ライフサイエンスコーパス: microcirculatory

1 dothelial cell P-selectin contributes to the microcirculatory abnormalities in sickle cell disease an

2 matched control subjects and determined the microcirculatory abnormalities in the T1DM and T1DM-MV p

3 Microcirculatory abnormalities of the retina and nail-fo

4 Microcirculatory alterations are associated with adverse

5 Microcirculatory alterations are stronger predictors of

6 We studied the prevalence of microcirculatory alterations in a heterogeneous ICU popu

7 We investigated which factors may influence microcirculatory alterations in patients with severe sep

8 The prevalence and significance of microcirculatory alterations in the general ICU populati

9 Modest microcirculatory alterations occur in dengue, are associ

10 Microcirculatory alterations were less severe in the lat

11 s in which a stent has been placed, coronary microcirculatory and epicardial vascular function are no

12 significant hemodynamic, blood gas, lactate, microcirculatory, and tissue Pco2 abnormalities were obs

13 potential therapy is linked to the enhanced microcirculatory angiogenesis that results from treatmen

14 hether early wave intensity analysis-derived microcirculatory (backward) expansion wave energy predic

15 e these obstacles using autologous explanted microcirculatory beds (EMBs) as bioscaffolds for enginee

16 to function as an oxygen sensor in mammalian microcirculatory beds and to regulate arteriolar caliber

17 ormability, the parameters influencing their microcirculatory behavior remain unexplored.

18 Hepatic microcirculatory blood flow (MBF) was measured throughou

19 -leukocyte interactions, leading to improved microcirculatory blood flow and improved survival.

20 Indomethacin restored microcirculatory blood flow and reduced TXA2 .

21 between RBCs and WBCs, resulting in improved microcirculatory blood flow and survival of sickle cell

22 en before the inflammatory stimuli increased microcirculatory blood flow and survival.

23 wever, no clinical studies have investigated microcirculatory blood flow behavior in hemorrhagic shoc

24 F-alpha) stimulation, and not only increased microcirculatory blood flow but also improved survival o

25 ity of T/HS exchange transfusion to decrease microcirculatory blood flow did not appear to be due to

26 stric and buccal tissue Pco2 with changes in microcirculatory blood flow in a rat model of circulator

27 Microcirculatory blood flow in small vessels increased (

28 Microcirculatory blood flow in vessels >20 microm was we

29 ere was an early and progressive decrease in microcirculatory blood flow in vessels <20 microm, mostl

30 Sublingual microcirculatory blood flow was assessed by sidestream d

31 Cortical microcirculatory blood flow was markedly reduced after e

32 Microcirculatory blood flow was quantitated with orthogo

33 prostaglandin F2alpha (PGF2alpha ), on skin microcirculatory blood flow, as well as to detect its ef

34 that older individuals would exhibit reduced microcirculatory blood flow, interstitial amino acid con

35 ntly affect systemic oxygen metabolism, skin microcirculatory blood flow, urine output, or splanchnic

36 ubsequent vascular injury and obstruction of microcirculatory blood flow.

37 d that epinephrine reduces cerebral cortical microcirculatory blood flow.

38 matory trigger of vasoocclusion and improved microcirculatory blood flow.

39 n arterial spin tagging was used to estimate microcirculatory CBF in depressed (N = 5) and comparison

40 l intensity ratios corresponding to relative microcirculatory CBF were calculated for four regions on

41 On the superior image, estimates of microcirculatory CBF were statistically significantly lo

42 nks between depression, cardiac disease, and microcirculatory cerebral blood flow (CBF).

43 ect correlation between the observed retinal microcirculatory changes and established plasma markers

44 Microcirculatory changes and tissue oxygenation were inv

45 onance (MR) imaging may be indicators of the microcirculatory changes in patients with nonalcoholic s

46 These effects were associated with microcirculatory collapse due to astrocyte swelling.

47 nitric oxide (NO) bioavailability and brain microcirculatory complications, with a marked decrease i

48 suction wave caused by relief of myocardial microcirculatory compression-the dominant backward-trave

49 ain ischemia of 30 min duration suggest that microcirculatory compromise develops during recirculatio

50 and endovascular glycocalyx degradation with microcirculatory compromise.

51 PEG-BSA produces improved microcirculatory conditions in the treatment of endotoxe

52 votal role of blood O(2) gradients in muscle microcirculatory control.

53 of a "suction" wave generated by myocardial microcirculatory decompression.

54 Altered cell migration due to microcirculatory deficiencies as well as excessive and p

55 ndicate that brain hypoxia can be related to microcirculatory derangements and cell edema without evi

56 tion between posttraumatic brain hypoxia and microcirculatory derangements with cell edema, we invest

57 surement to FFR, especially in patients with microcirculatory disease and impaired maximal hyperemia.

58 ation, microgliosis, oligodendrocyte injury, microcirculatory disease, and interstitial fluid stasis.

59 ia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases; its lipop

60 sion is influenced by the degree of cerebral microcirculatory disturbance.

61 erence)) theoretically normalizes for global microcirculatory disturbances and facilitates interpreta

62 emia-reperfusion (I/R) injury and a range of microcirculatory disturbances contribute to tissue damag

63 ports add to understanding of the control of microcirculatory disturbances in acute pancreatitis, and

64 The microcirculatory disturbances in sepsis have prompted mi

65 ences of portosystemic shunting resulting in microcirculatory disturbances, mild (secondary) periduct

66 d activation of inflammatory pathways and/or microcirculatory disturbances, whereas NO dysregulation

67 is preferentially triggered by mild/moderate microcirculatory disturbances.

68 sis, diffuse atherosclerotic narrowings, and microcirculatory dysfunction (MCD) contribute to limit m

69 rt: culprit and nonculprit vessel) and acute microcirculatory dysfunction (ST-segment-elevation myoca

70 Hepatic microcirculatory dysfunction and the vasoconstrictive re

71 Antithrombin ameliorates microcirculatory dysfunction and tissue injury in trauma

72 Microcirculatory dysfunction has been well reported in c

73 than vascular remodeling, influence coronary microcirculatory dysfunction in aortic stenosis (AS).

74 rculatory hemodynamic optimization; however, microcirculatory dysfunction is integral to sepsis patho

75 s and cirrhosis, marked portal hypertension, microcirculatory dysfunction, an enhanced vasoconstricti

76 tic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaire

77 was abnormal (<2.0), suggesting predominant microcirculatory dysfunction.

78 y bypass (C/CPB) is associated with coronary microcirculatory dysfunction.

79 wed by reperfusion for 1, 2 or 4 h, leads to microcirculatory dysfunction.

80 ponse to endothelin-1, and aggravate hepatic microcirculatory dysfunction; these events subsequently

81 This paper describes a self-contained microcirculatory EC culture system that efficiently stud

82 rican Americans, pharmacologic correction of microcirculatory endothelial dysfunction in this group i

83 In fact, vessel wall stiffening, and microcirculatory endothelial dysfunction, precedes hyper

84 Analysis of microcirculatory events included hepatic ischemia, endot

85 aracteristic analysis, a backward-traveling (microcirculatory) expansion wave threshold of 2.8 W m(-2

86 The backward-traveling (microcirculatory) expansion wave was derived from wave i

87 e infarct-related artery backward-traveling (microcirculatory) expansion wave was inversely correlate

88 a unique series of events characterized with microcirculatory failure and thrombosis progressing from

89 These observations suggest that microcirculatory failure in capillaries appears as an ea

90 hin 4 h of MCAO supports the hypothesis that microcirculatory failure in this region contributes to i

91 insights into septic encephalopathy include: microcirculatory failure precedes changes in evoked pote

92 , we found no association between changes in microcirculatory flow and lactate clearance or organ dys

93 urther aggravates ischemia by reducing local microcirculatory flow and oxygenation.

94 Decreases in buccal microcirculatory flow are closely associated with the se

95 morrhagic shock in which systemic and buccal microcirculatory flow are reduced.

96 injury within 24 hours were consistent with microcirculatory flow arrest and collagen preservation (

97 We performed experiments and simulations in microcirculatory flow conditions of viscosity, shear rat

98 and reduced RCD both contribute to decreased microcirculatory flow in severe disease.

99 Despite lower (by approximately 40-45%) microcirculatory flow in the older than in the younger p

100 Transfusion of RBC significantly increased microcirculatory flow index (from 2.3 [1.6-2.5] to 2.7 [

101 he primary outcome measure was the change in microcirculatory flow index.

102 ; timely interventions to preserve the renal microcirculatory flow may interrupt the downward spiral

103 cal microcirculatory flow, cerebral cortical microcirculatory flow was fully preserved during cardiog

104 However, cerebral microcirculatory flow was fully preserved.

105 and arterial pressures together with buccal microcirculatory flow, cerebral cortical microcirculator

106 ed plasma nitrite levels, it did not improve microcirculatory flow, lactate clearance, or organ dysfu

107 ed blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis.

108 ea under the curve 98 [SE 14] to 1024 [130]; microcirculatory flux from 5060 [462] to 74,800 [3940])

109 atients demonstrate persistent impairment in microcirculatory function after percutaneous coronary in

110 mally invasive evaluation of intramyocardial microcirculatory function and permits assessment of micr

111 ic roles in the optimization of cellular and microcirculatory function in critical illness and injury

112 ar mathematical models that will investigate microcirculatory function in health and disease.

113 Changes in coronary microcirculatory function in patients with AS after AVR

114 Peripheral microcirculatory function was measured with continuous r

115 Microcirculatory function was not significantly differen

116 nary vasodilator reserve (CVR), a measure of microcirculatory function, after AVR and determine the r

117 ar thrombi, thereby contributing to impaired microcirculatory function, the no-reflow phenomenon, and

118 AS, and coronary perfusion to impairment in microcirculatory function.

119 against CM is associated with improved brain microcirculatory hemodynamics and decreased vascular pat

120 od, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increa

121 romise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open q

122 usion may contribute to progressive cerebral microcirculatory impairment and ischemic neuronal injury

123 Recent studies show that coronary microcirculatory impairment is an independent predictor

124 Microcirculatory impairments have theoretically been pro

125 measured concurrently with determination of microcirculatory indices in buccal and cerebral areas.

126 characterized by endothelial activation with microcirculatory inflammation by monocytes/macrophages a

127 rect mechanistic significance or whether the microcirculatory injury is an epiphenomenon and a manife

128 s of breast milk involve enhanced intestinal microcirculatory integrity via augmentation of nitrate-n

129 ge characteristics of skeletal muscle at the microcirculatory level we tested the hypothesis that, fo

130 chanism of adenosine-induced dilation at the microcirculatory levels.

131 Microcirculatory measurements were obtained either early

132 Microcirculatory morphometric analyses were performed to

133 Impaired microcirculatory (nutritive) blood flow may contribute t

134 rocirculation, through the direct intravital microcirculatory observations after administration of NO

135 e role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstr

136 of forward (aorta-originating) and backward (microcirculatory-originating) coronary waves were determ

137 No difference was found between the microcirculatory parameters comparing dengue with other

138 During hypothermia, all sublingual microcirculatory parameters decreased significantly toge

139 rs; and 3) quantitative and semiquantitative microcirculatory parameters have a similar performance.

140 oped a new method to monitor and to quantify microcirculatory parameters in the tumor grown in the li

141 Semiquantitative and quantitative microcirculatory parameters were determined through the

142 ood flow resulting in concomitantly improved microcirculatory perfusion (P = 0.024).

143 Further, we found no association between microcirculatory perfusion and multiple organ dysfunctio

144 Presently, MCE uses microcirculatory perfusion as the basis to distinguish m

145 xed, suggest that changes in distribution of microcirculatory perfusion can modulate substrate uptake

146 haled nitric oxide at 40 ppm did not augment microcirculatory perfusion in patients with sepsis.

147 nclusion, MCAO induced severe impairments in microcirculatory perfusion within the core ischemic regi

148 It preserves microcirculatory perfusion within the endangered areas i

149 potentially influences hepatic function and microcirculatory perfusion.

150 bule, improve cell engraftment, and decrease microcirculatory perturbations.

151 d saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion an

152 Diabetes mellitus causes microcirculatory rarefaction and may impair the responsi

153 on characteristics, arteriolar constriction, microcirculatory rarefaction, metabolic abnormalities, c

154 THODS AND We established a model of complete microcirculatory regeneration after ischemia-induced obl

155 ts allocated to control group reached normal microcirculatory reperfusion (myocardial blush grade=3);

156 oretical as well as experimental approaches, microcirculatory research belongs within current definit

157 Microcirculatory research represents an example of a 'mi

158 hypothesized that impaired baseline coronary microcirculatory reserve, which reduces the ability to t

159 cular dysfunction, predefined by an index of microcirculatory resistance >20, was observed in 46% of

160 Index of microcirculatory resistance (IMR) and atherosclerotic bu

161 A novel index of microcirculatory resistance (IMR) has been shown in anim

162 valuate the predictive value of the index of microcirculatory resistance (IMR) in patients undergoing

163 picardial stenosis by comparing the index of microcirculatory resistance (IMR) levels in patients bef

164 for periprocedural MI and that the index of microcirculatory resistance (IMR) measured during PCI ca

165 remic mean transit time provides an index of microcirculatory resistance (IMR) that will correlate wi

166 microvascular resistance using the index of microcirculatory resistance (IMR), defined as the hypere

167 s study is to determine whether the Index of Microcirculatory Resistance (IMR), measured at the time

168 ion of coronary flow reserve (CFR), index of microcirculatory resistance (IMR), ratio of distal coron

169 coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR); and intravascular ult

170 sistance (IMR) that will correlate with true microcirculatory resistance (TMR), defined as the distal

171 thermodilution technique (apparent index of microcirculatory resistance [IMR(app)]).

172 The index of microcirculatory resistance has been shown to have progn

173 Previous studies demonstrating that microcirculatory resistance is dependent on epicardial s

174 We investigated whether the index of microcirculatory resistance is independent of epicardial

175 Coronary microcirculatory resistance is independent of functional

176 Increasingly, the index of microcirculatory resistance is used as a reference stand

177 However, controversy exists over whether microcirculatory resistance, a measure of coronary micro

178 The index of microcirculatory resistance-a thermodilution-derived mea

179 mal absolute coronary blood flow and minimal microcirculatory resistance.

180 sound, fractional flow reserve, and index of microcirculatory resistance.

181 for collateral flow in their measurement of microcirculatory resistance.

182 sessed using the recently described index of microcirculatory resistance.

183 vascular dysfunction assessed using index of microcirculatory resistances at 1 year was also associat

184 results support our hypotheses regarding the microcirculatory response to NO in tumors.

185 placebo controlled, cross-over study of the microcirculatory response to topical application of a ni

186 Cerebral microcirculatory responses consisted of changes in cereb

187 This study sought to determine the cerebral microcirculatory responses to hypoxia, hypotension, hypo

188 Two hours after the intervention, cerebral microcirculatory responses were examined.

189 Vitamin C restores coronary microcirculatory responsiveness and impaired coronary fl

190 e exact locations of occlusive events at the microcirculatory scale remains open.

191 The Microcirculatory Shock Occurrence in Acutely ill Patient

192 sional vasculature structure and determining microcirculatory speeds.

193 ukocytes, activating complement, and causing microcirculatory stasis.

194 irculatory resistance, a measure of coronary microcirculatory status, is dependent on epicardial sten

195 thus, homeostatic levels of ET-1 to maintain microcirculatory tone.

196 Quantitative and semiquantitative microcirculatory variables displayed similar behaviors.

197 Among microcirculatory variables, proportion of perfused small

198 value in an integrative model of macro- and microcirculatory variables.

199 Changes in skin microcirculatory volume and flux were measured bilateral

200 ing system can stimulate an increase in both microcirculatory volume and flux.

201 el both in patients with Raynaud's syndrome (microcirculatory volume from mean area under the curve 9