ライフサイエンスコーパス: miR

1 miR-101 expression was determined in lung tissues from p

2 miR-122, a pro-viral hepatitis C virus (HCV) host factor

3 miR-143 and miR-145 transfection decreased cervical cell

4 miR-146a levels are also significantly reduced in the gl

5 miR-155(-/-) mice developed exacerbated lung fibrosis, i

6 miR-18a directly targeted Smad4, Hif1a, and Rora, all ke

7 miR-193a interacts with major vault protein (MVP).

8 miR-193b also stimulated reactive oxygen species signali

9 miR-23 target genes, including the oncogenes Ccnd1 as we

10 miR-277 mimic injection partially rescued these phenotyp

11 miR-294 and let-7c were introduced into otherwise microR

12 miR-337-3p stimulates expression of cholangiocyte genes

13 miR-430 is crucial for the clearance of maternal mRNA du

14 miR-718 expression was also induced in the spleens of mi

15 MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid

16 er enhanced liver specificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K

17 ain-enriched miRNAs miR-9/9( *) and miR-124 (miR-9/9( *)-124) trigger reconfiguration of chromatin ac

18 miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p in PBMNCs had high diagnostic sen

19 r proinflammatory conditions, microRNA-146a (miR-146a) is transcriptionally upregulated by ligands of

20 man lung epithelial cells, the microRNA-150 (miR-150) was identified to interact with FOXD3-AS1; this

21 through the regulation of BIC/microRNA 155 (miR-155) and its target, suppressor of cytokine signalin

22 MicroRNA-155 (miR-155) regulates antitumor immune responses.

23 ng from specific miRNA loci (e.g., miR-200c, miR-21, the miR-17/92 cluster, the miR-183/96/182 cluste

24 the normal SC niche, we found that miR-206, miR-007-3, and miR-23b individually could distinguish co

25 rcR)-284 is a potential inhibitor of miR-221/miR-222 activity.

26 nvestigate the potential effects of miR-26a, miR-130an and antimiR-155 in CLL therapy.

27 oadly among vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria, suggesting a role i

28 th endothelial-specific deletion of miR-322 (miR-424 ortholog) and miR-503 have augmented angiogenic

29 Our results suggests that miR-203-3p, miR-664-3p and miR-708-5p may be implicated in pathways

30 In this study, we show that microRNA-134-5p (miR-134) can regulate Sabin-1 replication but not Sabin-

31 response to IL-1beta, including miR-146a-5p, miR-155-5p and miR-27b-3p.

32 Validation revealed that miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p i

33 led that miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p in PBMNCs had high diagn

34 dation revealed that miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p in PBMNCs ha

35 In addition, CKMT2, miR-93b-5p, miR-29b-3p were found to be positively/negatively correl

36 We demonstrate here that microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) can significantl

37 A miR-204 mimic (miR-204 M) decreased Cav1 in endothelial

38 DIAPH1, a miR-198 target, enhances directional migration through s

39 Perturbation experiments with a miR-218-5p mimic or inhibitor demonstrated a protective

40 In addition, miR-542-3p overexpression inhibited the morphological tr

41 Additionally, miR-124 regulates Smed-slit-1, which encodes an axon gui

42 Additionally, miR-150 mimics suppressed the level of FOXD3-AS1.

43 egulation of only miR-455-3p (P = 0.007) and miR-4668-5p (P = 0.016) in AD patients compared with hea

44 00HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known gen

45 Furthermore, we observed that miR-126* and miR-126 downregulation increased E-selectin and VCAM1, r

46 e was to determine the effect of miR-143 and miR-145 on the cervical epithelial barrier and to elucid

47 ll permeability was increased in miR-143 and miR-145 transfected cervical epithelial cells.

48 miR-143 and miR-145 transfection decreased cervical cell number by i

49 regulated with overexpression of miR-143 and miR-145.

50 tors of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation.

51 Elevated miR-15a and miR-16 levels down-regulated BMI1 and other polycomb gro

52 Our results suggest that miR-15a and miR-16 mediate the down-regulation of BMI1, which impede

53 redicts expression of microRNAs miR-181a and miR-181b in human brain and blood, greater nucleus accum

54 We provide evidence that miR-29a and miR-29c are increased in skeletal muscle from patients w

55 niche, we found that miR-206, miR-007-3, and miR-23b individually could distinguish colorectal cancer

56 miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p in PBMNCs had high diagnostic sensitivity and

57 retreatment plasma levels of miR-301a-3p and miR-145-5p were higher in responders (combined response

58 lts suggests that miR-203-3p, miR-664-3p and miR-708-5p may be implicated in pathways determining lif

59 embers of the miR-142 family, miR-142-5p and miR-142-3p, as inflammation-related miRNAs with potentia

60 1beta, including miR-146a-5p, miR-155-5p and miR-27b-3p.

61 Specifically, let-7 and miR-148 antagonism modified PTH secretion in vivo and in

62 at the brain-enriched miRNAs miR-9/9( *) and miR-124 (miR-9/9( *)-124) trigger reconfiguration of chr

63 t that the FGF13 locus, comprising FGF13 and miR-504, is transcriptionally repressed by p53, defining

64 with a strong concordance between GATA2 and miR-194 levels in clinical specimens.

65 Menin and miR-24 expression levels were measured in the following

66 c deletion of miR-322 (miR-424 ortholog) and miR-503 have augmented angiogenic response to LPS in a M

67 ates in the induction of IL-13 receptors and miR-126a expressed on/in the MDSCs.

68 Treatment with locked nucleic acid anti-miR-29a significantly improved survival in a mouse model

69 Weekly treatments of mice with MN-anti-miR-10b and low-dose doxorubicin resulted in complete re

70 Systemic delivery of anti-miR-181b in angiotensin II-infused Apoe(-/-) and Ldlr(-/

71 e enriched with proangiogenic miRNAs such as miR-126-3p.

72 ed a significant inverse correlation between miR-375 expression and RUNX1, vimentin, and L-plastin RN

73 interactions remain to be elucidated between miR-17-92 and as-of-yet unidentified molecules important

74 ated by a bi-directional interaction between miR-574-3p, a CA-rich microRNA, and hnRNP L.

75 Inverse correlations were observed between miR-218 levels and Slug/ZEB2 levels in cancer tissue sam

76 ays, functional interaction occurred between miR-18a-5p and the microRNA recognition element of miR-1

77 CD69 as a nonredundant key regulator of BIC/miR-155-dependent Treg cell development and homeostasis.

78 Whereas down-regulation of bta-miR-23a by its inhibitors increased lipid accumulation a

79 K1/2 signaling pathway inversely affected by miR-519d or EphA4 expression.

80 vator ICP0, inhibition of ICP0 expression by miR-H2 has been a major hypothesis to help explain the r

81 ing obesogenic diet on IRS-1 are mediated by miR-126 independent mechanisms, including increased IRS-

82 We find that PIM3 repression is mediated by miR-33, an intronic microRNA encoded within the SREBP lo

83 duction pathway, and that can be overcome by miR-7 overexpression.

84 ty acid oxidation is negatively regulated by miR-29 overexpression, potentially through the regulatio

85 ansduction rescues metastasis suppression by miR-452.

86 We proved that it was directly targeted by miR-124-3p with a luciferase reporter assay.

87 In addition, CKMT2, miR-93b-5p, miR-29b-3p were found to be positively/negat

88 cells transfected with miR-negative control, miR-143 or miR-145 were used in cell permeability and fl

89 of DCC and suggest that, by regulating DCC, miR-218 may be a switch of susceptibility versus resilie

90 ee signals explained late-onset degradation: miR-430 seeds, AU-rich sequences, and Pumilio recognitio

91 rthermore, we investigate that BMSCs deliver miR-9 to the injured pancreas or peripheral blood mononu

92 rticles capable of simultaneously delivering miR-34a mimic and targeting dysregulated polyamine metab

93 y restored expression of several derepressed miR-155 targets in tumor-infiltrating, miR-155-deficient

94 otch pathway inhibitor, as a critical direct miR-279/996 target.

95 Elevated miR-15a and miR-16 levels down-regulated BMI1 and other

96 We found that gammaSI enhanced miR-34a-dependent anti-tumor effects by activating the e

97 zation in microglia, and microglial exosomal miR-124-3p inhibited neuronal inflammation in scratch-in

98 udy demonstrated circulating plasma exosomal miR-125a-3p is readily accessible as diagnosis biomarker

99 ed two mature members of the miR-142 family, miR-142-5p and miR-142-3p, as inflammation-related miRNA

100 here for the first time a critical role for miR-424 in the regulation of HPV replication.

101 her, these data suggest a potential role for miR-7 as an RNA-based therapeutic to treat refractory an

102 We propose a role for miR-718 in controlling TLR4 signaling and inflammatory c

103 Introduction of expression vectors for miR-424 reduced both the levels of HPV genomes in undiff

104 act as intercellular carriers of functional miR-4443, which might exert heterotypic regulation of PT

105 tRFs arising from specific miRNA loci (e.g., miR-200c, miR-21, the miR-17/92 cluster, the miR-183/96/

106 Moreover, both gga-miR-219b and BCL11B influenced the expression of Meq gen

107 ere in accordance with that triggered by gga-miR-219b overexpression, suggesting that BCL11B was a st

108 erase reporter assays demonstrated that high miR-375 expression reduced vimentin promoter activity, s

109 trol (n = 15) and STOPP (n = 42), but higher miR-9-3p than STOPP.

110 hlighted correlation of hsa-miR-642a-3p, hsa-miR-4459 and hsa-miR-135a-3p expression with inosine in

111 RRMS patients versus HC: hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-301a-3p, and hsa-miR-532-5p.

112 sus HC: hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-301a-3p, and hsa-miR-532-5p.

113 ion of hsa-miR-642a-3p, hsa-miR-4459 and hsa-miR-135a-3p expression with inosine in the vein tissue,

114 p, hsa-miR-196b-5p, hsa-miR-301a-3p, and hsa-miR-532-5p.

115 ations in delivering hsa-miR-199a-3p and hsa-miR-590-3p both in primary neonatal mouse cardiomyocytes

116 Extracellular vesicle-associated hsa-miR-483-5p thus appears to be a promising minimally inva

117 fferent lipid formulations in delivering hsa-miR-199a-3p and hsa-miR-590-3p both in primary neonatal

118 ly expressed in RRMS patients versus HC: hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-301a-3p, and hsa-mi

119 pression of cel-mir-237 and its homolog, hsa-miR-125b, functions as sensitizers to gamma-irradiation

120 ation testing highlighted correlation of hsa-miR-642a-3p, hsa-miR-4459 and hsa-miR-135a-3p expression

121 silico and experimental analyses identified miR-141-3p as a direct target of circRNA_100338.

122 the KRas downstream pathway, and identified miR-193a-3p, which directly targets KRas.

123 r post-transcriptional regulators identified miR-495 as a novel regulator of multiple ARGs that have

124 Thus, our study identifies miR-146a as an important molecular brake that blocks the

125 ion analysis in clinical samples to identify miR-125b-5p down-regulated in gallbladder cancer.

126 Overall, we identify miR-500a-5p as an oxidative stress response miRNA whose

127 lds on previous studies that have implicated miR-17-92 in the regulation of important molecular compo

128 Focusing on the RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found th

129 Denervation resulted in a marked increase in miR-206 and reduced expression of miRs 1, 133a, and 133b

130 pithelial cell permeability was increased in miR-143 and miR-145 transfected cervical epithelial cell

131 he miRISC in response to IL-1beta, including miR-146a-5p, miR-155-5p and miR-27b-3p.

132 CXCR4 overexpression also increased miR-15a/16-1, shifting their oncogenic dependency from t

133 Maternal diet-induced obesity increased miR-126 expression however levels of this miR were not i

134 S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models and i

135 essed miR-155 targets in tumor-infiltrating, miR-155-deficient CD8(+) T cells, suggesting that miR-15

136 AD3 to bind to the miR-140 locus and inhibit miR-140 transcription.

137 t of OEPCs is improved in vivo by inhibiting miR-17.

138 more, transplantation of WT bone marrow into miR-155KO mice mitigated this phenotype.

139 n, our data show that by reducing CD82, KSHV miR-K6-5p expedites cell invasion and angiogenesis by ac

140 Consequently, mice lacking miR-34/449 display infertility as well as severe chronic

141 g carotid endarterectomy revealed that local miR-100 expression was inversely correlated with inflamm

142 shows that mutation of a single miRNA locus (miR-iab4/iab8) affects the capacity of the larva to corr

143 e adjusted risk ratios per one-SD higher log miR-122 were 1.60 (95% CI 1.30-1.96; P < 0.001) for meta

144 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis.

145 cise, START (n = 22) had significantly lower miR-22-3p than control (n = 15) and STOPP (n = 42), but

146 nally, we demonstrate that OA induces mature miR-7 production in HeLa cells.

147 Mechanistically, miR-520f inhibited tumor cell invasion by directly targe

148 uction of either the anti-migratory microRNA miR-198 or the pro-migratory follistatin-like 1 (FSTL1)

149 MicroRNA (miR)-155 has recently been described to regulate adaptiv

150 cargo includes proteins, mRNA and microRNA (miR) that can be transferred to recipient cells and regu

151 We examined HCV entry in HepG2/microRNA (miR) 122/CD81 cells, which support entry and replication

152 glycolysis through suppression of microRNA (miR)-455-3p.

153 -46 levels also restored perturbed microRNA (miR-2) function in smn-1(lf) animals.

154 of rs322931 predicts expression of microRNAs miR-181a and miR-181b in human brain and blood, greater

155 essential for functional immunity.MicroRNAs (miR) are important regulators of gene transcription, wit

156 jury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neuron

157 How microRNAs (miRs) regulate IOP and glaucoma in vivo is largely unkno

158 characterize the contribution of microRNAs (miRs) delivered by microvesicles to MC activation.

159 the study was to explore specific microRNAs (miRs) in rectal cancer that would predict response to ra

160 ing RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence

161 A miR-204 mimic (miR-204 M) decreased Cav1 in endothelial cells.

162 Here we show that the brain-enriched miRNAs miR-9/9( *) and miR-124 (miR-9/9( *)-124) trigger reconf

163 Moreover, miR-146a-deficient mice do not resolve inflammation afte

164 Mechanistically, acid-induced epithelial MV miR-17/221 promoted beta1 integrin recycling and present

165 ued by bone marrow exosomes from WT, but not miR-155(-/-), cells, suggesting that uptake of miR-155-c

166 Whole-genome RNA sequencing uncovers novel miR-141-regulated molecular targets in PCa cells includi

167 aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes renal fibrosis

168 Expression analyses of miR-383 in PCa clinical tissues established that low miR

169 Finally, analysis of miR-100 expression in >70 samples obtained during caroti

170 Application of miR-146b combined with stem cell therapy could enhance r

171 d region, phenocopied the characteristics of miR-223(-/y) mice.

172 t mice with endothelial-specific deletion of miR-322 (miR-424 ortholog) and miR-503 have augmented an

173 Ectopic delivery of miR-194 stimulated migration, invasion, and epithelial-m

174 genosensor was applied for determination of miR-221 in total RNA extracted from human lung and breas

175 udy objective was to determine the effect of miR-143 and miR-145 on the cervical epithelial barrier a

176 o screen downstream targets and effectors of miR-32, we identified RAC2 as a potential, and clinicall

177 odel to investigate the potential effects of miR-26a, miR-130an and antimiR-155 in CLL therapy.

178 a-5p and the microRNA recognition element of miR-18a-5p in the 3'-untranslated region of hPXR mRNA.

179 This work presents the first evidence of miR control of HCN4 and heart rate.

180 Expression of miR-193b in liposarcoma cells was downregulated by promo

181 High expression of miR-30a or miR-200c was associated with significantly be

182 Expression of miR-487b-3p is decreased in colon adenocarcinomas and in

183 LR4, but not TLR3, induced the expression of miR-718 in macrophages.

184 p to activate MYC signaling via induction of miR-33b.

185 Inhibition of miR-142-3p could be neuroprotective in MS.

186 Inhibition of miR-204 protects against tunicamycin-induced vascular/en

187 RNA (circR)-284 is a potential inhibitor of miR-221/miR-222 activity.

188 ansfection of MCs with mimic or inhibitor of miR-4443 resulted in decreased or enhanced PTPRJ express

189 re observed with spatiotemporal knockdown of miR-8 and luciferase assays.

190 RS-1 are associated with increased levels of miR-126 and consequently reduced translation of Irs1 mRN

191 Pretreatment plasma levels of miR-301a-3p and miR-145-5p were higher in responders (co

192 as an efficient small-molecule modulator of miR-34a to reverse chemoresistance and further enhance t

193 expression of miR-183, the human ortholog of miR-263a, can also directly target the expressions of al

194 Overexpression of miR-10b increased Ki-67 staining in human organ-cultured

195 1, were downregulated with overexpression of miR-143 and miR-145.

196 , we provide evidence that overexpression of miR-183, the human ortholog of miR-263a, can also direct

197 cer cell lines, and stable overexpression of miR-194 enhanced metastasis of intravenous and intrapros

198 Lentiviral overexpression of miR-26a in ZOS and 143B osteosarcoma cells decreases the

199 Conversely, overexpression of miR-31-3p ameliorated the severity of DSS-induced coliti

200 of iPSC generation and impedes processing of miR-125b, leading to Rybp upregulation and suppression o

201 nuclease 1 is required for the processing of miR-221/222 in regulating expression of the tumor suppre

202 nt study demonstrate that down-regulation of miR-214 may reverse acquired resistance to erlotinib in

203 t time, the transcriptional up-regulation of miR-34c-5p in response to TCR stimulation in naive CD4 T

204 r was identified as an upstream regulator of miR-194, consistent with a strong concordance between GA

205 We suggest that upregulation and release of miR-21 contribute to sensory neuron-macrophage communica

206 Restoration of miR-874 expression impeded S phase progression, suppress

207 ely, these results reveal a critical role of miR-122 in acetaminophen detoxification and implicate it

208 im of this study was to evaluate the role of miR-125a-5p in VSMCs phenotypic switch.

209 findings demonstrate the functional role of miR-146b in the chondrogenic differentiation of human bo

210 In this study, we investigated the role of miR-155 specifically within T cells during the immune re

211 inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced inflammation and C

212 vivo and required, in part, MV shuttling of miR-17 and/or miR-221.

213 otential, and clinically relevant, target of miR-32.

214 sting that vimentin is an indirect target of miR-375.

215 direct and functionally relevant targets of miR-141.

216 nd 8 (ilp7 and ilp8) are putative targets of miR-277; RNA immunoprecipitation and a luciferase report

217 , Notch2, and Jagged 1, as direct targets of miR-34a.

218 w that the levels of two putative targets of miR-424 that function in DNA damage repair, CHK1 and Wee

219 nd we subsequently validated upregulation of miR-139-5p in two independent clinical cohorts, wherein

220 mice, promotes ER stress via upregulation of miR-204, whereas overexpression of Sirt1 in endothelial

221 R-155(-/-), cells, suggesting that uptake of miR-155-containing exosomes is important for a proper LP

222 ncrease in miR-206 and reduced expression of miRs 1, 133a, and 133b in myofiber-derived exosomes.

223 Here we show that oncogenic miR-182 is a strong regulator of C/EBPalpha.

224 -PCR showed significant upregulation of only miR-455-3p (P = 0.007) and miR-4668-5p (P = 0.016) in AD

225 fected with miR-negative control, miR-143 or miR-145 were used in cell permeability and flow cytometr

226 High expression of miR-30a or miR-200c was associated with significantly better overal

227 ired, in part, MV shuttling of miR-17 and/or miR-221.

228 steoblasts, but in aggressive osteosarcomas, miR-874 is down-regulated, leading to elevated CCNE1 exp

229 Drosophila Larval fly hearts overexpressing miR-1 have profound defects in actin filament organizati

230 Of this miRNA panel, miR-26a was the most effective in reducing leukemic cell

231 Analyses of potential miR-1 targets revealed that miR-1 directly regulates the

232 lated with decreased expression of predicted miR-181b targets, tissue inhibitor of metalloproteinase-

233 that microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) can significantly reduce the pancreatic ede

234 ed virus 8 vector that expressed the primary miR-122 transcript (pri-MIR122, to overexpress MIR122 in

235 We propose miR-142-3p as a molecular mediator of the IL-1beta-depen

236 ime that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer,

237 We previously determined that low relative miR-375 expression was associated with poor patient prog

238 g the type I IFN-induced antiviral response, miR-BART16 provides a means to facilitate the establishm

239 NA profiling in the human brain has revealed miR-132 as one of the most severely down-regulated miRNA

240 of Tyr359-phosphorylated hnRNP L sequesters miR-574-3p, overcoming its decoy activity and seed seque

241 ics approach, the authors identified several miR-7a2 target genes and pathways that have not been pre

242 Ever since miR-H2's discovery as a viral microRNA bearing complete

243 abrogates KIT signaling cascade through Sp1/miR-29b network.

244 al oncogene that regulates TOP2A by sponging miR-411-5p in glioma.

245 In summary, miR-193b not only functions as a tumor suppressor in lip

246 ion of Sirt1 in endothelial cells suppresses miR-204-induced ER stress.

247 in upregulating NF-kappaB signaling and that miR-19a has roles in inflammation and CAC.

248 METHODS AND Here, we demonstrate that miR-181b was overexpressed in symptomatic human atherosc

249 These new findings demonstrate that miR-19a has a direct role in upregulating NF-kappaB sign

250 We demonstrate that miR-21-5p is released in the exosomal fraction of cultur

251 Herein, it is demonstrated that miR-194 is a driver of prostate cancer metastasis.

252 Together, our results demonstrated that miR-19a carried through the exosomes from HCV-infected h

253 Results of miRNA profiling demonstrated that miR-30a was markedly downregulated in diabetic cataract

254 We provide evidence that miR-29a and miR-29c are increased in skeletal muscle fro

255 We found that miR-124-3p promoted the anti-inflamed M2 polarization in

256 Consequently, we found that miR-155 expression by T cells is necessary for proper tu

257 ature for the normal SC niche, we found that miR-206, miR-007-3, and miR-23b individually could disti

258 We identified that miR-195 was packaged in the extracellular vesicles from

259 Our study indicates that miR-96 might be a potential target for therapy of pediat

260 Furthermore, we observed that miR-126* and miR-126 downregulation increased E-selectin

261 We observed that miR-874 inhibits CCNE1 expression in primary osteoblasts

262 We propose that miR-26a delivery might not be a viable therapeutic strat

263 Altogether, our data reveal that miR-155 collaborates with FLT3-ITD to promote myeloid ce

264 ses of potential miR-1 targets revealed that miR-1 directly regulates the 3'UTR of the E3 ubiquitin l

265 Validation revealed that miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and

266 Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocyt

267 uman clinical specimens, we also showed that miR-152 expression levels were negatively correlated wit

268 Our results suggest that miR-15a and miR-16 mediate the down-regulation of BMI1,

269 Our data suggest that miR-323-3p acts in a negative feedback loop to control t

270 55-deficient CD8(+) T cells, suggesting that miR-155 and ICB regulate overlapping pathways to promote

271 Our results suggests that miR-203-3p, miR-664-3p and miR-708-5p may be implicated

272 The miR-302 locus is found broadly among vertebrates, wherea

273 ific miRNA loci (e.g., miR-200c, miR-21, the miR-17/92 cluster, the miR-183/96/182 cluster) and from

274 miR-200c, miR-21, the miR-17/92 cluster, the miR-183/96/182 cluster) and from specific tRNA loci (e.g

275 ociation of a functional polymorphism in the miR-146a precursor (rs2910164).

276 llergen papain, mice selectively lacking the miR-17 approximately 92 cluster in ILC2s displayed reduc

277 viously identified two mature members of the miR-142 family, miR-142-5p and miR-142-3p, as inflammati

278 rophages, contributed by deregulation of the miR-155 target gene the liver X receptor (LXR)alpha in l

279 Overexpression of the miR-183 cluster reduced zinc transporter and intracellul

280 of a novel mouse line, with deletion of the miR-223 binding site in the NLRP3 3' untranslated region

281 al interaction studies, we revealed that the miR-144-3p target, PTEN, colocalized with miR-144-3p in

282 mor metastasis suppressor, we found that the miR-200b editing level correlates with patient prognosis

283 naling, causing phospho-SMAD3 to bind to the miR-140 locus and inhibit miR-140 transcription.

284 found broadly among vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria, suggesting

285 ion by hCMEC/D3 cells, suggesting that these miRs regulate leukocyte adhesion by modulating the expre

286 ed miR-126 expression however levels of this miR were not influenced by a post-weaning obesogenic die

287 lin signaling is up-regulated in response to miR-277 depletion.

288 NA with 3G ('22-3G') comprised <63% of total miR-122 in human liver, whereas other variants (23-3A, 2

289 1 (FSTL1) protein from a single transcript; miR-198 expression in healthy skin is down-regulated in

290 te to the pattern observed for the wild-type miR-200b expression.

291 In addition, we verified miR-449b could regulate the expression levels of CDK6, c

292 t differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of Tnrc6a mRNA to weaken its

293 growth is controlled by miRNAs, among which miR-352 is a novel candidate that negatively regulates a

294 ed E-selectin and VCAM1, respectively, while miR-126 overexpression reduced VCAM1 and CCL2 expression

295 ssion with inosine in the vein tissue, while miR-216a-5p, conversely, was correlated with phosphatidy

296 eature during the initiation of colitis with miR-223 deficiency.

297 he miR-144-3p target, PTEN, colocalized with miR-144-3p in the basolateral amygdala and showed functi

298 l maturation of the mouse visual cortex with miR-132/212 family being one of the top upregulated miRN

299 rtant regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activ

300 ical and endocervical cells transfected with miR-negative control, miR-143 or miR-145 were used in ce