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1 no)biphenyl (NPB) and N,N-diphenyl-N,N-bis(3-methylphenyl)-1,1-biphenyl)-4,4-diamine (TPD), respectiv
2 porting efficiency of N,N-diphenyl-N,N-bis(3-methylphenyl)-1,1-biphenyl)-4,4-diamine) (TPD, prototypi
4 ed several novel inhibitors, including 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one (PBIT), which
5 trimethyl bicyclo heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-car boxamide
6 ty cannabinoid CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1
7 time-dependent inhibition of Icmt by 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide (cysmethyn
8 ve small-molecule inhibitor of Icmt, 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide (cysmethyn
10 d, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol (SKF83959), foun
11 MMP-9) promoter and identified 5-methyl-2-(4-methylphenyl)-1H-benzimidazole (MPBD) inhibitory for MMP
12 ed inhibitors such as 2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine, 22a, and 2-(2-h
13 e c-Src inhibitor 1-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (PP1)
14 t-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-p yrazolyl)-4-[(4-methylpiperazino)met
15 methylphenyl), 2,2'-di-tert-butyl-6,6'-bis(2-methylphenyl), 2,2',6,6'-tetrakis(2,6-dimethylphenyl), a
16 PF(6))(2) where Nttpy = 4'-(p-nicotinamide-N-methylphenyl)-2,2':6',2' '-terpyridine, is observed to b
17 es with 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3 -benzazepine (SKF8
18 librium with its cyclic isomer 6-phenyl-3-(4-methylphenyl)-2,3-dihydro-1,2,4-triazin-4-oxide (6'), wh
19 (N3) (PN(-) = (N-(2-(diisopropylphosphino)-4-methylphenyl)-2,4,6-trimethylanilide), can be reduced wi
20 3,4-difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpr opanamide (16g, SNAP 94847) was
23 onoamine uptake inhibition test was 3beta-(4-methylphenyl-2 beta-[5-(3-nitrophenyl)thiazol-2-yl]tropa
24 ex (PNP)Ti=CH(t)Bu(CH3) (PNP=N[2-P(CHMe2)2-4-methylphenyl]2(-)), catalyses the dehydrogenation of cyc
25 t)Bu] (A; PNP(-) identical withN[2-P(i)Pr2-4-methylphenyl]2(-)), dehydrogenates ethane to ethylene at
26 plex (PNP)Nb(CH3)2(OAr) (PNP = N[2-P(i)Pr2-4-methylphenyl]2(-), Ar = 2,6-(i)Pr2C6H3), prepared from t
28 eCH(t)Bu(CH2(t)Bu) (PNP(-) = N[2-P(CHMe2)2-4-methylphenyl]2) reacts with H2CPPh3 to form the kappa(2)
29 )Bu(CH2(t)Bu) (2; PNP(-) = N[2-P(CHMe2)(2-)4-methylphenyl]2), prepared from the precursor (PNP)Ti[tri
30 )2(OAr)] (M=Zr or Hf; PNP(-)=N[2-P(CHMe2)2-4-methylphenyl]2); Ar=2,6-iPr2C6H3), which were readily pr
31 (mu2-CH3)2[Al(CH3)2]2 (PNP = N[2-P(CHMe2)2-4-methylphenyl]2-) can be prepared from the reaction of (P
32 identical withC(t)Bu (PNP = N[2-P(i)Pr(2)-4-methylphenyl](2)(-)), activates a C-H bond of ethane at
33 (PNP)FeCl(2)] (1) (PNP = N[2-P(CHMe(2))(2)-4-methylphenyl](2)(-)), prepared from one-electron oxidati
34 KF82958), 3-methyl-6-chloro-7,8-hydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-]H-3-b enzazepine (SKF8
35 the most interesting compounds was 3beta-(4-methylphenyl)-2beta-(4-methylphenyl)tropane (3d), which
37 enyl)isoxazol-5-yl]tropane (3p) and 3beta-(4-methylphenyl)-2beta-[3-(4'-methylphenyl)isoxazol-5-yl]tr
38 ork led to the identification of 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzen
39 4-triazole ligands employed, L(azine) = 4-(4-methylphenyl)-3-phenyl-5-(azine)-1,2,4-triazole, where a
40 ter (DAT) inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3, K(i)
42 rated the dimeric product 3-(2,3-dimethoxy-6-methylphenyl)-4-methyl-1,2-benzoquinone as the major pro
43 e K+-competitive, fluorescent inhibitor 1-(2-methylphenyl)-4-methylamino-6-methyl-2, 3-dihydropyrrolo
44 he atypical ligands AC-42 (4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)piperidine HCl) and 77-LH-28
45 interactions of carbachol, 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl] piperidine hydrogen chlorid
46 allosteric agonists AC-42 (4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine hydrogen chlorid
48 ' ' = n-propyl, n-butyl, isobutyl, phenyl, 4-methylphenyl, 4-(dimethylamino)phenyl) to yield the corr
49 4-methoxyphenyl, 3,4-methylenedioxyphenyl, 4-methylphenyl, 4-fluorophenyl, phenyl, 2-thienyl, methyl)
50 methylaminopropionyl)amino-2-methylpropyl]-6-methylphenyl]-4-[(2R )-methyl-3-(4-chlorophenyl)propiony
51 pplication of a selective FFA3 agonist (N-[2-methylphenyl]-[4-furan-3-yl]-2-methyl-5-oxo-1,4,5,6,7,8-
53 A candidate antitumor agent, 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203), was empiri
55 1-phenyl-4-(4-methylphenyl)butynone to 2-(4-methylphenyl)-5-phenylfuran displayed first-order kineti
56 ylthioethoxy)-5-(N-methyl- N-h ydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran
57 amino}}benzyl]-N,N-dimethyl-N- {{{4-{{{[2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptan-8-yl]carbo
58 a CCR5 inhibitor (N,N-dimethyl-N-{{4-{[2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl]car b
60 CCR2/CCR5 antagonist N-dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl] carbonyl]
62 nhibitor of Src family kinases, 4-amino-4-(4-methylphenyl)-7-(t-butyl) pyrazola[3,4-d]pyrimidine, pre
63 se inhibitors, herbimycin A and 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-D-3,4-pyrimidine (PP1)
64 ibited by genistein, but not by 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3, 4-d]pyrimidine, a s
65 tein (RAP) or the Src inhibitor 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (PP1
67 3-d]pyrimidin-7-one (PD173952), 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1)
68 mine (2MB-PP1) but not by other 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1)
69 nhibitors: Src kinase inhibitor 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1)
70 itors staurosporine (2 microM), 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1,
71 sporine (IC50, 0.06 microM) and 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1;
72 aurosporine and the Lck inhibitor 4-amino-5-(methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine was s
74 yrosine kinase activation with [4-Amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine] or c
76 protein-1 inhibitor SR-11302 [3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4
80 (CTPC), and N-(2-bromophenyl)-N'-{2-[ethyl(3-methylphenyl)amino]ethyl}-urea (SB-452533) exhibiting si
82 cation of flurandrenolide and 2-methoxy-N-(4-methylphenyl) benzamide (2-MMB) as compounds that reprod
85 dependence for the reaction of 1-phenyl-4-(4-methylphenyl)butynone to 2-(4-methylphenyl)-5-phenylfura
86 paste electrode modified by meso-tetrakis(3-methylphenyl) cobalt porphyrin (CP) and TiO(2) nanoparti
87 we were able to measure the acidity of 3-(4-methylphenyl)cyclopropene at the allylic position (delta
88 T-136088 (1-(4'-(3-methyl-4-(((1(R)-(3-(11)C-methylphenyl)ethoxy)carbonyl)amino)isoxazol-5 -yl)-[1,1'
92 5S,7R)-5-(3-hydroxypheny l)-4-methyl-2-[2-(2-methylphenyl)ethyl]-2-azabicyclo[3.3.1]non-7-yl}propan a
94 acylglycerol lactones built with a rigid 4-[(methylphenyl)ethynyl]phenyl rod that is separated from t
95 y containing a thin film of 2,7-bis[9,9-di(4-methylphenyl)-fluoren-2-yl]-9,9-di(4-methylphenyl)fluore
97 inhibitor HET0016 (N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine) to block 20-HETE synthesis.
100 nsition was accompanied by rotation of the 4-methylphenyl group of the axle component molecule and a
101 at the ATP-binding site of the kinase, and a methylphenyl group on PP1 is inserted into an adjacent h
102 e 7 ([(11)C]RO6924963), N-[(11)C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine 8 ([(11)C]R
103 -bis[2,6-bis[di(4-tert-butylphenyl)methyl]-4-methylphenyl]imidazol-2-ylidene) CuOPh [(IPr**)CuOPh] re
104 3beta-(4-Chlorophenyl) tropane-2beta-[3-(4'-methylphenyl) isoxazol-5-yl] Hydrochloride (RTI 336), a
105 (3p) and 3beta-(4-methylphenyl)-2beta-[3-(4'-methylphenyl)isoxazol-5-yl]tropane (3r) did not produce
106 j), and 3beta-(4-methoxyphenyl)-2beta-[3-(4'-methylphenyl)isoxazol-5-yl]tropane (9) were synthesized
107 -methylbenzyl)succinate was oxidized to E-(3-methylphenyl)itaconate (or a closely related isomer) and
108 ster) via (3-methylbenzyl)succinate and E-(3-methylphenyl)itaconate (or its CoA thioester) in a serie
109 xy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3, K(i) values of 492 and 360 nM in
110 1 of alpha-meso-phenylheme-IX, alpha-meso-(p-methylphenyl)-mesoheme-III, and alpha-meso-(p-trifluorom
111 thyl-1-(2-propylheptyl)pyridin-1-ium-4-yl)-3-methylphenyl)meth anide; three-ring 3TTMC, dicyano(4'-(3
112 d on [3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methanol induce an enlarged interaction int
113 ntagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimet hylbicyc
114 T2 receptors with (S)-1-[4-(dimethylamino)-3-methylphenyl]methyl-5-(diphenylacetyl)- 4, 5,6,7-tetrahy
116 e antiviral assembly inhibitor N-(3-chloro-4-methylphenyl)-N'-{2-[({5-[(dimethylamino)-methyl]-2-fury
117 tris-(8-hydroxyquinoline)aluminum/N,N'-bis(3-methylphenyl)-N,N'-diphenylbenzidin e) and light detecti
118 e diffusion of ultrathin films of N,N'-Bis(3-methylphenyl)-N,N'-diphenylbenzidine (TPD) (12 nm [Formu
121 rop-2-enyl)-2beta-carbofluoroethoxy-3beta-(4'methylphenyl)nor tropane ((18)F-FE-PE2I) is a newly deve
122 doprop-2E-enyl)-2-beta-carbomethoxy-3beta-(4-methylphenyl) nortropane ((123)I-PE2I) in patients with
123 odoprop-2E-enyl)-2beta-carbomethoxy-3beta-(4-methylphenyl)nortropane ((11)C-PE2I) and (11)C-N,N-dimet
124 nd selective compound was 3alpha-(3-fluoro-4-methylphenyl)nortropane-2beta-carboxylic acid methyl est
125 ifluoromethyl)phenyl]-2-hydroxyethoxy}-4- (2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H
126 trations that ranged from 20.1 ng/L for tris(methylphenyl) phosphate (TMPP) to 30100 ng/L for tris(2-
127 pecifically, a series of P-stereogenic (aryl)methylphenyl phosphines are shown to undergo rapid racem
128 H-DPAT and 1000 or 2000 ng of N-(3-trifluoro-methylphenyl) piperazine hydrochloride (TFMPP) or 2-(1-p
129 in vivo evaluation of Cimbi-712 (3-{4-[4-(4-methylphenyl)piperazine-1-yl]butyl}p-1,3-dihydro-2H-indo
130 isopropyl-4'-(trimethylammonium chloride)-5'-methylphenyl piperidine-1-carboxylate (AMO-1618) and cal
132 tramesitylporphyrin (TMP) or meso-tetrakis(4-methylphenyl)porphyrin (H(2)T-pMe-PP), and L = a thiol,
133 with genistein and 4-amino-1-tert-butyl-3-(p-methylphenyl)pyrazolo[3,4-d] pyrimidine abolished the in
136 henylethyl substituent in 13b and 37a or a 2-methylphenyl substituent in 37b also allowed the resulti
138 ,6-dimethylphenyl), and 2,2',6,6'-tetrakis(2-methylphenyl) substituents, respectively, were prepared
139 hibitor 49 [IC50 = 10 nM, 3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-5,6-dihydro-4 -hydroxy-6-phenyl-6
140 ([3-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-methylphenyl]sulfanyl)ethyl carbamates with the generic
141 plots and Bronsted-type plots of substituted methylphenyl sulfates vs hydrogen peroxide anions and su
142 2-methyl-4-oxo-6-quinazolinyl)methyl)-4-((2- methylphenyl)sulfinyl)-N-(prop-2-ynyl)aniline complexed
143 Two O4-arylsulfonylthymidine precursors, (4-methylphenyl)sulfonyl and (2,4,6-trimethylphenyl)sulfony
144 ltures with the NF-kappaB inhibitor (E)3-[(4-methylphenyl)sulfonyl]-2-propenenitrile (BAY 11-7082) pr
145 sing Lawesson's reagent, producing 1-[[4-[4-(methylphenyl)sulfonyl]-3,4,5,8-tetrahydro-2H-1,4-thiazoc
146 btype, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinyl methyl)-acet
147 ption 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NS
148 x between a hydroxamate, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H -
149 the aromatic donor group D = 2,5-dimethoxy-4-methylphenyl to be a suitable redox center for the const
150 oxidations of phenyltrimethylstannane and (4-methylphenyl)trimethylstannane by 1,2,4,5-tetracyanobenz
151 ctivities for phenyltrimethylstannane and (4-methylphenyl)trimethylstannane varied by factors of 26 a
152 ompounds was 3beta-(4-methylphenyl)-2beta-(4-methylphenyl)tropane (3d), which showed an IC50 of 1.23
153 ghly specific alpha4beta1 inhibitor 4-((N'-2-methylphenyl)ureido)-phenylacetyl-leucine-aspartic acid-
154 ide-based alpha4beta1 inhibitor (1; 4-[N'-(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val) derived fr
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