ライフサイエンスコーパス: methylcholanthrene

1 enobarbital, oltipraz, and, in particular, 3-methylcholanthrene.

2 h different doses of the chemical carcinogen methylcholanthrene.

3 ducing CYP1A1 mRNA were benzo[e]pyrene and 3-methylcholanthrene.

4 hylchrysene, 11,12-dihydroxy-11,12-dihydro-3-methylcholanthrene, 1,2-dihydroxy-1,2-dihydro-6-methylch

5 ss to oltipraz (2- to 5-fold increase) and 3-methylcholanthrene (10- to 30-fold increase).

6 l (2 mmol/L), oltipraz (50 micromol/L), or 3-methylcholanthrene (2.5 micromol/L) revealed UGT1A1-indu

7 Advanced 10-day 3-methylcholanthrene 205 intracranial tumors could be cure

8 For treatment of 10-day 3-methylcholanthrene 205 pulmonary metastases, systemic tr

9 tumors (B16), but not gp100-negative tumors (methylcholanthrene 205), implanted on opposing flanks of

10 y we confirmed that rejection of established methylcholanthrene-205 (MCA-205) pulmonary metastases di

11 Administration of 3-methylcholanthrene (3-MC) to these mice (Nrf1(flox/flox)

12 ed to determine whether tumor induction by 3-methylcholanthrene (3-MC), a carcinogenic hydrocarbon, c

13 ced lung tumors following exposure to BaP, 3-methylcholanthrene (3-MC), and urethane.

14 ue-Dawley rats were injected with PB, PCN, 3-methylcholanthrene (3-MC), or vehicle for 4 days.

15 exposure of liver slices to the model POP 3-methylcholanthrene (3-MC; 25 muM) at levels of hydrostat

16 3-Methylcholanthrene (3MC) is an aryl hydrocarbon receptor

17 he aryl-hydrocarbon receptor (AhR) agonist 3-methylcholanthrene (3MC) is involved in the antimigrator

18 ydrocarbon environmental toxicants such as 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-diox

19 sed by pretreatment with the CYP1A inducer 3-methylcholanthrene and decreased by coincubation with th

20 ignated AHR repressor (AHRR) is induced by 3-methylcholanthrene and represses the transcriptional act

21 stimulators, such as beta-naphthoflavone, 3-methylcholanthrene, and tBHQ, significantly upregulated

22 Polycyclic aromatic hydrocarbons such as 3-methylcholanthrene are toxic to rat epidermal cells in l

23 Cs with 0.3 or 3 microM hydrogen peroxide, 3-methylcholanthrene, benzo[a]pyrene-7,8-diol, 3-hydroxy b

24 Lung tumorigenesis was induced using a 3-methylcholanthrene/butylated hydroxytoluene (BHT; 3,5-di

25 r embryo fibroblasts with a single dose of 3-methylcholanthrene caused the activation of the transfor

26 s of CHE cells transformed by benz[a]pyrene, methylcholanthrene, dimethylbenzanthracene, and colcemid

27 Treatment of methylcholanthrene-induced (Meth A) ascites tumors with

28 When murine MC38 (methylcholanthrene-induced adenocarcinoma 38) cells were

29 de-specific CTL that reacted against several methylcholanthrene-induced BALB/c sarcomas, including CM

30 Incubations of 3-methylcholanthrene-induced colon slices dosed with 50 mi

31 Methylcholanthrene-induced fibrosarcoma (Meth-A) cells w

32 cination with hsp110 or grp170 purified from methylcholanthrene-induced fibrosarcoma caused complete

33 udies were carried out with locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c

34 or perfusion studies, using locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c

35 The s.c. methylcholanthrene-induced fibrosarcoma leg tumors were

36 ones, generated from mice immunized with the methylcholanthrene-induced fibrosarcoma Meth A (H-2(d)),

37 ogenesis was also observed in the nonrelated methylcholanthrene-induced fibrosarcoma model.

38 Our recent studies in methylcholanthrene-induced fibrosarcomas have indicated

39 We subjected a heterozygous 3-methylcholanthrene-induced murine sarcoma cell line to C

40 e established solid tumor (20 mm), MCA207, a methylcholanthrene-induced murine sarcoma.

41 ze expressed mutations in highly immunogenic methylcholanthrene-induced sarcomas derived from immunod

42 mpared the incidence and immunogenicity of 3'methylcholanthrene-induced sarcomas in syngeneic wild-ty

43 igens expressed by cell lines derived from 3-methylcholanthrene-induced sarcomas of (C57BL/6J X SPRET

44 n-specific CD8(+) T cells in mice bearing T3 methylcholanthrene-induced sarcomas that are susceptible

45 ed in significantly increased incidence of 3-methylcholanthrene-induced spontaneous sarcoma developme

46 The QT35 cell line was established from a methylcholanthrene-induced tumor in Japanese quail (Cotu

47 ive analysis of the antitumor response to 3'-methylcholanthrene-induced tumors, which either grow pro

48 rmone (insulin and glucagon) and chemical (3-methylcholanthrene) induction agents in a microfluidic d

49 We inoculated methylcholanthrene (MCA) 205 in the flanks of normal mic

50 In mice with 10-day established pulmonary 3-methylcholanthrene (MCA) 205 metastases, accumulation of

51 njection of ethyl carbamate (urethane), or 3-methylcholanthrene (MCA) and butylated hydroxytoluene (B

52 a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tumors unless t

53 The effects of conditioned media from the methylcholanthrene (MCA) fibrosarcoma on hepatocyte albu

54 protocols for chemical skin carcinogenesis [methylcholanthrene (MCA) or 7,12-dimethylbenz(a)anthrace

55 t after challenge with a chemical carcinogen methylcholanthrene (MCA) or inoculation with the melanom

56 or IFN-alpha reduce expression of H60 on 3'-methylcholanthrene (MCA) sarcomas from 129/Sv mice.

57 an hamster embryo fibroblasts initiated by 3-methylcholanthrene (MCA), and was shown to be a single c

58 Using the carcinogen 3-methylcholanthrene (MCA), we demonstrate with Fourier tr

59 reatment of mice challenged with a syngeneic methylcholanthrene (MCA)-induced fibrosarcoma would augm

60 3 deficiency suppressed the development of 3-methylcholanthrene (MCA)-induced fibrosarcomas through a

61 e equilibrium phase during immune control of methylcholanthrene (MCA)-induced or p53 mutant cancers a

62 aneous and experimental tumor metastases and methylcholanthrene (MCA)-induced sarcomas in mice defici

63 or prone when challenged with the carcinogen methylcholanthrene (MCA).

64 ere induced in Rosa26-Foxm1 mice using the 3-methylcholanthrene (MCA)/butylated hydroxytoluene (BHT)

65 in 1 week of treatment with the carcinogen 3-methylcholanthrene (MCA; 10 microg/g body weight), lung

66 e reduced the effects of both oltipraz and 3-methylcholanthrene on the P1 reporter.

67 Comparative effects of oltipraz and 3-methylcholanthrene on transfected cytochrome P4501A1 rep

68 Treatment with 3-methylcholanthrene or oltipraz had no effect compared wi

69 Clofibrate, 3-methylcholanthrene, or beta-naphthoflavone treatment of

70 Previously, we reported the absence of 3-methylcholanthrene- or oltipraz-responsive elements in t

71 ll as other known P450 inducers, including 3-methylcholanthrene, pregnenolone-16alpha-carbonitrile, a

72 on of AhR agonists beta-naphthoflavone and 3-methylcholanthrene, respectively, into partial agonists/

73 ferase activities expressed from basal and 3-methylcholanthrene-responsive UGT1A7 gene reporter const

74 a cell lines compared with that in edited 3'-methylcholanthrene sarcoma cell lines (i.e., some unedit

75 more heterogeneous in groups of unedited 3'-methylcholanthrene sarcoma cell lines compared with that

76 , hamsters, and mice by carcinogenic agents (methylcholanthrene, thioacetamide), oncogenic viruses (S

77 Using tumor cells derived from methylcholanthrene-treated IFN-gamma-insensitive mice, w

78 by TCDD but not by beta-naphthoflavone or 3-methylcholanthrene was significantly diminished.

79 as a reference for radiation effects, and 20-methylcholanthrene was used as a positive control for fo