ライフサイエンスコーパス: micromolar concentration

1 totoxicity against M14 melanoma cells at low micromolar concentration.

2 found to have enzyme inhibition activity at micromolar concentration.

3 d GPR35 of all three species at similar, low micromolar concentration.

4 y against a variety of bacterial taxa at low micromolar concentrations.

5 acid, inhibit FAAH activity in vitro at low micromolar concentrations.

6 effect on different tumor cell lines at low micromolar concentrations.

7 nown to be present in the mammalian brain at micromolar concentrations.

8 nd induced apoptosis in MM cell lines at low micromolar concentrations.

9 ell death during exposure for 24-48 h at low micromolar concentrations.

10 y-five arylstibonic acids showed activity at micromolar concentrations.

11 e., MOMIPP) that can induce methuosis at low micromolar concentrations.

12 f both CCR5- and CXCR4-using isolates at low micromolar concentrations.

13 ase domain to trigger its kinase activity at micromolar concentrations.

14 norketamine mimicked ketamine effects at sub-micromolar concentrations.

15 BG inhibits voltage-gated sodium channels at micromolar concentrations.

16 ining series that blocks this interaction at micromolar concentrations.

17 d transient increases in dopamine (DA) up to micromolar concentrations.

18 colloidal aggregates in aqueous solution at micromolar concentrations.

19 inhibited pUL89 endonuclease activity at low-micromolar concentrations.

20 rs and more complex quaternary structures at micromolar concentrations.

21 f the peptide, that occur in response to sub-micromolar concentrations.

22 was significantly inhibited by both drugs at micromolar concentrations.

23 good quality Raman spectra of carbendazim at micromolar concentrations.

24 orophore, also produced photopotentiation at micromolar concentrations.

25 AKT activation and causing apoptosis at low micromolar concentrations.

26 escence reduction is the dominant pathway at micromolar concentrations.

27 nhibited AR expression in LNCaP cells at low micromolar concentrations.

28 from additive to synergistic activity at low micromolar concentrations.

29 nd can be primed with fatty-acyl ACPp at low-micromolar concentrations.

30 plicing both in vivo and in vitro at similar micromolar concentrations.

31 of synaptic activity by Abeta42 oligomers at micromolar concentrations.

32 found to have enzyme inhibition activity at micromolar concentrations.

33 entrations but can form larger assemblies at micromolar concentrations.

34 the substrate APS to inhibit the reaction at micromolar concentrations.

35 tein and RNA expression, was achieved at low micromolar concentrations.

36 report that furamidine inhibits Tdp1 at low micromolar concentrations.

37 a fungal pathogen, Fusarium graminearum, at micromolar concentrations.

38 mposition, and overall amount of cysteine at micromolar concentrations.

39 revented growth of cultured parasites at low micromolar concentrations.

40 sn-2-azelaic acid, induced apoptosis at low micromolar concentrations.

41 were found to block viral replication at low micromolar concentrations.

42 for label-free DNA detection at picomolar to micromolar concentrations.

43 L. mexicana-infected J774 macrophages at low micromolar concentrations.

44 ranes mimicking bacterial inner membranes at micromolar concentrations.

45 bling to form homooligomeric bundles when in micromolar concentrations.

46 nhibits the activity of both isoforms at low micromolar concentrations.

47 ts cytochrome P450-dependent enzymes only at micromolar concentrations.

48 ibits fibrillogenesis of misfolded TTR under micromolar concentrations.

49 it more than 99% of HIV-1 infectivity at low micromolar concentrations.

50 ll growth, and induction of apoptosis at low micromolar concentrations.

51 er KDMs, as well as cellular activity at low micromolar concentrations.

52 sive methods for identifying analytes at sub-micromolar concentrations.

53 of complexes (0-24 h) in phosphate buffer at micromolar concentrations.

54 urospora crassa and Fusarium graminearum, at micromolar concentrations.

55 o 2-l-fucose (2F-Fuc) reduces root growth at micromolar concentrations.

56 intermediate BrO2(*) indirectly detected at micromolar concentrations.

57 ns to detect cytosolic peptide import at low micromolar concentrations.

58 ta-glucosidase activity in live cells at low-micromolar concentrations.

59 human and mouse breast cancer cells at high micromolar concentrations.

60 also demonstrated antiviral activity at low micromolar concentrations.

61 d selectively inhibiting WNV and DENV at low micromolar concentrations.

62 an form complexes with coralyne, even at low micromolar concentrations.

63 rupt MAPK and PI3K signaling in cells at low micromolar concentrations.

64 iazines as covalent protein modifiers at low micromolar concentrations.

65 t substrate inhibition of chain formation at micromolar concentrations.

66 ergic, and neuroprotective properties at low-micromolar concentrations.

67 yprotein synthesis was reduced <50%, even at micromolar concentrations.

68 one hand, assembles in inactive tetramers at micromolar concentrations.

69 ency (use) inhibition of Na+ currents at low micromolar concentrations.

70 th and splice variant AR forms at low to sub-micromolar concentrations.

71 s able to kill Pseudomonas aeruginosa at sub-micromolar concentrations.

72 ties of the catalytic core proteasome at low micromolar concentrations.

73 0 K suffice to polymerize 200-mers of RNA in micromolar concentrations.

74 ine inhibited dengue virus infections at low micromolar concentrations.

75 blastoma cells or primary human neurons with micromolar concentrations (10-100 microM) of D3T for 24

76 Remarkably, the addition of low micromolar concentrations (5 microM) of oleoyl-CoA resul

77 Compound 5 was potent at single-digit micromolar concentrations against a panel of cancer cell

78 Each of the aggregators was active at micromolar concentrations against the three GPCRs in cel

79 d in plaques, self-assembles into fibrils at micromolar concentrations and acidic pH.

80 oxidative inactivation by superoxide at low micromolar concentrations and by H 2O 2 at low millimola

81 ow line width, high analytical resolution at micromolar concentrations and enhanced sensitivity to mo

82 ds interrupted cell cycle progression at low micromolar concentrations and induced early and late sta

83 against schistosomula and adult worms at low micromolar concentrations and therefore represent promis

84 ease-activated Ca(2+) (CRAC) currents at low micromolar concentrations and to inhibit them at higher

85 SCRPZ-1 readily dimerizes at micromolar concentrations, and an empirical redesign of

86 ucing both pro-oxidant actions at low (5-20) micromolar concentrations, and antioxidant activity at a

87 opper-loaded dimers exist in solution at low micromolar concentrations, and head-to-head and side-to-

88 and 3'-phosphatase activities of APE1 at low micromolar concentrations, and is a specific inhibitor o

89 nanoparticle is stable upon dilution to low micromolar concentrations, and is cytotoxic at both 37 a

90 unds were obtained that activated RNase L at micromolar concentrations, and structure-activity relati

91 l phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the p

92 y source for biological reactions, for which micromolar concentrations are sufficient, we propose tha

93 ation of urinary metabolites present at low (micromolar) concentrations are major obstacles.

94 general anesthetics used clinically, acts at micromolar concentrations as an anesthetic and positive

95 lass of small molecules that function at low micromolar concentrations as both beta- and beta,delta-e

96 alene synthase inhibitory activity (at lower micromolar concentrations) as well as a significant anti

97 When nitric oxide (NO) is produced at micromolar concentrations, as during inflammation, expos

98 hat transient calcium increase up to tens of micromolar concentration at the micro/nano domain trigge

99 Verapamil blocked currents at micromolar concentrations at polarized potentials simila

100 At low micromolar concentrations, both LTRAs also inhibited cal

101 2-116 markedly enhanced GlyR currents at low micromolar concentrations but had no effects on the clos

102 is capable of inducing the arr system at low micromolar concentrations, but it does not induce the ar

103 latelet activation was sGC-dependent only at micromolar concentrations, but sGC-independent at millim

104 oid peptide produces apoptosis in neurons at micromolar concentrations, but the mechanism by which be

105 they allow the detection of fluoride ions at micromolar concentration by the naked eye, UV-vis absorp

106 e found that 3-NOP indeed inactivates MCR at micromolar concentrations by oxidation of its active sit

107 ed to nitrite, which also inactivates MCR at micromolar concentrations by oxidation of Ni(I).

108 At micromolar concentration, Ca(2+) inhibition is nonexclus

109 Methamphetamine at physiologically relevant micromolar concentrations caused apoptosis in NG108-15 c

110 , we report that, at clinically relevant low micromolar concentrations, CCI-779 completely suppressed

111 h granulysin-mediated cytotoxicity occurs at micromolar concentrations, chemoattraction occurs in the

112 on of cancer cell growth was demonstrated at micromolar concentrations, comparable to the concentrati

113 Our results show that at pH 7.2 and at micromolar concentrations, Cu(2+) inhibited conversion o

114 nic matter (DOM) can be detected down to low micromolar concentration, depending on the DOM backgroun

115 compounds that inhibited tetramerization at micromolar concentrations, designated PF4 antagonists (P

116 be detected within the same analysis time as micromolar concentrations detected without the use of th

117 cule drug cocaine at near physiological, low micromolar concentrations directly in undiluted, otherwi

118 M, is more efficacious than diazoxide at low micromolar concentrations, directly activates the channe

119 In addition, we discovered that zinc in micromolar concentrations drives ssDNA to a unique, high

120 e latter of which was found to accumulate to micromolar concentrations during simulated solar irradia

121 MPs, which may explain why most AMPs require micromolar concentrations for activity, show significant

122 PR (mFPR) 1 and mouse neutrophils, requiring micromolar concentrations for cell activation.

123 . monocytogenes HMG-CoA reductase, requiring micromolar concentrations for inhibition.

124 GLIC pore is predicted to be blocked at the micromolar concentrations for which inhibition by isoflu

125 At high micromolar concentration, FTY720 has been shown to induc

126 At low micromolar concentrations, Grp1 and ARNO are homodimeric

127 th this hypothesis was the finding that high micromolar concentrations (> or =600 microm) of oxygen a

128 bit matriptase activation with IC(50) at low micromolar concentration in both intact-cell and cell-fr

129 es, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous solution.

130 related congeners inhibited melanogenesis at micromolar concentrations in B16 mouse melanoma cells, n

131 tes of the kynurenine pathway are present at micromolar concentrations in blood and are regulated by

132 (LPC) is an oxidized phospholipid present in micromolar concentrations in blood and inflamed tissues.

133 assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammator

134 SH-I-048A reached micromolar concentrations in brain tissue, while the unb

135 that prevent HCV infection at nontoxic, low micromolar concentrations in cell culture.

136 actinides can be easily distinguished at low micromolar concentrations in complex salt mixtures.

137 a key uremic toxin that accumulates to high micromolar concentrations in kidney dialysis patients, b

138 embly of the Vernier complex is efficient at micromolar concentrations in nonpolar solvents, and unde

139 bited Bacillus anthracis bacterial growth at micromolar concentrations in the presence or absence of

140 eptides that block cellular signaling at low micromolar concentrations in vitro and in vivo.

141 These peptides induce autophagy at micromolar concentrations in vitro, have aggregate-clear

142 Both targets are detected at low micromolar concentrations, in seconds, and in a convenie

143 class of S-nitrosylating agents that, at low micromolar concentrations, increase DeltaF508 and wild-t

144 (1)H-(13)C HSQC spectrum of p51 obtained at micromolar concentrations indicates that a significant f

145 nin are also angiogenic factors that, at low micromolar concentrations, induce endothelial cell proli

146 Low micromolar concentrations inhibit Kir7.1, making VU590 t

147 tiomeric excess of several amino alcohols at micromolar concentrations is reported.

148 As the compound inhibits the kinase at micromolar concentrations, it is not known why therapeut

149 egassed aqueous buffer media at pH 7 down to micromolar concentration levels.

150 At micromolar concentrations, lipid-free ApoE exists predom

151 If glutamate were present tonically at low micromolar concentrations, many receptors, especially th

152 At micromolar concentrations, many small molecules self-ass

153 At micromolar concentrations, melittin induces stable pores

154 At low micromolar concentration, microalgae fixed all silver in

155 Unexpectedly, at sub-micromolar concentrations MTMs stabilize FLI1-DNA comple

156 When maintained at micromolar concentrations, NAE 18:3 specifically induced

157 get hybridization is selectively detected at micromolar concentrations (nanomoles of target) using re

158 st the bacterial challenge was observed at a micromolar concentration of Ceftriaxone or Cefotaxime in

159 Use of micromolar concentration of dye, which was required to g

160 xcision, and was potently inhibited by a low micromolar concentration of PI(4,5)P(2).

161 residue was complete within minutes at a mid-micromolar concentration of reactants.

162 in transferrin, allowing us to predict a low micromolar concentration of these binding sites in neoco

163 eport here that PP5 is strongly inhibited by micromolar concentrations of a natural polyamine spermin

164 Sub-micromolar concentrations of a novel potent Trk inhibito

165 photons per pixel from cells that contained micromolar concentrations of a Tb(III) complex.

166 imize an enzyme-coupled assay to measure low micromolar concentrations of acetate, coupling acetate p

167 produced cAMP in response to adenosine, and micromolar concentrations of adenosine were measured in

168 In this study we report that low micromolar concentrations of arsenite synergistically in

169 Picomolar to micromolar concentrations of ascr#18, the major ascarosi

170 Treatment of parasites with low micromolar concentrations of beta-lactone- or triazole u

171 Spectrin-4.2 binding is amplified by micromolar concentrations of Ca(2+) (but not Mg(2+)) by

172 cell function by responding specifically to micromolar concentrations of Ca(2+) in the presence of a

173 Micromolar concentrations of Ca(2+) lead to a robust blu

174 ivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultan

175 Caulobacter requires micromolar concentrations of calcium for normal growth a

176 and L3.6pL pancreatic cancer cells with low micromolar concentrations of CDDO or CDDO-Me resulted in

177 Low micromolar concentrations of certain compounds blocked t

178 X-linked IAP (XIAP), a recent one found that micromolar concentrations of cIAP1 only weakly inhibit c

179 , evidence for cross-link formation with low micromolar concentrations of copper phenanthroline or io

180 tuted oxazine and can be exploited to detect micromolar concentrations of cyanide in water.

181 conditions, TRPM4 currents were activated by micromolar concentrations of cytoplasmic Ca(2+) and prog

182 We previously showed that micromolar concentrations of dextromethorphan (DM), a ma

183 Chromatin immunoprecipitations revealed that micromolar concentrations of DIM-C-pPhtBu prevented asso

184 We also found micromolar concentrations of dissolved Mn(III) in the Ch

185 In this study, we report that femto- and micromolar concentrations of DM (both pre- and post-trea

186 campal slices were cultured and treated with micromolar concentrations of dopamine, with or without d

187 the original membrane was accomplished with micromolar concentrations of EDTA.

188 Here we demonstrate that low micromolar concentrations of extracellular NAD(+) or NAD

189 rated in vitro by stimulating microglia with micromolar concentrations of fibrillar Abeta, a major co

190 human enamel organ, are directly affected by micromolar concentrations of fluoride.

191 of Ca(2+)-dependent phospholipid binding at micromolar concentrations of free Ca(2+), suggesting tha

192 In addition, superfusion of low micromolar concentrations of glutamate had no effect on

193 e damage that depends on the synergy between micromolar concentrations of GzmA and sublytic perforin

194 Low micromolar concentrations of H2O2 completely blocked the

195 Brief exposure of T cells to micromolar concentrations of Hg(2+) leads to physiologic

196 We show that on addition of micromolar concentrations of hyaluronic acid, the result

197 susceptible to oxidation to sulfenic acid by micromolar concentrations of hydrogen peroxide.

198 We further show that micromolar concentrations of imatinib abrogate multiple

199 ultiple 0.5-1.0-cm(3) targets that contained micromolar concentrations of indocyanine green with 1:0

200 spond jointly to membrane depolarization and micromolar concentrations of intracellular Ca2+ ions, ar

201 or use in plants are monopartate and require micromolar concentrations of ligand for activation of th

202 Intriguingly, low micromolar concentrations of long chain fatty acyl-CoAs

203 ition of purified rabbit muscle PFK-1 by low micromolar concentrations of long chain fatty acyl-CoAs

204 In contrast, application of micromolar concentrations of lysophosphatidylcholine (LP

205 for AMTr-AuNPs in the presence of less than micromolar concentrations of melamine.

206 mately 10 and are the predominant species at micromolar concentrations of metallothionein in cells.

207 olated transgenic keratinocytes to show that micromolar concentrations of MFQ attenuated increased ma

208 d that pharmacological intervention with low micromolar concentrations of N-(4-hydroxyphenyl)retinami

209 Although the NH(4)Cl solution contains micromolar concentrations of NH(3) at pH 7.4, our eviden

210 Here we show that micromolar concentrations of nicotinamide adenine dinucl

211 from nitrate and resulted in accumulation of micromolar concentrations of nitric oxide during denitri

212 hat had undergone a more chronic exposure to micromolar concentrations of nitric oxide showed an appr

213 onsequence (gravitropism), were inhibited by micromolar concentrations of NPPB that did not affect gr

214 Micromolar concentrations of octreotide and NISAs are ne

215 The effects of nanomolar versus micromolar concentrations of phloroglucinol differed bot

216 ked Hcy, whereas cow milk and whey contained micromolar concentrations of protein N-linked Hcy.

217 ermediate is predicted not to exceed 0.5% at micromolar concentrations of protein under equilibrium a

218 reaction provides a modest driving force at micromolar concentrations of protein.

219 er millimolar concentrations of ornithine or micromolar concentrations of putrescine or by complement

220 Specifically, micromolar concentrations of pyrene in methanol/water so

221 in, a linear dynamic range from nanomolar to micromolar concentrations of R6G with a limit of detecti

222 y refolded in an aerobic solution containing micromolar concentrations of reduced PDI and nanomolar l

223 Surprisingly micromolar concentrations of S1P activated the wild type

224 While bacterial enzymes are inhibited by micromolar concentrations of serine bound to an alloster

225 Thus, sub-micromolar concentrations of short-chain polyP can accel

226 that the preservation of tissue perfusion by micromolar concentrations of SNO-Hb is a composite effec

227 f unlabeled NAADP or 5N(3)-NAADP, but not by micromolar concentrations of structurally related nucleo

228 bited by an N-terminal fragment of LF and by micromolar concentrations of tetrabutylammonium ions.

229 Micromolar concentrations of the bile salt deoxycholate

230 Thus, at the low micromolar concentrations of the cellular environment an

231 In this study we demonstrate that micromolar concentrations of the common cell metabolite

232 Moreover, SPCA1a is blocked by micromolar concentrations of the commonly used SERCA1a i

233 MP could only be demonstrated at hundreds of micromolar concentrations of the dinucleotide, and it ha

234 By contrast, in the presence of micromolar concentrations of the ligands methotrexate, n

235 ulated >2-fold but potently inhibited by low micromolar concentrations of the oxidizing reagent coppe

236 f QDs that is compatible with neutral pH and micromolar concentrations of the peptide target.

237 This was reversed in the presence of micromolar concentrations of the protein phosphatase inh

238 At micromolar concentrations of the receptor, sedimentation

239 mu-EME salt removal from samples containing micromolar concentrations of the target analytes and 150

240 In comparison, activation of mFPR2 requires micromolar concentrations of the two peptides.

241 Addition of high nanomolar to low micromolar concentrations of these inhibitors to cancer

242 we show that arsenicals bind tightly to low micromolar concentrations of these unfolded proteins wit

243 te (EGCG), but effects were observed only at micromolar concentrations of unclear clinical relevance.

244 We also found that incubation with low-micromolar concentrations of WT, A30P, or A53T alpha-syn

245 he rate of folding of SOD in the presence of micromolar concentrations of zinc demonstrates a signifi

246 rat hippocampal slices, we observed that low micromolar concentrations of zinc depress NMDAR synaptic

247 in cultured cells have demonstrated that low micromolar concentrations of zinc stimulate the endocyto

248 Plasma pH levels and micromolar concentrations of Zn(2+) inhibit WT Cx26 hemi

249 orters that are predominantly inward-facing, micromolar concentrations of Zn(2+) markedly potentiated

250 1 activity in the presence of physiological (micromolar) concentrations of Ca(2+) ions, as long as Mg

251 ibitors showed antibacterial activity at low micromolar concentration on Gram-positive and Gram-negat

252 At micromolar concentrations, pioglitazone increased mitoch

253 At low micromolar concentrations, polyunsaturated fatty acids (

254 At micromolar concentrations, procainamide was found to be

255 ation, and quantification of analytes at low-micromolar concentrations, provided they can weakly asso

256 The best compound was active in a very low micromolar concentration range against all three transpo

257 totoxic agents with IC(50) values in the low micromolar concentration range and demonstrated enhanced

258 promising anti-influenza activity in the low micromolar concentration range and good selectivity.

259 chitooligosaccharides with Kd values in the micromolar concentration range and that the binding ener

260 The initial steps in the micromolar concentration range follow apparent sigmoidal

261 tion of ciproxifan revealed IC50 values in a micromolar concentration range for human and rat monoami

262 ompounds 11 and 36 were effective in the low micromolar concentration range in a cellular assay syste

263 Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a nonspecific cell

264 With protein samples in the low micromolar concentration range, the two major experiment

265 Moreover, this method can be employed in the micromolar concentration range, which is not readily acc

266 showed selective detection of glucose in the micromolar concentration range, with a detection limit o

267 otoxic to Neuro2a neuroblastoma cells in the micromolar concentration range.

268 alcohols, with dissociation constants in the micromolar concentration range.

269 cient probing of fluoride and cyanide in the micromolar concentration range.

270 ilibrium dimer dissociation constants in the micromolar concentration range.

271 ion constants (K(D)) in the low nanomolar to micromolar concentration range.

272 vival of multiple cancer cell lines in a low micromolar concentration range.

273 essel and lymphatic endothelial cells in the micromolar concentration range.

274 Extracellular GsMTx4 at micromolar concentrations reversibly inhibited approxima

275 0.1) and cooperative substrate inhibition at micromolar concentrations ([S](1/2) = 740 +/- 240 nm; n

276 antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure

277 hantom images provide sufficient contrast at micromolar concentrations, showing promise for eventual

278 e show that zinc binds unaggregated hIAPP at micromolar concentrations similar to those found in the

279 On the contrary, at higher (micromolar) concentrations, tapentadol elicited proneuro

280 its the growth of melanoma cell lines at low micromolar concentrations that are clinically attainable

281 At low micromolar concentrations, the domain is predominantly m

282 eukemia cells and AML patient samples at low micromolar concentrations through a mechanism of action

283 seleninic acid (MSA), inactivated PKC at low micromolar concentrations through a redox modification o

284 AS-6 was cytotoxic when added at micromolar concentrations to cultures of three different

285 hibiting antioxidant character were able, at micromolar concentration, to slow down the photoinduced

286 ex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasio

287 ular-signal-regulated kinase (ERK) whereas a micromolar concentration was ineffective.

288 that c-di-GMP can form G-quadruplexes at low micromolar concentrations when aromatic molecules such a

289 kamides F and H inhibited HIV-1 entry at low micromolar concentrations while their linear counterpart

290 ma and MCF-7 breast carcinoma cell growth in micromolar concentration with the ability to arrest canc

291 from fluorometric measurements down into sub-micromolar concentrations with a limit of detection of 1

292 tes able to inhibit virus replication at low micromolar concentrations with no significant toxicity t

293 Ret-NH2 interacts only at micromolar concentrations with retinoic acid receptor, d

294 ion of a specific target protein in vitro at micromolar concentration, with a readout scheme that red

295 n cytomegalovirus (HCMV) replications at low micromolar concentration, with little or no cytotoxicity

296 n GABA(A) receptor function at nanomolar and micromolar concentrations, with maximum potentiation com

297 j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.

298 omponents, heroin, noscapine and morphine at micromolar concentration without any separation or pretr

299 At low micromolar concentrations, XN acutely increased uncouple

300 eta cells or intact pancreatic islets at low micromolar concentrations, ZIMIR labeled cells rapidly,