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1 cells in wild-type and RAGE-knockout C57BL6 mice.
2 gical properties of DMV neurons in A53T-SNCA mice.
3 ffect was delayed in interleukin 6-deficient mice.
4 o quantification of placental oxygenation in mice.
5 e correspondingly reduced in SR-AI-deficient mice.
6 grity under pathological conditions in adult mice.
7 and for brown adipose tissue development in mice.
8 tered to the hypoglossal nucleus of C57BL/6J mice.
9 able virtual reality system for unrestrained mice.
10 observed in Hhip (+/-) but not in Hhip (+/+) mice.
11 is in apolipoprotein E-deficient (ApoE(-/-)) mice.
12 creased humoral immune response in Rictor KO mice.
13 activity in the TAL of Ksp-cre;Pth1r(fl/fl) mice.
14 Es nor the regulation by 1,25D is present in mice.
15 tion is required for gonococcal infection in mice.
16 hich was corroborated using CXCL10-deficient mice.
17 o increased HDL levels in APOE*3-Leiden.CETP mice.
18 t was abolished in DEP+HDM-exposed Rag2(-/-) mice.
19 perimental rats and calvarial defects of Jax mice.
20 for 7 days and were compared with wild-type mice.
21 -alpha and beta-muricholic acid in Tgr5(-/-) mice.
22 es following infliximab treatment in hTNF-Tg mice.
23 OL progenitor cells purified from Thap1 null mice.
24 deliver RNA to the colonic mucosa of living mice.
25 hing irregularities, in both male and female mice.
26 -derived tumor xenografts in immunodeficient mice.
27 acute infection and chronic autoimmunity in mice.
28 liver and skeletal muscles of Cry-deficient mice.
29 erimental autoimmune encephalomyelitis (EAE) mice.
30 and duration, is not observed in Mc3r(TB/TB) mice.
31 eletion rejuvenates pulmonary health in aged mice.
32 before and after ischemia in CD73-deficient mice.
33 uxes in both sedentary and treadmill-running mice.
34 2G were altered in amygdala and mPFC of male mice.
35 nvolved in the regulation of the HPA axis in mice.
36 istant to bacterial infection than wild-type mice.
37 n expansion of sequence diversity in treated mice.
38 cisplatin and radiotherapy in tumor-bearing mice.
39 ibitory neurotransmission evident in Fmr1-KO mice.
40 uppresses PEL progression in immunodeficient mice.
41 adult but reduced in juvenile HDM-sensitized mice.
42 ap to inhibit cardiomyocyte proliferation in mice.
43 nasopharyngeal bacterial loads in ccl3(-/-) mice.
44 aling and mediates dermatosis in Ptpn6(spin) mice.
45 fibrosis, and hypertrophy in naive recipient mice.
46 disappearance of HSCs in livers of Lipa(-/-) mice.
47 as(+/G12D);LSL-Trp53(+/R172H);Pdx1-Cre (KPC) mice.
48 mature (2-4 months) and aged (20-26 months) mice.
49 tude and delayed in timing in Fbxl3(Afh/Afh) mice.
50 severe myocarditis similar to wild-type CVB3 mice.
51 OA using complementary genetic strategies in mice.
52 ion and biochemical differentiation in these mice.
53 lization to breast cancer bone metastases in mice.
54 rences seen in the immune responses of these mice.
55 al and synaptic toxicities in APP transgenic mice.
56 r, but was greater in livers from the female mice.
57 tabolism in injured kidneys from mPGC-1alpha mice.
58 of LY2828360 was absent in CB2 knockout (KO) mice.
59 ce reproduced the deficits seen in P311(-/-) mice.
60 estigated in L. braziliensis-infected BALB/c mice.
61 n the hypothalamus and starvation sensing in mice.
62 y lipoprotein receptor deficient (Ldlr(-/-)) mice.
63 and colon tissues from both female and male mice.
64 nal cells and reduced virulence in 2-day-old mice.
65 ediated cutaneous squamous cell carcinoma in mice.
66 mising approach for diabetes reversal in NOD mice.
67 egulated between WT, Cyp1a1-/- and Cyp1a2-/- mice.
68 prolongs the survival of brain tumor-bearing mice.
69 re control mice, but not in VgluT2-CB1 (-/-) mice.
70 filing data from hearts of T. cruzi infected mice.
71 hich were strongly minimized in HSC-depleted mice.
72 ity and performing animal behavior on T1R3KO mice.
73 he tibialis anterior (TA) muscles of C57BL/6 mice.
74 somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imb
75 ell-characterized mouse model for DM1 (HSALR mice), activation of AMPK signaling in muscle was impair
77 rated, not only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, but also in
78 s inhibited, and a significant protection in mice against the bacterial challenge was observed at a m
79 ons, effects that were also observed in aged mice, albeit to a lesser extent, indicating preserved im
80 s showed that deficiency of the Tgr5 gene in mice alleviated fasting-induced hepatic lipid accumulati
84 AND We generated cardiomyocyte-specific Cas9 mice and demonstrated that Cas9 expression does not affe
85 lture and in vivo Using conditional knockout mice and derived white and brown preadipocytes, we show
86 5 locus for regulatory regions in transgenic mice and fine-mapped separate enhancers controlling expr
90 of blood monocytes are commonly described in mice and humans: the classical inflammatory monocytes, w
92 in vivo gene transfer to induce arthritis in mice and showed that elevated serum LTB4 and synovial ex
93 duced in db/db mice compared to control db/+ mice and this deficit was greater compared to reductions
94 e production are impaired in M-ILK-deficient mice, and activation of epithelial NF-kappaB and PI3K si
95 ses that caused minimal effects in wild-type mice, and adoptive transfer of gammadelta T cells preven
96 ophages and neutrophils in the lungs of male mice, and depletion of inflammatory monocyte macrophages
97 blood ejection fraction relative to control mice, and eventual lethality in the absence of cardiac f
98 unoprecipitation assays, hRETNTg(+)Tlr4(-/-) mice, and human immune cell culture, we demonstrate that
99 pression of both genes was elevated in obese mice, and induction of Cadm1 in excitatory neurons facil
100 rial biogenesis and synaptic activity in APP mice; and that SS31 may confer protective effects agains
103 lated from the lungs A. alternata-challenged mice are cytokine-enriched compared to those from IL5tg
105 Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic steatosis, obes
106 LPS and bacterial infection, POP2 transgenic mice are more resistant to bacterial infection than wild
107 Vip, yet activity rhythms in Lhx1-deficient mice are similar to Vip(-/-) mice under light-dark cycle
108 mediated gene silencing of il17a in fibrotic mice arrested the progression of lung fibrosis, attenuat
109 used CGRP-induced light-aversive behavior in mice as a measure of migraine-associated photophobia.
110 odialysis procedures in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied i
111 racerebroventricular injection to ATXN2-Q127 mice, ASO7 localized to Purkinje cells, reduced cerebell
114 ming phase of liver regeneration) in control mice, but this effect was delayed in interleukin 6-defic
119 footpads was significantly reduced in db/db mice compared to control db/+ mice and this deficit was
122 as the use of Cldn14-lacZ knock-in reporter mice confirmed increased Cldn14 expression and promoter
123 enous Braf(D631A) kinase-inactive isoform in mice (corresponding to the human BRAF(D594A) mutation) t
124 wever, targeted deletion of the Lipa gene in mice decreased the liver levels of RE, most likely as th
127 mice that express one CRTC3 allele (CRTC2/3m mice) develop neutrophilia and splenomegaly in adulthood
135 re, we found that uninfected Irgm1-deficient mice displayed high levels of serum cytokines typifying
140 um calcium phenotype in Ksp-cre;Pth1r(fl/fl) mice, emphasizing the importance of PTH in inhibiting Cl
141 e/eGFP reporter (TFAR) cassettes to neonatal mice enabling longitudinal TFAR profiling by continued b
142 were quantified based on time spent by adult mice engaging in social behaviors toward a juvenile mous
146 xenograft tumours growing in immunodeficient mice exhibited enhanced hypoxia compared to the original
148 e the primary tumor microenvironment in nude mice, exhibited signatures of immune evasion, increased
149 eata bearing a Grp78(f/+) allele (PKC78(f/+) mice) expressing about 50% of GRP78 maintained normal si
152 ble to survive normally in the Ixodes ticks, mice fed upon by the DeltacheY2-infected ticks did not d
154 as induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with pur
155 cial transmission of food preference (STFP), mice form long-term memory of food odors presented by a
159 al proximal tubule cells did not protect the mice from obesity, but markedly attenuated the obesity-i
163 ely after delayed tPA treatment in ischaemic mice, haemorrhagic transformation was significantly decr
165 er2) transgenic mice were bred to female MNX mice having FVB/NJ nuclear DNA with either FVB/NJ, C57BL
167 Conversely, ATM Exos obtained from lean mice improve glucose tolerance and insulin sensitivity w
170 p(1) site both in male and female transgenic mice in vivo and in cell lines and primary neuronal cult
171 lian lncRNA, FOXD3-AS1, known as linc1623 in mice, in the setting of hyperoxia/reactive oxygen specie
172 ia, we developed a new mouse model, PMN(DTR) mice, in which injection of diphtheria toxin induces sel
173 tokine-enriched compared to those from IL5tg mice, including 800-fold higher levels of eotaxin-1.
174 adian clock function or environmental CRD in mice increased susceptibility to severe intestinal infla
175 t mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from
176 pplication of S100A8 to S100A9 knockout CVB3 mice induced a severe myocarditis similar to wild-type C
181 t efficacy, which was reduced in BDNF floxed mice injected in dHc with AAV-Cre, and in NBQX- and rapa
184 press cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferati
187 s of mTORC1, mTORC2, or both, we showed that mice lacking mTORC1 or mTORC1/mTORC2 but not mTORC2 alon
188 lowing intravenous injection of tumor cells, mice lacking PITPalpha develop fewer lung metastases due
191 ti-thymocyte/Thy-1 autoreactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light cha
193 itioned place preference and a task in which mice learn associations between cues and food rewards an
199 ved in livers from Ppargc1a(f/+)Alb-cre(+/0) mice of each sex, in a cell-autonomous manner, but was g
200 to the same extent as crypts from Cd44(+/+) mice on stimulation with HGF, but had the same response
201 y efficacy and improves survival of rats and mice orthotopically implanted with gliosarcoma tumors or
203 uterine gland-containing adult FOXA2-deleted mice, pregnancy failed by day 10 in neonatal FOXA2-delet
204 Inhibiting the fall of plasma FFAs in these mice prevented the suppression of EGP during a clamp, re
206 istent with this, we found that convalescent mice rapidly cleared the bacteria after reinfection.
208 t that disruption of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LECs) spe
209 fic deletion of talin in Tln1(fl/fl)Cd4(Cre) mice resulted in spontaneous lymphocyte activation, prim
210 2 genes in human embryonic stem cells and in mice results in changes in pluripotency and the primed s
211 l analysis of lung lesions from Muc4(ko)/NDL mice revealed a reduced association of disseminated cell
212 ic CD8 T cells transferred into antigen-free mice revealed that differentiation to memory cells was c
213 ransplantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-renewal and
217 n infected animals, whereas B cell-deficient mice showed CD4(+) T cell loss but recovered from infect
218 (-/-) Tlr7 (+/+) mice, Apoe (-/-) Tlr7 (-/-) mice showed reduced aortic arch and sinus lesion areas.
219 ew work on innate escape behavior shows that mice spontaneously form a spatially precise memory of th
220 ibody-mediated CD4(+) T-cell depletion in HF mice (starting 4 weeks after ligation) reduced cardiac i
224 t that optimization of caloric loading in B6 mice subject to HFS, characterized by increased meal siz
225 ivo, MR-409 mitigated cardiac hypertrophy in mice subjected to transverse aortic constriction and imp
226 ele into the cochlea of neonatal Tmc1(Bth/+) mice substantially reduced progressive hearing loss.
227 red air (FA)-exposed Scnn1b-Tg(+) (FA-Tg(+)) mice successfully cleared spontaneous bacterial infectio
228 rface homeostasis in unmanipulated NK1R(-/-) mice, suggesting the role of SP-NK1R signaling in ocular
229 hosphate cotransporter Npt2a in alphaKL-null mice supporting direct actions of cKL in the absence of
230 tion or gene ablation of the Ep3 receptor in mice suppresses accumulation of Ly6C(low) Mos/Mps in inf
232 change rate was significantly lower in LERKO mice than in Controls, suggesting an increase in lipid o
234 n of fluorescent marker into the VTA of male mice that had Cre-recombinase driven by OTR gene express
235 phoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansion of invariant
237 ion was marginally reduced in ILC2-deficient mice that received combined DEP+HDM, it was abolished in
238 inking mice, as well as in isogenic C57BL/6J mice that varied in their MA preference/taking, to exami
239 mory, resulting in goal-directed behavior in mice that would otherwise express stimulus-response habi
240 neurons from postnatal day 30 Snord116p-/m+ mice the reduction in neuronal cell body size was associ
241 f the human Vlambda locus in these humanized mice, the dominance of Vlambda pairing with human VH for
243 in NBQX- and rapamycin-pretreated wild-type mice, these compounds blocking alpha-amino-3-hydroxy-5-m
244 the acute and chronic phases of infection in mice through physiologic functions apart from fatty acid
245 ckdown approaches were also used in C57BL/6J mice to confirm the role for nucleus accumbens (NAC) glu
247 omic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CRF is in
251 Lhx1-deficient mice are similar to Vip(-/-) mice under light-dark cycles and only somewhat worse in
252 Allergen-specific IgG was administered to mice undergoing sensitization and desensitization to the
253 its interactions with intestinal bacteria in mice undergoing switches between high-fat, high-sugar (H
256 In contrast, synaptic transmission delays in mice varied depending on activity levels, and axonal mye
257 However, when the type I IFN response of mice was suppressed, then the adaptive immune responses
258 ith the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is unable to
261 FVB/N-Tg(MMTVneu)202Mul/J (Her2) transgenic mice were bred to female MNX mice having FVB/NJ nuclear
262 y, B6.DR1/LAIR-1(-/-) and B6.DR1/LAIR-1(+/+) mice were challenged for CIA and mean severity scores we
263 e knockout (Adipoq(-/-) ) and wild-type (WT) mice were crossed to produce pregnant mouse models with
264 rease in FFA accumulation in the liver after mice were given injections of deoxycholic acid and an in
267 -Type and dominant-negative-DISC1 (DN-DISC1) mice were injected with THC (10 mg/kg) or vehicle for 10
269 rmed that metabolite profiles in mdr1a (-/-) mice were remarkably unaffected by development of intest
270 This phenomenon was corroborated when WT mice were treated with a CB2-specific antagonist that ca
271 l as adoptive transfer in NOD/SCID/IL2Rgamma mice were used to assess for pathogen-specificity and ev
273 gation accelerated the progression of PDA in mice, whereas deletion of Clec7a-the gene encoding decti
277 tensive midzonal hepatocyte death in control mice, which were strongly minimized in HSC-depleted mice
278 ar defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly rescues the defect
279 increase movement in the TST in stress-naive mice, while stimulating above the carrier frequency of t
280 We therefore hypothesized that IL-15(-/-) mice will have reduced inflammatory responses during the
281 canonical TR signaling, we generated knockin mice with a mutation in the TR DNA-binding domain that a
284 nderstanding of MRN in cancer, we engineered mice with B lymphocytes lacking MRN, or harboring MRN in
285 endothelial cell (EC) biology, we generated mice with catalytic inactivation of one SHIP2 allele sel
287 ion of neural stem/precursor cells (NPCs) in mice with experimental autoimmune encephalomyelitis (EAE
289 r extent, cardiac CD3(+) T cells) from donor mice with HF induced long-term left ventricular dysfunct
291 educed cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in cont
292 allergy, we epicutaneously sensitized female mice with ovalbumin (OVA) followed by epicutaneous sensi
294 and drug candidates, we subjected Nos2 (-/-) mice with TB to monotherapy before or after establishmen
298 lso in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the number of tumor
300 -Cre x XBP1 (X-box binding protein-1) floxed mice (XBP1-conditional knockout), with antibody-mediated
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