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1 o the side chain length of the residue to be methylated.
2 n the human genome are thought to be heavily methylated.
3 promoter, and TBX21 regions of interest were methylated.
4 5% CpG islands were T-47D cell type-specific methylated.
5 ation did not occur when the target was also methylated.
6 nt samples, and the GLI3 locus is abnormally methylated.
7 the promoter for Mir133a-2 is differentially methylated.
8 mal large-subunit methyltransferase H (RlmH) methylates 23S ribosomal RNA pseudouridine 1915 (Psi1915
9 le guide RNA, dCas9-SunTag-DNMT3A is able to methylate a 4.5-kb genomic region and repress HOXA5 gene
10 (MTases) form a large family of enzymes that methylate a diverse set of targets, ranging from the thr
11 -dependent methyltransferase and found it to methylate a single protein in mitochondrial extracts, id
17 mine how a single HG bp trapped using the N1-methylated adenine (m1A) lesion affects the structural a
18 dinucleotides and was concentrated in dense methylated adenine clusters surrounding the transcriptio
19 or screens for HP resistance identified Mrr (Methylated adenine Recognition and Restriction), a Type
21 the utilization of methylamine, the simplest methylated amine, have mainly focussed on the fate of th
24 ation system methyltransferase (ctsM), which methylates an overrepresented 6-bp sequence in the chrom
25 DNA nucleoside deoxycytidine (dCyd) and its methylated analogue 5-methyldeoxycytidine (5mdCyd), know
26 itial design of a combinatorial library of N-methylated analogues of the stem peptide cyclo(d-Ala-Ala
27 everaged the differential reactivity of 2'-O-methylated and 2'-hydroxylated nucleosides to periodate
28 -replication resulted in 5,168 CpGs (39% age-methylated and 61% age-demethylated) which were characte
29 distribution patterns over gene regions for methylated and demethylated CpGs both relate to reduced
30 however, that MeCP2 can bind asymmetrically methylated and hydroxymethylated CpA dinucleotides and t
31 METHODS AND Quantitative global analysis, methylated and hydroxymethylated DNA sequencing, and gen
32 pectroscopy to characterize MeCP2 binding to methylated and hydroxymethylated mCG and mCA DNA, examin
33 alyses that characterise differences between methylated and non-methylated regions of the genome.
39 e of CP2 to N-varepsilon-trimethyl-lysine or methylated arginine results in cyclic peptide substrates
44 ize and composition after inorganic arsenic, methylated arsenical, or arsenobetaine exposure in drink
46 evolutionary step toward enzymes capable of methylating As(III), the result of a loss of function mu
47 ing epialleles, and (ii) transposon-derived, methylated at all cytosines, which may or may not form e
49 we identified an RBM25 species that is mono-methylated at lysine 77 (RBM25K77me1), and here we used
50 he central E-box CpG has the potential to be methylated at the 5-position of cytosine (5mC), or to un
53 In total, 4720 genes were differentially methylated between CCC patients and controls, of which 3
54 mine genomic regions that are differentially methylated between two or more biological conditions.
58 ed arthritis, zymosan-induced arthritis, and methylated BSA/IL-1 arthritis by both prophylactic and t
59 A variant of T2SS pseudopilin PulG remains N-methylated but is affected in interaction with the T2SS
60 as purified by Solid Phase Extraction (SPE), methylated by boron trifluoride in methanol, and injecte
65 at the potent SG-nucleating protein G3BP1 is methylated by protein arginine methyltransferase 1 and 5
66 ylation reactions, whereas homolysine can be methylated by representative examples of human KMTs.
73 udies reveal that recruitment of KLF4 to the methylated cis-regulatory elements of these genes result
74 re heterotrophic methyl-reducers that use C1-methylated compounds as electron acceptors and formate o
75 The structural determinants of binding to methylated CpA (mCA) and hydroxymethylated DNA have not
77 lation readers that preferentially recognize methylated CpG (mCpG), here we report the biological fun
80 st that MBD2 targets NuRD to unmethylated or methylated CpG islands where its distinct dynamic bindin
81 monstrate that B-lymphocytes activated by un-methylated CpG motifs, found in bacterial DNA, and beta-
82 the offspring genotype at sites close to the methylated CpG site as a proxy for DNA methylation in AL
83 XYS probes, there were 2,332 differentially methylated CpG sites (DMSs) between sexes, which were en
85 e, our method identifies eQTLs by leveraging methylated CpG sites in a LIM homeobox member gene (LHX9
90 tated versus wild-type cases, differentially methylated CpG sites were enriched in regions marked by
93 At 4 wk, we identified 63 differentially methylated CpGs (DMCs; false discovery rate < 5%) proxim
94 We identified 9421 sparse conserved under-methylated CpGs (scUMCs) from 31 high-quality methylomes
95 gene regulatory regions with multiple under-methylated CpGs (UMCs), such as promoters and enhancers.
96 scovery association analysis to identify age-methylated CpGs and replicated them in two independent D
99 e characterized by high concentration of age-methylated CpGs at 1stExon and TSS200 and a dominant pat
100 ed 106,252 cell type-specific differentially-methylated CpGs categorized into 7,537 differentially (4
101 ich were enriched within brain modules of co-methylated CpGs during brain development and also differ
103 epigenetic regulator with high affinity for methylated CpGs that localizes at pericentromeric hetero
104 etion isoform, which retains only binding to methylated CpGs, on the other hand, blocks Tet1-mediated
107 h the repressive chromatin marks H3K9me3 and methylated-CpGs, consistent with ORCA-bound origins init
108 ivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS a
109 he APOBEC members, was reported to deaminate methylated cytosine (mC) on DNA, and this mC deamination
112 methylated CpG sites and further flipping of methylated cytosines (mC) by the Set and Ring Associated
114 alyses, including 12 million differentially methylated cytosines in domesticated allotetraploid cott
116 ted DNA between an epigenetic signal (a hemi-methylated d(GATC) site or a single-stranded nick) and t
118 ctroscopy (SERS) sensor for the detection of methylated DNA (5-methylcytosine, 5mC) and its oxidation
119 the T158M mutation impaired MECP2 binding to methylated DNA and destabilized MeCP2 protein in an age-
120 replicated DNA by cooperatively binding hemi-methylated DNA and H3K9me2/3, but this model leaves a nu
121 ining a methyl-CpG-binding domain (MBD) bind methylated DNA and interpret epigenetic marks, providing
124 es, possess an MBD2/3 capable of recognizing methylated DNA and recruiting the associated nucleosome
125 knowledge has been gained for its conserved methylated DNA binding N-terminal ZF region; however, a
126 Interestingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active
127 rified SSRP1 or its isolated CID domain to a methylated DNA fragment containing alternating purine/py
128 ially methylated gene regions (DMRs) using a methylated DNA immunoprecipitation on chip (MeDIP-chip).
129 graphene, bisulfite-treated guanine-enriched methylated DNA leads to a larger amount of the adsorbed
132 remodeling and deacetylase complex (NuRD) to methylated DNA to modify chromatin and regulate transcri
133 -binding protein 2 (MeCP2) selectively binds methylated DNA to regulate transcription during the deve
134 to environmental cues in all organisms with methylated DNA, as we illustrate in mouse embryonic stem
140 e phenotype by enhancing EBNA2 activation of methylated EBV promoters.IMPORTANCE EBV establishes seve
143 udies indicated that deletion of the histone methylating enzyme EZH2 from podocytes decreased H3K27me
144 ascent mRNA, followed by activity of histone methylating enzymes, but not through DNA methylation.
145 igenetic regulation into (i) single copy and methylated exclusively at CpGs, readily forming epiallel
146 protein arginine methyltransferase 1, which methylates EYA1 at these residues both in vitro and in c
149 ammatory cells as well as for differentially methylated gene regions (DMRs) using a methylated DNA im
151 to breast cancer data to identify important methylated genes (such as polycomb target genes and gene
152 ignificant enrichment for the differentially methylated genes among the differentially expressed gene
153 ntially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targ
160 lso significantly overrepresented in the 661 methylated genes from two studies of buccal samples (N =
161 Interestingly, most of these differentially methylated genes function in cell adhesion and communica
163 ancer by determining whether smoking-related methylated genes led to enrichment in cancer-related pat
165 ell populations have distinct differentially methylated genes relative to their normal counterparts,
166 at S-(+)-fipronil caused more differentially methylated genes that are involved in developmental proc
171 metric double mutants revealed that a single methylated H3K36 per nucleosome was sufficient to silenc
175 h orally bioavailable and bioactive cyclic N-methylated hexapeptides as high affinity ligands for the
176 f HER2 are limited to the involvement of tri-methylated histone 3 lysine 4 (H3K4me3) and acetylated h
177 Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is requir
179 groups have reported that the TAD binds with methylated histones and plays a role in DNA damage respo
180 mpound with the composition C15H8O2 and four methylated homologues were shown to accumulate as a resu
181 N2B, and of RASSF1A were significantly hyper-methylated in 50% (n = 15), 47% (n = 14), and 90% (n = 2
182 majority of sites that become differentially methylated in AML occur in regulatory elements of the hu
184 ticularly for CpG sites found differentially methylated in brain tissue between patients with schizop
185 us de novo DNA methylation of genes commonly methylated in cancer, CDKN2A, RASSF1, HIC1 and PTEN in p
187 the CYP11B1 promoter was significantly less methylated in CPA than in adjacent unaffected adrenal ti
188 bserved that up to 2.8% of all adenines were methylated in early-diverging fungi, far exceeding level
190 ese regions were consistently differentially methylated in every subtype and all implicated genes are
194 revealed that 28 regions were differentially methylated in relation to tea consumption in women.
195 ng to DNAJC16 and TTC17, were differentially methylated in relation to tea consumption in women.
199 osylmethionine (SAM) methyltransferases that methylates inorganic As(III) into mono- (MAs(III)), di-
203 ation of TET1 relieves its repression of the methylated Lhb gene promoter, which is then hydroxymethy
205 l type-specific validation of differentially methylated loci was performed after fluorescence-activat
209 plant homeodomain (PHD) finger of Set3 binds methylated lysine 4 of histone H3 in vitro and in vivo;
210 file the binding of chromodomain proteins to methylated lysine peptides derived from the histone 3 pr
212 In this study, we show that WHSC1L1 mono-methylates lysine 721 in the tyrosine kinase domain of E
214 ysteine residues suggest that the ability to methylate MAs(III) may be an evolutionary step toward en
216 gestion of both MB substrate and maintenance methylated MB corresponds to de novo methylation event.
217 These results suggest that when decoys are methylated, MBD proteins can block them and thereby allo
218 s(V)) and arsenite (As(III)) into more toxic methylated metabolites methylarsenite (MAs(III)) and dim
223 ted the workflow by correctly identifying 10 methylated nucleosides and 6 methylated amino acids.
224 en situated at the third codon position, the methylated nucleosides did not compromise the speed or a
225 We provide evidence of the existence of free methylated nucleotides capable of distinguishing plasma
227 egions results in enrichment of the targeted methylated or unmethylated minority-epigenetic-alleles.
229 ent CpG sites in mammalian genomes can be co-methylated owing to the processivity of methyltransferas
231 alogenated piperazic acid, and a novel delta-methylated piperazic acid in svetamycins B-C, E, and G.
232 lygenic risk score-associated differentially methylated positions and regions, which are not enriched
233 genes implicated by the most differentially methylated probes implicated gamma-aminobutyric acid (GA
234 ntially methylated regions or differentially methylated probes, after adjustment for age, sex, race/e
237 ment cultures converted 63% of arsenite into methylated products, with dimethylarsinic acid as the ma
239 silent, yet a sizable fraction of genes with methylated proximal promoters exhibit elevated expressio
240 ved mechanism of transcription of genes with methylated proximal promoters in a tissue-specific fashi
241 molecular dynamics simulations of PulG(E5A), methylated PulG(WT) (MePulG(WT)), and MePulG(E5A) varian
246 A total of 853 significantly differentially methylated regions (DMRs) and 963 differentially methyla
247 roach (called ABBA) to detect differentially methylated regions (DMRs) from whole-genome bisulfite se
249 ancreatic islets, to identify differentially methylated regions (DMRs) in diabetic islets, and to inv
251 gulation and the detection of differentially methylated regions (DMRs) is enthralling for many diseas
252 within a sample by leveraging differentially methylated regions (DMRs) specific to cell type, identif
253 66 and 2136 genes containing differentially methylated regions (DMRs) with negative correlation betw
256 al approaches for identifying differentially methylated regions from high-throughput bisulfite sequen
257 alysis identified a number of differentially methylated regions in TET2-deficient versus wild-type CD
258 ines and determined that over 99.998% of the methylated regions in the genome are stably inherited ac
259 ere able to identify specific differentially methylated regions in the parental genomes that are asso
260 er showed that these parental differentially methylated regions most likely mediate the remodeling of
263 nificant methylation changes, differentially methylated regions or differentially methylated probes,
265 tal immune cells harbored 589 differentially methylated regions that distinguished IIS children who d
267 dation of selected cord blood differentially methylated regions, using bisulfite amplicon sequencing.
268 network of asthma-associated, differentially methylated regions, was selectively increased in asthmat
272 ng and RNA-seq show that dCas9-SunTag-DNMT3A methylates regions of interest with minimal impact on th
276 at the embryos with NTD failed to adequately methylate septin2, a key regulator of cilium structure a
280 g we followed up the two most differentially methylated sites in 214 vaginal cell samples serially co
283 These proteins recognize histone H3 lysine 9 methylated tails via their chromodomain and recruit addi
286 First, we show that ATXR5 preferentially methylates the R/F-K*-S/C-G/A-P/C motif with striking pr
287 s well as the S-methyltransferase DTCMT that methylates the resulting dithiocarbamate, together compl
290 odon loop of Trypanosoma brucei tRNA(Thr) is methylated to 3-methylcytosine (m(3)C) as a pre-requisit
291 of methylation, functional classification of methylated transcripts, and position bias within the tra
292 tionship between these two enzymes when they methylate two distinct sites of the same substrate may a
293 As are unusual in that they are predicted to methylate two nucleotides in a single target region.
294 aluate the likelihood that a region is truly methylated under any given experimental condition, allow
295 NaME reactions (177-plex) using dilutions of methylated/unmethylated DNA and in DNA from clinical lun
296 viral transcription factor EBNA2 to activate methylated viral promoters that are expressed in type II
300 ted pectin from OFI cladodes (EAEPC) was low methylated, with a high uronic acid content, a water and
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