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1 n to tetrahydrofolate, generating N(5),N(10)-methylenetetrahydrofolate.
2 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.
3 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.
4 f serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.
5 arbon group to tetrahydrofolate to form 5,10-methylenetetrahydrofolate.
6 y complex formation with [32P]FdUMP and 5,10-methylenetetrahydrofolate.
7 arcosine is coupled to the formation of 5,10-methylenetetrahydrofolate.
9 relapse risk by potentially increasing 5,10-methylenetetrahydrofolate and dTMP, enhancing DNA synthe
10 unique tRNA methyltransferase using instead methylenetetrahydrofolate and reduced flavin adenine din
11 ts for dTMP biosynthesis in the form of 5,10-methylenetetrahydrofolate, are direct targets of As2O3-i
13 eoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as h
15 hylate sp(2)-hybridized carbon centers using methylenetetrahydrofolate as the source of the appended
16 ed this enzyme regulates the partitioning of methylenetetrahydrofolate between the thymidylate and ho
17 und to be rate-limiting for the oxidation of methylenetetrahydrofolate by kinetic isotope experiments
18 erichia coli catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) by NADH via
19 catalyzes the NADH-linked reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl
20 erichia coli catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl
21 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl
22 lyze the NAD(P)H-dependent reduction of 5,10-methylenetetrahydrofolate (CH(2)-H(4)folate) to 5-methyl
23 -90 times higher, while K(m) values for 5,10-methylenetetrahydrofolate (CH(2)H(4)folate) were 1.5-16-
24 able with the wild-type values, but K(m) for methylenetetrahydrofolate (CH(2)H(4)PteGlu) was >10-fold
26 yces cerevisiae possesses two cytosolic 5,10-methylenetetrahydrofolate (CH2-THF) dehydrogenases that
27 enzyme that catalyzes the oxidation of 5,10-methylenetetrahydrofolate (CH2-THF) in adult mammalian m
28 sm-based inhibitor 5-fluoro-dUMP (FdUMP) and methylenetetrahydrofolate (CH2THF) have been determined
29 tion pathways compete for a limiting pool of methylenetetrahydrofolate cofactors and that thymidylate
30 g covalent thymidylate synthase-5-fluorodUMP-methylenetetrahydrofolate complex; hence, the Asp side c
32 ificance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes.
33 osophila homolog of the trifunctional enzyme methylenetetrahydrofolate dehydrogenase (MTHFD; E.C.1.5.
36 olism associated with mutations in the human methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene
38 (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrofolate dehydrogenase 1 (Mthfd1), was
40 We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L)
41 ondrial tetrahydrofolate (mTHF) cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) being
42 ic transformation is MTHFD2, a mitochondrial methylenetetrahydrofolate dehydrogenase and cyclohydrola
43 amide ribonucleotide formyltransferase, 5,10-methylenetetrahydrofolate dehydrogenase, and 10-formylte
44 production through the reaction catalyzed by methylenetetrahydrofolate dehydrogenase, thus allowing p
45 sociation in premenopausal women of the 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allel
46 ls who were carriers of the very common 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allel
47 The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2
48 ommon polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahyd
49 e (WT)], MTR reductase (MTRR) rs1801394, and methylenetetrahydrofolate dehydrogenase-methenyltetrahyd
52 tion (R175Q) in the cytoplasmic bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahyd
53 de phosphate-dependent, trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahyd
54 ydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis
56 ogenase 1 (MTHFD1), an enzyme that generates methylenetetrahydrofolate from formate, ATP, and NADPH,
57 zyme methylenetetrahydrofolate reductase for methylenetetrahydrofolate in a glycine-dependent manner,
60 s the oxidation of methyltetrahydrofolate to methylenetetrahydrofolate in the presence of menadione,
61 ovalerate and (ii) deuterium exchange in the methylenetetrahydrofolate-independent enolization of alp
63 evious metabolic studies that indicated 5,10-methylenetetrahydrofolate is preferentially directed tow
64 olon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but
65 ancer probably because higher levels of 5,10-methylenetetrahydrofolate may prevent imbalances of nucl
67 or thymidylate biosynthesis, (2) it depletes methylenetetrahydrofolate pools for SAM synthesis by syn
68 amide ribonucleotide transformylase (347GG), methylenetetrahydrofolate reductase (1298AC/CC), methion
69 strain of Escherichia coli that overproduces methylenetetrahydrofolate reductase (MetF) has been cons
70 l6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 12
71 tatus, DNA methylation, and polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677C-->T and
72 morphic genes involved in folate metabolism--methylenetetrahydrofolate reductase (MTHFR C677T and A12
73 on mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) (5-methyltet
76 of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1
78 em for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs18
79 genes coding for folate pathway enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and
80 the combined effects of the TC 776C-->G and methylenetetrahydrofolate reductase (MTHFR) 677C-->T pol
83 n capability is demonstrated by analyzing 96 methylenetetrahydrofolate reductase (MTHFR) alleles in p
85 at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methioni
87 The single nucleotide polymorphism (SNP) methylenetetrahydrofolate reductase (MTHFR) C677T (rs180
98 treatment on outcome in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency i
99 d families, each with 2 siblings with severe methylenetetrahydrofolate reductase (MTHFR) deficiency m
102 estigated whether a polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T)
103 ariant form (the C677T genotype) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and ris
104 ly reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at posi
106 ozygosity for the variant 677T allele in the methylenetetrahydrofolate reductase (MTHFR) gene increas
107 etermine whether the C677T transition in the methylenetetrahydrofolate reductase (MTHFR) gene is asso
109 ions in cystathionine beta-synthase (CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to
110 abolism and the 677C-->T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be
111 at nucleotide 677 (677C-->T) mutation of the methylenetetrahydrofolate reductase (MTHFR) gene may be
113 p of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with th
114 hol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--
115 is illustrated here using the example of the methylenetetrahydrofolate reductase (MTHFR) gene, homocy
116 ssociation between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, includ
117 ion of chromosome 1 that contains a putative methylenetetrahydrofolate reductase (MTHFR) gene, which
120 risk factors, C-reactive protein (CRP), and methylenetetrahydrofolate reductase (MTHFR) genotype.
121 0 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.
123 e induced by deficiency in a key OCM enzyme, methylenetetrahydrofolate reductase (MTHFR) in Mthfr(+/-
130 her homocysteine or MTX toxicity differed by methylenetetrahydrofolate reductase (MTHFR) or reduced f
135 ions in cystathionine beta-synthase (Cbs) or methylenetetrahydrofolate reductase (Mthfr) results in n
140 with hypertension and stroke, independent of methylenetetrahydrofolate reductase (MTHFR) variants.
141 ymorphism (TT genotype) in the gene encoding methylenetetrahydrofolate reductase (MTHFR) was responsi
142 AS1-VNTR; OR = 2.50, 95% CI: 1.54-4.05); and methylenetetrahydrofolate reductase (MTHFR)(Val/Val) (OR
145 (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofolate reductase (Mthfr), adenosyl-ho
147 on of polymorphisms in thymidylate synthase, methylenetetrahydrofolate reductase (MTHFR), and VEGF.
149 of a prototypical vitamin-dependent enzyme, methylenetetrahydrofolate reductase (MTHFR), from 564 in
150 combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine
151 in the following folate-metabolizing genes: methylenetetrahydrofolate reductase (MTHFR), reduced fol
152 in the methionine synthase reductase (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydr
157 The presence of a nonsynonymous SNP in the methylenetetrahydrofolate reductase (MTHFR)gene was asso
159 e thermolabile mutation (TT genotype) of the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20)
162 D1 G870A (AA) polymorphism (P = 0.0138), and methylenetetrahydrofolate reductase (NAD(P)H) C677T (TT)
163 the cyclin D1 G870A (AA) polymorphism or the methylenetetrahydrofolate reductase (NAD(P)H) C677T (TT)
164 bstitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofa
165 s low: choline dehydrogenase (CHDH) rs12676, methylenetetrahydrofolate reductase 1 (MTHFD1) rs2236225
166 factor V 1691A (Leiden), factor II 20 210A, methylenetetrahydrofolate reductase 667T, type 1 plasmin
167 splant body mass index >or= 25, or carry the methylenetetrahydrofolate reductase 677 TT genotype shou
168 oning regimens, body mass index >or= 25, and methylenetetrahydrofolate reductase 677 TT genotype were
169 mes involved in homocysteine metabolism (ie, methylenetetrahydrofolate reductase [MTHFR] 677C>T and 1
170 onine) and related gene polymorphisms (C677T methylenetetrahydrofolate reductase [MTHFR] and C1420T c
171 perhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase and cystathionine be
173 R506G, factor II (prothrombin) G20210A, and methylenetetrahydrofolate reductase C677T, compared with
174 Other genetic variants (prothrombin 20210A, methylenetetrahydrofolate reductase C677T, factor XIII V
176 ed serine synthesis competes with the enzyme methylenetetrahydrofolate reductase for methylenetetrahy
178 ene (Factor V Leiden), a variant in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR), and an
180 e +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increas
181 of the common C677T base substitution in the methylenetetrahydrofolate reductase gene in 110 DNA samp
182 iation of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutat
186 iffer from those of the ferredoxin-dependent methylenetetrahydrofolate reductase isolated from the ho
188 igned to usual care or GERA, which evaluated methylenetetrahydrofolate reductase polymorphisms and se
190 which acts as an allosteric inhibitor of the methylenetetrahydrofolate reductase reaction and as an a
191 ual disease (hazard ratio 7.3; P < .001) and methylenetetrahydrofolate reductase rs1801131 (hazard ra
192 pathway (i.e. folate or B12 deficiencies or methylenetetrahydrofolate reductase thermolability).
194 point mutation (C677T) in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved
195 , hemoglobin S, the thermolabile mutation of methylenetetrahydrofolate reductase, and the cystic fibr
196 ystathionine-gamma-lyase, paraxonase 1, 5,10-methylenetetrahydrofolate reductase, betaine:homocystein
197 receptors; and vascular redox determinants (methylenetetrahydrofolate reductase, endothelial nitric
198 brinogen, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase, glycoprotein Illa,
199 deficiencies in cystathionine beta synthase, methylenetetrahydrofolate reductase, or in enzymes invol
202 (<301 microg/d) of folate, the substrate for methylenetetrahydrofolate reductase; low intake (<1.8 mg
203 (<1.8 mg/d) of vitamin B2, the cofactor for methylenetetrahydrofolate reductase; low intake (<8.0 mi
206 ase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymi
207 folate; (2) chemical reduction of liver 5,10-methylenetetrahydrofolate (stabilized at pH 10) to 5-met
209 ) catalyzes the reversible oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofola
210 plication by blocking the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by
211 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, t
212 tase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, u
213 EC 1.5.1.20) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.
214 ine hydroxymethyltransferase (cSHMT)-derived methylenetetrahydrofolate to de novo thymidylate biosynt
216 reductase (MTHFR) catalyzes the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, the
217 eductase (MTHFR) catalyzes the conversion of methylenetetrahydrofolate to methyltetrahydrofolate, the
218 e purified enzyme catalyzes the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, usi
219 rahydrofolate reductase (MTHFR) directs 5,10-methylenetetrahydrofolate toward methionine synthesis at
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