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1 s were significantly associated with low H19 methylation.
2 by attenuating the effect of local arginine methylation.
3 H mutations); and 1 patient had somatic MLH1 methylation.
4 ially sensitive region with mostly decreased methylation.
5 rous splicing factors, microRNAs and m6A RNA methylation.
6 Silencing did not require H3K9me3 or DNA methylation.
7 d patterns based on anonymous markers of DNA methylation.
8 f gene expression regulated, in part, by DNA methylation.
9 sequence variation on proximal CpG site DNA methylation.
10 cide, nor on epigenetic changes, such as DNA methylation.
11 MPO and PRTN3 expression correlated with DNA methylation.
12 lectrochemical sensing and biosensing of DNA methylation.
13 espread redistribution of repressive histone methylation.
14 ide RNAs does not increase the efficiency of methylation.
15 HPV-negative HNSCCs driven by aberrant H3K36 methylation.
16 MLH1 [including one with constitutional MLH1 methylation]; 16, MSH2; 1, MSH2/monoallelic MUTYH; 2, MS
17 is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), range
22 roles in disease development, thus averaging methylation across RE may lose significant biological in
23 to cause a dominant negative loss of DNMT3A methylation activity, but 15% of DNMT3A mutations are pr
24 P = 0.50), but the presence of TERT promoter methylation, alone or concurrent with promoter mutations
26 Future studies need to explore whether DNA methylation alterations influence the risk of AD-ND code
29 a statistical approach for differential RNA methylation analysis with count-based small-sample seque
31 l TBT exposure induces global changes in DNA methylation and altered expression of metabolism-relevan
32 in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers and ne
34 azacytidine-treated patients lacked aberrant methylation and DNMTi treatment of primary MDS stroma en
35 ficant negative correlation between promoter methylation and expression of an alternative transcripti
37 showed a significant association between DNA methylation and gene expression changes were PYGM, which
38 train to examine the genome-wide nuclear DNA methylation and gene expression patterns of brain tissue
42 studies relied on the identification of DNA methylation and histone modifications at specific genes.
44 s of the method by inferring allele-specific methylation and nucleosome occupancy in cell lines, and
45 ion, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a.
46 genome-wide analysis of gene expression, DNA methylation and small RNAs in the rice endosperm and fun
47 amming, by comparing genome-wide patterns of methylation and variation at the DNA level in hatchery-r
48 are known to affect TF binding (such as DNA methylation) and providing increased specificity as comp
49 ific genetic changes to gene expression, DNA methylation, and histone marks but these investigations
50 onfiguration of chromatin accessibility, DNA methylation, and mRNA expression to induce a default neu
51 enetic processes, such as alterations in DNA methylation, and perhaps through alterations in the gut
52 nal differentiation marker FoxA1 by promoter-methylation, and that is regulated by the Plk1 phosphory
55 the initiating events that lead to gene body methylation are discussed as a model illustrating how in
56 ption and a high metabolic COMT capacity for methylation are key factors for high HVAL concentrations
58 cting m(6)A, the researchers show that m(6)A methylations are enriched in exons and are added to tran
59 escents, we demonstrate that changes in gene methylation associated with lower socioeconomic status (
60 first to demonstrate the involvement of DNA methylation-associated alterations in patients with mono
61 Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median absolu
62 previously reported BMI-related differential methylation at 83 CpGs that replicated across cohorts; B
65 e the relationship between variations in DNA methylation at birth and the development of allergic dis
66 1B-YWHAQ) influences BP, while BP influences methylation at cg00533891 (ZMIZ1), cg00574958 (CPT1A), a
67 opean ancestry from 4 cohorts suggested that methylation at cg08035323 (TAF1B-YWHAQ) influences BP, w
68 mors, inflammation-induced tumors gained DNA methylation at CpG islands, some of which are associated
72 ation between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA,
77 our results demonstrated the association of methylation at specific genomic locations as contributin
79 as9-SunTag-DNMT3A dramatically increases CpG methylation at the HOXA5 locus in human embryonic kidney
83 epigenome-wide scan suggested differences in methylation between soy formula-fed and cow formula-fed
85 igated and compared the effects of DOM on Hg methylation by an iron-reducing bacterium Geobacter sulf
89 d that cancer-specific expression-associated methylation changes differ from tissue-specific changes.
91 enes also have significant asthma-associated methylation changes in nasal epithelia of adult white as
92 3 The novel AKT3 transcriptional variant and methylation changes were confirmed using qRT-PCR and qMS
96 file of skeletal muscle, indicating that DNA methylation constitutes a rapidly adaptive epigenetic ma
97 in the subset of participants with DLPFC DNA methylation data (n = 648), we found that residual cogni
98 al lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposur
102 sion of hundreds of loci, acting in both DNA methylation-dependent and methylation-independent pathwa
104 tend to share demethylated promoters, while methylation differences between alpha- and beta-cells ar
106 nalysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human interactome.
109 es on translation could be attributed to the methylation-elicited alterations in base pairing propert
111 e combined with inhibitors targeting histone methylation for synergistic effects while still maintain
112 etter understanding of how resistance to DNA methylation from the A2UCOE is conferred, and whether th
113 D2/PHIP, which colocalizes with histone H3K4 methylation genome-wide in human cells, mouse embryonic
114 model to measure the relationship among DNA methylation, genomic segment distribution, differential
118 ne, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to
119 ls, we performed genome-wide analysis of DNA methylation, histone marking (acetylated lysine 9 in his
121 d miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, followed by targeted se
122 PUFA diets increased the mean degree of DNA methylation in adipose tissue, particularly in promoter
123 ociations of prenatal lead exposure with DNA methylation in cord blood at epigenome-wide significance
125 to define the contribution of As3MT-mediated methylation in different cell types to the development o
126 Set1A SET domain does not diminish bulk H3K4 methylation in ESCs; instead, only a subset of genomic l
129 p3k, indicating extensive involvement of DNA methylation in honeybee olfactory learning and memory pr
132 erative disorders in humans, the role of DNA methylation in mast cell biology is not understood.
134 investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide DNA
135 emphasize the significance of histone lysine methylation in normal human development and the importan
136 etic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function met
145 aternal lead exposure and epigenome-wide DNA methylation in umbilical cord blood nucleated cells in P
146 sted for association between genome-wide DNA methylation in WBCs and total IgE levels in 2 studies of
147 nt of one epigenetic mark in particular, DNA methylation, in human populations, and the examination o
148 Its expression is also regulated by DNA methylation, including at an upstream enhancer that is p
149 into two groups, on the basis of whether DNA methylation increased or decreased from active disease t
158 uman populations, and the examination of DNA methylation is becoming increasingly common in psycholog
159 ogical validation showed that PCSK9 promoter methylation is conserved across tissues and positively c
163 na's 450k array and showed that aberrant DNA methylation is significantly altered at enhancer regions
164 ic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signature 3 and,
165 e of miR487b editing, as well as 2'-O-ribose-methylation, is increased in murine muscle tissue during
166 yrosine kinase domain of EGFR, and that this methylation leads to enhanced activation of its downstre
168 tive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Esch
169 tly altered at enhancer regions and that the methylation levels at specific enhancers predict overall
176 Indeed, we detected stark differences in methylation levels within promoters and regulatory regio
177 tion of these DMRs revealed differential DNA methylation localized to a 600 bp region in the promoter
178 in wild cottons but highly expressed due to methylation loss in all domesticated cottons tested.
179 at ORCA coordinates with the histone and DNA methylation machinery to establish a repressive chromati
182 -familial and familial NSCLP and altered DNA methylation may be a second hit contributing to penetran
184 , these data suggest that differences in DNA methylation may partly explain the enantioselectivity of
186 chor to help decipher the likely role of DNA methylation measured in peripheral blood in the etiology
187 e Bisulfite Sequencing provides high-quality methylation measurements at the resolution of nucleotide
188 Collectively, our data revealed a novel rRNA methylation mechanism by a radical SAM superfamily enzym
191 leotide polymorphisms (SNPs) and genome-wide methylation (methylation quantitative trait loci [mQTLs]
192 rehensive molecular profiling, including DNA methylation microarray analysis, and did unsupervised cl
193 ring method and an R function which uses DNA methylation microarray data to infer tumor subtypes with
195 f cancer samples, using gene expression, DNA methylation, noncoding microRNA, and copy number variati
196 om the 2 diet groups were combined, the mean methylation of 1444 genes, including fatty acid binding
197 PNP pincer complex was shown to catalyze the methylation of 2-naphtol rather than its aminomethylatio
198 tudies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart
199 and HBV replicating cells, and examined DNA methylation of a CpG island located downstream from SALL
200 or during recovery from LT-IH prevented DNA methylation of AOE genes, normalized the expression of A
201 on by M6CK results in a dramatic decrease in methylation of arginines adjacent to M6CK-phosphorylated
204 Chromatin modifications, such as cytosine methylation of DNA, play a significant role in mediating
205 biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics.
208 tution and NSD1 defects converge on altering methylation of histone H3 at K36 (H3K36), subsequently b
210 ically, COX2/PGE2 signaling induced promoter methylation of let-7, resulting in its downregulation an
211 and PG species was developed after one-step methylation of lipid extracts in combination with high m
212 ient to increase ANO1 expression, suggesting methylation of positively correlated CpG's likely serves
213 Only a few studies have investigated DNA methylation of selected candidate genes or a very small
214 levels in OA chondrocytes and the percentage methylation of the CpG sites in the RUNX2 P1 promoter.
215 he production of 2-hydroxyglutarate, reduced methylation of the Foxp3 gene locus, and increased Foxp3
216 ne extraction and assembly, is followed by N-methylation of the mature (pseudo)pilin N terminus.
219 ed by real-time quantitative RT-PCR, and DNA methylation of their promoter regions was analyzed by PC
221 al cognition was related to differential DNA methylation of UNC5C and ENC1 (false discovery rate < 0.
223 igated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial samp
225 actor receptor (EGFR), the effect of protein methylation on its function has not been well characteri
226 RS and polydextrose did not affect SFRP1 methylation or alter the expression of 10 microRNAs pred
227 s result suggests that quantitatively little methylation or demethylation occurs in cytoplasmic mRNA.
228 ric point of effector proteins, induce their methylation or demethylation, and alter their conformati
233 covered characteristic accessibility and DNA methylation patterns at DNase hypersensitive sites (DHSs
235 pluripotent stem cells (iPSCs) show variable methylation patterns between lines, some of which reflec
236 reliable detection of disease-associated DNA methylation patterns has major potential to advance mole
237 rthermore, we identified distinct epigenetic methylation patterns that are conserved across tissues,
238 le (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future therapeut
239 - treated FAP patient tissue after which the methylation patterns were visualized by Next Generation
241 randomization approach to assess whether DNA methylation plays a mediating and causal role in associa
242 Comprehensive studies have shown that DNA methylation plays vital roles in both loss of pluripoten
243 e effect of genome sequence variation on DNA methylation precludes a comprehensive assessment of the
245 n and glucose exposure acutely alter the DNA methylation profile of skeletal muscle, indicating that
248 ongitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of P
250 mory cells was coupled to erasure of de novo methylation programs and re-expression of naive-associat
251 Moreover, these exhaustion-associated DNA-methylation programs were acquired in tumor-infiltrating
253 orphisms (SNPs) and genome-wide methylation (methylation quantitative trait loci [mQTLs]) were identi
255 ith levels of inflammatory markers using cis-methylation quantitative trait loci single nucleotide po
260 osarcoma cells was downregulated by promoter methylation, resulting at least in part from increased e
262 tin, these losses are counteracted such that methylation returns to a normal level over four generati
263 rovide additional mechanisms by which lysine methylation signaling impacts on cell fate decisions.
264 of A/B compartments precedes and defines DNA methylation signatures during differentiation and matura
266 nning method that incorporates bacterial DNA methylation signatures, which are detected using single-
267 f the fusion proteins selectively alters the methylation state and also regulates gene activity.
268 of the EBV type III latency program and DNA methylation state.IMPORTANCE Epstein-Barr virus (EBV) la
269 overage and hence methods to predict missing methylation states are critical to enable genome-wide an
270 I IFN-alpha/beta protein levels with the DNA methylation status as well as the expression profiles of
271 lopment of allergic disease, we examined the methylation status of CpG loci within the promoter regio
273 Gene expression levels were opposite to methylation status, and both correlated with birth weigh
274 IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation with final cha
275 of Tv6-931 can perform two consecutive alpha-methylation steps on the last beta-keto intermediate to
276 ncing (WGBS) data that enable us to quantify methylation stochasticity genome-wide using Shannon's en
277 the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to re
278 iver to have a pattern of acquisition of DNA methylation targeted to candidate enhancers active in li
279 CG methylome and entirely miss two forms of methylation that are common in brain and likely of parti
280 gests the existence of context-specific H3K4 methylation that regulates transcriptional outputs durin
281 are needed to determine MGMT activity as DNA methylation, the current standard, does not accurately r
283 e during cellular reprogramming requires DNA methylation to silence somatic gene expression and dynam
287 amework that learns a regulatory code of DNA methylation using a deep convolutional neural network an
289 he exploratory study of the major sources of methylation variation, which should lead to a deeper und
290 ted across cohorts; BMI-related differential methylation was associated with concurrent changes in th
294 scriptase-polymerase chain reaction, and DNA methylation was quantified at 7 CpG sites within the SFR
295 of the NCR genes, whereas in most genes DNA methylation was unaffected by the ploidy levels and was
298 ation is suggested, as no differences in DNA methylation were observed between 24-h aerobically and a
299 eotide and a small-molecule inhibitor of DNA methylation, which, together, achieve 30,000-fold MECP2
300 We then investigated the association of DNA methylation with levels of inflammatory markers using ci
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