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1 bisulfite treatment of DNA reflects the DNA methylation level.
2 substantially improves the quantification of methylation level.
3 positive) association between RBC folate and methylation level.
4 ry was used to examine leukocyte genomic DNA methylation level.
5 etabolism pathway in relation to genomic DNA methylation level.
6 sociated with intrapair difference in global methylation level.
7 at3 pollen affected transfer RNA and histone methylation levels.
8 between multiple low frequency variants and methylation levels.
9 ications were found to be most predictive of methylation levels.
10 mprinted genes and a global reduction in DNA methylation levels.
11 er YKL-40 levels were associated with higher methylation levels.
12 biomarkers of chronological age based on DNA methylation levels.
13 1 function in regulating global histone H3K4 methylation levels.
14 eosomes containing specific CpG patterns and methylation levels.
15 variation can be used as predictors of gene methylation levels.
16 tiation by controlling the stability of H3K4 methylation levels.
17 e SOLiD sequencer to investigate genome-wide methylation levels.
18 ction and changes in the gene expression and methylation levels.
19 els, and both treatments restored global DNA methylation levels.
20 bitor H89 represses them by suppressing H3K4 methylation levels.
21 ated resulting in enhanced histone H3K27 tri-methylation levels.
22 ygous loss in female ESCs leads to male-like methylation levels.
23 be corrected in order to determine accurate methylation levels.
24 and the time since smoking cessation affects methylation levels.
25 d rare variants that are associated with DNA methylation levels.
26 ing upon the predictive power of average DNA methylation levels.
27 d ALU repeats showed significantly decreased methylation levels (4-7 percentage points for MEST, 1-2
30 und that Spirodela has the lowest global DNA methylation levels (9%) of any plant species tested.
34 irical Bayes method are recommended when DNA methylation levels across CpG loci are independent, whil
35 riate FDR control and the highest power when methylation levels across CpG loci were independent.
36 riate FDR control and the highest power when methylation levels across CpG sites were correlated.
38 g to different correlation structures in CpG methylation levels across the genome while taking into a
39 11 out of 12 cases, methylCRF predictions of methylation level agree better with validated results th
42 We identified extensive variation of histone methylation levels among individuals and mapped hundreds
43 sociation between pre-diagnostic genomic DNA methylation level and colorectal cancer risk among diver
44 and to broaden the E component by including methylation level and gene expression as promising ways
45 Noticing that the age is associated with methylation level and the methylation data are not norma
46 modified the association between genomic DNA methylation level and the risk of colorectal cancer (all
47 between pre-diagnostic leukocyte genomic DNA methylation level and the risk of colorectal cancer in a
48 corporate local information to improve group methylation level and/or variance estimation for experim
49 to evaluate the causal relationships between methylation levels and 14 cardiovascular disease traits.
53 c organisms, is required for maintaining DNA methylation levels and for controlling the expression of
54 ms (SNPs) is important for quantification of methylation levels and for study of allele-specific epig
55 ically significant correlations between gene methylation levels and gene expression and plasma marker
56 sing features including neighboring CpG site methylation levels and genomic distance, co-localization
57 formatics pipeline to accurately obtain both methylation levels and genotypes from sequencing of bisu
58 ion in Drosophila results in changes of H3K9 methylation levels and heterochromatic silencing defects
61 igin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused
63 e observed relation between decreases in DNA methylation levels and PTSD symptoms at genomic regions
64 quencing errors and contaminants on inferred methylation levels and recommend the most appropriate wa
66 en applied to a study of association between methylation levels and smoking status of individuals.
67 Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect varieg
68 ry, we show that neuronal Tet1 regulates DNA methylation levels and that its expression, independent
69 -3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants.
70 -coding genes, lncRNAs showed overall higher methylation levels and their expression was less affecte
71 ultiple CpG sites, as well as their starting methylation levels, and estimates the age of each indivi
72 with their ancestral functions, dynamic DNA methylation levels, and histone modification abundances.
73 G sites with the largest absolute changes in methylation level, approximately 30% correlated with gen
74 We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of l
75 ne promoters enriched for CpG sites at which methylation levels are associated with leukocyte telomer
76 ne promoters enriched for CpG sites at which methylation levels are associated with telomere length i
81 wever, nerve injury had no effect on the DNA methylation level around the Panx1 promoter in the DRG.
82 how that dnmt3 RNAi decreased global genomic methylation level as expected and in addition caused wid
83 tive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Esch
84 e required in vivo to maintain siRNA and DNA methylation levels as well as Pol-IV occupancy at RdDM t
85 lly, we show that the genomic loci whose DNA methylation levels associate most strongly with expressi
87 assays as well as the quantification of the methylation level at every cytosine from the raw peak in
88 y release, concomitantly with changes in the methylation level at specific lysine residues of histone
89 panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated wit
92 ificantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomi
94 ation450 Bead Chips, we measured genome-wide methylation levels at 482,397 CpG loci in umbilical cord
95 ISIS) method with elastic net penalty to DNA methylation levels at 484,548 CpG markers from 659 human
96 stry were each significantly associated with methylation levels at 916 and 194 CpGs, respectively, an
97 Together, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast ca
99 built a random forest classifier to predict methylation levels at CpG site resolution using features
100 ed us to develop a classifier to predict DNA methylation levels at CpG site resolution with high accu
102 also observed a modest parental bias in DNA methylation levels at every CpG analyzed across approxim
103 lood glucose and insulin resistance; (v) DNA methylation levels at five CpG sites, mapping to three w
109 (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 x 10(-8)),
113 tly altered at enhancer regions and that the methylation levels at specific enhancers predict overall
114 (Setdb1) results in reduced H3K9me3 and DNA methylation levels at specific loci, concomitant with in
115 n 24-nucleotide siRNA levels also affect DNA methylation levels at such loci and inversely correlate
116 ng in a PEV model by modulating histone H3K9 methylation levels at the heterochromatin-euchromatin bo
117 owever, the suvh1 mutation did not alter DNA methylation levels at the LUC transgene or on a genome-w
119 orporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a tra
120 many samples, computationally predicting DNA methylation levels based on 450K data would be valuable
121 analyzing the changes that occur at the DNA methylation level between primary cancer cells and metas
122 f CpGs displaying significant differences in methylation levels between fimbrial and proximal fallopi
123 es critical to accurately model variation in methylation levels between replicates and account for in
125 demethylase that does not purposely decrease methylation levels, but specifically prevents aberrant m
127 usually exist a large number of genes whose methylation level cannot be accurately estimated due to
128 ntimate relationships between TF binding and methylation level changes around the binding sites.
129 These changes are also accompanied by DNA methylation level changes in several imprinted domains,
131 and high CRP levels had higher log FOXP3 DNA methylation levels compared with children with OSA and l
134 he HLA-A promoter region where increased DNA methylation levels correlated significantly with reduced
135 trisomy 12 CLL were overall methylated, the methylation levels correlating inversely to CD49d expres
140 MRs as sites where the maternal and paternal methylation levels diverge significantly from the bipare
141 e evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS d
142 We show that our method provides accurate methylation level estimates and accurate detection of di
143 show that neuronal Tet1 regulates normal DNA methylation levels, expression of activity-regulated gen
148 (Zea mays) inbred lines found that while DNA methylation levels for more than 99% of the analyzed gen
151 ns to describe the relationship between gene methylation levels, GC(3), expression, length, and other
152 s did not follow this developmental pattern; methylation levels gradually increased over the first th
153 easurements, demonstrating that the receptor-methylation level has only minor effects on receptor coo
155 disease risk are mediated by changes in DNA methylation levels has not been systematically explored.
156 hes to identify methylated proteins, measure methylation levels, identify substrates of methyltransfe
157 our method confirms the hypervariability of methylation level in cancer patients, and it detects cle
158 the end of the zygotic stage the genome-wide methylation level in male pronuclei is already lower tha
160 hermore, this method has been used to detect methylation levels in a collection of DNA samples taken
161 t under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in
163 combined promoter methylation pattern of low methylation levels in ALDH1A2 and OSR2 promoters and hig
167 Among them, 2 and 3 increase H3K4 and H3K9 methylation levels in cells and cause growth arrest and
170 (K4M) mutant, which reduces endogenous H3K4 methylation levels in ES cells, decreases the protein st
171 evels in ALDH1A2 and OSR2 promoters and high methylation levels in GATA4, GRIA4, and IRX4 promoters w
172 pplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.0
174 ant differences were observed in the guanine methylation levels in mouse and human samples, consisten
176 type-specific differences in chloroplast DNA methylation levels in plus versus minus mating type game
178 g to examine the cross-sectional genome-wide methylation levels in the Ce of 23 age-matched monkeys (
180 slands (n = 44), most (75%) exhibited higher methylation levels in the highest exposed group compared
182 entified 1,194 target loci showing different methylation levels in tumors compared with controls.
183 re we estimate the total heritability of DNA methylation levels in whole blood and estimate the varia
184 pecific CG density threshold to predetermine methylation levels in wild-type cells and the magnitude
185 redox and methylation status (including DNA methylation levels) in cultured neuronal SH-SY5Y cells.
186 of the myoblasts proceeded, their global DNA methylation level increased and their methylation patter
187 airs of duplicated genes, divergence in body methylation levels increases with physical distance and
192 omputational prediction of CpG site-specific methylation levels is critical to enable genome-wide ana
194 ression modulated by structural variants and methylation levels likely leads to the differential expr
195 t smoking status was associated with the DNA methylation levels (M values) of cg03636183 in the coagu
196 ethylation, suggesting that protein arginine methylation level may, in general, be controlled by the
197 oci (cis-meQTLs) using SNP genotypes and DNA methylation levels measured across the IREB2-HYKK-PSMA4-
198 rsed nuclear elements (LINE1) and AluYb8 DNA methylation levels measured in newborn blood spot tests,
199 2) placentae were used to determine the mean methylation level (ML) for the ERVW-1 promoter region.
203 evel of DNA methylation than the average DNA methylation level of all the DH sites located in the pro
206 high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human
207 These findings reveal that modulating the methylation level of phospholipid headgroups is a simple
210 AC3B dysfunction does not alter promoter DNA methylation level of the transgene d35S::LUC, although t
212 active protein (hsCRP) were assessed for DNA methylation levels of 24 inflammatory-related genes.
214 de association study begun in 2008 using DNA methylation levels of 456513 CpG loci measured on the In
217 roach can be used to sensitively analyze the methylation levels of cancer-related genes, which might
221 R, ERL1 and ERL2 Stomatal phenotypes and DNA methylation levels of ER genes in ibm1 and edm2 mutants
224 he impact of maternal weight loss surgery on methylation levels of genes involved in cardiometabolic
226 hermore, an association between the promoter methylation levels of IFNgamma and IL13 was modulated by
228 ladder surgical model and compare global DNA methylation levels of intestinal epithelial cells pre- a
229 l methylcytosine number, reduces the average methylation levels of methylcytosines, and alters (incre
231 3000/avrRpt2 induces biphasic changes in DNA methylation levels of NPR1 and PHYTOALEXIN DEFICIENT4 (P
232 2 diabetes risk variant rs2237895 influenced methylation levels of regulatory sequence in fetal pancr
235 lfite pyrosequencing was used to compare the methylation levels of seven imprinted genes involved in
238 lytic responses that are proportional to the methylation levels of the gene locus in the presence of
241 y, LOI status did not correspond to aberrant methylation levels of the imprinted DMRs or with changes
244 ores were inversely correlated with IL-4 DNA methylation levels (P<.0002) and positively correlated w
246 uencing of the two feeding groups found that methylation levels progressively diverged with age, with
247 In rice (Oryza sativa), we computed a body methylation level (proportion of methylated CpG within c
249 fite sequencing, and for 92.0% of CpG sites, methylation levels ranging over [0,1] were in concordanc
251 d, gene, or microRNA (miRNA) gene-associated methylation levels separated the tumor cohort according
252 that accounts for the spatial correlation of methylation levels, sequence depth and biological variat
254 Unsupervised hierarchical clustering of DNA methylation levels showed that LGSCs differ distinctly f
255 th CAPS treated with anti-IL-1 drugs display methylation levels similar to those of healthy control s
256 educed chromatin accessibility and increased methylation levels specifically at these enhancers, indi
257 ntify stocks with stronger reductions in DNA methylation levels than provided by single gene mutation
259 namic alterations to histone acetylation and methylation levels that are largely reversible upon read
261 nes to be sequenced as thymine, which allows methylation levels to reflected in the number of 'C'-'C'
262 genetic biomarker of aging based on host DNA methylation levels to study accelerated aging effects du
263 epigenome of cancer cells, direct global DNA methylation levels toward a hypomethylated state, and im
264 d earlier findings and revealed reversion of methylation levels toward the non-psoriatic state after
266 3' regions of genes, which show overall low methylation levels, underwent differential methylation i
268 of DNase I hypersensitivity and regional DNA methylation levels using dense in vivo cleavage data.
272 sociation between SAM/SAH ratio and high H19 methylation levels was detected among infants with low B
276 d between beta values and M values only when methylation levels were correlated across CpG loci.
279 5'-region is enriched with CpG sites, whose methylation levels were markedly reduced by 5-Aza-dC.
280 her OXTR methylation at birth and (iii) OXTR methylation levels were more stable across time (birth-a
281 oteomics showed that cellular global histone methylation levels were not significantly affected by SM
282 ord white blood cells (p = 0.05), but global methylation levels were positively associated with the p
283 Mass spectrometry demonstrated that DNA methylation levels were several orders of magnitude belo
286 , and long interspersed nucleotide element 1 methylation level) were available for a subset of cases.
287 study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with childhood asthm
288 were linked to developmental genes and have methylation levels which are associated with development
289 anog and, overall, had decreased genomic CpG methylation levels, which included the promoters of Oct4
290 TT genotype was associated with reduced DNA methylation levels, while MTHFR c. 1298A > C AC genotype
292 omic regions that, along with differences in methylation levels with respect to normal colon tissue,
293 transcript behavior by jointly analyzing DNA-methylation levels with the presence of mutations in a G
294 ratio of X chromosomes to autosomes dictates methylation levels, with female hybrids being hypomethyl
295 ggressiveness associated with Cav1 CGI shore methylation levels, with shore hypermethylation in minim
296 sms of Cav1 gene regulation, we compared DNA methylation levels within promoter 'CpG islands' (CGIs)
297 Indeed, we detected stark differences in methylation levels within promoters and regulatory regio
300 on coefficient (ICC) to compare variation of methylation levels within- and between-replicate pairs,
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