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1 e most bulky alkoxy moiety, S(P)-cycloheptyl methylphosphonate.
2 ve fluoro[5-methoxy-2-(pyrimidin-2-yl)phenyl]methylphosphonate.
3 re starved for phosphate, or when growing on methylphosphonate.
4 t C2 of the substrate to the methyl group of methylphosphonate.
5 onverts 2-hydroxyethylphosphonate (2-HEP) to methylphosphonate.
6 cted phosphate in each strand with uncharged methylphosphonate.
7 on neutralizing the phosphate backbone with methylphosphonates.
8 0% less than duplexes neutralized by racemic methylphosphonates.
9 ctive substitution of backbone phosphates by methylphosphonates.
11 e herein the total asymmetric synthesis of 3-methylphosphonate, 3-(monofluoromethyl)phosphonate and 3
14 The cleavage of the C-P bond within ribose-1-methylphosphonate-5-phosphate to form methane and 5-phos
15 e reacts with MgATP to form alpha-D-ribose-1-methylphosphonate-5-triphosphate (RPnTP) and adenine.
17 differentiation and quantitative analysis of methylphosphonate (a nerve gas byproduct), glyphosate (a
18 e increase in vapor sensitivity for dimethyl methylphosphonate (a Sarin simulant) detection using a s
19 Methylphosphonate synthase (MPnS) produces methylphosphonate, a metabolic precursor to methane in t
20 charge-neutralized or substituted by neutral methylphosphonates across the major or minor groove have
21 d cyclic sulfamidate 22 with lithium dialkyl methylphosphonate, affording 13 and 23, respectively.
22 both ADP and its nonhydrolyzable alpha, beta-methylphosphonate analog were strong inhibitors of APAF-
25 results of the enzyme activity assays on the methylphosphonate and 2'-O-methyl-modified substrates.
31 n 2'-O-methylribonucleosides and alternating methylphosphonate and phosphodiester internucleotide lin
32 DNA duplexes with patches of alternating methylphosphonate and phosphodiester linkages are less b
34 complexes, the catalyzed hydrolysis of aryl methylphosphonates and aryl phosphates are much more sim
36 CWA) simulants trimethyl phosphate, dimethyl methylphosphonate, and diisopropyl methylphosphonate wer
37 applied to oligomers having phosphodiester, methylphosphonate, and phosphorothioate backbone linkage
39 However, the ability of OS-B' to utilize methylphosphonate as a sole phosphorus source occurred o
42 nd one mutant lacking the ability to grow on methylphosphonate as the sole P source was isolated.
43 s containing isomerically pure S(p) and R(p) methylphosphonates at single positions for the purpose o
44 d to triplex formation, the advantage of the methylphosphonate backbone on the purine strand is clear
45 may be offset by the reduced ability of the methylphosphonate backbone to assume an A-type conformat
48 trosopumilus maritimus encodes a pathway for methylphosphonate biosynthesis and that it produces cell
49 thway in metagenomic data sets suggests that methylphosphonate biosynthesis is relatively common in m
52 ) stereoisomer, although only one of the six methylphosphonate centers has the S(p) stereochemistry).
53 ribonucleotides and oligodeoxyribonucleoside methylphosphonates comprised exclusively of the fluoresc
54 ivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by
56 rmed between a single strand heptanucleotide methylphosphonate, d(Cp(Me)Cp(Me)Ap(Me)Ap(Me)Ap(Me)Cp(Me
58 ntus, was determined as a complex with the N-methylphosphonate derivative of l-arginine (PDB code 3MT
59 was also determined as a complex with the N-methylphosphonate derivative of l-Pro (PDB code 3N2C ).
61 lants (dimethyl methylphosphonate, pinacolyl methylphosphonate, diethyl phosphoramidate, and 2-(butyl
62 mits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in pos
63 ed from the stereochemically pure nucleoside methylphosphonate dimer building block, prepared as a ph
65 ion on the nerve agent simulants diisopropyl methylphosphonate (DIMP) and dimethyl methylphosphonate
66 agent (CWA) surrogate compound, diisopropyl methylphosphonate (DIMP), demonstrated that the HSA-SPME
67 three pairs of compounds, that is, dimethyl methylphosphonate (DMMP) and acetone, methyl tert-butyl
68 mical warfare agent (CWA) stimulant dimethyl methylphosphonate (DMMP) and several other standard comp
70 l impurity profiles from commercial dimethyl methylphosphonate (DMMP) samples to illustrate the type
71 to respond strongly to the analyte dimethyl methylphosphonate (DMMP) that simulates phosphonate nerv
73 propyl methylphosphonate (DIMP) and dimethyl methylphosphonate (DMMP) was studied while solutions of
74 (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in bot
75 xture of one G-type nerve simulant (dimethyl methylphosphonate (DMMP)) in four (water, kerosene, gaso
76 ropyl methylphosphonate (DIMP) and di-methyl methylphosphonate (DMMP), and three sorbent polymers wer
77 position of a nerve-agent simulant, dimethyl methylphosphonate (DMMP), on UiO-66, UiO-67, MOF-808, an
83 eavage for oligonucleotides substituted with methylphosphonates downstream from the cleavage site.
84 onate (IMPA), GB degradate; 61-91% for ethyl methylphosphonate (EMPA), VX degradate; and 60-98% for p
85 ational heterogeneity was confirmed with the methylphosphonate ester anion adduct of the active-site
88 on proton (third order) and proton acceptor, methylphosphonate (first order for 1.8 mM </= [MeP(i)] <
90 (1mp) where PS is trimethylpsoralen and p is methylphosphonate, forms a stable triplex with env-DNA w
95 3'-terminal phosphodiester of the TFO with a methylphosphonate group significantly increased the resi
97 However, the introduction of chirally pure methylphosphonate groups shows that the effect of substi
101 At 15 mM Mg(2+), the nuclease-resistant all-methylphosphonate hexamer, d(AmTmGmAmCm)rU, with a seque
102 Both operons individually support growth on methylphosphonate; however, the phn operon supports grow
103 states for aryl phosphate monoester and aryl methylphosphonate hydrolysis reactions that are much mor
104 ermeable surfaces were 60-103% for isopropyl methylphosphonate (IMPA), GB degradate; 61-91% for ethyl
105 fuse reflection data are presented for ethyl methylphosphonate in a fine Utah dirt sample as a model
106 h the sodium salt of diethyl (phenylsulfonyl)methylphosphonate in DME at 140 degrees C for 4 h gives
107 ced P substrate hypophosphite, phosphite, or methylphosphonate, in addition to excess Pi, did not res
108 with a methyl group by the introduction of a methylphosphonate instead of the natural phosphate in fu
110 phate neutralization by substituting neutral methylphosphonate internucleoside linkages at relevant p
111 ntaining microbes supports the proposal that methylphosphonate is a source of methane in the upper, a
113 en suggested to explain this phenomenon, yet methylphosphonate is not a known natural product, nor ha
114 es neutralized by incorporation of pure (RP)-methylphosphonate isomers are bent approximately 30% les
116 perator sequence and a single diastereomeric methylphosphonate linkage are each prepared from the ste
117 by showing that introduction of an Sp or Rp methylphosphonate linkage at the cleavage site transform
118 onucleotides prepared with these R(P) chiral methylphosphonate linkage synthons bind RNA with signifi
119 d by the asymmetric incorporation of racemic methylphosphonate linkages creating a neutral region on
121 AAGGA), where MP corresponds to positions of methylphosphonate linkages in the pure R(p) stereoconfig
123 Surrounding the GTG sequence with nonionic methylphosphonate linkages inhibited or eliminated cross
124 substrates persisted unabated when multiple methylphosphonate linkages were inserted between the sit
125 basic tetrahydrofuran linkages, neutralizing methylphosphonate linkages, and conformationally locked
128 scissile phosphate (P) by the charge neutral methylphosphonate (MeP) makes Arg-308 dispensable during
130 ubstitution of the scissile phosphate (P) by methylphosphonate (MeP) permits strand cleavage by a Cre
131 , we measured the kinetic effects of neutral methylphosphonate (MeP) stereoisomers at the +1 and +2 p
132 ive charge on the scissile phosphate through methylphosphonate (MeP) substitution does not stimulate
133 nucleotides, as well as phosphorothioate and methylphosphonate modifications within the tRNA acceptor
135 ds and experiments with different length and methylphosphonate-modified primer-templates demonstrate
138 een performed on a hybrid duplex formed by a methylphosphonate (MP) oligodeoxyribonucleotide (MPO) an
139 methanogenesis substrates found only (13) C-methylphosphonate (MPn) resulted in (13) CH4 generation.
141 -resistant, 5'-psoralen-conjugated, chimeric methylphosphonate oligodeoxyribo- or oligo-2'-O-methylri
142 and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents
143 f methylphosphonate/DNA chimeras and neutral methylphosphonate oligonucleotides to a ribozyme that is
144 ze the effects of a small molecule, diphenyl methylphosphonate, on oil mobilization in Arabidopsis th
146 Using exogenous nucleophiles and synthetic methylphosphonate or 5'-thiolate substrates, we decipher
147 phosphonate analogue containing a 6-[3,5-bis(methylphosphonate)]phenylazo moiety, 9, had IC50 values
148 nt antisense effects induced by the chimeric methylphosphonate-phosphodiester compounds were found to
150 ssion was specifically disrupted by chimeric methylphosphonate/phosphodiester antisense oligodeoxynuc
151 thesized oligonucleotides having alternating methylphosphonate/phosphodiester internucleotide linkage
153 e of four G/V-type nerve simulants (dimethyl methylphosphonate, pinacolyl methylphosphonate, diethyl
157 modified oligonucleotide possessed a single methylphosphonate replacement on the phosphate backbone,
158 six proximal phosphate residues with neutral methylphosphonates resulted in DNA bent spontaneously to
159 Of these analogs, only (R)-2-aminopropyl methylphosphonate significantly diminished the response
160 cissile phosphate by an electrically neutral methylphosphonate significantly impairs the rate of bond
161 detection of a pesticide simulant, dimethyl methylphosphonate sorbed onto silica gel (DMMP/SG), usin
166 Molecular dynamics simulations on partially methylphosphonate substituted helical chains of d(TATAGG
168 ctive neutralization of phosphate charges by methylphosphonate substitution demonstrates the differen
172 differential flexibility of duplex DNA when methylphosphonate substitutions are made and find that t
173 the AATT sequence is normally narrow and the methylphosphonate substitutions have a smaller but measu
174 onformation averaged over all stereospecific methylphosphonate substitutions is nearly the same as th
175 then compared the damaging effects of these methylphosphonate substitutions on catalysis with their
176 rivative of c-di-GMP containing 2'-deoxy and methylphosphonate substitutions that is charge neutral a
177 xamine this, we introduced single and tandem methylphosphonate substitutions through the region of th
178 further using DNA substrates carrying unique methylphosphonate substitutions, together with mutations
179 The enzymatic hydrolysis of a series of aryl methylphosphonate substrates yields a Bronsted beta(lg)
180 droxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS) are nonheme iron oxyge
186 -pentyl-4-biphenylcarbonitrile, and dimethyl methylphosphonate to metal cation models representing th
187 Cells sequentially limited by phosphate and methylphosphonate transformed >75% of their lipids to ph
189 f three chemical warfare simulants, dimethyl methylphosphonate, triethyl phosphate, and dipropylenegl
190 acceleration in the rate of hydrolysis of a methylphosphonate versus phosphodiester suggests that re
192 e of the two resulting diastereomers, the SP methylphosphonate, was compatible with efficient GTPase
193 dimethyl methylphosphonate, and diisopropyl methylphosphonate were captured by passing air through a
195 a diethanolamine amide group and an aryl di(methylphosphonate) were both less potent than 10 as anta
196 , methyl ethyl ketone, toluene, and dimethyl methylphosphonate, were released from the packed column
197 I reagent ion leading to protonated dimethyl methylphosphonate, while the monomer is mainly responsib
198 thoxyphenyl)(fluoro)(pyrimidin-2-ylsulfonyl)]methylphosphonate with Bu(3)SnH resulted in an intramole
199 d high nuclease stability of the P-C bond of methylphosphonates with the high membrane permeability,
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