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1  bisulfite treatment of DNA reflects the DNA methylation level.
2 substantially improves the quantification of methylation level.
3 positive) association between RBC folate and methylation level.
4 ry was used to examine leukocyte genomic DNA methylation level.
5 etabolism pathway in relation to genomic DNA methylation level.
6 sociated with intrapair difference in global methylation level.
7 at3 pollen affected transfer RNA and histone methylation levels.
8  between multiple low frequency variants and methylation levels.
9 ications were found to be most predictive of methylation levels.
10 mprinted genes and a global reduction in DNA methylation levels.
11 er YKL-40 levels were associated with higher methylation levels.
12 biomarkers of chronological age based on DNA methylation levels.
13 1 function in regulating global histone H3K4 methylation levels.
14 eosomes containing specific CpG patterns and methylation levels.
15  variation can be used as predictors of gene methylation levels.
16 tiation by controlling the stability of H3K4 methylation levels.
17 e SOLiD sequencer to investigate genome-wide methylation levels.
18 ction and changes in the gene expression and methylation levels.
19 els, and both treatments restored global DNA methylation levels.
20 bitor H89 represses them by suppressing H3K4 methylation levels.
21 ated resulting in enhanced histone H3K27 tri-methylation levels.
22 ygous loss in female ESCs leads to male-like methylation levels.
23  be corrected in order to determine accurate methylation levels.
24 and the time since smoking cessation affects methylation levels.
25 d rare variants that are associated with DNA methylation levels.
26 ing upon the predictive power of average DNA methylation levels.
27 d ALU repeats showed significantly decreased methylation levels (4-7 percentage points for MEST, 1-2
28 nce contexts, concentrations (20-1900nM) and methylation levels (5-100%).
29                                   Global DNA methylation level (%5-mC) was quantified using ELISA met
30 und that Spirodela has the lowest global DNA methylation levels (9%) of any plant species tested.
31                 A decreasing trend in global methylation levels according to deposition date shows in
32 mapping accuracy, methylation call accuracy, methylation level accuracy and space efficiency.
33      FadE reported widespread differences in methylation levels across CpG islands and a large number
34 irical Bayes method are recommended when DNA methylation levels across CpG loci are independent, whil
35 riate FDR control and the highest power when methylation levels across CpG loci were independent.
36 riate FDR control and the highest power when methylation levels across CpG sites were correlated.
37 ape gbM, we first tested for correlations in methylation levels across orthologues(1,2).
38 g to different correlation structures in CpG methylation levels across the genome while taking into a
39 11 out of 12 cases, methylCRF predictions of methylation level agree better with validated results th
40 actors for colorectal cancer and genomic DNA methylation level (all p for trend >0.05).
41          In colorectal cancer patients, EGFR methylation level also correlated with a higher recurren
42 We identified extensive variation of histone methylation levels among individuals and mapped hundreds
43 sociation between pre-diagnostic genomic DNA methylation level and colorectal cancer risk among diver
44  and to broaden the E component by including methylation level and gene expression as promising ways
45     Noticing that the age is associated with methylation level and the methylation data are not norma
46 modified the association between genomic DNA methylation level and the risk of colorectal cancer (all
47 between pre-diagnostic leukocyte genomic DNA methylation level and the risk of colorectal cancer in a
48 corporate local information to improve group methylation level and/or variance estimation for experim
49 to evaluate the causal relationships between methylation levels and 14 cardiovascular disease traits.
50            The Brassicaceae have reduced CHG methylation levels and also reduced or loss of CG gene b
51                     Correlations between DNA methylation levels and biochemical recurrence were asses
52                    Using pre-deployment SKA2 methylation levels and childhood trauma exposure, we fou
53 c organisms, is required for maintaining DNA methylation levels and for controlling the expression of
54 ms (SNPs) is important for quantification of methylation levels and for study of allele-specific epig
55 ically significant correlations between gene methylation levels and gene expression and plasma marker
56 sing features including neighboring CpG site methylation levels and genomic distance, co-localization
57 formatics pipeline to accurately obtain both methylation levels and genotypes from sequencing of bisu
58 ion in Drosophila results in changes of H3K9 methylation levels and heterochromatic silencing defects
59 preferentially from genomic regions with low methylation levels and high recombination rates.
60 et methylome and found a strong link between methylation levels and histone marks.
61 igin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused
62 involving sixmers and their association with methylation levels and other gene level properties.
63 e observed relation between decreases in DNA methylation levels and PTSD symptoms at genomic regions
64 quencing errors and contaminants on inferred methylation levels and recommend the most appropriate wa
65       The locations of the gDMRs, as well as methylation levels and repression effects, were also con
66 en applied to a study of association between methylation levels and smoking status of individuals.
67     Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect varieg
68 ry, we show that neuronal Tet1 regulates DNA methylation levels and that its expression, independent
69 -3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants.
70 -coding genes, lncRNAs showed overall higher methylation levels and their expression was less affecte
71 ultiple CpG sites, as well as their starting methylation levels, and estimates the age of each indivi
72  with their ancestral functions, dynamic DNA methylation levels, and histone modification abundances.
73 G sites with the largest absolute changes in methylation level, approximately 30% correlated with gen
74  We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of l
75 ne promoters enriched for CpG sites at which methylation levels are associated with leukocyte telomer
76 ne promoters enriched for CpG sites at which methylation levels are associated with telomere length i
77  bump hunting method is recommended when DNA methylation levels are correlated across CpG loci.
78              We previously showed that H3K79 methylation levels are induced at T3 target genes during
79 me by silencing repetitive elements when DNA methylation levels are low.
80                            Additionally, CHH methylation levels are reduced in regions near genes and
81 wever, nerve injury had no effect on the DNA methylation level around the Panx1 promoter in the DRG.
82 how that dnmt3 RNAi decreased global genomic methylation level as expected and in addition caused wid
83 tive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Esch
84 e required in vivo to maintain siRNA and DNA methylation levels as well as Pol-IV occupancy at RdDM t
85 lly, we show that the genomic loci whose DNA methylation levels associate most strongly with expressi
86                                          The methylation level at -163 bp was inversely associated wi
87  assays as well as the quantification of the methylation level at every cytosine from the raw peak in
88 y release, concomitantly with changes in the methylation level at specific lysine residues of histone
89 panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated wit
90                                              Methylation levels at 1308 GAD1 regulatory network-assoc
91         Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood
92 ificantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomi
93                            We determined the methylation levels at 27,578 CpG sites in skin samples f
94 ation450 Bead Chips, we measured genome-wide methylation levels at 482,397 CpG loci in umbilical cord
95 ISIS) method with elastic net penalty to DNA methylation levels at 484,548 CpG markers from 659 human
96 stry were each significantly associated with methylation levels at 916 and 194 CpGs, respectively, an
97 Together, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast ca
98           We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the assoc
99  built a random forest classifier to predict methylation levels at CpG site resolution using features
100 ed us to develop a classifier to predict DNA methylation levels at CpG site resolution with high accu
101                In contrast, neither SNPs nor methylation levels at CpG sites in CHI3L1 were associate
102  also observed a modest parental bias in DNA methylation levels at every CpG analyzed across approxim
103 lood glucose and insulin resistance; (v) DNA methylation levels at five CpG sites, mapping to three w
104                               The balance of methylation levels at histone H3 lysine 4 (H3K4) is regu
105 SD1) is responsible for maintaining balanced methylation levels at histone H3 lysine 4 (H3K4).
106                          We examined whether methylation levels at identified sites also showed an as
107                                          DNA methylation levels at individual CpG sites generated fro
108 rest of the group in having highly disrupted methylation levels at many CpG sites.
109  (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 x 10(-8)),
110  is concurrent with aberrantly increased DNA methylation levels at promoter CpG islands (CGIs).
111 yme (MRE-seq) sequencing data to predict DNA methylation levels at single-CpG resolution.
112 ieves 92% prediction accuracy of genome-wide methylation levels at single-CpG-site precision.
113 tly altered at enhancer regions and that the methylation levels at specific enhancers predict overall
114  (Setdb1) results in reduced H3K9me3 and DNA methylation levels at specific loci, concomitant with in
115 n 24-nucleotide siRNA levels also affect DNA methylation levels at such loci and inversely correlate
116 ng in a PEV model by modulating histone H3K9 methylation levels at the heterochromatin-euchromatin bo
117 owever, the suvh1 mutation did not alter DNA methylation levels at the LUC transgene or on a genome-w
118 anMX silencing and decreased repressive H3K9 methylation levels at the transgene.
119 orporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a tra
120 many samples, computationally predicting DNA methylation levels based on 450K data would be valuable
121  analyzing the changes that occur at the DNA methylation level between primary cancer cells and metas
122 f CpGs displaying significant differences in methylation levels between fimbrial and proximal fallopi
123 es critical to accurately model variation in methylation levels between replicates and account for in
124                                     Genic CG methylation levels, but not CHG or CHH levels, are corre
125 demethylase that does not purposely decrease methylation levels, but specifically prevents aberrant m
126                       Using this method, the methylation levels can be quantitatively determined by m
127  usually exist a large number of genes whose methylation level cannot be accurately estimated due to
128 ntimate relationships between TF binding and methylation level changes around the binding sites.
129    These changes are also accompanied by DNA methylation level changes in several imprinted domains,
130                            Second, these DNA methylation level changes were further confirmed manuall
131 and high CRP levels had higher log FOXP3 DNA methylation levels compared with children with OSA and l
132                Over half of the regions show methylation levels consistent with cis inheritance, wher
133         Certain gene bodies with the highest methylation levels correlate with lower expression level
134 he HLA-A promoter region where increased DNA methylation levels correlated significantly with reduced
135  trisomy 12 CLL were overall methylated, the methylation levels correlating inversely to CD49d expres
136 n active chromatin state including lower DNA methylation levels despite higher CpG content.
137                                   Global DNA methylation levels did not follow this developmental pat
138 r IGF2 DMR0 and IGF2 DMR2, although absolute methylation levels differed.
139 oriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10).
140 MRs as sites where the maternal and paternal methylation levels diverge significantly from the bipare
141 e evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS d
142    We show that our method provides accurate methylation level estimates and accurate detection of di
143 show that neuronal Tet1 regulates normal DNA methylation levels, expression of activity-regulated gen
144                                         Body methylation levels follow a bimodal distribution, but sh
145                                          The methylation level for each of these DMRs was also assaye
146                              Modeling of the methylation levels for a CpG site in the AHRR gene indic
147                                              Methylation levels for exposed parents and their offspri
148 (Zea mays) inbred lines found that while DNA methylation levels for more than 99% of the analyzed gen
149 was realized with the ability to distinguish methylation levels from a mixture at 0.1%.
150                                         TET1 methylation levels from DNA derived from nasal airway ep
151 ns to describe the relationship between gene methylation levels, GC(3), expression, length, and other
152 s did not follow this developmental pattern; methylation levels gradually increased over the first th
153 easurements, demonstrating that the receptor-methylation level has only minor effects on receptor coo
154         The genome-wide investigation of DNA methylation levels has been limited to reference transpo
155  disease risk are mediated by changes in DNA methylation levels has not been systematically explored.
156 hes to identify methylated proteins, measure methylation levels, identify substrates of methyltransfe
157  our method confirms the hypervariability of methylation level in cancer patients, and it detects cle
158 the end of the zygotic stage the genome-wide methylation level in male pronuclei is already lower tha
159          Furthermore, berberine enhances DNA methylation level in whole genome but reduces that in pr
160 hermore, this method has been used to detect methylation levels in a collection of DNA samples taken
161 t under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in
162                                              Methylation levels in AHRR were also significantly decre
163 combined promoter methylation pattern of low methylation levels in ALDH1A2 and OSR2 promoters and hig
164  throughout the genome that regulate histone methylation levels in an allele-specific manner.
165  normal cells, but frequently shows elevated methylation levels in cancer samples.
166            Next, we quantified CDH1 promoter methylation levels in CDH1 mutation-positive families, i
167   Among them, 2 and 3 increase H3K4 and H3K9 methylation levels in cells and cause growth arrest and
168                     Additionally, global DNA methylation levels in cells exposed to CNPs at 0.1 mg/L
169                                          CHH methylation levels in cotyledons changed greatly from 6%
170  (K4M) mutant, which reduces endogenous H3K4 methylation levels in ES cells, decreases the protein st
171 evels in ALDH1A2 and OSR2 promoters and high methylation levels in GATA4, GRIA4, and IRX4 promoters w
172 pplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.0
173 se of our current study was to correlate DNA methylation levels in MM to gene expression.
174 ant differences were observed in the guanine methylation levels in mouse and human samples, consisten
175 osure to O3 was associated with higher LINE1 methylation levels in newborn blood spots.
176 type-specific differences in chloroplast DNA methylation levels in plus versus minus mating type game
177                      For regulatory regions, methylation levels in promoter CpG islands are actually
178 g to examine the cross-sectional genome-wide methylation levels in the Ce of 23 age-matched monkeys (
179 ize leaf, concomitant with differential CCGG methylation levels in the four zones.
180 slands (n = 44), most (75%) exhibited higher methylation levels in the highest exposed group compared
181                      We explicitly show that methylation levels in the internal and terminated invert
182 entified 1,194 target loci showing different methylation levels in tumors compared with controls.
183 re we estimate the total heritability of DNA methylation levels in whole blood and estimate the varia
184 pecific CG density threshold to predetermine methylation levels in wild-type cells and the magnitude
185  redox and methylation status (including DNA methylation levels) in cultured neuronal SH-SY5Y cells.
186 of the myoblasts proceeded, their global DNA methylation level increased and their methylation patter
187 airs of duplicated genes, divergence in body methylation levels increases with physical distance and
188       Overall, our results indicate that the methylation level is a long-term property of individual
189                                     Elevated methylation level is associated with increased disease s
190                   Our results imply that DNA methylation level is differentially correlated with the
191 he promoter is minimally methylated, and the methylation level is not altered by SFN treatment.
192 omputational prediction of CpG site-specific methylation levels is critical to enable genome-wide ana
193  melanomas, which also corresponded with DNA methylation levels isolated from tissue samples.
194 ression modulated by structural variants and methylation levels likely leads to the differential expr
195 t smoking status was associated with the DNA methylation levels (M values) of cg03636183 in the coagu
196 ethylation, suggesting that protein arginine methylation level may, in general, be controlled by the
197 oci (cis-meQTLs) using SNP genotypes and DNA methylation levels measured across the IREB2-HYKK-PSMA4-
198 rsed nuclear elements (LINE1) and AluYb8 DNA methylation levels measured in newborn blood spot tests,
199 2) placentae were used to determine the mean methylation level (ML) for the ERVW-1 promoter region.
200           Ke and colleagues found that m(6)A methylation levels negatively correlate with transcript
201                                              Methylation levels observed in leukocyte and mammary tis
202                 Here, we correlated the mean methylation level of 12 CpG sites within the L1 gene, to
203 evel of DNA methylation than the average DNA methylation level of all the DH sites located in the pro
204                                          The methylation level of GPC5 was negatively correlated with
205          UVB has no effect on the global tri-methylation level of histone H3 (H3K4me3, H3K9me3, and H
206  high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human
207    These findings reveal that modulating the methylation level of phospholipid headgroups is a simple
208 traction from membranes by the change of the methylation level of phospholipid headgroups.
209                                          The methylation level of several CpG modules, specifically t
210 AC3B dysfunction does not alter promoter DNA methylation level of the transgene d35S::LUC, although t
211                      The initial overall DNA methylation level of the two de novo regions was at a lo
212 active protein (hsCRP) were assessed for DNA methylation levels of 24 inflammatory-related genes.
213             We profiled peripheral blood DNA methylation levels of 384 CpGs in promoter regions of 82
214 de association study begun in 2008 using DNA methylation levels of 456513 CpG loci measured on the In
215  blood tissues heterozygous for IGF2 and H19 methylation levels of 48 placentas.
216 entified >100 TRs associated with expression/methylation levels of adjacent genes.
217 roach can be used to sensitively analyze the methylation levels of cancer-related genes, which might
218                                      The DNA methylation levels of cg03636183 in F2RL3 were associate
219 leukin-18 levels through the decrease in DNA methylation levels of cg03636183 in F2RL3.
220  of MAADP and ADP% were also associated with methylation levels of CpG 11 and CpG 12 + 13.
221 R, ERL1 and ERL2 Stomatal phenotypes and DNA methylation levels of ER genes in ibm1 and edm2 mutants
222                          We compared the DNA-methylation levels of FTD cases (n = 128), and of FTD ca
223                       Significantly elevated methylation levels of GCK CpG4 methylation were observed
224 he impact of maternal weight loss surgery on methylation levels of genes involved in cardiometabolic
225            This reduction markedly decreases methylation levels of histones, resulting in dramatic al
226 hermore, an association between the promoter methylation levels of IFNgamma and IL13 was modulated by
227                              We analyzed DNA methylation levels of inflammasome-related genes in pati
228 ladder surgical model and compare global DNA methylation levels of intestinal epithelial cells pre- a
229 l methylcytosine number, reduces the average methylation levels of methylcytosines, and alters (incre
230                                 Moreover, as methylation levels of neighboring CpG sites are known to
231 3000/avrRpt2 induces biphasic changes in DNA methylation levels of NPR1 and PHYTOALEXIN DEFICIENT4 (P
232 2 diabetes risk variant rs2237895 influenced methylation levels of regulatory sequence in fetal pancr
233                                      Dynamic methylation levels of scUMCs correlate with the intensit
234                                Leukocyte DNA methylation levels of selected imprinted genes may there
235 lfite pyrosequencing was used to compare the methylation levels of seven imprinted genes involved in
236 tosines, and alters (increases or decreases) methylation levels of specific methylcytosines.
237  how our covariate model accurately predicts methylation levels of the Foxp3 locus.
238 lytic responses that are proportional to the methylation levels of the gene locus in the presence of
239           Before hormonal treatment, the DNA methylation levels of the genes encoding for the aromata
240 placentas not associated with differences in methylation levels of the H19ICR.
241 y, LOI status did not correspond to aberrant methylation levels of the imprinted DMRs or with changes
242                                 In addition, methylation levels of two CpG loci within the putative G
243 igher proportion of ALS patients with a high methylation level (P = 0.09).
244 ores were inversely correlated with IL-4 DNA methylation levels (P<.0002) and positively correlated w
245 lated with IFN-gamma and Foxp3 gene promoter methylation levels (P<.0011) (P<.0165).
246 uencing of the two feeding groups found that methylation levels progressively diverged with age, with
247   In rice (Oryza sativa), we computed a body methylation level (proportion of methylated CpG within c
248 howed global methylome patterns with overall methylation levels ranging from 17% to 84%.
249 fite sequencing, and for 92.0% of CpG sites, methylation levels ranging over [0,1] were in concordanc
250 tion was reduced in suvh1; in contrast, H3K9 methylation levels remained unchanged.
251 d, gene, or microRNA (miRNA) gene-associated methylation levels separated the tumor cohort according
252 that accounts for the spatial correlation of methylation levels, sequence depth and biological variat
253                                     Cytosine methylation levels showed a gradual decrease within appr
254  Unsupervised hierarchical clustering of DNA methylation levels showed that LGSCs differ distinctly f
255 th CAPS treated with anti-IL-1 drugs display methylation levels similar to those of healthy control s
256 educed chromatin accessibility and increased methylation levels specifically at these enhancers, indi
257 ntify stocks with stronger reductions in DNA methylation levels than provided by single gene mutation
258 d exons that demonstrate significantly lower methylation levels than their surrounding introns.
259 namic alterations to histone acetylation and methylation levels that are largely reversible upon read
260                                     We found methylation levels to be significantly higher in the pen
261 nes to be sequenced as thymine, which allows methylation levels to reflected in the number of 'C'-'C'
262 genetic biomarker of aging based on host DNA methylation levels to study accelerated aging effects du
263 epigenome of cancer cells, direct global DNA methylation levels toward a hypomethylated state, and im
264 d earlier findings and revealed reversion of methylation levels toward the non-psoriatic state after
265                                To assess DNA methylation levels, treated and untreated Pit-1/0 genomi
266  3' regions of genes, which show overall low methylation levels, underwent differential methylation i
267                             It then compares methylation levels using beta-binomial hierarchical mode
268 of DNase I hypersensitivity and regional DNA methylation levels using dense in vivo cleavage data.
269                  Interestingly, most histone methylation level variation was trans-linked and the mos
270                          Overall genomic DNA methylation level was not associated with the risk of co
271                                              Methylation level was significantly higher in FTLD expan
272 sociation between SAM/SAH ratio and high H19 methylation levels was detected among infants with low B
273        No significant difference in promoter methylation levels was shown between omega-3 PUFA-supple
274                                          DNA methylation levels were assessed by pyrosequencing of th
275                            In addition, high methylation levels were associated with subsequent diagn
276 d between beta values and M values only when methylation levels were correlated across CpG loci.
277                          Moreover, decreased methylation levels were found in the promoters of Myh7,
278                            LINE-1 and AluYb8 methylation levels were found to be significantly positi
279  5'-region is enriched with CpG sites, whose methylation levels were markedly reduced by 5-Aza-dC.
280 her OXTR methylation at birth and (iii) OXTR methylation levels were more stable across time (birth-a
281 oteomics showed that cellular global histone methylation levels were not significantly affected by SM
282 ord white blood cells (p = 0.05), but global methylation levels were positively associated with the p
283      Mass spectrometry demonstrated that DNA methylation levels were several orders of magnitude belo
284                                 In vivo tRNA methylation levels were stimulated by growth of cells in
285                       After quality control, methylation levels were tested for association with BMI.
286 , and long interspersed nucleotide element 1 methylation level) were available for a subset of cases.
287  study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with childhood asthm
288  were linked to developmental genes and have methylation levels which are associated with development
289 anog and, overall, had decreased genomic CpG methylation levels, which included the promoters of Oct4
290  TT genotype was associated with reduced DNA methylation levels, while MTHFR c. 1298A > C AC genotype
291 eptional diet may persistently influence DNA methylation levels with phenotypic consequences.
292 omic regions that, along with differences in methylation levels with respect to normal colon tissue,
293 transcript behavior by jointly analyzing DNA-methylation levels with the presence of mutations in a G
294 ratio of X chromosomes to autosomes dictates methylation levels, with female hybrids being hypomethyl
295 ggressiveness associated with Cav1 CGI shore methylation levels, with shore hypermethylation in minim
296 sms of Cav1 gene regulation, we compared DNA methylation levels within promoter 'CpG islands' (CGIs)
297     Indeed, we detected stark differences in methylation levels within promoters and regulatory regio
298 th local extremes of gene expression and DNA methylation levels within the population.
299 nal complexity of having to estimate the DNA methylation levels within the sample.
300 on coefficient (ICC) to compare variation of methylation levels within- and between-replicate pairs,

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