ライフサイエンスコーパス: mice had

1 While the DeltaF508 mice had a normal immune cell repertoire, unchanged serum imm

2 ) analyses showed that 100% of male and female Erk5 (fl/fl) mice had a severely deformed curved thoracic spine, with an a

3 HR), OVA allergen-challenged Ormdl3(Delta2-3/Delta2-3)/CC10 mice had a significant increase in AHR compared with wild-typ

4 We showed that JNK1-deficient mice had a significantly higher survival rate than wild-type

5 The bone marrow cells of Dnmt3a+/- mice had a subtle but statistically significant DNA hypomethy

6 d on the brain cytokine levels, MAV-1-infected Unc93b1(-/-) mice had a very different inflammatory profile from infected

7 Notch2HCS mice had an increase in CD21/35(high)CD23(-) splenic MZ B cel

8 Nod2-deficient (Nod2(-/-)) mice had an inherently altered skin microbiome compared with

9 Septic fabpi-TAg mice had an unexpected increase in villus proliferation compa

10 Biochemically, Rrh(-/-) mice had approximately 2-fold higher vitamin A (all-trans-ret

11 SEC mice had decreased lipogenesis mediated by hepatic cholestero

12 M. tuberculosis-infected IL-21R KO mice had enhanced bacterial burden and reduced infiltration o

13 e with maternal separation and from Sox9(flox/flox)-vil-cre mice had evidence for intestinal dysbiosis of the microbiota,

14 Compared with wild-type controls, HAT-L4-deficient newborn mice had greater body fluid loss and higher mortality in a tr

15 SC-Dep mice had >93% depletion of satellite cells compared to SC-WT

16 On chow, JAK2L mice had hepatic steatosis and severe whole-body and hepatic

17 At early but not at later stages of infection, WT mice had higher circulatory proinflammatory cytokines and low

18 Lgr5(Creert2)/Met(fl/fl)/LacZ mice had impaired regeneration of MET-deficient ISCs.

19 In addition, fasted Tgr5(-/-) mice had increased activation of hepatic growth hormone-signa

20 At 24 hours, Darc(E2) mice had increased airway hyperresponsiveness; however, at 7

21 Hyperplastic livers and tumors from YAP(S127A) mice had increased CIN25 and CIN70 gene expression patterns,

22 Aortic tissue from Micu2(-/-) mice had increased expression of extracellular matrix remodel

23 KERKO mice had increased LH pulse frequency, indicating loss of neg

24 Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold highe

25 Hdc(-/-) HFD mice had increased steatosis compared with WT HFD mice.

26 n/+) mice, resulting from the cross of V33 with Apc (Min/+) mice, had increased intestinal tumor burden compared with lit

27 ior to the onset of photoreceptor degeneration, Mertk (-/-) mice had less accumulation of retinyl esters and dysregulatio

28 d for normal platelet exocytosis or hemostasis, VAMP-3(-/-) mice had less platelet-associated Fg, indicating a defect in

29 ional studies showed that, on a high-salt diet, Tmem27(Y/-) mice had lower renal blood flow, higher abundance of renal so

30 Folate deficient mice had lower serum folate (-60%).

31 In contrast to C3(-/-) mice, C5-deficient mice had no apparent defect in platelet activation in vitro,

32 itional knockout of MYPT1 or the knock-in mutation T853A in mice had no effect on muscarinic force responses in isolated

33 Although Il18(-/-) mice had normal levels of inflammatory monocytes, their NK ce

34 Bone marrow cells from CLP-treated mice had normal OC precursor frequency, but formed significan

35 By contrast, Ilk(fl/+) ;Pkhd1-Cre mice had normal renal morphology and function and survived >1

36 At two years, CalpTG mice had preserved kidney tissue, less vascular remodelling a

37 Moreover, Th17 cells from 13R(-/-) mice had reduced ability to convert to Th1 cells and displaye

38 Intestines of Atp7b(-/-) mice had reduced Cu storage pools in intestine, Cu depletion,

39 eloid cells in the colon of DSS-treated LysM-Cre; Egfr(f/f) mice had reduced expression of interleukin 6 (IL6), and epith

40 Finally, CysLT1R(-/-) mice had reduced lung eosinophils and ILC2 responses after ex

41 CalpTG mice had reduced macrophage infiltration with aging and CalpT

42 In response to Ang-II, TLR4 deficient mice had reduced renal resistive index and increased renal co

43 Remarkably, SIRT5KO mice had reduced survival upon TAC compared with wild-type mi

44 Behaviorally, the mutant mice had reduced voluntary locomotion and exploration, increa

45 The stressor-exposed mice had significant differences in microbial community compo

46 The large polyps from the Slco2a1 (-/-) /Apc (716/+) mice had significant reductions in microvascular density, con

47 ndens stent peritonitis surgery, we observed that wild type mice had significantly elevated proinflammatory cytokine leve

48 rs in Cdc73(+/-), Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre mice had significantly increased proliferation, with rates >f

49 Our data revealed that male WD-fed FXR KO mice had the most severe steatosis and highest hepatic and se

50 At 12 months of age, P2X7-null mice had thickening of Bruchs membrane and retinal pigment ep