmN is a dual-specificity RNA methylase that modifies C2 of adenosine 2503 (A2503) in

265 t has been demonstrated that it is a protein methylase that symmetrically dimethylates the omega-N(G)

266 d mutations in SET2, which encodes a histone methylase that targets lysine 36 of histone H3 and, like

267 g domain in SahR is related to SAM-dependent methylases that are able to tightly bind SAH.

268 sis, for example, small-molecule kinases and methylases that are expanded independently in the fly an

269 ibed class of S-adenosylmethionine-dependent methylases that convert a phospholipid 18 carbon cis uns

270 mparable to that of the cell cycle-regulated methylases that include Dam and CcrM methylases.

271 acking Sas2 histone acetylase or the histone methylases that modify lysines 4 (Set1) or 79 (Dot1) of

272 Plasmids modified in E. coli with methylases that protect in vitro against restriction by

273 of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-conta

274 e association of Set1 and Set2 (the H3-Lys36 methylase), this association is largely independent of R

275 y PvuII methylation still requires the PvuII methylase to be maintained in vivo, arguing against this

276 family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters b

277 t of Set1, the histone H3-lysine 4 (H3-Lys4) methylase, to a highly localized domain at the 5' portio

278 lso illustrated the evolution of the LlaKR2I methylase toward a new and separate cellular function.

279 contributed to the evolution of the LlaKR2I methylase toward a novel role comparable to that of the

280 and most closely resembles the m(2)G10 tRNA methylase Trm11.

281 calculated molecular mass suggests that the methylase undergoes posttranslational cleavage, possibly

282 n-2, these studies show CbiL to be the first methylase unique to the anaerobic pathway, methylating a

283 These Class D methylases, unlike Class A, B, and C enzymes, which use

284 Class A methylases use two cysteine residues to methylate sp(2)-

285 2-aa sequence of an internal fragment of the methylase was determined (GLVPGCGGGYDVVAMANPER FMVGLDIXE

286 trains studied, the average number of active methylases was 8.2 +/- 1.9 with no significant variation

287 In direct competition assays with HPA:II methylase we observe that the mispaired substrate is met

288 nt roles and functional targets for the H3K4 methylases, we have undertaken a genome-wide analysis of

289 To our great surprise, no methylases were found by this method; rather, two small

290 ctive in cap methylation in vitro, yet their methylases were less sensitive to SIN inhibition than th

291 . lactis without the presence of the LlaKR2I methylase, which is required to protect L. lactis from A

292 and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4)

293 the viral helicase, papain-like protease and methylase, which suggest a regulatory function for ORF3

294 HOTTIP, members of the MLL/COMPASS-like H3K4 methylases, which regulate chromatin in the Hox/HOX clus

295 that COMPASS family members function as exo-methylases, which we have confirmed by in vitro and in v

296 Our intention was to identify other methylases whose specificities overlapped enough with th

297 d 1038 bp, respectively, encoding the 331-aa methylase with a predicted molecular mass of 36.9 kDa, a

298 5-bp spacers, and bpm encodes a DNA adenine methylase with unusual site specificity and a homopolyme

299 tides, generated by using bacterial cytosine methylases with four-base recognition sequences, were lo

300 us lactis ssp. lactis consists of a bidomain methylase, with close evolutionary ties to type IIS meth

301 ns nine conserved motifs of N-4 cytosine DNA methylases within the beta group of aminomethyltransfera