ライフサイエンスコーパス: methyltransferase

1 of PRDM9, a polymorphic histone H3 (H3K4Me3) methyltransferase.

2 e determined by PRDM9, a DNA-binding histone methyltransferase.

3 codes the As(III) S-adenosylmethionine (SAM) methyltransferase.

4 dependent radical S-adenosylmethionine (SAM) methyltransferase.

5 26695, encodes a N(6)-adenosine type III DNA methyltransferase.

6 mes due to phase variation in genes encoding methyltransferases.

7 differs from other characterized radical SAM methyltransferases.

8 ling, nucleosomes are strong barriers to DNA methyltransferases.

9 the activities of two cobalamin-dependent C-methyltransferases.

10 mocysteine (SAH), a product and inhibitor of methyltransferases.

11 g DNA synthesis may depend upon these lysine methyltransferases.

12 thylation mediated by the family of arginine methyltransferases.

13 ecific functions of the different MLL lysine methyltransferases.

14 Coactivator associated arginine methyltransferase 1 (CARM1) is a member of the protein a

15 PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for c

16 Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein methyltransfera

17 , we define not only a dominant role for DNA methyltransferase 1 (DNMT1) but also distinct roles of 3

18 istically, Naa10p facilitates binding of DNA methyltransferase 1 (Dnmt1) to DNA substrates, including

19 etically silenced from infancy onward by DNA methyltransferase 1 (DNMT1).

20 r deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main causes of

21 Protein arginine methyltransferase 1 (PRMT1) is an essential enzyme contr

22 r coactivator 1 (SRC1), and protein arginine methyltransferase 1 (PRMT1) only modestly increase hepat

23 tein G3BP1 is methylated by protein arginine methyltransferase 1 and 5 (PRMT1 and PRMT5).

24 conjunction with CG methylation by MET1 (DNA METHYLTRANSFERASE 1), CHG methylation by CMT3 (CHROMOMET

25 1 physically interacts with protein arginine methyltransferase 1, which methylates EYA1 at these resi

26 with reduced activity of the E2F target, DNA methyltransferase 1.

27 scription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and struct

28 by haploinsufficiency of euchromatic histone methyltransferase-1 (EHMT1).

29 RNA POLYMERASE V (POL V), DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and SAWADEE HOMEODOMAIN HOMOL

30 e inhibitors of euchromatic histone lysine N-methyltransferase-2 (EHMT2, also known as G9a)-activated

31 binding protein 7 (CHD7(LOF)) and lysine (K) methyltransferase 2D (KMT2D(LOF)), respectively.

32 infarction, the PRMT3 gene (protein arginine methyltransferase 3) with stroke, and the LHFPL2 gene (l

33 ultiple copies of antibody-fused de novo DNA methyltransferase 3A (DNMT3A) (dCas9-SunTag-DNMT3A) to a

34 Despite a recognized role of DNA methyltransferase 3a (DNMT3a) in human cancer, the natur

35 The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated in a

36 h is then followed by the recruitment of DNA methyltransferase 3a (DNMT3a), ultimately resulting in t

37 This process is dependent on DNA methyltransferase 3B (DNMT3B) and leads to suppression o

38 H19 knockdown activates SAHH, enabling DNA methyltransferase 3B to methylate a subset of genes.

39 assembly factors united in protein arginine methyltransferase 5 (PRMT5) and survival motor neuron (S

40 Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 c

41 Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic en

42 M6CKs) bind subunits of the protein arginine methyltransferase 5 (PRMT5) molecular complex that make

43 Protein arginine methyltransferase 7 (PRMT7) catalyzes the introduction o

44 Here we use mice lacking protein arginine methyltransferase 8 (PRMT8) in the brain to examine how

45 Recently, Methyltransferase Accessibility Protocol for individual

46 eral molecular determinants regulate ATXR5/6 methyltransferase activity and epigenetic inheritance of

47 binds and phosphorylates KMT2D, attenuating methyltransferase activity and ER function, whereas PI3K

48 anosine synthases based both on its in vitro methyltransferase activity and on its ability to rescue

49 Silencing EZH2 or inhibiting its histone methyltransferase activity conferred increased apoptosis

50 plicates a critical role for Set1A catalytic methyltransferase activity in regulating ESC differentia

51 DNMT1-mediated methyltransferase activity is also reduced in these cell

52 Importantly, by inhibiting methyltransferase activity of CARM1, the enzyme responsi

53 Blocking the methyltransferase activity of G9a inhibited cellular pro

54 s to the 3 stem loop of 7SK and inhibits the methyltransferase activity of MEPCE through a C-terminal

55 nt of CARM1 not only adds a protein arginine methyltransferase activity to the ER-coactivator complex

56 explore the novel approach of inhibiting DNA methyltransferase activity using 5-azacytidine (Aza; a c

57 ited Ras-mediated dependence on PRC2 histone methyltransferase activity, a finding that is similar to

58 2, a SET and MYND domain protein with lysine methyltransferase activity, as a regulator of renal cyst

59 raction with its obligatory co-substrate for methyltransferase activity, S-adenosyl-l-methionine (SAM

60 inds to cyclic-di-GMP, which potentiates its methyltransferase activity.

61 ontributes to both chromatin association and methyltransferase activity.

62 ose presence is required for cytoplasmic cap methyltransferase activity.

63 Methyltransferases add a methyl group to mRNA while deme

64 Phosphoethanolamine methyltransferases add three methyl groups successively

65 uman S-adenosylmethionine (AdoMet)-dependent methyltransferase and found it to methylate a single pro

66 f EOC, that clinically relevant doses of DNA methyltransferase and histone deacetylase inhibitors (DN

67 knockdown of the histone 3 lysine 27 (H3K27) methyltransferase and part of the polycomb recessive com

68 n of a single gene (modA) that encodes a DNA methyltransferase and results in two phenotypically dist

69 tivities critical for virus replication, the methyltransferase and RNA-dependent RNA polymerase.

70 Gene knockouts of the Bacillus C-methyltransferase and the 4-reductase confirmed their in

71 mutations to inhibit a wide range of histone methyltransferases and are thought to promote tumorigene

72 chain reaction array, we found that histone methyltransferases and demethylases that regulate the tr

73 After screening different histone lysine methyltransferases and demethylases, we identified JMJD2

74 Histone methyl marks are written by methyltransferases and erased by demethylases, and resul

75 It interacts with histone methyltransferases and facilitates their recruitment to

76 ill review the emerging functions of histone methyltransferases and histone demethylases in AML, espe

77 self-reinforcing feedback loops between DNA methyltransferases and histone modifications characteris

78 rformed an RNAi-based screen of human lysine methyltransferases and identified the SET and MYND domai

79 reactions are uniquely coordinated by plant methyltransferases and provides insights into the evolut

80 ceptor modifications by two enzymes: CheR, a methyltransferase, and CheB, a methylesterase.

81 DP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltransferase, and NADPH-dependent CDP-3-C-methyl-6-

82 mber of the SpoU-TrmD (SPOUT) superfamily of methyltransferases, and Trm10 homologs are widely conser

83 nts, the histone H3.1 lysine 27 (H3K27) mono-methyltransferases ARABIDOPSIS TRITHORAX RELATED PROTEIN

84 sociated with Set1) family of histone lysine methyltransferases are associated with a large number of

85 The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian het

86 S-Adenosyl methionine (SAM)-dependent C-methyltransferases are responsible for the C2-methylatio

87 enetic landscapes in organisms where histone methyltransferases are uncharacterized.

88 zyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM).

89 ical screen identified SETD8, the H4(K20me1) methyltransferase, as a druggable NB target.

90 d mutations in met-1, which encodes an H3K36 methyltransferase, as potent suppressors of morc-1(-) an

91 rrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or homeotic)-li

92 for melatonin synthesis, N-acetylserotonin-O-methyltransferase (ASMT), was cloned from apple rootstoc

93 s were also obtained with three additional C-methyltransferases-BaeMT9, DifMT1, and MupMT1-from the b

94 Here we report that both methyltransferases can be UV cross-linked to RNA in vivo

95 NA modification, and is installed by a large methyltransferase complex (the m(6)A 'writer'), not only

96 t that METTL14, a key component of the m(6)A methyltransferase complex, is highly expressed in normal

97 ine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent interna

98 RNAs that is catalysed by the METTL3-METTL14 methyltransferase complex.

99 a protein with homology to the catecholamine methyltransferase COMT that is linked to schizophrenia,

100 unctional genetic variants in the catechol-O-methyltransferase (COMT) gene result in a different cata

101 Catechol O-methyltransferase (COMT) inhibitors are an established t

102 Additionally, catechol-O-methyltransferase (COMT) polymorphism has been reported

103 inary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes were measured.

104 R and functional polymorphisms in catechol-O-methyltransferase (COMT), DRD2, and DRD4 were evaluated.

105 ingle-nucleotide polymorphism for catechol-O-methyltransferase (COMT).

106 ssion of tyrosine hydroxylase and catechol-O-methyltransferase (COMT).

107 The methyltransferase contains in-line pockets for substrate

108 we term Campylobacter transformation system methyltransferase (ctsM), which methylates an overrepres

109 nes to small-molecule inhibitors against DNA methyltransferases (DAC), histone deacetylases (Depsi),

110 essary for the lifespan extension of H3K4me3 methyltransferase-deficient worms, and dietary MUFAs are

111 via TRMT61B, a mitochondria-localizing m(1)A methyltransferase, demonstrates that m(1)A in mitochondr

112 calization and catalytic activity of the DNA methyltransferase DIM-2.

113 ra crassa Artificial recruitment of the H3K9 methyltransferase DIM-5 (defective in methylation-5) ind

114 ransferase, DIM-5, and a DNMT1-like cytosine methyltransferase, DIM-2.

115 , respectively, by a conserved SUV39 histone methyltransferase, DIM-5, and a DNMT1-like cytosine meth

116 ation, which is carried out by only a single methyltransferase, disruptor of telomeric silencing-1-li

117 Furthermore, we find that inhibition of DNA methyltransferase (DNMT), whether during training or sho

118 in part from increased expression of the DNA methyltransferase DNMT1 in WDLS/DDLS.

119 els, we found that downregulation of the DNA methyltransferase DNMT1 induced by the brain microenviro

120 Conditional deletion of the de novo methyltransferase Dnmt3a at an early stage of effector d

121 nerve injury increases expression of the DNA methyltransferase DNMT3a in the injured DRG neurons via

122 The DNA methyltransferase Dnmt3a suppresses tumorigenesis in mod

123 that in the brain during early life, the DNA methyltransferase DNMT3A transiently binds across transc

124 In this work, we employed a DNA methyltransferase Dnmt3a-Dnmt3L construct fused to the n

125 restricts the expression of the de novo DNA methyltransferases Dnmt3a and Dnmt3b while up-regulating

126 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a/b is delayed.

127 Persistent downregulation of methyltransferase DNMT3b and deacetylase SIRT1 may expla

128 Hypomorphic mutations in DNA-methyltransferase DNMT3B cause majority of the rare diso

129 Recent evidence associating the de novo DNA methyltransferase Dnmt3b with H3K36me3-rich chromatin ra

130 ablishment and maintenance activities of DNA methyltransferases (DNMTs) can help in the development o

131 DNAm during OS through interacting with DNA methyltransferases (DNMTs) in a "Yin-Yang" complex targe

132 iated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential can

133 T1 and AtPMT2 reveal unique features in each methyltransferase domain, including active sites that us

134 Histone methyltransferase Dot1L is a coactivator for thyroid hor

135 -isothiocyanate conjugates, as well as the S-methyltransferase DTCMT that methylates the resulting di

136 ere an inactive form of Cas9 is fused to DNA methyltransferase effectors.

137 We also identify the Rere-binding histone methyltransferase Ehmt2/G9a, as a RA coactivator control

138 s of in vitro characterization of a carboxyl methyltransferase encoded in the cluster, Her8, are pres

139 netically controlled by the polycomb histone methyltransferase enhancer of zeste homolog 2 (Ezh2) and

140 ctivity of the epigenetic repressor, histone methyltransferase enhancer of zeste homolog 2 (EZH2).

141 Protein arginine methyltransferase enzyme 5 (PRMT5) regulates many cellul

142 d risks of routine measurement of thiopurine methyltransferase enzyme activity or genotype before sta

143 DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the path

144 in any organism, dsyB, which encodes the key methyltransferase enzyme of this pathway and is a reliab

145 irect tethering' strategy attaching the Ezh2 methyltransferase enzyme to dCas9, as well as a 'recruit

146 essential Staphylococcus aureus tRNA m(1)G37 methyltransferase enzyme TrmD, which is conserved in all

147 rvations suggest that the conserved U6 snRNA methyltransferase evolved an additional function in vert

148 f histone H1, thereby recruiting the histone methyltransferase EZH2 and elevating H3K27me3 levels, th

149 Here, we identified loss of the histone methyltransferase EZH2 and subsequent reduction of histo

150 was inactive when complexed with the histone methyltransferase EZH2 and transcription factors YY1 and

151 Herein, we show that the histone methyltransferase Ezh2 controls CD8(+) T memory precurso

152 eveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation o

153 lation of Rb and release of E2F1.The histone methyltransferase EZH2 silences genes by generating H3K2

154 SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there i

155 t Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromati

156 ions in DNA methylation at potential histone methyltransferase EZH2-binding sites.

157 knockouts, we demonstrate that COMPASS H3K4 methyltransferase family members differentially regulate

158 ncer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophi

159 Despite adopting a complete class I methyltransferase fold containing conserved SAM-binding

160 Dot1L, a unique methyltransferase for H3K79, forms complexes with distin

161 Nonstructural protein 5 (NS5) contains a methyltransferase for RNA capping and a polymerase for v

162 urther show that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear

163 mTOMT in hair cells is independent of mTOMT methyltransferase function and mCOMT cannot substitute f

164 vitro reconstitution of TbtI, a class C rSAM methyltransferase, further adds to the chemical versatil

165 genome tagging in vivo by Mef2c-Dam adenine methyltransferase fusion protein confirmed the link betw

166 Here, we show that the protein lysine methyltransferase G9a (also known as EHMT2) and GLP1 (al

167 port that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB/TFE3/MITF-independe

168 rther yielded a novel association in the DNA methyltransferase gene DNMT3B.

169 ished in cells upon depletion of the histone methyltransferase gene SET-domain containing 2 (SETD2) a

170 The MLL1 histone methyltransferase gene undergoes many distinct chromosom

171 ISTONE DEACETYLASE 6 (HDA6), or the cytosine methyltransferase genes MET1 or CMT3, erases HISN6B's si

172 endent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identified through sequence

173 M (Ki value <1 nM) and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 value of 1

174 e used gene targeted inactivation of histone methyltransferase (HMT) multiple myeloma SET domain (MMS

175 Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal pre

176 with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A has been

177 rotein target CheR1, a chemotaxis-regulating methyltransferase in Pseudomonas aeruginosa This cocryst

178 Although the role of some histone methyltransferases in establishing the transcriptional p

179 CMTs are evolutionary conserved DNA methyltransferases in Viridiplantae.

180 DNA is the preferred substrate of eukaryotic methyltransferases in vivo.

181 nown as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically asso

182 function of regulatory T cells using the DNA methyltransferase inhibitor 5-azacytidine (Aza).

183 cancer who received carboplatin plus the DNA methyltransferase inhibitor guadecitabine or a standard-

184 bound to S-adenosyl-methionine (SAM) and the methyltransferase inhibitor sinefungin.

185 roma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly unde

186 Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with histone deac

187 Overall, our results demonstrated that DNA methyltransferase inhibitors preferentially target cance

188 In contrast, certain histone methyltransferase inhibitors stimulate metastatic outgro

189 nhibitors to increase euchromatin or histone methyltransferase inhibitors to decrease heterochromatin

190 The EZH2 histone methyltransferase is a member of the polycomb repressive

191 The EZH2 histone methyltransferase is required for B cells to form germin

192 oreover, we find that a family of salamander methyltransferases is expressed specifically in adult ap

193 eins associated with Set1) family of histone methyltransferases is known to activate transcription of

194 KMT2D, a histone H3 lysine 4 methyltransferase, is required for FOXA1, PBX1, and ER r

195 we also show that when co-expressed with the methyltransferase its mutagenicity is kept in check.

196 Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underp

197 For example, specific lysine methyltransferases (KMTs) and lysine demethylases (KDMs)

198 he responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive.

199 Histone lysine methyltransferases (KMTs) represent an important class o

200 Using METTL7A (Methyltransferase Like 7A), a novel tumor suppressor gen

201 actor or unmethylated O(6)-methylguanine-DNA methyltransferase may benefit from Ona + Bev.

202 ts provide evidence for a non-canonical tRNA methyltransferase mechanism that characterizes the Trm10

203 3, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 also show functionally re

204 ize, resection extent, O-6-methylguanine-DNA methyltransferase-methylation, and isocitrate dehydrogen

205 We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human

206 Depletion of the methyltransferase METTL3 selectively inhibits translatio

207 ed the same in cells lacking the major m(6)A methyltransferase Mettl3.

208 ddition to changes in O(6)-methylguanine DNA methyltransferase (MGMT) activity, small changes in mism

209 us of the promoter of O(6)-methylguanine-DNA methyltransferase (MGMT) was assessed.

210 enes, Schlafen 11 (SLFN11) and methylguanine methyltransferase (MGMT), served as indicators of therap

211 he DNA repair protein O(6)-methylguanine-DNA-methyltransferase (MGMT).

212 me2 marks, but also helps to recruit histone methyltransferase MLL1 to promote H3K4 methylation, ther

213 LDTFs coordinate with H3K4 mono-methyltransferases MLL3/MLL4 (KMT2C/KMT2D) and H3K27 ace

214 t that DICER mediates the recruitment of the methyltransferase MMSET to the DNA damage site.

215 9 (dCas9) with an engineered prokaryotic DNA methyltransferase MQ1.

216 The methyltransferase (MT) domain of Tv6-931 can perform two

217 unctional enzyme carrying RNA cap guanine N7-methyltransferase (MTase) and 3'-5' exoribonuclease (Exo

218 adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymera

219 main of DENV NS5 has guanylyltransferase and methyltransferase (MTase), and the C-terminal region has

220 Methyltransferases (MTases) form a large family of enzym

221 The advent of engineered DNA methyltransferases (MTases) to target DNA methylation to

222 pression profiling identified nicotinamide N-methyltransferase (NNMT) as a downstream target that was

223 Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biot

224 Nicotinamide N-methyltransferase (NNMT)-ASO prevents diet-induced obesi

225 e that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of he

226 ly associated with damaging mutations of the methyltransferases NSD1 and NSD2, with findings confirme

227 studied C57Bl/6J Bhmt (betaine-homocysteine methyltransferase)-null mice at age 4, 12, 24, and 52 wk

228 mes involved in epigenetic processes such as methyltransferases or demethylases are becoming highly u

229 e co-methylated owing to the processivity of methyltransferases or demethylases, yet discordant methy

230 Inhibition of H3K27 methyltransferases or of the PRC2 (Polycomb Repressive C

231 s is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethan

232 Protein l-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the human p

233 and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% seq

234 ational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs

235 ne cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enz

236 we reveal that BCL11A interacts with histone methyltransferase (PRC2) and histone deacetylase (NuRD a

237 tional modifications catalyzed by the lysine methyltransferase PRDM9 or the lysine demethylase JMJD2E

238 h low, wild-type and high expression of HOL1 methyltransferase previously shown to be responsible for

239 Protein arginine methyltransferase (PRMT) activity has been implicated in

240 , a conclusive role for the protein arginine methyltransferase (PRMT) enzymes that catalyze these rea

241 (CARM1) is a member of the protein arginine methyltransferase (PRMT) family and methylates a range o

242 A screen, we identified the protein arginine methyltransferase Prmt1 as a vulnerable intervention poi

243 Here we identify the arginine methyltransferase PRMT5 as a key regulator of homologous

244 get genes, we confirmed the protein arginine methyltransferase Prmt5 is a direct target that is posit

245 Cell, Braun et al. report that the arginine methyltransferase PRMT5 is critical for tumor cell proli

246 The type II arginine methyltransferase PRMT5 is responsible for the symmetric

247 lar dynamics, we focused on protein arginine methyltransferases (PRMTs) 1, 3, 5, and 10.

248 Protein arginine methyltransferases (PRMTs) affect many processes; howeve

249 Protein arginine methyltransferases (PRMTs) introduce arginine methylatio

250 in eukaryotes catalyzed by protein arginine methyltransferases (PRMTs) that are typically thought to

251 tocyte growth factor, O(6)-methylguanine-DNA methyltransferase promoter methylation, and glioblastoma

252 A lysine methyltransferase regulates both the magnitude and polar

253 targets CTCF binding at the promoter of DNA methyltransferases, regulating their expression.

254 enetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including t

255 the preferred substrate of plant and animal methyltransferases remains unresolved.

256 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetiti

257 ArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only two conserved cysteine

258 romatin folding that restricts access to DNA methyltransferases responsible for gene body methylation

259 Moreover, depletion of SETDB1, a histone methyltransferase, resulted in a loss of transcriptional

260 ofactor biosynthetic enzyme MoaA and the RNA methyltransferase RlmN, which methylates specific nucleo

261 e current study identifies the canonical cap methyltransferase (RNMT) as the enzyme responsible for g

262 Here, we show that the histone H4 lysine 20 methyltransferase SET-4, which also influences dosage co

263 either SAM synthetase (Sam-S) or the histone methyltransferase Set1 is restored to near normal levels

264 result from preferential binding of the H3K4 methyltransferase Set1/complex associated with Set1 (COM

265 e 2 kinases Ctk1 and Bur1 and the histone H3 methyltransferases Set1 and Set2.

266 We prove that the histone H3K4 methyltransferase SETD1A is differentially recruited bet

267 stage-specific effects, loss of the histone methyltransferase Setd2 had robust tumor-promoting conse

268 as9 screening platform, we identify the H3K9 methyltransferase SETDB1 as a novel, negative regulator

269 issue, Cuellar et al. find that the histone methyltransferase SETDB1 enables acute myeloid leukemia

270 om that in murine EC cell lines: the histone methyltransferase SETDB1 is required, but the widely uti

271 ial genes in ES cells, including the histone methyltransferase Setdb1.

272 chanistic investigations of the class C rSAM methyltransferase TbtI involved in the biosynthesis of t

273 ivation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation.

274 nvestigated the role of G9a/Ehmt2, a histone methyltransferase that defines a repressive epigenetic s

275 decreased the expression of Prdm2, a histone methyltransferase that monomethylates histone 3 at the l

276 ine methyltransferase 1 (CARM1) is a protein methyltransferase that negatively regulates synaptic gen

277 omb repressive complex 2 (PRC2) is a histone methyltransferase that trimethylates H3K27, a mark of re

278 The plant PMTs are di-domain methyltransferases that divide the methylation of pEA in

279 Plants encode a diverse repertoire of DNA methyltransferases that have specialized to target cytos

280 have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methylates inorganic As(III) int

281 dulator of signal transduction pathways, but methyltransferases themselves may also be modulated.

282 ither by covalent cross-linking of the HpaII methyltransferase to DNA or through binding of a transcr

283 r S100A4, which interacts with L-isoaspartyl methyltransferase to promote p53 degradation and MPC sel

284 ndings reveal how CTCF binding regulates DNA methyltransferase to reprogram the methylome in response

285 we examined a number of cytosine and adenine methyltransferases to generate double base modifications

286 Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-s

287 The tRNA m1G9 methyltransferase (Trm10) is a member of the SpoU-TrmD (

288 res the presence of both the T. brucei m(3)C methyltransferase TRM140 and the deaminase ADAT2/3.

289 Perturbing the RNA m(5)C methyltransferase TRM4B resulted in the loss of m(5)C si

290 inguishing it from the other known SPOUT m1G methyltransferase, TrmD.

291 tes enzymatic activity of a protein arginine methyltransferase vital to abiotic stress tolerance.

292 ces pombe homologue of mammalian SUV39H H3K9 methyltransferases, we design active-site mutations that

293 to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylat

294 sible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which catalyzes the formation of 5-me

295 e polymerase conformation is affected by the methyltransferase, which enables a more efficiently elon

296 Here we show that a deficiency in H3K4me3 methyltransferase, which extends lifespan, promotes fat

297 We have identified a highly conserved DNA methyltransferase, which we term Campylobacter transform

298 ted oncogenic function of the protein lysine methyltransferase WHSC1L1 in SCCHN, which is mediated th

299 KMT2D) is a major enhancer H3K4 mono- and di-methyltransferase with a partial functional redundancy w

300 CARM1 is an arginine methyltransferase with diverse histone and non-histone s