ライフサイエンスコーパス: methylguanine

1 uenced by sequence context than that of O(6)-methylguanine.

2 atic side chains in a pocket that excludes 7-methylguanine.

3 repair kinetics of another Aag substrate, 7-methylguanine.

4 -methylhypoxanthine, 1-methylguanine, and N2-methylguanine.

5 tory, though less so than those containing 7-methylguanine.

6 role in the interaction with the flipped O6-methylguanine.

7 ontaining O6-benzylguanine and the other, O6-methylguanine.

8 stranded oligodeoxynucleotides containing O6-methylguanine.

9 4 cells can be decreased by treatment with 7-methylguanine.

10 cytotoxic of lesions generated by TMZ, O(6)-methylguanine.

11 ass spectrometry analysis of unrepaired O(6)-methylguanine.

12 f AlkA purine substrates (7-methyladenine, 7-methylguanine, 3-methyladenine, 3-methylguanine, purine,

13 examine the functions of this enzyme on O(6)-methylguanine (6mG) adducts in the four-stranded structu

14 transferase (AGT) show that it forms an O(6)-methylguanine (6mG)-specific complex on duplex DNA that

15 or methylazoxymethyl acetate (MAMAc), and 7-methylguanine (7-MeG) and O(6)-methylguanine (O(6)-MeG)

16 mals to release 3-methyladenine (3-meA) or 7-methylguanine (7-meG) from 3H-methylated calf thymus DNA

17 N-Methylpurines (NMPs), including N(7)-methylguanine (7MeG) and N(3)-methyladenine (3MeA), can

18 nd purine, whereas YjcD and YgfQ recognize 1-methylguanine, 8-azaguanine, 6-thioguanine, and 6-mercap

19 t, the pH-rate profile for the reaction of 7-methylguanine, a positively charged substrate, shows onl

20 pr-null mice correlated with reduced lung O6-methylguanine adduct levels, without decreases in NNK bi

21 otides containing a single well defined O(6)-methylguanine adduct were used to examine the extent of

22 This work shows a mechanism whereby O(6)-methylguanine adducts formed by temozolomide lead to inh

23 The ability of temozolomide to form O(6)-methylguanine adducts is important for inhibition of NF-

24 methyl sulfate-induced 3-methyladenine and 7-methylguanine adducts were measured at nucleotide resolu

25 alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts.

26 itive to alkylating agents that result in O6-methylguanine adducts.

27 causes cellular cytotoxicity by forming O(6)-methylguanine adducts.

28 ntly, whereas 7,8-dihydro-8-oxoguanine, O(6)-methylguanine, adenine, and guanine were not.

29 ma and found that the enzyme releases both 7-methylguanine and 3-methyladenine from DNA.

30 ng in a fully functional protein for both O6-methylguanine and apurinic/apyrimidinic (AP) site repair

31 tized cells to the cytotoxic DNA lesion O(6)-methylguanine and caused a synthetic lethal interaction

32 is across SOS-independent lesions such as O6-methylguanine and DNA uracil is around 90%, very close t

33 -pyridyl)-1-butanone-induced short-term O(6)-methylguanine and long-term adenoma formation in the lun

34 gh a majority of the TMZ-induced lesions (N7-methylguanine and N3-methyladenine) are base excision re

35 for the repair of alkylated bases such as N7-methylguanine and N3-methyladenine.

36 itrosoguanidine (MNNG), which generates O(6)-methylguanine and O(4)-methylthymine recognized by MMR s

37 atinum(II), as well as base pairs between O6-methylguanine and thymine or cytosine, or between O4-met

38 gnize certain forms of DNA damage such as O6-methylguanine and UV photoproducts, and, therefore, mism

39 a C residue opposite an abasic site, an O(6)-methylguanine, and an 8-oxoguanine lesion, respectively.

40 ,N6-dimethyladenine, 1-methylhypoxanthine, 1-methylguanine, and N2-methylguanine.

41 ibited the formation of N7-methylguanine, O6-methylguanine, and O6-pyridyloxobutylguanine at a neighb

42 bind to oligodeoxynucleotides containing O6-methylguanine; and (d) react with the low molecular weig

43 tion is the result of MutS recognition of O6-methylguanine base pairs.

44 Slow excision rates for 7-methylguanine bases afforded the opportunity to study th

45 ro excision data indicates that removal of 7-methylguanine by the MPG protein is the rate-limiting st

46 ever, the persistence of a premutagenic O(6)-methylguanine can also be invoked.

47 most methylating agents (which form mainly 7-methylguanine), can specifically induce sister chromatid

48 ukaryotes is the addition of a 5'-terminal 7-methylguanine cap (m7GpppN) to nascent pre-mRNAs in the

49 rotein is capable of tightly binding to O(6)-methylguanine-containing DNA and disrupting its repair b

50 Demethylation of methylguanine could explain the presence in E. coli of t

51 LMO1 and MGMT, and thereby able to repair O6-methylguanine DNA adducts induced by MNU, would be prote

52 in family protein 1A (RASSF1A) (57%), and O6-methylguanine DNA methylatransferase (MGMT) (34%), and d

53 showed that, in addition to changes in O(6)-methylguanine DNA methyltransferase (MGMT) activity, sma

54 ve measurement of alkylation repair via O(6)-methylguanine DNA methyltransferase (MGMT) and base exci

55 The human DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) dealkylates m

56 l inactivation of the non-X-linked human O-6-methylguanine DNA methyltransferase (MGMT) gene has been

57 structure in the CpG island of the human O6-methylguanine DNA methyltransferase (MGMT) gene.

58 noic acid receptor-beta2 (RAR-beta2), and O6-methylguanine DNA methyltransferase (MGMT) genes were as

59 O6-methylguanine DNA methyltransferase (MGMT) is a DNA repa

60 the gene encoding the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) might be redu

61 cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that

62 The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl

63 O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl

64 O6-Methylguanine DNA methyltransferase (MGMT) repairs the m

65 O(6)-methylguanine DNA methyltransferase (MGMT) suppresses mu

66 ed in this study to specifically target O(6)-methylguanine DNA methyltransferase (MGMT) to the mitoch

67 carcinogens and the protective effect of O6-methylguanine DNA methyltransferase (MGMT), heterozygous

68 Gene transfer of the AGT gene, methylguanine DNA methyltransferase (MGMT), results in o

69 ction of four different proteins, avidin, O6-methylguanine DNA methyltransferase (MGMT), SNAP-tag, an

70 plished in mammalian cells by the protein O6-methylguanine DNA methyltransferase (MGMT).

71 chors capable of covalent attachment to O(6)-methylguanine DNA methyltransferase (SNAP-tag) fusion pr

72 ease protein resulted in the retention of O6-methylguanine DNA methyltransferase activity but loss of

73 se results demonstrate that the fusion of O6-methylguanine DNA methyltransferase and apurinic endonuc

74 cted a human fusion protein consisting of O6-methylguanine DNA methyltransferase coupled with an apur

75 MGMT (O(6)-methylguanine DNA methyltransferase) and APNG (alkylpuri

76 the apurinic endonuclease portion of the O6-methylguanine DNA methyltransferase-apurinic endonucleas

77 ture-function information about the human O6-methylguanine-DNA methyltransferase (EC 2.1.1.63), as we

78 l-mediated delivery of the P140K mutant O(6)-methylguanine-DNA methyltransferase (MGMT(P140K)) into h

79 Pretreatment leukemia cell O6-methylguanine-DNA methyltransferase (MGMT) activity, tum

80 liomas expressing the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) are resistant

81 a vector containing or lacking the human O6-methylguanine-DNA methyltransferase (MGMT) cDNA.

82 The repair of TMZ-induced DNA damage by O-6-methylguanine-DNA methyltransferase (MGMT) confers one m

83 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) confers resis

84 evel expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates wi

85 he p16(INK4a) tumor suppressor gene and O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repair ge

86 Patients with unmethylated O(6)-methylguanine-DNA methyltransferase (MGMT) fare worse, p

87 O6-methylguanine-DNA methyltransferase (MGMT) functions to

88 Expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) in tumor corr

89 The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the

90 O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repa

91 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major de

92 The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly o

93 mechanism whereby the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is silenced i

94 O(6)-methylguanine-DNA methyltransferase (MGMT) methylation s

95 evated expression of the repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) or a defect i

96 Tumor tissue was assayed to determine O(6)-methylguanine-DNA methyltransferase (MGMT) promoter meth

97 methylation data from a CpG island in the O6-methylguanine-DNA methyltransferase (MGMT) promoter.

98 ion in the disposition of the inactivated O6-methylguanine-DNA methyltransferase (MGMT) protein in hu

99 he role of the promoter methylation of O (6)-methylguanine-DNA methyltransferase (MGMT) remains contr

100 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes mutag

101 O(6)-methylguanine-DNA methyltransferase (MGMT) repairs the m

102 e methylation status of the promoter of O(6)-methylguanine-DNA methyltransferase (MGMT) was assessed.

103 O(6)-Methylguanine-DNA methyltransferase (MGMT)(1), a ubiquit

104 O6-Methylguanine-DNA methyltransferase (MGMT), a constituti

105 We have previously shown that O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair

106 he context of the targeted knockdown of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair

107 stabilized methyltransferases, chiefly O(6)-methylguanine-DNA methyltransferase (MGMT), a key enzyme

108 O6-methylguanine-DNA methyltransferase (MGMT), a ubiquitous

109 O6-Methylguanine-DNA methyltransferase (MGMT), a ubiquitous

110 ncreased levels of the DNA repair protein O6 methylguanine-DNA methyltransferase (MGMT), also referre

111 O6-Methylguanine-DNA methyltransferase (MGMT), an enzyme th

112 errant promoter methylation of the p16, O(6)-methylguanine-DNA methyltransferase (MGMT), death-associ

113 This lesion is repaired by O6-methylguanine-DNA methyltransferase (MGMT), the expressi

114 sion of the DNA damage reversal protein O(6)-methylguanine-DNA methyltransferase (MGMT), which protec

115 atives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which remove

116 required for the cytotoxic response of O(6)-methylguanine-DNA methyltransferase (MGMT)-deficient mam

117 MeG, a DNA lesion repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT).

118 reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT).

119 he normal cell by the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT).

120 mechanisms may be the high expression of O6-methylguanine-DNA methyltransferase (MGMT).

121 n receptor (ER), E-cadherin (ECAD) and O (6)-methylguanine-DNA methyltransferase (MGMT)] examined.

122 the P140K mutant of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT*).

123 be attributed to the down-regulation of O(6)-methylguanine-DNA methyltransferase activity.

124 (methylated in tumor 1), MINT2, MINT31, O(6)-methylguanine-DNA methyltransferase gene, and hMLH1 mism

125 hat for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone

126 een limited to the methylation status of O-6-methylguanine-DNA methyltransferase in patients with gli

127 epatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase may benefit from Ona

128 of MET ligand hepatocyte growth factor, O(6)-methylguanine-DNA methyltransferase promoter methylation

129 ate analysis, the factors age, WHO grade, O6-methylguanine-DNA methyltransferase promoter methylation

130 ioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard t

131 tumors, which do not express measurable O(6)-methylguanine-DNA methyltransferase protein, is probably

132 prognostic significance, with WHO grade, O6-methylguanine-DNA methyltransferase status, age, and TTP

133 identified in GBMs, except for loss of O(6-)methylguanine-DNA methyltransferase via promoter methyla

134 he percentage of patients methylated at O(6)-methylguanine-DNA methyltransferase was lower than on th

135 onal 39 kDa Escherichia coli Ada protein (O6-methylguanine-DNA methyltransferase) (EC 2.1.1.63), prod

136 , c-Jun, Rb2/p130, JAK1, p67phox, Grb2, O(6)-methylguanine-DNA methyltransferase, and Ercc-1.

137 in molecules involved in DNA repair (eg, O6-methylguanine-DNA methyltransferase, DNA topoisomerase I

138 A repair enzymes, DNA polymerase beta and O6-methylguanine-DNA methyltransferase, have been shown to

139 s coli, APC; mut-L homolog 1, MLH1; and O(6)-methylguanine-DNA methyltransferase, MGMT) by liquid chr

140 g for age, tumor size, resection extent, O-6-methylguanine-DNA methyltransferase-methylation, and iso

141 ylase, Nth protein (endonuclease III) and O6-methylguanine-DNA methyltransferase.

142 methylated bases from DNA, and suicidal O(6)-methylguanine-DNA methyltransferases to transfer alkyl g

143 DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.63, MGMT

144 or gene p16 (CDKN2A), the DNA repair gene O6-methylguanine-DNA-methyltransferase (MGMT) and the putat

145 116 and HCT15 cells that highly express O(6)-methylguanine-DNA-methyltransferase (MGMT) displayed a t

146 These include the importance of O6-methylguanine-DNA-methyltransferase (MGMT) in glioblasto

147 f metalloproteinase 3 (TIMP-3), p16INK4a, O6-methylguanine-DNA-methyltransferase (MGMT), death-associ

148 O6-methylguanine-DNA-methyltransferase (MGMT), which repair

149 latter fused to the DNA repair protein O(6)-methylguanine-DNA-methyltransferase (MGMT).

150 d cells in vivo, selection based on P140K O6-methylguanine-DNA-methyltransferase (MGMT[P140K]) gene t

151 radiotherapy alone, with consideration of O6-methylguanine-DNA-methyltransferase gene (MGMT) promoter

152 -specific PCR and included: p16 (CDKN2A), O6-methylguanine-DNA-methyltransferase, glutathione S-trans

153 S-transferase P1, and the DNA repair gene O6-methylguanine-DNA-methyltransferase.

154 ed: 27% (26/95) at p16, 33% (31 of 95) at O6-methylguanine-DNA-methyltransferase; and 18% (17 of 92)

155 c effects of the TMZ-induced DNA lesion O(6)-methylguanine due to elevated expression of the repair p

156 idative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadeni

157 tein does not transfer methyl groups from O6-methylguanine in [3H]-methylated DNA but reversibly inhi

158 ylating agent MNNG to create a level of O(6)-methylguanine in cellular DNA equal to that found in nor

159 Temozolomide (TMZ) produces O(6)-methylguanine in DNA, which in turn mispairs with thymin

160 TMZ produces O6-methylguanine in DNA, which mispairs with thymine during

161 tions arise as a result of formation of O(6)-methylguanine in DNA.

162 he alkyltransferase activity in repairing O6-methylguanine in methylated DNA.

163 r of MGMT protein and increased repair of O6-methylguanine in nitrosomethylurea-treated human bronchi

164 Surprisingly, 7-methylguanine is removed equally efficiently in AAG:(+/+

165 O6-Methylguanine is removed from DNA via the transfer of th

166 posite this lesion, and it bypasses the O(6)-methylguanine lesion by inserting a C or a T.

167 ing the first direct visualization of the N7-methylguanine lesion nucleobase in DNA.

168 In contrast, O(6)-methylguanine lesion used as a control does not induce s

169 li and purified to homogeneity repaired O(6)-methylguanine lesions in DNA via alkyl transfer action d

170 tributor to the endogenous formation of O(6)-methylguanine lesions in E. coli.

171 Interestingly, O(6)-methylguanine lesions when paired with either a C or T w

172 ance of 3-methyladenine, and in some cases 3-methylguanine, lesions in cellular toxicity, and the dom

173 r of the cytotoxic and mutagenic lesion O(6)-methylguanine (m(6)G) in DNA.

174 nd replication of a DNA lesion, such as O(6)-methylguanine (m(6)G), can, in principle, be influenced

175 thylthymine (m(4)T) relative to that of O(6)-methylguanine (m(6)G).

176 the well-known epsilonA and Hx substrates, 1-methylguanine (m1G) was also excised efficiently by AAG.

177 Replication in vivo across unrepaired O6-methylguanine (m6dG) lesions by mammalian DNA polymerase

178 A synthesis in vitro across site-specific O6-methylguanine (m6dG) residues by DNA polymerase beta (po

179 O(6)-Methylguanine (m6G) and abasic site TLS was examined in

180 O(6)-Methylguanine (m6G) is formed by the action of alkylatin

181 e 7,8-dihydro-8-oxoguanine (8-oxoG) and O(6)-methylguanine (m6G) lesions.

182 orm specific and stable complexes with an O6-methylguanine (m6G)-containing oligonucleotide substrate

183 We have studied the processing of O(6)-methylguanine (m6G)-containing oligonucleotides and N-me

184 ytotoxic lesions N(3)-methyladenine and N(7)-methylguanine, may contribute to TMZ resistance.

185 by Sn1 methylators has been attributed to O6-methylguanine (MeG), we have constructed nicked circular

186 he course of removing a methyl group from O6-methylguanine (meG)-DNA or O4-methylthymine (meT)-DNA.

187 ge via the formation of base-labile residues methylguanine, methoxyguanine, and 8-oxo-G.

188 s are TMZ resistant due to overexpression of methylguanine methyltransferase (MGMT(hi)).

189 ine DNA alkyltransferase (AGT) from the O(6)-methylguanine methyltransferase (MGMT) cDNA, which confe

190 used an oncoretroviral vector to transfer a methylguanine methyltransferase (MGMT) drug-resistance g

191 We hypothesized that expression of methylguanine methyltransferase (MGMT) in the tumor woul

192 retinoic acid receptor beta (RARbeta), O(6)-methylguanine methyltransferase (MGMT), and human mutL h

193 control of erythroid regulatory elements and methylguanine methyltransferase (MGMT), driven by a cons

194 lly relevant genes, Schlafen 11 (SLFN11) and methylguanine methyltransferase (MGMT), served as indica

195 the P140K mutant of the drug resistance gene methylguanine methyltransferase (MGMT), which encodes a

196 s (FV) vector expressing the P140K mutant of methylguanine methyltransferase (MGMTP140K) for in vivo

197 In vivo selection with mutant methylguanine methyltransferase (MGMTP140K) has been pro

198 ediated by a mutant of the DNA-repair enzyme methylguanine methyltransferase could circumvent this li

199 Human TK6 cells, which are methylguanine methyltransferase deficient (MGMT(-)), wer

200 e-DNA alkyltransferase (AGT), encoded by the methylguanine methyltransferase gene [MGMT], removes the

201 Mutant forms of the DNA repair-enzyme methylguanine methyltransferase in particular have allow

202 Overexpression of methylguanine methyltransferase P140K (MGMTP140K) has be

203 chromosome 19, or 1p19q codeletion; and (c) methylguanine methyltransferase promoter methylation.

204 cell transplantation, and thus we evaluated methylguanine methyltransferase-mediated chemoprotection

205 s end joining, homologous recombination, and methylguanine methyltransferase.

206 oficient tumor cells that lack expression of methylguanine methyltransferase.

207 l gammaretrovirus vector backbone expressing methylguanine methyltransferase.

208 The MutSDelta800 protein binds to O6-methylguanine mismatches but not to intrastrand platinat

209 O6-methylguanine mispairs with thymine during replication,

210 he structures of the interaction between O 6-methylguanine ( O 6mG) and cytosine and thymine during r

211 y, DNA adducts of biological relevance, O(6)-methylguanine (O(6)-MeG) and O(6)-carboxymethylguanine (

212 O(6)-Methylguanine (O(6)-MeG) is a highly mutagenic DNA adduc

213 O(6)-Methylguanine (O(6)-meG) is a major mutagenic, carcinoge

214 O(6)-methylguanine (O(6)-MeG) is a miscoding DNA lesion arisi

215 nce of the signaling pathway induced by O(6)-methylguanine (O(6)-MeG) lesions is poorly understood.

216 des containing the known MGMT substrate O(6)-methylguanine (O(6)-MeG) or O(6)-CMG effectively inactiv

217 DNA polymerase Dpo4-catalyzed bypass of O(6)-methylguanine (O(6)-MeG) proceeds largely in an accurate

218 MAMAc), and 7-methylguanine (7-MeG) and O(6)-methylguanine (O(6)-MeG) were measured in the DNAs of va

219 rimer/templates containing guanine (G), O(6)-methylguanine (O(6)-MeG), or O(6)-benzylguanine (O(6)-Bz

220 er/template DNA containing guanine (G), O(6)-methylguanine (O(6)-MeG), or O(6)-benzylguanine (O(6)-Bz

221 O(6)-Methylguanine (O(6)-meG), which is produced in DNA follo

222 ed formation of the promutagenic adduct O(6)-methylguanine (O(6)-meGua) by 73 and 80%, respectively,

223 O(6)-methylguanine (O(6)-methylG) is highly mutagenic and is

224 ylating agents, which produce cytotoxic O(6)-methylguanine (O(6)-mG) DNA lesions.

225 Previous studies indicated that O(6)-methylguanine (O(6)-mG) persistence is critical for lung

226 cluding methylating agents that produce O(6)-methylguanine (O(6)MeG) adducts.

227 oxic, and we recently demonstrated that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine (O(6

228 O(6)-methylguanine (O(6)meG) and related modifications of gua

229 Alkylation-induced O(6)-methylguanine (O(6)MeG) DNA lesions can be mutagenic or

230 to a single type of DNA lesion, namely O(6)-methylguanine (O(6)MeG).

231 O(6)-methylguanine (O(6)mG) is a potent mutagenic and procarc

232 Hence, an O:(6)-methylguanine (O:(6)meG) lesion would be inaccessible to

233 MNU produces carcinogenic O6-methylguanine (O6-meG) adducts, resulting in thymic lymp

234 ormation of human fibroblasts and whether O6-methylguanine (O6-MeG) is involved, two populations of i

235 We examined the effect of a single O6-methylguanine (O6-MeG) template residue on catalysis by

236 Uracil, O6-methylguanine (O6-meG), and 8-oxoguanine (8-oxoG) were p

237 repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltr

238 the O6 position of guanine in DNA to form O6-methylguanine (O6-meG).

239 resence of MeC inhibited the formation of N7-methylguanine, O6-methylguanine, and O6-pyridyloxobutylg

240 lowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) approximately 30-fold more frequen

241 nd a monoclonal antibody which recognizes O6-methylguanine (O6MeGua).

242 protein makes critical interactions with O6-methylguanine (O6mG) at the N1- and O6-positions.

243 with the 3-position of the mutagenic base O6-methylguanine (O6mG).

244 ine and 1,N6-ethenoadenine, as well as at O6-methylguanine (O6mG).

245 nce context-dependent rate differences for 7-methylguanine of up to 185-fold from position to positio

246 basicity (GB)) of adenine, guanine, and O(6)-methylguanine (OMG) have been examined using both theore

247 We also examined O(6)-methylguanine (OMG), a highly mutagenic damaged base tha

248 The effects of substitution of O6-methylguanine on the structure and stability of a human

249 ed DNA containing the endogenous lesion O(6)-methylguanine or cigarette-smoke-derived O(6)-4-(3-pyrid

250 2) IN, the replacement of the guanine with 6-methylguanine or hypoxanthine not only reduced 3'-proces

251 , and no detectable activity in repairing N1-methylguanine or N3-methylthymine.

252 The N7-methylguanine portion of the mRNA cap structure interact

253 PvuII is inhibited by O6-methylguanine, positioned within the restriction site.

254 adenine, 7-methylguanine, 3-methyladenine, 3-methylguanine, purine, 6-chloropurine, xanthine) that ha

255 AGT repairs O6-methylguanine; PvuII cleaves at its restriction site, yi

256 Rates of 7-methylguanine repair showed a 30-fold dependence on nucl

257 We quantified the number of O6-methylguanine residues in methylated DNA by HPLC-MS/MS a

258 ltransferase compete for the MNNG-induced O6-methylguanine residues, and MMR-induced cytotoxicity is

259 These results suggest that O(6)-methylguanine uniquely activates the molecular switch fu

260 ates of deamination of 9-methyladenine and 9-methylguanine were found to be similar to each other (t1

261 of the NOC-specific DNA adduct O(6)-carboxy-methylguanine when pork underwent a more intense heating

262 er oligodeoxyribonucleotides containing O(6)-methylguanine, where a minimum of four nucleotides 3' to

263 lkylated bases such as 3-methyladenine and 7-methylguanine whereas methyl-formamidopyrimidine was exc