ライフサイエンスコーパス: methylguanosine

1 e methylation of the exocyclic N2 amine of 7-methylguanosine.

2 unmethylated counterparts, or nucleoside N7-methylguanosine.

3 guanosine, gamma-monomethyl phosphate, nor 7-methylguanosine.

4 ne, inosine, xanthosine, pseudouridine, N(2)-methylguanosine, 1-methyladenosine, and N(2),N(2)-dimeth

5 ) and for 2'-O-methylcytidine (24%) and 2'-O-methylguanosine (22%) in 23S rRNA.

6 rategy for efficient synthesis for 2'-C-beta-methylguanosine (3).

7 nspecific binding of RNA, recognition of a 7-methylguanosine 5' mRNA cap, and methylation of a nuclei

8 of beta-D-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methylguanosine-5'-monophosphate.

9 re we describe the synthesis of 8-nitro-2'-O-methylguanosine, a ribonucleoside analogue of this lesio

10 mical studies demonstrated that 8-nitro-2'-O-methylguanosine adopts a syn conformation about the glyc

11 thway, since mature tRNA(Val(AAC)) lacking 7-methylguanosine and 5-methylcytidine is rapidly degraded

12 se from Drosophila that cleaves m(7)GMP to 7-methylguanosine and inorganic phosphate.

13 es and previous crystallographic data for N7-methylguanosine and its phosphorylated derivatives, thes

14 The modified nucleosides N(2)-methylguanosine and N(2)(2)-dimethylguanosine in transfe

15 ganism were dihydrouridine, pseudouridine, 7-methylguanosine, and 5-methyluridine.

16 tly identified 2'-C-methyladenosine and 2'-C-methylguanosine as potent nucleoside inhibitors of HCV R

17 to frameshift suppressor tRNA(SufA6) and N1-methylguanosine at position 37 (m(1)G37) modification-de

18 The 7-methylguanosine cap added to the 5' end of mRNA is requi

19 ctions that result in the formation of an N7-methylguanosine cap during mRNA maturation.

20 mRNAs are appended at the 5' end, with the 7-methylguanosine cap linked by a 5'-5'-triphosphate bridg

21 ex, made up of eIF4E, which recognizes the 7-methylguanosine cap of messenger RNA, and eIF4G, which s

22 initiation factor 4E (eIF4E) binds to the 7-methylguanosine cap of mRNA and facilitates binding of m

23 sphorylation subsequent to addition of the 7-methylguanosine cap on pre-mRNA in a manner that facilit

24 The cotranscriptional placement of the 7-methylguanosine cap on pre-mRNA is mediated by recruitme

25 20 and CBP80, respectively) that binds the 7-methylguanosine cap on RNAs transcribed by RNA polymeras

26 of protein synthesis, the mRNA 5'-terminal 7-methylguanosine cap structure and several recognition pr

27 The 7-methylguanosine cap structure at the 5' end of eukaryoti

28 f an mRNA through its interaction with the 7-methylguanosine cap, and it subsequently scans along the

29 eIF4A is part of the 5'-7-methylguanosine cap-binding complex, eIF4F, along with e

30 f the translational repressor 4EBP1 to the 7-methylguanosine cap-binding complex.

31 on initiation independent of the 5' end N(7)-methylguanosine cap.

32 e first encoded nucleotide adjacent to the 7-methylguanosine cap.

33 in eukaryotes requires the addition of the 7-methylguanosine cap.

34 In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed b

35 e gene promoters was introduced along with 7-methylguanosine capped RNAs encoding piggyBac transposas

36 this study, we discovered and characterized methylguanosine-capped and polyadenylated small RNAs (CP

37 igh affinity variant of eIF-4E to capture 5'-methylguanosine-capped RNA followed by 3'-RACE sequencin

38 NA is transcribed by RNA polymerase II and 7-methylguanosine-capped, binds the seven Sm proteins, bec

39 y related to mammalian eIF4E-1, binds only 7-methylguanosine caps and is essential for viability.

40 iardia mRNAs have blocked 5'-ends and that 7-methylguanosine caps promote translation of transfected

41 ow that aprataxin hydrolyzes inosine and 6-O-methylguanosine caps, but is not adept at removing a deo

42 IFE-4, which binds only 7-methylguanosine caps, is most closely related to an unus

43 Fifty-eight analogues of the 5'-terminal 7-methylguanosine-containing cap of eukaryotic messenger R

44 ding of the initiation factor eIF4E to the 7-methylguanosine-containing cap of mRNAs.

45 truct bearing a conventional cap analogue (7-methylguanosine) failed to produce ITGA4 protein, but ex

46 able substrate and replacement of dG by 2'-O-methylguanosine generated a substrate with a low specifi

47 The terminal 7-methylguanosine is recognized by cap-binding proteins th

48 The minimal 'cap0' consists of N7-methylguanosine linked to the first nucleotide via a 5'-

49 uch as N(1) -methyladenosine (m(1) A), N(1) -methylguanosine (m(1) G), N(3) -methylcytosine (m(3) C),

50 her analysis showed the accumulation of N(1)-methylguanosine (m(1)G(37)) in tRNA from cells bearing a

51 m(1)A), N(3)-methylcytidine (m(3)C) and N(1)-methylguanosine (m(1)G), all commonly found in tRNAs.

52 ively converts m(2)2 G modification to N(2) -methylguanosine (m(2) G).

53 e (DAP), 7-deazaguanosine (7-deaza-G), and 7-methylguanosine (m(7)G) diphosphates efficiently accepte

54 is unique among eukaryotes and consists of 7-methylguanosine (m(7)G) followed by four methylated nucl

55 N(7)-methylguanosine (m(7)G) introduced at position 1575 on 1

56 7-Methylguanosine (m(7)G), also known as the mRNA "cap", i

57 re, we document microprocessor-independent 7-methylguanosine (m(7)G)-capped pre-miRNAs, whose 5' ends

58 lity of a monoclonal antibody to recognize 7-methylguanosine (m(7)G).

59 ment located immediately downstream of the 7-methylguanosine [m(7)G] cap of TOP mRNAs, which encode r

60 In addition, the novel ser-tRNACAG has 1-methylguanosine (m1G-37) at position 37, 3' to the antic

61 germ extract translation systems, whereas N2-methylguanosine (m2G) moderately impeded translation.

62 To investigate this possibility for N 2-methylguanosine (m2G), which is present in a wide variet

63 ) did not perturb translational fidelity, O6-methylguanosine (m6G) at the first and second codon posi

64 bed by RNA polymerase II and their initial 7-methylguanosine (m7G) 5' cap structures subsequently bec

65 In eukaryotes, a 7-methylguanosine (m7G) cap is added to newly transcribed

66 ny eukaryotic viruses, contain an inverted 7-methylguanosine (m7G) cap linked to the 5' nucleotide of

67 to be the first factor to bind mRNA during 7-methylguanosine (m7G) cap-dependent translation initiati

68 nscripts being modified by addition of the 7-methylguanosine (m7G) cap.

69 he orthologue of trm8, which catalyses the 7-methylguanosine modification of tRNA in Saccharomyces ce

70 e methylated cap nucleotide in the form of 7-methylguanosine monophosphate (m(7)GMP) or diphosphate (

71 P39 with a genuine nucleobase analogue of N7-methylguanosine, namely, N7,9-dimethylguanine, indicated

72 2'-C-Methylguanosine, on the other hand, was neither efficien

73 triphosphate, cap0 (triphosphate-bridged N7-methylguanosine), or cap1 (cap0 with RNA 2'-O-methylatio

74 ross-resistance exists between the 2'-F-2'-C-methylguanosine prodrugs and other classes of HCV inhibi

75 1 is the enzyme responsible for converting 7-methylguanosine RNA caps to the 2,2,7-trimethylguanosine

76 N7,9-dimethylguanine, indicated that the N7-methylguanosine rotational orientation within the stack

77 snoRNAs) undergoes hypermethylation from a 7-methylguanosine to a 2,2, 7-trimethylguanosine structure

78 ne nucleoside phosphorylase with substrate 7-methylguanosine to reduce the calculated internal [Pi] i

79 we report the synthesis of 5'-O-(1-thio)-N2-methylguanosine triphosphate (m2GalphaS) and its incorpo

80 igand binding between VPg and anthraniloyl-7-methylguanosine triphosphate for eIFiso4E.

81 2'-C-Methylguanosine triphosphate has been known as a potent

82 2'-C-Methyladenosine and 2'-C-methylguanosine were identified as potent inhibitors of