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1 ein, Unc119, varies between subnanomolar and micromolar.
2 ater sulfate concentrations of less than 2.5 micromolar.
3 n constants ranging from subnanomolar to low micromolar.
4 tion equilibrium constants from picomolar to micromolar.
5 d their already substantial proliferation in micromolar 4-hydroxytamoxifen and fulvestrant/ICI 182,78
8 ted analogue of apoptolidin A, displayed sub-micromolar activity against H292 lung carcinoma cells.
10 ty (Ki = 38 pM), coupled with a single-digit micromolar activity against Trypanosoma brucei brucei (E
11 activate adenosine receptors (ARs) revealed micromolar activity at serotonin 5HT2B and 5HT2C recepto
13 Both types of Aip1 bind actin filaments with micromolar affinities and weakly nucleate actin polymeri
14 pe II NKT TCR binds with CD1d-bound LPC with micromolar affinities similar to that for sulfatide.
15 ide-based inhibitor scaffold that showed sub-micromolar affinities toward collagenase H (ColH) from t
18 found to bind human IL-12 (hIL-12) with low micromolar affinity and increase hIL-12 bioactivity by m
19 Lipid binding by purified MpPR-1 occurs with micromolar affinity and is saturable in vitro Sterol bin
20 ts bind the IL-36R extracellular domain with micromolar affinity but do not detectably bind IL-1RAcP.
21 domains of Myo10 and DdMyo7 bind to MT with micromolar affinity but, surprisingly, their MT binding
22 mor potency and systemic off-tumor toxicity, micromolar affinity CAR T cells demonstrated superior an
25 ne of these derivatives (DCUK-OEt) displayed micromolar affinity for brain gamma-aminobutyric acid ty
27 region, and show that they all have nano to micromolar affinity for HSA Peptide 40 and nab-paclitaxe
28 e 4-acylpyrrole 6 which shows a single-digit micromolar affinity for the CREBBP bromodomain and a lig
32 ysine mimetic ligands ranging from mM to low micromolar affinity that were identified using fragment
33 its isolated N and C domains, bind with low micromolar affinity to a heme-free, truncated version of
34 to p97, showing that ataxin3 binds with low-micromolar affinity to both wild-type p97 and mutants li
36 ionally, we show that CASPR2 associates with micromolar affinity with CNTN1 but, under the same condi
37 GEF catalytic activity, binding to SOS1 with micromolar affinity, and disrupting GEF-Ras interaction.
38 orter binds to cholate and deoxycholate with micromolar affinity, and transport assays performed on i
39 ch peptide was able to bind DNA and RNA with micromolar affinity, but did not display nuclease activi
41 icient to mediate specific interaction, with micromolar affinity, with all the class IIa HDACs (HDACs
49 lion fragments, which revealed another three micromolar agonists unrelated either to 28 or known musc
51 ion at coastal and open ocean sites with sub-micromolar ammonia/ammonium concentrations was inhibited
53 y congener within this series to demonstrate micromolar antihuman cytomegalovirus (HCMV) potency.
54 entified specific inhibitors of Mtb ADK with micromolar antimycobacterial activity and low cytotoxici
55 (where p-cym=para-cymene) exhibit potent sub-micromolar antiproliferative activity towards human canc
58 p of a protein domain; the protein exhibited micromolar binding affinity for the MVCB[8] complex, mat
59 zolidinedione fragment was found to have low micromolar binding affinity to the zinc metalloenzyme ca
64 s nanomolar Ch fluctuations, on top of which micromolar Ch increases occurred during periods of theta
65 e, we show both l- and d-BTZ enantiomers are micromolar competitive betaLIs of all MBL classes in vit
66 hat transient calcium increase up to tens of micromolar concentration at the micro/nano domain trigge
67 they allow the detection of fluoride ions at micromolar concentration by the naked eye, UV-vis absorp
69 st the bacterial challenge was observed at a micromolar concentration of Ceftriaxone or Cefotaxime in
70 The best compound was active in a very low micromolar concentration range against all three transpo
71 promising anti-influenza activity in the low micromolar concentration range and good selectivity.
72 chitooligosaccharides with Kd values in the micromolar concentration range and that the binding ener
74 tion of ciproxifan revealed IC50 values in a micromolar concentration range for human and rat monoami
75 Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a nonspecific cell
78 n cytomegalovirus (HCMV) replications at low micromolar concentration, with little or no cytotoxicity
79 0.1) and cooperative substrate inhibition at micromolar concentrations ([S](1/2) = 740 +/- 240 nm; n
81 against schistosomula and adult worms at low micromolar concentrations and therefore represent promis
82 y source for biological reactions, for which micromolar concentrations are sufficient, we propose tha
83 lass of small molecules that function at low micromolar concentrations as both beta- and beta,delta-e
84 e found that 3-NOP indeed inactivates MCR at micromolar concentrations by oxidation of its active sit
86 be detected within the same analysis time as micromolar concentrations detected without the use of th
88 MPs, which may explain why most AMPs require micromolar concentrations for activity, show significant
89 related congeners inhibited melanogenesis at micromolar concentrations in B16 mouse melanoma cells, n
90 assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammator
96 imize an enzyme-coupled assay to measure low micromolar concentrations of acetate, coupling acetate p
99 ivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultan
102 olated transgenic keratinocytes to show that micromolar concentrations of MFQ attenuated increased ma
103 from nitrate and resulted in accumulation of micromolar concentrations of nitric oxide during denitri
104 hat had undergone a more chronic exposure to micromolar concentrations of nitric oxide showed an appr
105 onsequence (gravitropism), were inhibited by micromolar concentrations of NPPB that did not affect gr
107 er millimolar concentrations of ornithine or micromolar concentrations of putrescine or by complement
111 ulated >2-fold but potently inhibited by low micromolar concentrations of the oxidizing reagent coppe
113 mu-EME salt removal from samples containing micromolar concentrations of the target analytes and 150
116 tes able to inhibit virus replication at low micromolar concentrations with no significant toxicity t
117 ation, and quantification of analytes at low-micromolar concentrations, provided they can weakly asso
118 antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure
119 hantom images provide sufficient contrast at micromolar concentrations, showing promise for eventual
146 1 activity in the presence of physiological (micromolar) concentrations of Ca(2+) ions, as long as Mg
149 e that single-stranded RNAs bind to PKR with micromolar dissociation constants and can induce activat
150 ow doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroid
151 infected neuroblastoma cells by >90% at low micromolar doses, and inhibits PrP(Sc)-induced synaptoto
159 nal topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer frag
161 inylmethylene)aniline) ]Cl (4) displayed low micromolar IC50 values in ovarian cancers (A2780, A2780c
165 nhibited representative deubiquitinases with micromolar IC50, and its proapoptotic activity was studi
167 iniums as a promising scaffold with very low micromolar (IC50 approximately 1 muM) NNMT inhibition.
168 es, including a phthalimide derivative, show micromolar IC50s and KDs while demonstrating cytotoxicit
169 6-inducible Axl receptor activation with low micromolar IC50s in cell-based reporter assays, inhibit
175 A gyrase inhibitors, some of which exhibited micromolar inhibition of E. coli topoisomerase IV and of
177 lkaloid oroidin analogues, we identified low micromolar inhibitors of Escherichia coli DNA gyrase bas
179 e anomeric in the sugar were found to be low micromolar inhibitors of the alpha-glucosidase from bake
183 using OctetRed instrument, which yielded low micromolar KD against GtfB and nanomolar KD against GtfC
184 molar range for choline and glycine betaine, micromolar Kd for stachydrine and trigonelline and a Kd
187 igh affinity binding, characterized by a low micromolar Kd, that is selective for the murine Importin
188 for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete deple
190 goal of engineering an hASNase3 variant with micromolar KM, we conducted a structure/function analysi
191 imization of a series of naphthyridones from micromolar leads with no selectivity over the BET bromod
192 pound 50), showed inhibition on PRMT1 at the micromolar level and 6- to 25-fold selectivity over CARM
193 nd pancreatic adenocarcinoma cells generated micromolar level H2O2 during just 1 min of direct CAP tr
194 al-time detection of cellular glucosamine at micromolar level in living Caco-2 cells is also demonstr
196 tection of primary alkylamines in water at a micromolar level, based on a cavitary recognition proces
197 o the occluded E2(2K), where free Pi (at the micromolar levels found in millimolar ATP solutions) pro
198 se potent kinase inhibitors demonstrated low micromolar levels of inhibition of the Trypanosoma bruce
199 tion of ligand efficient lead molecules with micromolar levels of inhibition, cellular activity, and
206 yperpolarization allows DOSY analysis of low-micromolar mixtures, thus reducing the concentration req
209 idase enzymes with Ki and IC50 values in the micromolar/nanomolar concentration range and further sub
212 zolines with EC50 values in the single digit micromolar or high nanomolar range in addition to favora
213 ides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activiti
216 old led to the discovery of ligands with low micromolar potency (KD = 4 muM) and selectivity for BCL-
219 situ in the veins of live animals, achieving micromolar precision over many hours without the use of
220 ritical threshold concentration (approaching micromolar) prior to the observation of HIV-1 Gag associ
221 show that domain swapping of FoxP1 occurs at micromolar protein concentrations within hours of incuba
224 All probes exhibited affinities in the low micromolar range (1.6 muM < Kd < 14.6 muM) and had rapid
226 play almost identical IC50 values in the sub-micromolar range (25-335-fold more active than cisplatin
227 icardipine, nilotinib, and sorafenib) or low micromolar range (abiratone, candesartan, celecoxib, das
228 on of the ING3PHD with H3K4me3 is in the sub-micromolar range (KD ranging between 0.63 and 0.93 mum)
229 ave minimal inhibitory concentrations in the micromolar range against a range of bacteria and fungi.
231 d BChE with IC50 values in submicromolar and micromolar range and exhibited selective inhibitory acti
232 with high affinities in the nanomolar to low-micromolar range and have two phosphoinositide (PIP)-bin
234 3 domain with a dissociation constant in the micromolar range and modifies its tertiary structure lea
235 ntagonists at the GPRC6A receptor in the low micromolar range and show that 7 and 34b display >9-fold
236 ent inhibitor shows an IC50 value in the low micromolar range and successfully abolishes the synthesi
237 oducible sensitivity towards H2O2 in the low micromolar range and towards antimalarial compounds at p
240 a pseudotyped infection model was in the low micromolar range for fullerenes with 12 and 36 mannoses.
241 ng potencies in the nanomolar and in the low micromolar range for hMAO B and eeAChE, respectively, we
242 udies revealed binding affinities in the low micromolar range for polymeric substrates that are due i
243 ch as DRI-C21045, activity (IC50) in the low micromolar range has been confirmed in cell assays inclu
244 inhibitory concentrations (MICs) in the low micromolar range in addition to favorable physicochemica
245 tained concentrations within the stimulatory micromolar range in contrast to previously reported pico
246 these compounds have IC50 values in the low micromolar range in Pf lines and low toxicity in human A
247 hibited HIV RT-associated RNase H in the low micromolar range in the absence of significant inhibitio
248 inhibited the growth of Mtb cells in the low micromolar range indicating that cleavage specificity of
249 t DNA polymerase activity of HIV-1 RT in the micromolar range while retaining potency against RT vari
250 wed substantial potency against HIV-1 at low micromolar range while the parent nucleosides were not e
251 ed numerous analogues inhibiting TDP2 in low micromolar range without appreciable inhibition against
252 yl group (9 and 10) inhibited RNase H in low micromolar range without significantly inhibiting RT pol
253 s compound binds with an affinity in the low micromolar range yet exerts suitable unexpected selectiv
254 d ISEs have poor limits of detection (in the micromolar range) relative to conventional solid-contact
255 onist activity profile at mGlu2 (EC50 in the micromolar range), whereas 2c/2d were both selective ago
258 nds obtained exhibited MIC values in the low micromolar range, excellent intracellular antimycobacter
259 d RB3 - that penetrate the brain and, in the micromolar range, inhibit phosphorylation of ERK, histon
260 Even at starting concentrations in the low micromolar range, KcsA has a tremendous impact on the su
261 with a reported apparent affinity in the low micromolar range, making it an interesting lead compound
263 ient and binding affinity of proteins in the micromolar range, the implementation of modern detection
264 at concentrations of the peptide in the low micromolar range, the mid-point of the inhibition being
266 hat inflicted outer membrane damage at a low micromolar range, whereas measurable bacterial growth in
267 gyrase from Escherichia coli were in the low micromolar range, with the best compound, (4-(4,5-dibrom
288 structural states was perturbed only by high micromolar [S100A1], which promoted a shift of bound CaM
293 ta relating to their activity range from low micromolar to sub-nanomolar EC50, the most interesting c
294 C analyzer meant that low concentration (few micromolar to submicromolar), highly turbid subglacial m
297 ost sensitive, with Kd values in the tens of micromolar, whereas the C2D domain was least sensitive,
298 Sestrin2 with a dissociation constant of 20 micromolar, which is the leucine concentration that half
299 ils (Kd values are submillimolar rather than micromolar) yet physiologically relevant because of the
300 ities of KLK2, i.e. reversible inhibition by micromolar Zn(2+) concentrations and permanent inactivat
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