ライフサイエンスコーパス: mice were generated by

1 P2Y12-null mice were generated by a gene-targeting strategy.

2 However, when class IA PI-3 kinase-deficient mice were generated by a targeted deletion of the p85alpha re

3 TLR-9-deficient MRL mice were generated by backcrossing a TLR-9-deficient allele

4 Bcl-3-deficient NOD mice were generated by backcrossing Bcl-3-deficient C57BL/6 m

5 In addition, chimeric mice were generated by bone marrow transplant to limit expres

6 Chimeric mice were generated by bone marrow transplantation (BMT) usin

7 gamma-globin gene in adult erythroid cells, betaYAC/MBD2-/- mice were generated by breeding betaYAC mice with MBD2-/- mic

8 prominent endothelial connexins, Cx40 and Cx43, transgenic mice were generated by breeding Cx40-deficient mice (Cx40(-/-

9 ndrocyte-targeted glucocorticoid receptor-knockout (chGRKO) mice were generated by breeding GR(flox/flox) mice with tamox

10 Klf4CN mice were generated by breeding Le-Cre with Klf4-LoxP mice.

11 Rpe65(-)(/)(-)/Nrl(-)(/)(-) mice were generated by breeding Rpe65(-)(/)(-) and Nrl(-)(/)(

12 in the intestinal epithelium and TLR4 knockout (TLR4(-/-)) mice were generated by breeding TLR4(loxp/loxp) mice with vil

13 elucidate the molecular basis for the phenotype, transgenic mice were generated by cardiac-restricted expression of the w

14 (IEC)LEPR-B-knockout (KO) and wild-type (WT) mice were generated by Cre-Lox strategy and fed a normal or h

15 Cell-specific knockout mice were generated by Cre/loxP recombination.

16 COX10 conditional knockout mice were generated by crossing a LoxP-tagged COX10 mouse wit

17 Two strains of CM-CXCR4(flox/flox) mice were generated by crossing CXCR4(flox/flox) mice with MC

18 Ikkbeta(Deltastom) mice were generated by crossing Foxa3-Cre mice to Ikkbeta(F/F

19 Conditional HIF-1alpha knockout (KO) mice were generated by crossing transgenic mice expressing Cr

20 Transgenic FvB mice were generated by DNA injections of a 3.8 kb transgene c

21 Bone marrow chimeric mice were generated by engraftment of hematopoietic stem and

22 Rgs6(-/-) mice were generated by gene targeting, and the cardiac effect

23 Knock-in mice were generated by gene targeting.

24 Trpml1-null mice were generated by gene targeting.

25 To ascertain the function of KLF13 in vivo, Klf13-deficient mice were generated by gene targeting.

26 ALS2-deficient mice were generated by gene targeting.

27 nction of c-IAP1 in a physiologic setting, c-IAP1-deficient mice were generated by homologous gene recombination.

28 g the specific role of NKCC2A in kidney function, NKCC2A-/- mice were generated by homologous recombination.

29 For in vivo analysis, transgenic mice were generated by injecting a construct carrying a 2.5-k

30 Chimeric mice were generated by injecting human haematopoietic stem ce

31 ese diabetic severe combined immunodeficiency (HU-NOD/SCID) mice were generated by inoculation of NOD/SCID mice with CD34

32 Such mice were generated by introducing a thymocyte-specific IL-7

33 These mice were generated by introduction of HLA class II genes, va

34 Control mice were generated by mating C57BL/6J females with 129/SvJ m

35 These mice were generated by pronuclear injection of a bacterial ar

36 Transgenic mice were generated by pronuclear injection of a construct ca

37 Transgenic mice were generated by pronuclear microinjection.

38 T. cruzi-immune CCR5(-/-) and wild-type C57BL/6 mice were generated by repeated infectious challenges with T.

39 THTR-2-deficient mice were generated by SLC19A3 gene knockout and used to exam

40 vivo functions of these metalloproteases, meprin beta null mice were generated by targeted disruption of the meprin beta

41 ight into other potential TPST substrates, TPST-2-deficient mice were generated by targeted disruption of the Tpst2 gene.

42 cts of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleo

43 E_mut+/- mice were generated by targeting a 5-bp deletion (AACTT) in t

44 The p47phox KO chimeric mice were generated by the combination of liposomal clodronat

45 xpression of the human beta-globin gene cluster, transgenic mice were generated by transfer of yeast artificial chromosom

46 tural killer T (NKT) and gammadelta T cell-double-deficient mice were generated by treating TCR-delta(-/-) mice with anti

47 Conditional cardiac myocyte CXCR4 (CM-CXCR4) null mice were generated by use of tamoxifen-inducible cardiac-spe

48 mTert-GFP mice were generated by using a two-step embryonic stem cell-b

49 Transgenic mice were generated by using the E40K, constitutively active

50 In this study, chondrocyte-specific Opg transgenic mice were generated by using type II collagen promoter.