ライフサイエンスコーパス: microenvironment

1 dependent on the presence of an inflammatory microenvironment.

2 to mediate these effects of FTY720 in tumor microenvironment.

3 dendritic cells were identified in the tumor microenvironment.

4 rived suppressor cells (MDSC) into the tumor microenvironment.

5 ts survival pathways for adapting to hypoxic microenvironment.

6 the expression profile of the cervical tumor microenvironment.

7 yeloid-derived suppressor cells in the tumor microenvironment.

8 promotes cancer cell migration in the tumor microenvironment.

9 alignant behaviour can be dominated by their microenvironment.

10 patocytes through IL-6 produced in the liver microenvironment.

11 e crosstalk with an altered bone marrow (BM) microenvironment.

12 tating drug availability in the acidic tumor microenvironment.

13 emarkably acellular, mitogen-poor metastasis microenvironment.

14 ithin tumor cells and the composition of the microenvironment.

15 ttenuate the Treg-mediated suppressive tumor microenvironment.

16 naling network in stromal cells in the tumor microenvironment.

17 endent on functional interaction within this microenvironment.

18 nt ligands and/or paracrine Wnts from the BM microenvironment.

19 ty and composition of the surrounding tumour microenvironment.

20 the presence of IFN-gamma within the tumour microenvironment.

21 metabolism in the context of the endothelial microenvironment.

22 to interconvert depending on the host tissue microenvironment.

23 lls alone and in the presence of bone marrow microenvironment.

24 ool of naive CD8(+) T cells within the liver microenvironment.

25 s help the primary tumor to adapt to the new microenvironment.

26 ue-engineered microvessel model of the tumor microenvironment.

27 as specific imaging biomarkers of the glioma microenvironment.

28 ory (Treg) lymphocyte densities in the tumor microenvironment.

29 e marrow adipocytes to generate a protumoral microenvironment.

30 enitor cells (HSPCs) in the bone marrow (BM) microenvironment.

31 of Pten, but alters tumor histopathology and microenvironment.

32 immunosuppressive adenosine within the tumor microenvironment.

33 e phenotypic diversity of cells in the tumor microenvironment.

34 es to recapitulate key aspects of the tumour microenvironment.

35 near-complete blockade of CD47 in the tumor microenvironment.

36 rability to free oxygen species in the tumor microenvironment.

37 ty of primary tumors, independently of tumor microenvironment.

38 ells and the establishment of the protumoral microenvironment.

39 kpoints on individual cells within the tumor microenvironment.

40 lar membranes that mimic the agonist-induced microenvironment.

41 fatty acid uptake directly within the tumor microenvironment.

42 etween cancer subclones and the local immune microenvironment.

43 nfigure protective immunity within the tumor microenvironment.

44 ct from the ECM within the normal epithelial microenvironment.

45 avily on local immune responses in the tumor microenvironment.

46 that disrupt the photoreceptors' subretinal microenvironment.

47 are powerful immune modulators of the tissue microenvironment.

48 which is specifically targeted to the tumor microenvironment.

49 naling in cancer cells can affect the immune microenvironment.

50 and solid tumor cells) and their protective microenvironment.

51 ks induced by TGFbeta expressed in the tumor microenvironment.

52 ventions, which target the colorectal cancer microenvironment.

53 adopted in response to a nutrient-deficient microenvironment.

54 nfiltrate into tumors and modulate the tumor microenvironment.

55 h these CAR T cells overcome a hostile tumor microenvironment.

56 sue-specific immune development in the tumor microenvironment.

57 ted with retention of TRM cells in the tumor microenvironment.

58 er originates within immunologically complex microenvironments.

59 eglected in the absence of specific cellular microenvironments.

60 hano-chemical perturbations that mimic tumor microenvironments.

61 ent, as well as differences in intracellular microenvironments.

62 e cancer cell survival within TNF-rich tumor microenvironments.

63 , from multiple cell types and in a range of microenvironments.

64 y, allowing cancer cells to adapt to various microenvironments.

65 Cohousing experiments showed that the microenvironment also played an important role in the st

66 immunoregulatory proteins that shape the cHL microenvironment and allow tumor cells to evade immune s

67 by: (i) inducing an immunosuppressive tumor microenvironment and angiogenesis via cytokine productio

68 respond in vivo to variations in the stomach microenvironment and at different stages of disease prog

69 ue-resident immune cells controls the tissue microenvironment and barrier homeostasis.

70 The relative importance of the tumor microenvironment and cancer cell-intrinsic signaling in

71 well as stress signals imparted by the tumor microenvironment and could be an important mechanism dri

72 the role of off-target drug effects on tumor microenvironment and development of acquired drug resist

73 We sought to better define the microenvironment and distinct cellular contributions dur

74 trating the capacity to manipulate the tumor microenvironment and enhance the progression of EBV-asso

75 borated by melanoma cells dominate the tumor microenvironment and highlight the need to target extrin

76 indings highlight the role of the inhibitory microenvironment and how CAR T cells can be further engi

77 o sense their immediate surrounding cellular microenvironment and make appropriate behavioural decisi

78 TAMs) are essential components of the cancer microenvironment and play critical roles in the regulati

79 y expressed MGL2 and PD-L2 in the metastatic microenvironment and preferentially induced the expansio

80 t in vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary

81 prevent the release of NLGN3 into the tumour microenvironment and robustly block HGG xenograft growth

82 g to regulate the immune status of the tumor microenvironment and support the strategic use of clinic

83 ary cells that internalized PLN in the tumor microenvironment and that PLN-induced tumor growth was d

84 O3 is produced by stromal cells in the tumor microenvironment and the activating mutations appear to

85 etwork database, a network between the CD147 microenvironment and the CD147-dependent phosphoproteins

86 ptides, we examined the dynamic of the CD147 microenvironment and the CD147-dependent phosphoproteome

87 er was distributed within the colony and its microenvironment and the copper oxidation state and succ

88 e relationship between tumor cells and local microenvironment and the mechanisms of B-cell transcript

89 fill an important niche in the ever-changing microenvironment and the role of advanced microscopic im

90 The mechanical properties of the cellular microenvironment and their spatiotemporal variations are

91 t is shed in microvesicles into the cellular microenvironment and therefore confers TRAIL resistance

92 raints imposed normally by a Notch-inductive microenvironment and undergo DC development.

93 Optimizing the microenvironment and understanding drug effects will ena

94 In mice, ammonia accumulated in the tumor microenvironment and was used directly to generate amino

95 aging of histologic sections captures tissue microenvironments and cytologic details in expansive hig

96 ework is well suited for analysis of protein microenvironments and may be useful for other protein st

97 ce revealed no alteration in the cellular MZ microenvironment, and analysis of bone marrow chimeras i

98 e primordial components of the extracellular microenvironment, and as a component of BM, collagen IV

99 pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells

100 s luminal content, senses changes in the gut microenvironment, and releases immune regulators that si

101 lls (GSCs) are enriched in the hypoxic tumor microenvironment, and that monocarboxylate transporter-4

102 s required for iTreg conversion in the tumor microenvironment, and the deletion of moesin from recipi

103 cacy of TSL treatment within different tumor microenvironments, and further advance our understanding

104 Fibroblasts within the mammary tumor microenvironment are active participants in carcinogenes

105 s and related alterations of the bone marrow microenvironment are commonly found in SM.

106 incorporate diverse cues from the myocardial microenvironment are expected to lead to more physiologi

107 owever, their potential effects on the tumor microenvironment are largely unknown.

108 the contributing conditions within the tumor microenvironment are not well understood.

109 last response to physical forces in the bone microenvironment are poorly understood.

110 their chromosomal location, suggesting that microenvironments are highly differentiated transcriptio

111 of high relative water availability - mesic microenvironments - are generated by a wide array of hyd

112 Our findings implicate the mechanical microenvironment as a potent contributor to PDAC progres

113 nication between liposarcoma cells and their microenvironment as a process critically involved in lip

114 ast in part, to signals from the bone marrow microenvironment (BMM).

115 we developed a biomimetic microfluidic tumor microenvironment (bMTM) comprising co-culture of tumor a

116 mmunological homoeostasis in the bone marrow microenvironment, both in physiological conditions and a

117 tion of infiltrating leukocytes in the tumor microenvironment but altered the phenotype of myeloid ce

118 vestigate leukocyte trafficking in the tumor microenvironment, but parameterizing such models is diff

119 enhance invasion and metastasis in the tumor microenvironment, but the basis for their effects is not

120 Tumors adapt to an unfavorable microenvironment by controlling the balance between cell

121 ls adjust to hypoxic stress within the tumor microenvironment by downregulating energy-consuming proc

122 Microglia regulate the brain microenvironment by sensing damage and neutralizing pote

123 al constructs, one can precisely control the microenvironment by specifically formulating the bioink

124 Their cellular microenvironment, called 'niche', regulates hematopoiesi

125 neighboring cells or factors in the diseased microenvironment can underlie white matter defects.

126 l systems and the generation of well-defined microenvironments can be used to develop novel devices a

127 nform the design of efficient self-assembled microenvironment catalysts.

128 alpha to promote an immune-suppressive tumor microenvironment characterized by an abundance of myeloi

129 suggest that multiple distinct tumor immune microenvironments co-exist within a single individual an

130 We thus propose that the tissue microenvironment, combined with ontogeny, provides the s

131 ds high resolution 3D maps of multiple tumor microenvironment components and biomarkers throughout a

132 p between KRAS-mutant cancer cells and their microenvironment components.

133 To understand how cellular microenvironments composed of intricate microfibrillar n

134 D8 T cells to establish an immunosuppressive microenvironment conducive to metastasis formation.

135 The inflammatory tumor microenvironment contributes to metastasis, for instance

136 indings not only shed light on how the tumor microenvironment contributes to premetastatic niche form

137 brain tumors is also influenced by the tumor microenvironment contributing to drug resistance and tum

138 ggesting a mechanism through which the tumor microenvironment controls tumor progression and endocrin

139 e found that myofibroblasts and the fibrotic microenvironment created by myofibroblasts impact the st

140 Here we report that the tumor microenvironment creates an immunosuppressive signature

141 n drug resistance through cell-nonautonomous microenvironment-dependent effects.

142 methyltransferase DNMT1 induced by the brain microenvironment-derived clusterin resulted in decreased

143 l interactions between tumor cells and their microenvironment drive cancer progression and therapy re

144 therapy, and the potential to overcome tumor microenvironment-driven immunosuppression is being explo

145 Our findings show how the tumor microenvironment drives the acquisition of CD39 as an im

146 Cell death is a perpetual feature of tissue microenvironments; each day under homeostatic conditions

147 ve hyaluronan (HA) accumulation in the tumor microenvironment, elevating interstitial pressure and im

148 apeutic intervention.Significance: The tumor microenvironment elicits a subset of functionally exhaus

149 ous nanoparticles are initially deposited in microenvironments enriched in organic material; they the

150 rliest phases of stem/progenitor clonal (and microenvironment) evolution/diversity with new single-ce

151 Exogenous NO in the microenvironment facilitates paracrine signaling, mediat

152 nding to either endogenously produced TPO (a microenvironment factor in hematologic malignancies) or

153 transplantation of FCSCs into a bone defect microenvironment, FCSCs engrafted and regenerated intram

154 ctural features, thus providing a controlled microenvironment for in vitro experiments.

155 site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to

156 and interact with immune cells in the cancer microenvironment for survival and growth.

157 The intratumor microenvironment generates phenotypically distinct but i

158 ration of immature thymocytes through thymic microenvironments generates both adaptive MHC restricted

159 rd since they provide a specialized cellular microenvironment guiding proper morphology and functiona

160 Targeting the hypoxic tumor microenvironment has a broad impact in cancer epigenetic

161 al organization of collagen within the tumor microenvironment has been implicated in modulating cance

162 Analysis of the tumour immune microenvironment has yielded a wealth of information on

163 Endothelial cells (ECs) in the tumor microenvironment have been reported to play a more activ

164 on of B-cell malignancies in chronic hypoxic microenvironment have not been studied.

165 on on the importance of exploiting the tumor microenvironment in cancer therapy, and how this could b

166 l in shaping the protumorigenic inflammatory microenvironment in colon cancer.

167 uperior capacity to establish pre-metastatic microenvironment in distant organs is unclear.

168 stigate the interplay of fusion proteins and microenvironment in lineage choice, we transplanted huma

169 for loss of HBEGF in the neuroblastoma tumor microenvironment in neuroblastoma pathogenesis.-Gaviglio

170 and functional orientation within the tumor microenvironment in non-small cell lung cancer (NSCLC) h

171 idly formed tumors outside the primary tumor microenvironment in nude mice, exhibited signatures of i

172 the production of an immunosuppressive tumor microenvironment in pancreatic cancer.

173 logies and methods for analysis of the tumor microenvironment in patients with GBM.

174 e mechano-chemical stiffness of the cellular microenvironment in primary cell culture.

175 inflammation and contribute to a tolerogenic microenvironment in tumors.

176 mphasis on the subplasmalemmal-mitochondrial microenvironment in Type I cells and how theories of acu

177 ming might protect DPCs from the post-trauma microenvironment in which DPCs infiltrate and resident i

178 trollable hydrogels that can provide hypoxic microenvironments in vitro.

179 engaged in developing the immunosuppressive microenvironment, including galectin-1 and PD-L1/2.

180 We address strategies to modulate the DLBCL microenvironment, including the use of immune checkpoint

181 ed delivery of a TLR7/8 agonist to the tumor microenvironment, increasing the proportion of tumor-inf

182 Related enhancers colocalize to the same microenvironments independently of their chromosomal loc

183 a result of the differential response to the microenvironment induced by biological stimuli.

184 Gene signature-based tumor microenvironment inference revealed a decrease in invadi

185 ted with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA

186 The bone marrow microenvironment influences malignant hematopoiesis, but

187 f ILCs, little is known about how the tissue microenvironment influences the plasticity, phenotype, a

188 he research in multiple areas, including the microenvironment inside live tissues, cell-cell communic

189 A hypoxic microenvironment is a hallmark for solid tumors.

190 Thus, the wound microenvironment is a key determinant of Schwann cell id

191 However, whether quantifying T cell-inflamed microenvironment is a useful pan-tumor determinant of PD

192 The microenvironment is an important regulator of hematopoie

193 programmed cell death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive

194 eutic targets derived from the hypoxic tumor microenvironment is of major importance.

195 ilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjusting the structure

196 and functional orientation within the tumor microenvironment is regulated by beta2-adrenergic recept

197 e complex immunological interplay within the microenvironment is required.

198 -derived suppressor cells (MDSC) in melanoma microenvironment is supported by chemokine receptor/chem

199 The tumour microenvironment is very complex, and essential in tumou

200 the adaptation of cancer cells to the tumor microenvironment is vital for subsequent oncogenesis, we

201 for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets.

202 ction, all of which may perpetuate a noxious microenvironment leading to pain.

203 ur results reveal how LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC d

204 thesize that specific targeting of the tumor microenvironment may constitute an alternative or additi

205 an prostate cancer cells and the bone marrow microenvironment mediate bone metastasis during prostate

206 ic changes triggered by interaction with the microenvironment modulate cancer cell phenotypes and pro

207 tumor progression, clarifying how the tumor microenvironment modulates ECM homeostasis control.

208 umor morphogens that impose order within the microenvironment, much like signaling molecules convey p

209 ely affected gene expression in the cervical microenvironment of HPV-transgenic mice compared with no

210 ression to micrometastases; as well as tumor microenvironment of metastasis function, the hallmark of

211 new type of protumorigenic CAF in the tumor microenvironment of neuroblastoma and to STAT3 and ERK1/

212 ould ultimately, by characterizing the tumor microenvironment of patients who have been treated with

213 cted by a rebinding model that considers the microenvironment of postsynaptic D2 receptors and integr

214 Here, we identify dense innervation in the microenvironment of precancerous pancreatic lesions, kno

215 Thus, microenvironments of high local transcription factor and

216 encounters many pressures within the various microenvironments of its human host as the disease cours

217 heir week-long journey through the different microenvironments of the fly s interior organs, the ince

218 n three-dimensional maps of the tumor immune microenvironment, offering a new tool to examine tumor h

219 To better understand the effect of the BM microenvironment on drug responses in AML, we conducted

220 a DC-poietic organ, which provides selective microenvironments permissive for DC development.

221 The mechanical properties of the microenvironment play a large role in influencing cellul

222 urvival time in vivo, indicating that tissue microenvironment plays a critical role in promoting AML

223 The tumor microenvironment plays an important role in tumor growth

224 RNA to the acidic (pH approximately 6) tumor microenvironment, PNAs were conjugated to pH-low inserti

225 The tumor microenvironment presents metabolic constraints to immun

226 ta provide evidence that nerves of the PanIN microenvironment promote oncogenesis, likely via direct

227 sion and stabilization within the hypoxic BM microenvironment promotes disease progression, therapy r

228 r cell deposition of tenascin-C in the tumor microenvironment promotes invasive migration and metasta

229 matrix glycoprotein tenascin-C in the tumor microenvironment promotes invasive migration and metasta

230 l1 adhesin specifically recognizes the wound microenvironment, promotes adhesion and biofilm formatio

231 The microenvironment provides a functional substratum suppor

232 e, reprogramming of PGE2 metabolism in tumor microenvironment provides an opportunity to reduce immun

233 ate that after metastatic dissemination, the microenvironment provides signals to promote phenotype s

234 antigens, overcome immunosuppressive tumour microenvironments, reduce toxicities, and prevent antige

235 tolytic molecules suggests that the decidual microenvironment reduces CD8(+) dT effector responses to

236 Extracellular matrix signals from the microenvironment regulate gene expression patterns and c

237 r data fuels the view that the extracellular microenvironment regulates synaptic NMDAR signaling.

238 rs within the cellular and the extracellular microenvironment regulating oligodendrocyte properties a

239 opic tumor suppressor, but its role in tumor microenvironment regulation is poorly characterized.

240 products, the function of 5-LO in the tumor microenvironment remains unclear.

241 ession: modulation of immune response, tumor microenvironment reprogramming, and metastasis.

242 of sustained immune activation in the tumour microenvironment restricts antitumour immunity.

243 3-acetate and ionomycin, recapitulating CAVD microenvironment, resulted in IFN-gamma release.

244 rupt the interaction of CLL cells with their microenvironment, resulting in induced cell death.

245 er, persistent antigen exposure in the tumor microenvironment results in sustained LAG3 expression, c

246 unication between cancer cells and the tumor microenvironment results in the modulation of complex si

247 rion infectivity within the cervid pregnancy microenvironment, revealing a source of fetal CWD exposu

248 To test the non-tumor cell microenvironment role of RAGE, we performed syngeneic st

249 These data suggest that DDR2 is a microenvironment sensor that regulates fibroblast migrat

250 this effect depends on the cells' mechanical microenvironment.-Shumakovich, M.

251 ave showed preferential BTZ release in tumor-microenvironment, specific binding to MM cells, and an i

252 ikely precipitate within particle-associated microenvironments supplied with additional barium and su

253 The tumor microenvironment supplies proinflammatory cytokines favo

254 w that bone marrow adipocytes from the tumor microenvironment support the survival and proliferation

255 yield information regarding the hydrophobic microenvironment surrounding the reactive AO group, and

256 will facilitate drug screening in a relevant microenvironment thanks to its simple, effective and use

257 tome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasio

258 ages are prominent immune cells in the tumor microenvironment that exert potent effects on cancer met

259 itis causes long-term changes in the corneal microenvironment that influence immune responses to subs

260 sical and biological parameters of the tumor microenvironment that mediate intravasation of tumor cel

261 l need also to target elements of the tumour microenvironment that promote glioma progression.

262 (CAFs) are major components of the carcinoma microenvironment that promote tumor progression.

263 1, Rapamycin, and IL-2, to locally sustain a microenvironment that promotes Treg differentiation.

264 ear subsea alkaline hydrothermal vents embed microenvironments that make them potential hot spots for

265 arriers for nano-carriers presented in tumor microenvironment, the characteristics and formation meth

266 tic resistance of GBM cells to RT in hypoxic microenvironments through enhanced activation of caspase

267 to the metabolic constrains within the tumor microenvironment (TME) and to what degree this affects t

268 While it is clear that the tumor microenvironment (TME) contributes to cancer cell plasti

269 The tumor microenvironment (TME) in pancreatic ductal adenocarcino

270 T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming

271 y of PD-L1(+) and PD-1(+) cells in the tumor microenvironment (TME) of cHL.

272 ll-intrinsic mechanisms in addition to tumor microenvironment (TME)-mediated extrinsic resistance.

273 a mechanism by which T cells regulate the DC microenvironment to control DC-induced T-cell responses

274 folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tum

275 ve to overcome challenges in the host tissue microenvironment to metastasize successfully to distant

276 hages in integrating signals from the immune microenvironment to promote innate type 2 immunity, and

277 at condition pre-metastatic niches in remote microenvironments to favor metastasis.

278 y multiple approaches in the tumor and tumor microenvironment, to inhibit the metastatic process.

279 which reprograms the immunosuppressive tumor microenvironment toward immunostimulation and improves d

280 a subset of regulatory T cells in the tumor microenvironment triggers Treg instability locally and r

281 spite the presence of TLR ligands within the microenvironment, tumors progress, and the mechanisms th

282 heterogeneity in colorectal tumors and their microenvironments using single-cell RNA-seq from 11 prim

283 -cell lung cancer tumours generate their own microenvironment via activation of Notch signalling in a

284 d a crucial determinant of immunosuppressive microenvironment via recruiting Treg cells by directly t

285 igration involving stimulation of the thymic microenvironment via type 2 cytokines from innate T cell

286 anisms to increase LIGHT in the colon cancer microenvironment warrant further investigation and hold

287 cells (ECs), a critical component of the BM microenvironment, was sufficient to drive hematopoietic

288 or cell-intrinsic and non-tumor cells of the microenvironment, we performed in vivo treatment of xeno

289 derstanding of living cells as well as their microenvironment which is needed to assess the developme

290 cell is determined by its genetic makeup and microenvironment, which dynamically modulates the tumor

291 f acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-assoc

292 novel epigenetic changes in the bone marrow microenvironment, which lead to beta-catenin activation

293 tending in an ordered array as the catalytic microenvironment, which shows significant esterase activ

294 We argue that mesic microenvironments will act as species-specific refugia o

295 d indirectly by promoting an antitumor brain microenvironment with a key protective role played by th

296 pture the cellular interactions of the tumor microenvironment with high-resolution imaging, we direct

297 nique enables characterization of the glioma microenvironment with respect to the disease-driving cel

298 nistically linked obesity and an obese tumor microenvironment with signaling pathways that predict ag

299 Glioblastoma (GBM) contains diverse microenvironments with uneven distributions of oncogenic

300 take in various tumors and their surrounding microenvironment, with a special emphasis on the role of