1 candidates for such introgression, including
microcephalin,
a gene influencing brain development.
2 ly, illustrated by the identification of the
Microcephalin,
abnormal spindle in microcephaly and atax
3 It also makes
Microcephalin an attractive candidate locus for studying
4 Indeed, evolutionary analyses of
Microcephalin and ASPM reveal evidence for positive sele
5 ously identified primary microcephaly genes,
microcephalin and ASPM.
6 recent adaptive evolution of either ASPM or
Microcephalin and changes in IQ.
7 Here, we examine the evolution of the
microcephalin gene, whose null mutation in humans causes
8 Two primary microcephaly genes, ASPM and
Microcephalin,
have been implicated not only in the adap
9 We show that one genetic variant of
Microcephalin in modern humans, which arose approximatel
10 Additionally,
microcephalin interacts with Chk1.
11 This gene,
microcephalin,
is expressed in the developing cerebral c
12 t the notion that the molecular evolution of
microcephalin may have contributed to brain expansion in
13 al. reported that human genetic variants of
Microcephalin (
MCPH1) and abnormal spindle-like microcep
14 Microcephalin (
MCPH1) and ASPM (abnormal spindle-like mi
15 Mutations of
microcephalin (
MCPH1) can cause the neurodevelopmental d
16 Microcephalin (
MCPH1) is a BRCA1 COOH terminal (BRCT) do
17 Microcephalin (
MCPH1) is one of the causative genes for
18 Microcephalin (
MCPH1) is the first gene identified among
19 The gene
Microcephalin (
MCPH1) regulates brain size and has evolv
20 The gene
microcephalin (
MCPH1) regulates brain size during develo
21 ral, biochemical, and cellular evidence that
Microcephalin (
MCPH1), an early DNA damage response prot
22 Microcephalin (
MCPH1), one of the genes mutated in prima
23 Microcephalin (
MCPH1), the first gene identified as caus
24 ractions with checkpoint kinase 1 (CHK1) and
microcephalin (
MCPH1).
25 Microcephalin/
MCPH1 is one of the causative genes respon
26 genes have been identified: MCPH1, encoding
Microcephalin;
MCPH3, encoding CDK5RAP2; MCPH5, encoding
27 about 45 advantageous amino acid changes in
microcephalin might have fixed during the 25-30 million
28 We show that the evolution of
microcephalin'
s protein sequence is highly accelerated t