ライフサイエンスコーパス: microcytic

1 identify the causative mutation in mice with microcytic anaemia (mk).

2 encing of arhgef3 in Danio rerio resulted in microcytic and hypochromic anemia.

3 ted with higher odds of anemia, particularly microcytic anemia (asthma: 1.61; 1.09-2.38; P = .02; ecz

4 9 nmol/L]), leukocytosis (13 800/mm(3)), and microcytic anemia (hemoglobin level, 7.2 g/dL).

5 Microcytic anemia (mk) mice and Belgrade (b) rats have s

6 notype are similar to those reported for the microcytic anemia (mk) mutation in the mouse.

7 hianti (cia) mutant manifests a hypochromic, microcytic anemia after the onset of embryonic circulati

8 Mice lacking Pcbp1 exhibited microcytic anemia and activation of compensatory erythro

9 ns or deletions may be a cause of refractory microcytic anemia and bone marrow iron depletion in pati

10 It is characterized by microcytic anemia and by iron loading, and can be treate

11 entified in a female with severe hypochromic microcytic anemia and iron overload.

12 Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with

13 bdh2 null mice developed microcytic anemia and tissue iron overload, especially i

14 The mutation, zinfandel, has a hypochromic microcytic anemia as an embryo, but later recovers in ad

15 deficiency anemia patients, who present with microcytic anemia caused by hyperhepcidinemia, and of qu

16 These animals exhibit hypochromic microcytic anemia due to impaired intestinal iron absorp

17 cythemia in heterozygotes and a hypochromic, microcytic anemia in homozygotes.

18 yses reveal a mild, congenital, hypochromic, microcytic anemia intrinsic to the hematopoietic system

19 athogenesis of a new recessive, hypochromic, microcytic anemia mouse mutant, nm1054.

20 a genetic locus not previously implicated in microcytic anemia or iron phenotypes.

21 e normal recipients of HBD marrow obtained a microcytic anemia similar to the donor.

22 and alpha2-globulin and more frequently had microcytic anemia than those without such deposits (P =

23 ene symbol hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-rece

24 A hypochromic, microcytic anemia was present from birth, and platelet c

25 The Rac1(-/-);Rac2(-/-) mice developed microcytic anemia with a hemoglobin drop of about 20% an

26 Homozygous sublytic mice develop hypochromic microcytic anemia with reduced osmotic fragility of RBCs

27 ice alters actin assembly in RBCs and causes microcytic anemia with reticulocytosis, implicating Rac

28 yndrome (joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced childhood-on

29 rized by joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystroph

30 (cdy), a zebrafish mutant with hypochromic, microcytic anemia, and positioned the mutant gene on lin

31 ome akin to typhoid fever with splenomegaly, microcytic anemia, extramedullary erythropoiesis, and in

32 nhibition of mTORC1 results in macrocytic or microcytic anemia, respectively.

33 These Tf-deficient mice have severe microcytic anemia, tissue iron overload, and hepcidin de

34 d-specific ALA synthase 2 (ALAS2) gene cause microcytic anemia, whereas mitochondrial DNA deletions a

35 Chronic turpentine treatment led to microcytic anemia, which was prevented by concurrent adm

36 moderately severe, congenital, hypochromic, microcytic anemia, with an elevated red cell zinc protop

37 nduction, iron deficiency and a hypochromic, microcytic anemia.

38 ssive loss of body (but not facial) hair and microcytic anemia.

39 Heterozygous gammabeta(0) mice suffer from microcytic anemia.

40 ion by red blood cells leads to hypochromic, microcytic anemia.

41 -/- mice represent a new paradigm of genetic microcytic anemia.

42 Hypochromic, microcytic anemias are typically the result of inadequat

43 plinary guidelines on the management of rare microcytic anemias due to genetic disorders of iron meta

44 derstanding of the pathogenesis of inherited microcytic anemias has gained from the identification of

45 nd transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases i

46 drome [ATMDS]) characterized by hypochromic, microcytic, anisopoikilocytic red blood cells with hemog

47 st cases, the red cells were hypochromic and microcytic, consistent with abnormalities in hemoglobin

48 the sla mutation develop moderate to severe microcytic hypochromic anaemia.

49 esults in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia

50 HNF1A(-/-) mice displayed microcytic hypochromic anemia with reticulocytosis that

51 Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in

52 The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemogl

53 Belgrade rats exhibit microcytic, hypochromic anemia and systemic iron deficie

54 cit (hbd) mouse mutant, which suffers from a microcytic, hypochromic anemia apparently due to defecti

55 rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal

56 These mice exhibited microcytic, hypochromic anemia, as did lethally irradiat

57 e (median hemoglobin, 7.1 g/dL) and markedly microcytic (median mean corpuscular volume, 62.0 fL).

58 mice developed thrombocytopenia and altered microcytic red blood cell counts.