ライフサイエンスコーパス: methylenetetrahydrofolate

1 n to tetrahydrofolate, generating N(5),N(10)-methylenetetrahydrofolate.

2 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.

3 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.

4 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.

5 arbon group to tetrahydrofolate to form 5,10-methylenetetrahydrofolate.

6 y complex formation with [32P]FdUMP and 5,10-methylenetetrahydrofolate.

7 arcosine is coupled to the formation of 5,10-methylenetetrahydrofolate.

8 ynthesis of thymidylate, which requires 5,10-methylenetetrahydrofolate (5,10-CH(2)-THF).

9 relapse risk by potentially increasing 5,10-methylenetetrahydrofolate and dTMP, enhancing DNA synthe

10 unique tRNA methyltransferase using instead methylenetetrahydrofolate and reduced flavin adenine din

11 ts for dTMP biosynthesis in the form of 5,10-methylenetetrahydrofolate, are direct targets of As2O3-i

12 aracterized mechanism for methylation, using methylenetetrahydrofolate as a methyl group donor.

13 eoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as h

14 in adenine dinucleotide together with N5,N10-methylenetetrahydrofolate as the one-carbon donor.

15 hylate sp(2)-hybridized carbon centers using methylenetetrahydrofolate as the source of the appended

16 ed this enzyme regulates the partitioning of methylenetetrahydrofolate between the thymidylate and ho

17 und to be rate-limiting for the oxidation of methylenetetrahydrofolate by kinetic isotope experiments

18 erichia coli catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) by NADH via

19 catalyzes the NADH-linked reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl

20 erichia coli catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl

21 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl

22 lyze the NAD(P)H-dependent reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl

23 -90 times higher, while K(m) values for 5,10-methylenetetrahydrofolate (CH(2)H(4)folate) were 1.5-16-

24 able with the wild-type values, but K(m) for methylenetetrahydrofolate (CH(2)H(4)PteGlu) was >10-fold

25 ofolate (H4folate) to yield glycine and 5,10-methylenetetrahydrofolate (CH2-H4folate).

26 yces cerevisiae possesses two cytosolic 5,10-methylenetetrahydrofolate (CH2-THF) dehydrogenases that

27 enzyme that catalyzes the oxidation of 5,10-methylenetetrahydrofolate (CH2-THF) in adult mammalian m

28 sm-based inhibitor 5-fluoro-dUMP (FdUMP) and methylenetetrahydrofolate (CH2THF) have been determined

29 tion pathways compete for a limiting pool of methylenetetrahydrofolate cofactors and that thymidylate

30 g covalent thymidylate synthase-5-fluorodUMP-methylenetetrahydrofolate complex; hence, the Asp side c

31 5,10-Methylenetetrahydrofolate dehydrogenase (MTD) catalyzes

32 ificance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes.

33 osophila homolog of the trifunctional enzyme methylenetetrahydrofolate dehydrogenase (MTHFD; E.C.1.5.

34 tains a monofunctional NAD(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase (yMTD).

35 Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and s

36 olism associated with mutations in the human methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene

37 In this study we demonstrate that methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), an e

38 (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrofolate dehydrogenase 1 (Mthfd1), was

39 Serine and glycine interconversion and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)-media

40 We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L)

41 ondrial tetrahydrofolate (mTHF) cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) being

42 ic transformation is MTHFD2, a mitochondrial methylenetetrahydrofolate dehydrogenase and cyclohydrola

43 amide ribonucleotide formyltransferase, 5,10-methylenetetrahydrofolate dehydrogenase, and 10-formylte

44 production through the reaction catalyzed by methylenetetrahydrofolate dehydrogenase, thus allowing p

45 sociation in premenopausal women of the 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allel

46 ls who were carriers of the very common 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allel

47 The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2

48 ommon polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahyd

49 e (WT)], MTR reductase (MTRR) rs1801394, and methylenetetrahydrofolate dehydrogenase-methenyltetrahyd

50 dao-3 encodes a putative methylenetetrahydrofolate dehydrogenase.

51 The bifunctional enzyme N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclo hydrolase

52 tion (R175Q) in the cytoplasmic bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahyd

53 de phosphate-dependent, trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahyd

54 ydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis

55 SHMT1 generates 5,10-methylenetetrahydrofolate for de novo thymidylate biosyn

56 ogenase 1 (MTHFD1), an enzyme that generates methylenetetrahydrofolate from formate, ATP, and NADPH,

57 zyme methylenetetrahydrofolate reductase for methylenetetrahydrofolate in a glycine-dependent manner,

58 A method for the determination of 5,10-methylenetetrahydrofolate in liver is described.

59 (1) from (3) gives the concentration of 5,10-methylenetetrahydrofolate in liver.

60 s the oxidation of methyltetrahydrofolate to methylenetetrahydrofolate in the presence of menadione,

61 ovalerate and (ii) deuterium exchange in the methylenetetrahydrofolate-independent enolization of alp

62 The folate coenzyme 5,10-methylenetetrahydrofolate is an important folate metabol

63 evious metabolic studies that indicated 5,10-methylenetetrahydrofolate is preferentially directed tow

64 olon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but

65 ancer probably because higher levels of 5,10-methylenetetrahydrofolate may prevent imbalances of nucl

66 Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for me

67 or thymidylate biosynthesis, (2) it depletes methylenetetrahydrofolate pools for SAM synthesis by syn

68 amide ribonucleotide transformylase (347GG), methylenetetrahydrofolate reductase (1298AC/CC), methion

69 strain of Escherichia coli that overproduces methylenetetrahydrofolate reductase (MetF) has been cons

70 l6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 12

71 tatus, DNA methylation, and polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677C-->T and

72 morphic genes involved in folate metabolism--methylenetetrahydrofolate reductase (MTHFR C677T and A12

73 on mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) (5-methyltet

74 A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C-->T) i

75 A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (

76 of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1

77 The methylenetetrahydrofolate reductase (MTHFR) 677C>T polym

78 em for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs18

79 genes coding for folate pathway enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and

80 the combined effects of the TC 776C-->G and methylenetetrahydrofolate reductase (MTHFR) 677C-->T pol

81 Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C-->T pol

82 Low-penetrance risk genotypes in methylenetetrahydrofolate reductase (MTHFR) 677TT, thymi

83 n capability is demonstrated by analyzing 96 methylenetetrahydrofolate reductase (MTHFR) alleles in p

84 Four fetal genetic variants of the 5,10-methylenetetrahydrofolate reductase (MTHFR) and dihydrof

85 at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methioni

86 Methylenetetrahydrofolate reductase (MTHFR) and thymidyl

87 The single nucleotide polymorphism (SNP) methylenetetrahydrofolate reductase (MTHFR) C677T (rs180

88 The effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genoty

89 The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genoty

90 Methylenetetrahydrofolate reductase (MTHFR) catalyzes th

91 Escherichia coli methylenetetrahydrofolate reductase (MTHFR) catalyzes th

92 Methylenetetrahydrofolate reductase (MTHFR) catalyzes th

93 Methylenetetrahydrofolate reductase (MTHFR) catalyzes th

94 Methylenetetrahydrofolate reductase (MTHFR) catalyzes th

95 The flavoprotein Escherichia coli methylenetetrahydrofolate reductase (MTHFR) catalyzes th

96 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes th

97 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes th

98 treatment on outcome in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency i

99 d families, each with 2 siblings with severe methylenetetrahydrofolate reductase (MTHFR) deficiency m

100 Methylenetetrahydrofolate reductase (MTHFR) directs 5,10

101 The flavoprotein methylenetetrahydrofolate reductase (MTHFR) from Escheri

102 estigated whether a polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T)

103 ariant form (the C677T genotype) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and ris

104 ly reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at posi

105 A common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has bee

106 ozygosity for the variant 677T allele in the methylenetetrahydrofolate reductase (MTHFR) gene increas

107 etermine whether the C677T transition in the methylenetetrahydrofolate reductase (MTHFR) gene is asso

108 The methylenetetrahydrofolate reductase (MTHFR) gene is impo

109 ions in cystathionine beta-synthase (CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to

110 abolism and the 677C-->T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be

111 at nucleotide 677 (677C-->T) mutation of the methylenetetrahydrofolate reductase (MTHFR) gene may be

112 Functional polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene result

113 p of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with th

114 hol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--

115 is illustrated here using the example of the methylenetetrahydrofolate reductase (MTHFR) gene, homocy

116 ssociation between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, includ

117 ion of chromosome 1 that contains a putative methylenetetrahydrofolate reductase (MTHFR) gene, which

118 Methylenetetrahydrofolate reductase (MTHFR) generates me

119 The methylenetetrahydrofolate reductase (MTHFR) genotype is

120 risk factors, C-reactive protein (CRP), and methylenetetrahydrofolate reductase (MTHFR) genotype.

121 0 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.

122 Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been as

123 e induced by deficiency in a key OCM enzyme, methylenetetrahydrofolate reductase (MTHFR) in Mthfr(+/-

124 Methylenetetrahydrofolate reductase (MTHFR) is a key enz

125 Methylenetetrahydrofolate reductase (MTHFR) is a key enz

126 Methylenetetrahydrofolate reductase (MTHFR) is central t

127 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is involved

128 Methylenetetrahydrofolate reductase (MTHFR) is involved

129 Methylenetetrahydrofolate reductase (MTHFR) is the least

130 her homocysteine or MTX toxicity differed by methylenetetrahydrofolate reductase (MTHFR) or reduced f

131 Importance: Methylenetetrahydrofolate reductase (MTHFR) polymorphism

132 Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes

133 The methylenetetrahydrofolate reductase (MTHFR) protein and

134 Methylenetetrahydrofolate reductase (MTHFR) provides met

135 ions in cystathionine beta-synthase (Cbs) or methylenetetrahydrofolate reductase (Mthfr) results in n

136 Variants impairing folate metabolism, methylenetetrahydrofolate reductase (MTHFR) rs1801133, m

137 (AdoMet) is thought to be controlled at the methylenetetrahydrofolate reductase (MTHFR) step.

138 Methylenetetrahydrofolate reductase (MTHFR) synthesizes

139 In human methylenetetrahydrofolate reductase (MTHFR) the Ala222Va

140 with hypertension and stroke, independent of methylenetetrahydrofolate reductase (MTHFR) variants.

141 ymorphism (TT genotype) in the gene encoding methylenetetrahydrofolate reductase (MTHFR) was responsi

142 AS1-VNTR; OR = 2.50, 95% CI: 1.54-4.05); and methylenetetrahydrofolate reductase (MTHFR)(Val/Val) (OR

143 Methylenetetrahydrofolate reductase (MTHFR), a critical

144 Methylenetetrahydrofolate reductase (MTHFR), a pivotal e

145 (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofolate reductase (Mthfr), adenosyl-ho

146 A common genetic mutation in methylenetetrahydrofolate reductase (MTHFR), an enzyme r

147 on of polymorphisms in thymidylate synthase, methylenetetrahydrofolate reductase (MTHFR), and VEGF.

148 Concomitantly, methylenetetrahydrofolate reductase (Mthfr), betaine-hom

149 of a prototypical vitamin-dependent enzyme, methylenetetrahydrofolate reductase (MTHFR), from 564 in

150 combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine

151 in the following folate-metabolizing genes: methylenetetrahydrofolate reductase (MTHFR), reduced fol

152 in the methionine synthase reductase (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydr

153 One such enzyme, methylenetetrahydrofolate reductase (MTHFR), synthesizes

154 r methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR).

155 hymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).

156 abolized to methionine by the action of 5,10 methylenetetrahydrofolate reductase (MTHFR).

157 The presence of a nonsynonymous SNP in the methylenetetrahydrofolate reductase (MTHFR)gene was asso

158 Human methylenetetrahydrofolate reductase (MTHFR, EC 1.5.1.20)

159 e thermolabile mutation (TT genotype) of the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20)

160 Methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20)

161 Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5)

162 D1 G870A (AA) polymorphism (P = 0.0138), and methylenetetrahydrofolate reductase (NAD(P)H) C677T (TT)

163 the cyclin D1 G870A (AA) polymorphism or the methylenetetrahydrofolate reductase (NAD(P)H) C677T (TT)

164 bstitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofa

165 s low: choline dehydrogenase (CHDH) rs12676, methylenetetrahydrofolate reductase 1 (MTHFD1) rs2236225

166 factor V 1691A (Leiden), factor II 20 210A, methylenetetrahydrofolate reductase 667T, type 1 plasmin

167 splant body mass index >or= 25, or carry the methylenetetrahydrofolate reductase 677 TT genotype shou

168 oning regimens, body mass index >or= 25, and methylenetetrahydrofolate reductase 677 TT genotype were

169 mes involved in homocysteine metabolism (ie, methylenetetrahydrofolate reductase [MTHFR] 677C>T and 1

170 onine) and related gene polymorphisms (C677T methylenetetrahydrofolate reductase [MTHFR] and C1420T c

171 perhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase and cystathionine be

172 The methylenetetrahydrofolate reductase C677T genotype was n

173 R506G, factor II (prothrombin) G20210A, and methylenetetrahydrofolate reductase C677T, compared with

174 Other genetic variants (prothrombin 20210A, methylenetetrahydrofolate reductase C677T, factor XIII V

175 V Leiden (FVL), factor II G20210A (FII), and methylenetetrahydrofolate reductase C677T.

176 ed serine synthesis competes with the enzyme methylenetetrahydrofolate reductase for methylenetetrahy

177 The flavoprotein methylenetetrahydrofolate reductase from Escherichia col

178 ene (Factor V Leiden), a variant in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR), and an

179 Although the methylenetetrahydrofolate reductase gene has been linked

180 e +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increas

181 of the common C677T base substitution in the methylenetetrahydrofolate reductase gene in 110 DNA samp

182 iation of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutat

183 thymidine mutation at nucleotide 677 in the methylenetetrahydrofolate reductase gene.

184 h homozygosity for the C677T mutation in the methylenetetrahydrofolate reductase gene.

185 Using methylenetetrahydrofolate reductase genotype as the inst

186 iffer from those of the ferredoxin-dependent methylenetetrahydrofolate reductase isolated from the ho

187 Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR

188 igned to usual care or GERA, which evaluated methylenetetrahydrofolate reductase polymorphisms and se

189 to variation in folate status in those with methylenetetrahydrofolate reductase polymorphisms.

190 which acts as an allosteric inhibitor of the methylenetetrahydrofolate reductase reaction and as an a

191 ual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ra

192 pathway (i.e. folate or B12 deficiencies or methylenetetrahydrofolate reductase thermolability).

193 nzyme, estrogen receptor, androgen receptor, methylenetetrahydrofolate reductase).

194 point mutation (C677T) in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved

195 , hemoglobin S, the thermolabile mutation of methylenetetrahydrofolate reductase, and the cystic fibr

196 ystathionine-gamma-lyase, paraxonase 1, 5,10-methylenetetrahydrofolate reductase, betaine:homocystein

197 receptors; and vascular redox determinants (methylenetetrahydrofolate reductase, endothelial nitric

198 brinogen, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase, glycoprotein Illa,

199 deficiencies in cystathionine beta synthase, methylenetetrahydrofolate reductase, or in enzymes invol

200 c acid targets including Factor V Leiden and methylenetetrahydrofolate reductase.

201 ation were until recently largely limited to methylenetetrahydrofolate reductase.

202 (<301 microg/d) of folate, the substrate for methylenetetrahydrofolate reductase; low intake (<1.8 mg

203 (<1.8 mg/d) of vitamin B2, the cofactor for methylenetetrahydrofolate reductase; low intake (<8.0 mi

204 Methylenetetrahydrofolate reductases (MTHFRs; EC 1.7.99.

205 (SHMT) or at the genes encoding one or both methylenetetrahydrofolate reductases.

206 ase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymi

207 folate; (2) chemical reduction of liver 5,10-methylenetetrahydrofolate (stabilized at pH 10) to 5-met

208 The sarcosine dehydrogenase and 5,10-methylenetetrahydrofolate synthase sites are 35 A apart

209 ) catalyzes the reversible oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofola

210 plication by blocking the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by

211 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, t

212 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, u

213 EC 1.5.1.20) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.

214 ine hydroxymethyltransferase (cSHMT)-derived methylenetetrahydrofolate to de novo thymidylate biosynt

215 atalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP.

216 reductase (MTHFR) catalyzes the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, the

217 eductase (MTHFR) catalyzes the conversion of methylenetetrahydrofolate to methyltetrahydrofolate, the

218 e purified enzyme catalyzes the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, usi

219 rahydrofolate reductase (MTHFR) directs 5,10-methylenetetrahydrofolate toward methionine synthesis at