ライフサイエンスコーパス: microbiome

1 st inflammatory response to a dysbiotic oral microbiome.

2 ties, but they also show an overlapping core microbiome.

3 sition and diversity of the gastrointestinal microbiome.

4 quencing, and analysis of the human salivary microbiome.

5 the presence of an altered or more abundant microbiome.

6 nked to specific components of the bacterial microbiome.

7 the CNS may start with modulation of the gut microbiome.

8 dietary lipid content may influence the gut microbiome.

9 ies from bacterial neighbours within the gut microbiome.

10 ghts into the implications of disrupting the microbiome.

11 Antibiotic exposure can alter the gut microbiome.

12 Firmicutes as well as a reduced diversity in microbiome.

13 iated with an altered composition of the gut microbiome.

14 health directly or by promoting a beneficial microbiome.

15 , and perhaps through alterations in the gut microbiome.

16 d immunity, as well as new areas such as the microbiome.

17 orted temporal dynamics of the chronic wound microbiome.

18 d areolar skin microbiomes to the infant gut microbiome.

19 rm effects of antibiotic TB treatment on the microbiome.

20 a set and then applied it to the Tara Oceans microbiome.

21 ence, we identified a core beech rhizosphere microbiome.

22 driven diseases that are caused by dysbiotic microbiomes.

23 accounting for interpersonal differences in microbiomes.

24 unity approaches to understand environmental microbiomes.

25 ersal can independently alter the ecology of microbiomes.

26 ated tools were devoted to understanding the microbiome (a term coined in 2001), attention would turn

27 flammation correlates with variations in the microbiome across asthmatic patients, whereas neutrophil

28 stent host factors that explain variation in microbiomes across hosts, despite large-scale sampling e

29 um levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusti

30 It is a matter of fact that the human gut microbiome also includes a non-bacterial fraction repres

31 asthma; less is known regarding the role of microbiome alterations in food allergy development.

32 tic implementation and clinical relevance of microbiome alterations on disease susceptibility is stil

33 We investigated the caries-associated microbiome among Canadian First Nations children with S-

34 udies could use these collection methods for microbiome analyses.

35 article we review the current methods of gut microbiome analysis and the resulting data regarding how

36 cal observations, including overviews on the microbiome and a brief review of the use of probiotics.

37 broad overview of the importance of the host microbiome and accumulating knowledge of how it regulate

38 ugmented intestinal permeability, an altered microbiome and activation of inflammatory pathways that

39 integral interaction between the human skin microbiome and ADSCs.

40 patients through alterations in the urinary microbiome and antimicrobial peptides.

41 al network algorithm, vedoNet, incorporating microbiome and clinical data, provided highest classifyi

42 demonstrated associations between the human microbiome and disease, yet fundamental questions remain

43 s for investigating interactions between the microbiome and host environmental/clinical factors.

44 studies of the effects of these molecules on microbiome and host.

45 suggest a link between a dysbiotic cutaneous microbiome and HS.

46 se studies identify unexpected roles for the microbiome and innate immune signalling in the pathogene

47 en observed dramatic fluctuations in the gut microbiome and intensified medication due to a flare of

48 The composition of the vaginal microbiome and its influence on pregnancy outcome varies

49 ic inflammation, which led to a less-diverse microbiome and loss of protective gut commensal strains

50 y, limited collaborative interaction between microbiome and obesity researchers has delayed progress.

51 et affects the most abundant taxa within the microbiome and that a specific group of methanogenic arc

52 ts into the complex relationship between the microbiome and the host, how it is modified by variables

53 robes influence the development of the human microbiome and the immune system is important to enable

54 with a significant contraction of the fecal microbiome and were partially rescued by fecal microbiot

55 tions and reference genomes, (2) define core microbiomes and metagenomes in these model systems, (3)

56 importance of microbial dispersal to animal microbiomes and motivate its integration into the study

57 ffected by antibiotics that destroy existing microbiomes and replace them with less helpful ones.

58 ffects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such

59 mechanisms include the influence of the gut microbiome, and also metabolic, genetic, and immunologic

60 clock and metabolism, the importance of the microbiome, and how they relate to aging.

61 is exacerbated by significant changes to the microbiome, and innate and adaptive immune responses tha

62 us strains are often part of the human nasal microbiome, and this carrier state has often been associ

63 suggest that HGT is prevalent in cheese rind microbiomes, and that identification of genes that are f

64 ve led to recent breakthroughs in the use of microbiome approaches for forensic science, particularly

65 d-naive asthma, differences in the bronchial microbiome are associated with immunologic and clinical

66 biofilms but do not disturb the overall oral microbiome are available.

67 The numerous species that make up the oral microbiome are now understood to play a key role in esta

68 Alterations in the intestinal microbiome are prospectively associated with the develop

69 comparing airway inflammation and the airway microbiome are sparse, especially in subjects not receiv

70 Vertebrate ocular microbiomes are poorly characterized and virtually unexp

71 animals, collectively referred to as their "microbiome," are critical for host health, but the mecha

72 Recent findings implicate the microbiome as a driver of this systemic immune dysregula

73 to the gut-immune axis and highlight the gut microbiome as a potential therapeutic target to countera

74 nced impact of deterministic assembly in all microbiomes as well as seasonal shifts from heterotrophi

75 ogramming, and the manipulation of the coral microbiome) as a means to enhance environmental stress t

76 from the moment we are born and appropriate microbiome assembly during childhood are essential for e

77 ules of synthetic, functionally programmable microbiome assembly, (4) determine functional mechanisms

78 implicating metabolite misbalance with host-microbiome-associated disease.

79 Unlike existing methods for microbiome association analysis, our framework does not

80 Considering microbiomes at appropriate phylogenetic scales allows us

81 clinical tests, metabolomes, proteomes, and microbiomes at three time points; and daily activity tra

82 significantly shift the ecology of the oral microbiome (at species level) resulting in a community w

83 ossible small-molecule therapeutic modality (microbiome-biosynthetic gene therapy).

84 (-/-) mice, indicating the importance of the microbiome, but did not fully reinstate HMOX-1 levels an

85 and refine plant genotype-by-environment-by-microbiome-by-management interactions.

86 body sites implies that the premature infant microbiome can exhibit very low microbial diversity.

87 The plant microbiome can influence plant phenotype in diverse ways

88 t patterns characterizing disease-associated microbiome changes.

89 Preterm infants exhibit different microbiome colonization patterns relative to full-term i

90 d2(-/-)) mice had an inherently altered skin microbiome compared with wild-type controls.

91 resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-

92 d the impact of diazinon exposure on the gut microbiome composition and its metabolic functions in C5

93 Characterisation of marine copepod gut microbiome composition and its variability provides info

94 ule out a potential effect of antibiotics on microbiome composition and the use of antibiotics should

95 e hypothesize that differences in intestinal microbiome composition correlate with the decreased RVV

96 Shifts in gut microbiome composition have also been associated with th

97 er, there is a lack of knowledge about fecal microbiome composition in several animals and imperfect

98 In maize, the microbiome composition was altered by the genotype and l

99 : Association analysis of microbiome composition with disease-related outcomes pro

100 We compared the microbiome composition, assessed by both 16S rDNA and me

101 ce to ICIs can be attributed to abnormal gut microbiome composition.

102 se of omega-3 supplementation to improve the microbiome composition.

103 ontrol study comparing prevaccination, fecal microbiome compositions between 6-week old, matched RVV

104 icant role in the evolution of mammalian gut microbiome compositions.

105 cal disturbances exhibited over space on the microbiome continuum in a groundwater-derived system.

106 Proper analysis of sparse compositional microbiome data is challenging.

107 BhGLM, providing a useful tool for analyzing microbiome data.

108 ion studies and the application to mouse gut microbiome data.

109 t make any distributional assumptions on the microbiome data; it allows for the adjustment of confoun

110 its and taxonomy assigned via the Human Oral Microbiome Database, then analyzed at the community leve

111 t predictably alters a dysbiotic subgingival microbiome, decreasing pathogen richness and increasing

112 We conclude that microbiome depletion as a result of broad-spectrum antib

113 S-rRNA components of this aerosol revealed a microbiome derived predominantly from animal sources.

114 microbiome toward a dysbiotic layout, where microbiome-derived molecules may contribute to a disease

115 Herein, we review recent efforts to uncover microbiome-derived natural products, describe the key ap

116 al room environment may contribute to infant microbiome development.

117 regnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of

118 Asthmatic patients have higher microbiome diversity and an altered composition, with mo

119 Five metabolites were associated with microbiome diversity and replicated in the independent s

120 luate the effects of azithromycin on the gut microbiome diversity of children from an antibiotic-naiv

121 uted to a deregulated immune response to gut microbiome dysbiosis.

122 gic manifestations such as eczema, but exact microbiome dysfunctions underlying allergies remain uncl

123 12-deficient mice showed that NLRP12 and the microbiome each contributed to immunological signaling t

124 The human microbiome encodes vast numbers of uncharacterized enzym

125 The skin microbiome exists in dynamic equilibrium with the host,

126 de direct evidence that a resident commensal microbiome exists on the ocular surface and identify the

127 left immunologists wondering whether a true microbiome exists there.

128 nd suggest directions to advance the obesity-microbiome field as a whole, with particular emphasis on

129 on (CDI) is facilitated by alteration of the microbiome following antibiotic administration.

130 to thermal bleaching conditions changes the microbiome for heat-sensitive corals, but not for heat-t

131 ly being recognized as common members of the microbiomes found on nearly all mucosal surfaces, and in

132 designed a board game called "Gut Check: The Microbiome Game" to fill this gap.

133 Recent microbiome genome-wide association studies reveal that v

134 In this context, the diet, microbiome, geographical location, as well as environmen

135 e assessment and characterization of the gut microbiome has become a focus of research in the area of

136 The microbiome has emerged as a major determinant of the fun

137 nalyses of neuroimaging data suggest the gut microbiome has minimal effects on regional brain volumes

138 The oral microbiome has numerous advantages that make it particul

139 Large-scale sequencing of environmental microbiomes has the potential to shed light on the richn

140 The components of the human gut microbiome have been found to influence a broad array of

141 Perturbations of the intestinal microbiome have been observed in patients with new-onset

142 ion is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amp

143 e importance of our viral counterpart in the microbiome-host co-evolutionary process.

144 ty and taxonomic composition of the salivary microbiome; however, we also found that short-term hospi

145 these goals is to integrate beneficial plant microbiomes-i.e., those enhancing plant growth, nutrient

146 n order to determine if dysbiosis of the gut microbiome impacts honeybee health, and we performed exp

147 rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposit

148 ncreasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders,

149 More recently, a direct role for the gut microbiome in determining this type of RI in Drosophila

150 derstanding the role of the dysbiotic tissue microbiome in HNSCC.

151 results highlight the importance of the gut microbiome in honeybee health, but they also provide ins

152 The study demonstrated that the microbiome in HS differs significantly from that in heal

153 Insight into the cutaneous microbiome in HS using next-generation sequencing may pr

154 t the long-term dynamic behaviour of the gut microbiome in IBD and differentiate this from normal var

155 The gut microbiome in infancy influences immune system maturatio

156 uggesting that age strongly affects the skin microbiome in infants.

157 e show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacil

158 2017) reveal a putative role for the vaginal microbiome in modulating heterosexual transmission of HI

159 s been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, a

160 topes that are homologous to bacteria in the microbiome in persons with previous TB disease may refle

161 urther investigations on the role of the gut microbiome in promoting or preventing ACVD as well as ot

162 mposition and functional capacity of the gut microbiome in relation to cardiovascular diseases have n

163 ationship between host genetics and the oral microbiome in the context of health and disease.

164 eview the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulat

165 sts for RI associated with diet-specific gut microbiomes in D. melanogaster Despite observing replica

166 stence and functional importance of resident microbiomes in larval Lepidoptera (caterpillars) is lack

167 ancers with Fusobacterium and its associated microbiome-including Bacteroides, Selenomonas, and Prevo

168 Antibiotic treatment elicits microbiome-independent changes in local metabolites, but

169 ally, we highlight new insights into how the microbiome influences the host response to infection, va

170 ions; however, current understanding of host-microbiome interactions derives mostly from studies in w

171 (4) determine functional mechanisms of plant-microbiome interactions, and (5) characterize and refine

172 integrates unique information about host-gut microbiome interactions, gastrointestinal functionality,

173 The gut microbiome is a complex and metabolically active communi

174 Because the skin microbiome is a rich source of LTA, a Toll-like receptor

175 e finding indicate that the gastrointestinal microbiome is an important modulator of physiological re

176 Our microbiome is complex and challenging to understand, but

177 The gut microbiome is comprised of microbes from multiple kingdo

178 The oral microbiome is established within a few minutes after bir

179 udy provides evidence that the dynamic wound microbiome is indicative of clinical outcomes and may be

180 Together, these results suggest that the microbiome is largely resistant to changes during sleep

181 The skin microbiome is largely variable between individuals and b

182 design and implement effective agricultural microbiome manipulations and management strategies, whic

183 icrobial peptide responses and the bacterial microbiome may be used to predict susceptibility to urin

184 sensitization and allergy suggests that the microbiome may have a causal role in the development of

185 This study reveals the gut microbiome-mediated diabetogenic nature of organophospha

186 Therefore, microbiome-mediated RI would be transient and would brea

187 rmine if Bd-inhibitory bacteria are dominant microbiome members.

188 tool further created browsable maps of a 3D microbiome/metabolome reconstruction map on a radiologic

189 mance computing and high-resolution imaging, microbiome, metabolomics, and transcriptomics into futur

190 eview we discuss the origin and influence of microbiome-modulated metabolites, with an emphasis on im

191 Our knowledge of the fungal microbiome (mycobiome) is limited to a few studies invol

192 im of this study was to explore the salivary microbiome of 61 FA patients regarding their oral health

193 The microbiome of 80 anaerobic lesions was compared to that

194 tions, we studied the root-associated fungal microbiome of Arabis alpina (Brassicaceae) with the hypo

195 ssociated microbes were increased in the gut microbiome of breastfed infants compared to formula-fed

196 initively decreases the diversity of the gut microbiome of children in an antibiotic-naive community.

197 h to show that these dominant members of the microbiome of H. heliophila represent nitrogen cycling t

198 s indicated a definitive change in the fecal microbiome of lactose-intolerant individuals, increasing

199 Here, we show that the microbiome of reef corals is different across thermally

200 ters, selected inflammatory markers, and the microbiome of subject-matched tooth and implant sites du

201 ther this effect operates through an altered microbiome of the mucosal surfaces of the airways.

202 osition, diversity, and function of the oral microbiomes of 121 oral cancer patients to 242 age- and

203 ne disorder of the CNS and thus analyzed the microbiomes of 71 MS patients not undergoing treatment a

204 observing replicable differences in the gut microbiomes of flies maintained on different diets, we f

205 glycyl radical enzyme superfamily among the microbiomes of healthy humans.

206 Microbiomes of IBD subjects fluctuate more than those of

207 nd to infer ancient diets from the predicted microbiomes of mammalian ancestors.

208 Intriguingly, the microbiomes of some IBD subjects periodically visited th

209 ergens, air pollution, and the environmental microbiome, on disease etiology and pathogenesis.

210 Manipulation of the airway microbiome, particularly in early life, might be a strat

211 sponges lack organs but harbour a symbiotic microbiome performing various functions.

212 methods to provide new characterizations of microbiome personalization.

213 Gut microbiomes play crucial roles in animal health, and shi

214 The gut microbiome plays a central role in inflammatory bowel di

215 dis, a commensal bacterium in the human skin microbiome, produces short-chain fatty acids by glycerol

216 Here, we examine the microbiome profile of 350 stool samples collected longit

217 e nasopharyngeal airway metabolome profiles, microbiome profiles, and severity in infants with bronch

218 Microbiome profiling of wild-caught sand flies will be o

219 The new algorithm was tested on the human microbiome project (HMP) dataset, currently one of the l

220 The National Institutes of Health Human Microbiome Project has provided one of the broadest such

221 ly available dataset obtained from the Human Microbiome Project which associates taxa abundances with

222 f variability in taxonomic profiling for the Microbiome Quality Control (MBQC) project baseline study

223 limiting epithelial damage and facilitating microbiome recovery.

224 nding exposed dental implants form a diverse microbiome regardless of the periodontal profile of pati

225 Nutrition and the gut microbiome regulate many systems, including the immune,

226 Recent evidence suggests the commensal microbiome regulates host immunity and influences brain

227 There is increasing evidence that the microbiome regulates host metabolism, but specific mecha

228 and immune system functioning, yet cetacean microbiomes remain largely unexplored, in part due to sa

229 ts role in the assembly of animal-associated microbiomes remains underexplored.

230 es will help overcome the correlation era in microbiome research and lead to a rational evaluation of

231 ological interactions, with implications for microbiome research and synthetic ecology.

232 Here, we discuss the current status of microbiome research as it relates to understanding obesi

233 Achieving sufficient reproducibility in microbiome research has proven challenging.

234 nd methodological limitations in obesity and microbiome research have made it difficult to establish

235 Skin microbiome research in healthy individuals and patients

236 ovides an overview of the recent advances in microbiome research in relation to neuro(auto)immune and

237 d we suggest steps for scaling translational microbiome research to high-throughput target discovery

238 logy, carbon sequestration, biogeochemistry, microbiome research, niche construction, and ecosystem e

239 ade in this area, it is unknown how the oral microbiome responds to short-term hospitalization.

240 l-like receptor 2 ligand, we mimicked the GF microbiome's effect on MCs by applying LTA to the skin o

241 agenomic cohorts, we show that shifts in the microbiome's functional capacity can be traced back to s

242 tic elements to their host species in a real microbiome sample.

243 The Integrated Microbial Genomes with Microbiome Samples system contains annotated DNA and RNA

244 Intestinal microbiome samples were collected at age 3-6 months in c

245 nvironmental, host associated and engineered microbiome samples.

246 tection and grouping of viral sequences from microbiome samples.

247 validate our method using synthetic and real microbiome sequences.

248 Microbiome sequencing was performed to investigate the i

249 We suggest that the health benefits of the microbiome should be understood, and studied, as an inte

250 ove the reproducibility and comparability of microbiome signatures at a meaningful taxonomic resoluti

251 intained in distal metastases, demonstrating microbiome stability between paired primary and metastat

252 ironment is more influential in shaping skin microbiome structure than host differences in these cong

253 e and underwent more heterogeneous shifts in microbiome structure.

254 ristics that covary with elevation influence microbiome structure.

255 Although IBD is dynamic, microbiome studies have primarily focused on single time

256 cial steps in high-throughput sequence-based microbiome studies is the taxonomic assignment of sequen

257 ty to the placental microbiota and placental microbiome studies should consider regional differences,

258 In order for human microbiome studies to translate into actionable outcomes

259 ution statistical bioinformatics in clinical microbiome studies, and suggest that previous conflictin

260 chers in experimental design choices for gut microbiome studies.

261 al profiling revealed three distinct vaginal microbiome subtypes, one of which was characterized by e

262 iruses infect dominant members of the marine microbiome such as Prochlorococcus and Pelagibacter.

263 Studies of the human skin microbiome suggest that Propionibacterium acnes strains

264 implants has been said to be similar to the microbiome surrounding teeth.

265 esearch in this area: (1) develop model host-microbiome systems for crop plants and non-crop plants w

266 th particular emphasis on the development of microbiome-targeted therapies for obesity prevention and

267 To date, however, microbiome taxonomy and function have mostly been studie

268 S-ECC have a significantly different plaque microbiome than their caries-free counterparts, with the

269 nd eukaryotes interact in many ways-from the microbiome that educates the mammalian immune system and

270 rial and archaeal symbiont communities (i.e. microbiomes) that play important roles in digestive and

271 ith damaged epithelia and with the recipient microbiome, the impact of the alarmin interleukin-33 on

272 recent thrust of scientific research on the microbiome, the importance of its interface with the hos

273 d that sleep restriction may perturb the gut microbiome to contribute to a disease state.

274 ramework to precisely manipulate the dryland microbiome to mitigate N2 O emissions in situ using emer

275 he evidence linking perturbations of the gut microbiome to pancreatic autoimmunity.

276 s that reduce the ability of the host or its microbiome to regulate community composition.

277 that evaluated microbial biofilms and entire microbiomes to establish their similarities and differen

278 re a common and important response of animal microbiomes to stressors that reduce the ability of the

279 ribution of the breast milk and areolar skin microbiomes to the infant gut microbiome.

280 etabolites and signaling molecules (e.g. gut microbiome-to-intestine-to-blood-to-liver-to-kidney-to-u

281 our intestinal counterpart, pushing the gut microbiome toward a dysbiotic layout, where microbiome-d

282 p guide therapies that will redirect the gut microbiome towards a healthy state and maintain remissio

283 mphibian bacterial therapy that can govern a microbiome trajectory at critical timepoints and may imp

284 Five articles evaluated the entire microbiome using genomic sequencing.

285 To further explore the gut microbiome variation in human populations, here we chara

286 The fecal microbiome was also analyzed from mice that express only

287 pact of F. johnsoniae on the tadpole surface microbiome was assessed with shotgun metagenomics.

288 The skin microbiome was characterized in 30 patients with HS (mea

289 Diversity of the gut microbiome was significantly lower in the treated group

290 relationship between infant health and their microbiome were analyzed.

291 d that emulsifier-induced alterations in the microbiome were necessary and sufficient to drive altera

292 ifts in composition and function of the oral microbiome were observed with poor oral hygiene, tobacco

293 The different microbiomes were investigated using next-generation sequ

294 is primarily driven by inflammation and the microbiome, while age is a driving force for small intes

295 ls host multi-species microbial communities (microbiomes) whose properties may result from inter-spec

296 s in feces, setting the stage for metabolome-microbiome-wide association studies (MMWAS).

297 the interaction of some members of the skin microbiome with host cells will result in changes in cel

298 Nurturing a beneficial gut microbiome with prebiotics, such as fructo-oligosacchari

299 previously described in marine invertebrate microbiomes with possible links to ammonia-oxidization,

300 highly variable component of the human skin microbiome, yet factors that determine their abundance c