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1 e most bulky alkoxy moiety, S(P)-cycloheptyl methylphosphonate.
2 ve fluoro[5-methoxy-2-(pyrimidin-2-yl)phenyl]methylphosphonate.
3 re starved for phosphate, or when growing on methylphosphonate.
4 t C2 of the substrate to the methyl group of methylphosphonate.
5 onverts 2-hydroxyethylphosphonate (2-HEP) to methylphosphonate.
6 cted phosphate in each strand with uncharged methylphosphonate.
7  on neutralizing the phosphate backbone with methylphosphonates.
8 0% less than duplexes neutralized by racemic methylphosphonates.
9 ctive substitution of backbone phosphates by methylphosphonates.
10                                 2-Aminoethyl methylphosphonate (2-AEMP), an analog of GABA, has been
11 e herein the total asymmetric synthesis of 3-methylphosphonate, 3-(monofluoromethyl)phosphonate and 3
12 ly catalyzes the hydrolysis of 4-nitrophenyl methylphosphonate (4NPMP).
13 olysed to pyrophosphate and alpha-D-ribose-1-methylphosphonate-5-phosphate (PRPn).
14 The cleavage of the C-P bond within ribose-1-methylphosphonate-5-phosphate to form methane and 5-phos
15 e reacts with MgATP to form alpha-D-ribose-1-methylphosphonate-5-triphosphate (RPnTP) and adenine.
16 and tested for their sensitivity to dimethyl methylphosphonate (a nerve agent simulant).
17 differentiation and quantitative analysis of methylphosphonate (a nerve gas byproduct), glyphosate (a
18 e increase in vapor sensitivity for dimethyl methylphosphonate (a Sarin simulant) detection using a s
19   Methylphosphonate synthase (MPnS) produces methylphosphonate, a metabolic precursor to methane in t
20 charge-neutralized or substituted by neutral methylphosphonates across the major or minor groove have
21 d cyclic sulfamidate 22 with lithium dialkyl methylphosphonate, affording 13 and 23, respectively.
22 both ADP and its nonhydrolyzable alpha, beta-methylphosphonate analog were strong inhibitors of APAF-
23       Using the purine oligomer, d(AG)8, its methylphosphonate analog, d(AG)8, and the complementary
24                                        The 5-methylphosphonate analogue containing a 6-[3,5-bis(methy
25 results of the enzyme activity assays on the methylphosphonate and 2'-O-methyl-modified substrates.
26 erons of P. stutzeri abolishes all growth on methylphosphonate and aminoethylphosphonate.
27                                              Methylphosphonate and borate electrolytes support cataly
28 bound dimer ions were obtained with dimethyl methylphosphonate and butanone.
29                   At 3-15 mM Mg(2+), the all-methylphosphonate and DNA oligonucleotides trans-splice
30      These chimeric TFOs contain mixtures of methylphosphonate and phosphodiester internucleotide bon
31 n 2'-O-methylribonucleosides and alternating methylphosphonate and phosphodiester internucleotide lin
32     DNA duplexes with patches of alternating methylphosphonate and phosphodiester linkages are less b
33                                          The methylphosphonate and phosphodiester linkages of these o
34  complexes, the catalyzed hydrolysis of aryl methylphosphonates and aryl phosphates are much more sim
35         Electrolysis of Co(2+) in phosphate, methylphosphonate, and borate electrolytes effects the e
36 CWA) simulants trimethyl phosphate, dimethyl methylphosphonate, and diisopropyl methylphosphonate wer
37  applied to oligomers having phosphodiester, methylphosphonate, and phosphorothioate backbone linkage
38                                     Diphenyl methylphosphonate appears to be a fairly specific inhibi
39     However, the ability of OS-B' to utilize methylphosphonate as a sole phosphorus source occurred o
40 g methyl ethyl ketone, toluene, and dimethyl methylphosphonate as a test mixture.
41  the cells grew rapidly in fresh medium with methylphosphonate as the only source of phosphorus.
42 nd one mutant lacking the ability to grow on methylphosphonate as the sole P source was isolated.
43 s containing isomerically pure S(p) and R(p) methylphosphonates at single positions for the purpose o
44 d to triplex formation, the advantage of the methylphosphonate backbone on the purine strand is clear
45  may be offset by the reduced ability of the methylphosphonate backbone to assume an A-type conformat
46 -pyrimidinone residues or the base-sensitive methylphosphonate backbone.
47                                              Methylphosphonate-bearing oligonucleotides are character
48 trosopumilus maritimus encodes a pathway for methylphosphonate biosynthesis and that it produces cell
49 thway in metagenomic data sets suggests that methylphosphonate biosynthesis is relatively common in m
50                                     Diphenyl methylphosphonate causes peroxisome clustering around oi
51                       Stereochemistry at the methylphosphonate center for the heptanucleotide was eit
52 ) stereoisomer, although only one of the six methylphosphonate centers has the S(p) stereochemistry).
53 ribonucleotides and oligodeoxyribonucleoside methylphosphonates comprised exclusively of the fluoresc
54 ivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by
55 ssible only for alpha-amino (2-alkynylphenyl)methylphosphonates containing a benzene ring.
56 rmed between a single strand heptanucleotide methylphosphonate, d(Cp(Me)Cp(Me)Ap(Me)Ap(Me)Ap(Me)Cp(Me
57                                Chirally pure methylphosphonate deoxyribooligonucleotides were synthes
58 ntus, was determined as a complex with the N-methylphosphonate derivative of l-arginine (PDB code 3MT
59  was also determined as a complex with the N-methylphosphonate derivative of l-Pro (PDB code 3N2C ).
60                Use of isolated S(p) and R(p) methylphosphonate diastereomers demonstrates that interf
61 lants (dimethyl methylphosphonate, pinacolyl methylphosphonate, diethyl phosphoramidate, and 2-(butyl
62 mits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in pos
63 ed from the stereochemically pure nucleoside methylphosphonate dimer building block, prepared as a ph
64       Two nerve agent simulants, diisopropyl methylphosphonate (DIMP) and di-methyl methylphosphonate
65 ion on the nerve agent simulants diisopropyl methylphosphonate (DIMP) and dimethyl methylphosphonate
66  agent (CWA) surrogate compound, diisopropyl methylphosphonate (DIMP), demonstrated that the HSA-SPME
67  three pairs of compounds, that is, dimethyl methylphosphonate (DMMP) and acetone, methyl tert-butyl
68 mical warfare agent (CWA) stimulant dimethyl methylphosphonate (DMMP) and several other standard comp
69 centration for the first time using dimethyl methylphosphonate (DMMP) as a test case.
70 l impurity profiles from commercial dimethyl methylphosphonate (DMMP) samples to illustrate the type
71  to respond strongly to the analyte dimethyl methylphosphonate (DMMP) that simulates phosphonate nerv
72 ence enhancement at the presence of dimethyl methylphosphonate (DMMP) vapors.
73 propyl methylphosphonate (DIMP) and dimethyl methylphosphonate (DMMP) was studied while solutions of
74 (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in bot
75 xture of one G-type nerve simulant (dimethyl methylphosphonate (DMMP)) in four (water, kerosene, gaso
76 ropyl methylphosphonate (DIMP) and di-methyl methylphosphonate (DMMP), and three sorbent polymers wer
77 position of a nerve-agent simulant, dimethyl methylphosphonate (DMMP), on UiO-66, UiO-67, MOF-808, an
78 as been shown to react readily with dimethyl methylphosphonate (DMMP).
79 e, tetrabutylammonium chloride, and dimethyl methylphosphonate (DMMP).
80 A, phosphorothioate RNA, 2'-O-methyl RNA and methylphosphonate DNA.
81                                     Based on methylphosphonate-DNA mapping, pol eta interacts with th
82                     We report the binding of methylphosphonate/DNA chimeras and neutral methylphospho
83 eavage for oligonucleotides substituted with methylphosphonates downstream from the cleavage site.
84 onate (IMPA), GB degradate; 61-91% for ethyl methylphosphonate (EMPA), VX degradate; and 60-98% for p
85 ational heterogeneity was confirmed with the methylphosphonate ester anion adduct of the active-site
86                  The S(p) enantiomers of the methylphosphonate esters are far more reactive in formin
87 nthesis and that it produces cell-associated methylphosphonate esters.
88 on proton (third order) and proton acceptor, methylphosphonate (first order for 1.8 mM </= [MeP(i)] <
89 where phosphorus-starved microbes catabolize methylphosphonate for its phosphorus.
90 (1mp) where PS is trimethylpsoralen and p is methylphosphonate, forms a stable triplex with env-DNA w
91 cid (IMPA) and O-isopropyl O'-(2-amino)ethyl methylphosphonate (GB-MEA adduct).
92                                  Diisopropyl methylphosphonate, GB impurity, was not recovered from s
93 cid (PMPA) and O-pinacolyl O'-(2-amino)ethyl methylphosphonate (GD-MEA adduct).
94       Here, we report that introduction of a methylphosphonate group into the quinoxalinedione skelet
95 3'-terminal phosphodiester of the TFO with a methylphosphonate group significantly increased the resi
96                      Substitution of neutral methylphosphonate groups for anionic DNA phosphate group
97   However, the introduction of chirally pure methylphosphonate groups shows that the effect of substi
98 ster linkages of T(pT)(8) were replaced with methylphosphonate groups.
99 s and lithiated methyl alpha-(trimethylsilyl)methylphosphonate has been developed.
100         Replacement of phosphates by neutral methylphosphonates has previously been shown to be a mod
101  At 15 mM Mg(2+), the nuclease-resistant all-methylphosphonate hexamer, d(AmTmGmAmCm)rU, with a seque
102  Both operons individually support growth on methylphosphonate; however, the phn operon supports grow
103 states for aryl phosphate monoester and aryl methylphosphonate hydrolysis reactions that are much mor
104 ermeable surfaces were 60-103% for isopropyl methylphosphonate (IMPA), GB degradate; 61-91% for ethyl
105 fuse reflection data are presented for ethyl methylphosphonate in a fine Utah dirt sample as a model
106 h the sodium salt of diethyl (phenylsulfonyl)methylphosphonate in DME at 140 degrees C for 4 h gives
107 ced P substrate hypophosphite, phosphite, or methylphosphonate, in addition to excess Pi, did not res
108 with a methyl group by the introduction of a methylphosphonate instead of the natural phosphate in fu
109 ly rapid hydrolysis of a covalent enzyme-DNA methylphosphonate intermediate.
110 phate neutralization by substituting neutral methylphosphonate internucleoside linkages at relevant p
111 ntaining microbes supports the proposal that methylphosphonate is a source of methane in the upper, a
112                          In these organisms, methylphosphonate is converted to phosphate and methane.
113 en suggested to explain this phenomenon, yet methylphosphonate is not a known natural product, nor ha
114 es neutralized by incorporation of pure (RP)-methylphosphonate isomers are bent approximately 30% les
115 osphate groups with an uncharged (R)- or (S)-methylphosphonate linkage (MeP).
116 perator sequence and a single diastereomeric methylphosphonate linkage are each prepared from the ste
117  by showing that introduction of an Sp or Rp methylphosphonate linkage at the cleavage site transform
118 onucleotides prepared with these R(P) chiral methylphosphonate linkage synthons bind RNA with signifi
119 d by the asymmetric incorporation of racemic methylphosphonate linkages creating a neutral region on
120 o presence and possibly the chirality of the methylphosphonate linkages in the oligomer.
121 AAGGA), where MP corresponds to positions of methylphosphonate linkages in the pure R(p) stereoconfig
122                              When two of the methylphosphonate linkages in the region complementary t
123   Surrounding the GTG sequence with nonionic methylphosphonate linkages inhibited or eliminated cross
124  substrates persisted unabated when multiple methylphosphonate linkages were inserted between the sit
125 basic tetrahydrofuran linkages, neutralizing methylphosphonate linkages, and conformationally locked
126 he AP-1 site with various numbers of neutral methylphosphonate linkages.
127 hen it is partially substituted with neutral methylphosphonate linkages.
128 scissile phosphate (P) by the charge neutral methylphosphonate (MeP) makes Arg-308 dispensable during
129 neutralization of the scissile phosphate via methylphosphonate (MeP) modification.
130 ubstitution of the scissile phosphate (P) by methylphosphonate (MeP) permits strand cleavage by a Cre
131 , we measured the kinetic effects of neutral methylphosphonate (MeP) stereoisomers at the +1 and +2 p
132 ive charge on the scissile phosphate through methylphosphonate (MeP) substitution does not stimulate
133 nucleotides, as well as phosphorothioate and methylphosphonate modifications within the tRNA acceptor
134                                Our data with methylphosphonate-modified DNA suggests that thioredoxin
135 ds and experiments with different length and methylphosphonate-modified primer-templates demonstrate
136 were tested in enzyme activity assays on the methylphosphonate-modified substrates.
137                                              Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are
138 een performed on a hybrid duplex formed by a methylphosphonate (MP) oligodeoxyribonucleotide (MPO) an
139  methanogenesis substrates found only (13) C-methylphosphonate (MPn) resulted in (13) CH4 generation.
140            These alternating oligonucleoside methylphosphonates, mr-AOMPs, contain 2'-O-methylribonuc
141 -resistant, 5'-psoralen-conjugated, chimeric methylphosphonate oligodeoxyribo- or oligo-2'-O-methylri
142  and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents
143 f methylphosphonate/DNA chimeras and neutral methylphosphonate oligonucleotides to a ribozyme that is
144 ze the effects of a small molecule, diphenyl methylphosphonate, on oil mobilization in Arabidopsis th
145 ng enzyme activity assays on substrates with methylphosphonate or 2'-O-methyl substitutions.
146   Using exogenous nucleophiles and synthetic methylphosphonate or 5'-thiolate substrates, we decipher
147 phosphonate analogue containing a 6-[3,5-bis(methylphosphonate)]phenylazo moiety, 9, had IC50 values
148 nt antisense effects induced by the chimeric methylphosphonate-phosphodiester compounds were found to
149                  In conclusion, the chimeric methylphosphonate-phosphodiester oligodeoxynucleotides p
150 ssion was specifically disrupted by chimeric methylphosphonate/phosphodiester antisense oligodeoxynuc
151 thesized oligonucleotides having alternating methylphosphonate/phosphodiester internucleotide linkage
152                           The application of methylphosphonate:phosphodiester chimaeric oligonucleoti
153 e of four G/V-type nerve simulants (dimethyl methylphosphonate, pinacolyl methylphosphonate, diethyl
154 MPA), VX degradate; and 60-98% for pinacolyl methylphosphonate (PMPA), GD degradate.
155                            Here we show that methylphosphonate reacts with MgATP to form alpha-D-ribo
156 as been compared with the standard lithiated methylphosphonate reagent.
157  modified oligonucleotide possessed a single methylphosphonate replacement on the phosphate backbone,
158 six proximal phosphate residues with neutral methylphosphonates resulted in DNA bent spontaneously to
159     Of these analogs, only (R)-2-aminopropyl methylphosphonate significantly diminished the response
160 cissile phosphate by an electrically neutral methylphosphonate significantly impairs the rate of bond
161  detection of a pesticide simulant, dimethyl methylphosphonate sorbed onto silica gel (DMMP/SG), usin
162 nionic phosphates) and explore the effect of methylphosphonate stereochemistry.
163                     The hybridization of the methylphosphonate strand does not perturb the structure
164 d effect on the hybridization ability of the methylphosphonate strand.
165                    The results show that the methylphosphonate strands in the heteroduplexes exhibit
166  Molecular dynamics simulations on partially methylphosphonate substituted helical chains of d(TATAGG
167         The degree of DNA bending induced by methylphosphonate substitution (approximately 3.5 degree
168 ctive neutralization of phosphate charges by methylphosphonate substitution demonstrates the differen
169                                            5-Methylphosphonate substitution, anticipated to increase
170 half-site DNA were chemically neutralized by methylphosphonate substitution.
171                          A series of further methylphosphonate substitutions and mutations and trunca
172  differential flexibility of duplex DNA when methylphosphonate substitutions are made and find that t
173 the AATT sequence is normally narrow and the methylphosphonate substitutions have a smaller but measu
174 onformation averaged over all stereospecific methylphosphonate substitutions is nearly the same as th
175  then compared the damaging effects of these methylphosphonate substitutions on catalysis with their
176 rivative of c-di-GMP containing 2'-deoxy and methylphosphonate substitutions that is charge neutral a
177 xamine this, we introduced single and tandem methylphosphonate substitutions through the region of th
178 further using DNA substrates carrying unique methylphosphonate substitutions, together with mutations
179 The enzymatic hydrolysis of a series of aryl methylphosphonate substrates yields a Bronsted beta(lg)
180 droxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS) are nonheme iron oxyge
181                                              Methylphosphonate synthase (MPnS) produces methylphospho
182 droxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS).
183                                              Methylphosphonate synthase is a non-heme iron-dependent
184 , identifying the molecular requirements for methylphosphonate synthesis.
185                      The ability of chimeric methylphosphonate TFOs to bind to DNA, combined with the
186 -pentyl-4-biphenylcarbonitrile, and dimethyl methylphosphonate to metal cation models representing th
187  Cells sequentially limited by phosphate and methylphosphonate transformed >75% of their lipids to ph
188 were used to examine the effects of diphenyl methylphosphonate treatment on seedlings.
189 f three chemical warfare simulants, dimethyl methylphosphonate, triethyl phosphate, and dipropylenegl
190  acceleration in the rate of hydrolysis of a methylphosphonate versus phosphodiester suggests that re
191                          The corresponding 5-methylphosphonate was equipotent at P2X1 receptors.
192 e of the two resulting diastereomers, the SP methylphosphonate, was compatible with efficient GTPase
193  dimethyl methylphosphonate, and diisopropyl methylphosphonate were captured by passing air through a
194       We found that a phosphorothioate and a methylphosphonate were excised with low efficiency.
195  a diethanolamine amide group and an aryl di(methylphosphonate) were both less potent than 10 as anta
196 , methyl ethyl ketone, toluene, and dimethyl methylphosphonate, were released from the packed column
197 I reagent ion leading to protonated dimethyl methylphosphonate, while the monomer is mainly responsib
198 thoxyphenyl)(fluoro)(pyrimidin-2-ylsulfonyl)]methylphosphonate with Bu(3)SnH resulted in an intramole
199 d high nuclease stability of the P-C bond of methylphosphonates with the high membrane permeability,

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