ライフサイエンスコーパス: microgravity

1 t animal and its symbiont use during modeled microgravity.

2 t, has emerged as a possible major impact of microgravity.

3 otein during cardiac adaptation in simulated microgravity.

4 ts were clustered in the subapical region in microgravity.

5 and matrix were measured after activation in microgravity.

6 How cells (might) sense microgravity.

7 orientation of the FN matrix after 27.5 h in microgravity.

8 ease PDGF-BB showed significant responses in microgravity.

9 ctivated osteoblasts even during exposure to microgravity.

10 action data collected from crystals grown in microgravity.

11 n pulmonary function that occur in sustained microgravity.

12 late the host stress responses under modeled microgravity.

13 visual impairments in astronauts exposed to microgravity.

14 c reticulum were differentially modulated in microgravity.

15 e observed in the 3D culture under simulated microgravity.

16 ty, and gene expression was suppressed under microgravity.

17 d with limb muscles, which were unaltered in microgravity.

18 f fluctuations during transient diffusion in microgravity.

19 ts to ameliorate some effects of exposure to microgravity.

20 mals spending nine days (from P15 to P24) in microgravity.

21 N mRNA synthesis is significantly reduced in microgravity (0-G) when compared to ground (GR) osteobla

22 easured by RT-qPCR, was also up-regulated in microgravity (+12.94, +2.98 and +16.85 fold respectively

23 4 +/- 2 mmHg) and ICP (supine, 17 +/- 2 vs. microgravity, 13 +/- 2 mmHg) were reduced in acute zero

24 central venous pressure (supine, 7 +/- 3 vs. microgravity, 4 +/- 2 mmHg) and ICP (supine, 17 +/- 2 vs

25 y (parabolic flight) and prolonged simulated microgravity (6 deg head-down tilt bedrest).

26 tions induced by thermophoretic diffusion in microgravity, a regime not accessible to analytical calc

27 istimulation, and (iii) in the stimulus-free microgravity aboard the Space Shuttle.

28 In addition, microgravity affects virulence, growth kinetics, and bio

29 Exposure to microgravity alters the distribution of body fluids and

30 esults reported here indicate that simulated microgravity alters the expression of miRNAs and genes i

31 Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid

32 Microgravity and 3D culture can profoundly modulate cell

33 indlimb unloading (HU) is an animal model of microgravity and bed rest.

34 rcadian timing of crews exposed to prolonged microgravity and confinement.

35 closing volume was approximately the same in microgravity and in normal gravity, emphasizing the impo

36 Microgravity and unloading are known to cause osteoclast

37 ht, quiescent osteoblasts were launched into microgravity and were then sera activated with and witho

38 All astronauts had previous exposure to microgravity and, thus, control data were not available

39 eton as an active site of rapid bone loss in microgravity, and indicate that this loss is not limited

40 h in experiments using vibrated grains under microgravity, and we describe novel predicted spatiotemp

41 ich simulates the headward fluid shifting in microgravity, as spaceflight analogues.

42 g centrifuged or ground controls, confirmed microgravity-associated apoptosis.

43 uous extravehicular activities or to monitor microgravity-associated changes in musculoskeletal anato

44 In adapting to acute plethora in microgravity, astronauts' red-cell mass falls too rapidl

45 h suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic

46 ouse islets cultured in stationary dishes or microgravity bioreactors were transplanted to streptozot

47 f amyloplasts per cell remained unchanged in microgravity but decreased on the clinostat, and (iii) t

48 at individual amyloplast volume increased in microgravity but remained constant in seedlings grown fo

49 hat pulmonary function is greatly altered in microgravity, but none of the changes observed so far wi

50 d trabecular bone surfaces also increased in microgravity by 170% (p = 0.004), indicating osteoclasti

51 Cell growth was stimulated in microgravity by increasing serum concentration.

52 cephalogram (EEG) arousals also decreased in microgravity (by 19%), and this decrease was almost enti

53 e, a combination of 3D culture and simulated microgravity can be used to efficiently generate highly

54 a possible physiological explanation for how microgravity can cause symptoms similar to those seen in

55 Exposure to microgravity can result in a spectrum of intraorbital an

56 These data support our conclusion that in microgravity cardiomyocytes attempt to maintain mitochon

57 Myofibril force measurements revealed that microgravity caused a 3-fold decrease in specific force

58 Microgravity condition decreases immunogenicity and sign

59 s was changed significantly in the simulated microgravity condition including miR-150, miR-34a, miR-4

60 Under microgravity conditions and at steady-state, non-equilib

61 ant (P < 0.05) suppression of 85 genes under microgravity conditions compared to normal gravity sampl

62 RNA-Seq analysis of squid exposed to modeled microgravity conditions exhibited extensive differential

63 Human bladder 5637 cells cultivated under microgravity conditions formed organoids that displayed

64 The crystals were grown under microgravity conditions on Space Shuttle mission STS-67.

65 remedy these problems we cultured islets in microgravity conditions to improve their function and to

66 R2, ETS1, and c-REL was altered in simulated microgravity conditions.

67 NA (miRNA) and related genes under simulated microgravity conditions.

68 st 24 h of activation using both spaceflight microgravity culture and a ground-based model system tha

69 hibition of T cell proliferative response in microgravity culture is a result of alterations in signa

70 nvolvement was confirmed with a ground-based microgravity culture model.

71 lation of purified T cells with Bead-Leu4 in microgravity culture resulted in the engagement and inte

72 uble anti-CD3 (Leu4) in clinorotation and in microgravity culture shows a dramatic reduction in surfa

73 en T cells were stimulated with Bead-Leu4 in microgravity culture, they were able to partially expres

74 only partial expression of CD25 occurred in microgravity culture.

75 Prolonged periods of simulated microgravity did not cause progressive elevations in ICP

76 Microgravity does not significantly alter the volume of

77 The microgravity environment during space flight imposes num

78 little is known regarding the effects of the microgravity environment of space flight upon the action

79 re, a corresponding 24-hour average TLCPD in microgravity environment was simulated to be 6.7mmHg.

80 To simulate the microgravity environment, host squid and symbiosis-compe

81 for subject and operator to facilitate US in microgravity environment.

82 of connective tissue might be impaired in a microgravity environment.

83 photosynthetic functions are affected by the microgravity environment.

84 known, particularly for the spaceflight (SF) microgravity environment.

85 did not occur while the animals were in the microgravity environment.

86 s an adaptation of the flight animals to the microgravity environment.

87 ed time under conditions of minimal gravity (microgravity) experience an array of biological alterati

88 ndividing human fibroblast cells in culture, microgravity experienced in space has little effect on g

89 ower in sponges from animals with 10 days of microgravity exposure (P<0.01, ANOVA) and further reduce

90 and results published earlier indicate that microgravity exposure augments sympathetic, and diminish

91 during early microgravity exposure, fell as microgravity exposure continued, and descended to prefli

92 during early microgravity exposure, rose as microgravity exposure continued, and drifted back to pre

93 R intervals) rose significantly during early microgravity exposure, fell as microgravity exposure con

94 preflight levels: pressure fell during early microgravity exposure, rose as microgravity exposure con

95 on and identify changes, if any, provoked by microgravity exposure.

96 16-week-old female C57BL/6J mice (n = 8) to microgravity for 15-days on the STS-131 space shuttle mi

97 ture environment has also been used to model microgravity for ground-based studies regarding the impa

98 In comparison with static 1 x g, microgravity has been shown to alter global gene express

99 ased animal models simulating the effects of microgravity have shown that decrements in cerebral perf

100 Actual microgravity, however, has been shown to either increase

101 mune response was suppressed under simulated microgravity; however, there was an acceleration of bact

102 It is unclear, however, how microgravity impacts those cellular interactions between

103 y, we tested the hypothesis that exposure to microgravity impairs autonomic neural control of sympath

104 , and tested the hypothesis that exposure to microgravity impairs sympathetic as well as vagal barore

105 Simulated microgravity impairs vagal baroreceptor-cardiac reflex f

106 , we found that these macrophages adapted to microgravity in an ultra-fast manner within seconds, aft

107 in spinal cord tissue from animals reared in microgravity in comparison with 1G-reared controls.

108 h either in the rotating condition to model microgravity in space or in the static condition as a co

109 ng cultured cells will sense the presence of microgravity in space.

110 The surprisingly ultra-fast adaptation to microgravity indicates that mammalian macrophages are eq

111 herefore, this study offers new evidence for microgravity-induced osteocytic osteolysis, and CDKN1a/p

112 in a clinostat to produce a vector-averaged microgravity-like environment.

113 eviously demonstrated that low-shear modeled microgravity (LSMMG) under optimized rotation suspension

114 transitions from a 1 g linear force field to microgravity (<1 g); however, it appears that the three-

115 logical perturbations in cardiac function in microgravity may be a consequence of alterations in mole

116 rrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architec

117 that bull sperm swim with higher velocity in microgravity (microG) than at 1 G.

118 ound-based studies of the effects of modeled microgravity (MMG) on cell-mediated immunity.

119 rica serovar Typhimurium grown under modeled microgravity (MMG) were more virulent and were recovered

120 the analogous immune suppression observed in microgravity, MMG, and aging, further investigation may

121 We previously showed that simulated microgravity (muXg) using the NASA developed rotary cell

122 Microgravity, obtained during parabolic flight aboard NA

123 Lack of immune response in microgravity occurs at the cellular level.

124 ve) cells of Zea mays seedlings grown in the microgravity of outer space allocate significantly less

125 Given that microgravity of space and SMG also compromise human immu

126 tested the hypothesis that adaptation to the microgravity of space impairs sympathetic neural respons

127 Some of the observed effects of microgravity on head and arm movement control appear to

128 Despite the observed severe effects of microgravity on mammalian cells, many astronauts have co

129 otion; therefore, we examined the effects of microgravity on mouse shoulder muscles for the 15-d Spac

130 nature of their pathologies, the effects of microgravity on pathophysiology, and the alterations in

131 We have investigated the effects of microgravity on root nodule formation, with preliminary

132 ould yield new information on the effects of microgravity on the biological activities of various cla

133 the first to report the effects of simulated microgravity on the expression of miRNA and related gene

134 een conducted in space or by using simulated microgravity on the ground have focused on the growth or

135 In this study, we examine the impact of microgravity on the interactions between the squid Eupry

136 We examined the impact of simulated microgravity on the timeline of bacteria-induced develop

137 ture during flight, rather than an effect of microgravity on uropontin synthesis.

138 neonatal cardiomyocytes exposed to simulated microgravity or normal gravity.

139 or 2 weeks either in the absence of gravity (microgravity) or at 1G.

140 Microgravity, or an altered gravity environment differen

141 Removal of loading via microgravity, paralysis, or bed rest leads to rapid loss

142 al volume was unexpectedly reduced by 18% in microgravity, possibly because of uniform alveolar expan

143 Continued loading in microgravity prevents atrophy, but masticatory muscles h

144 Intestinal cells grown in microgravity produce a three-dimensional tissue assembly

145 We confirmed experimentally that in microgravity protein synthesis was decreased while apopt

146 Microgravity provides unique, though experimentally chal

147 se interactions occur in a confined space in microgravity, providing ample opportunity for heavy micr

148 ut experienced presyncope after the mission, microgravity provoked major changes.

149 During space travel, exposure to microgravity, radiation, and stress alter human immunore

150 trast to prevailing theory, we observed that microgravity reduces central venous and intracranial pre

151 We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impa

152 pace medicine, incorporating past studies of microgravity-related conditions and their terrestrial co

153 host health and examining its resiliency in microgravity represents a new frontier for space biology

154 te that the environment created by simulated microgravity represents a novel environmental regulatory

155 The reduction in gravity, or microgravity, represents a novel environment that can di

156 f Escherichia coli under low-shear simulated microgravity (SMG) conditions resulted in enhanced stres

157 stem can be used for a variety of controlled microgravity studies of cartilage and other tissues.

158 cation of cTnI up-regulated during simulated microgravity suggests a potential role of the NH(2)-term

159 erating deltoid muscle was more sensitive to microgravity than the joint-stabilizing rotator cuff mus

160 ugh the fetal otolith organs are unloaded in microgravity, the fetus' semicircular canals receive hig

161 ntermeasures probably reduced the effects of microgravity, the results support the idea that ground-b

162 stigates the health effects of adaptation to microgravity: the nature of their pathologies, the effec

163 n the absence of the symbiont during modeled microgravity there was an enrichment of genes and pathwa

164 Following exposure to microgravity, there is a reduced ability of astronauts t

165 m cells and exposed the spheres to simulated microgravity using a random positioning machine for 3 da

166 catory and appendicular muscles responses to microgravity, using mice aboard the space shuttle Space

167 Microgravity was associated with a 55% reduction in the

168 Instead amyloplasts in microgravity were grouped near the cell centers while th

169 In summary, muscle responses to microgravity were muscle-type specific, short-duration S