ライフサイエンスコーパス: microsecond

1 ary impulse is on the order of a few hundred microseconds).

2 electrochemical time constant less than one microsecond.

3 product formation is complete in less than a microsecond.

4 by Rydberg-level interactions in less than a microsecond.

5 c reaction zone was limited to a few hundred microseconds.

6 tes are Mo2deltadelta* with lifetimes in the microseconds.

7 nformations that exchange within hundreds of microseconds.

8 e microenvironmental parameters within a few microseconds.

9 nces into functioning proteins, sometimes in microseconds.

10 omains undergo a left handed rotation within microseconds.

11 ry slow in CH3NH3PbI3, lasting up to tens of microseconds.

12 est that complete mixing occurs within a few microseconds.

13 closing of the capsule in the time range of microseconds.

14 *YA forms misplaced helical structure within microseconds.

15 n structural reorganization is observed over microseconds.

16 acy by generating trajectories of just a few microseconds.

17 improve spike timing on the scale of tens of microseconds.

18 their fast discharge capability at a rate of microseconds.

19 tens of nanometers and timescales of tens of microseconds.

20 e mutants in explicit solvent within several microseconds.

21 ructure occur in a time range of hundreds of microseconds.

22 echanical coherence times on the order of 10 microseconds.

23 ge carriers over a time range from femto- to microseconds.

24 thousand lipids and timescales up to several microseconds.

25 d to enhanced carrier lifetime up to several microseconds.

26 known to deprotonate, at most, within a few microseconds.

27 ination lifetime from several nanoseconds to microseconds.

28 these approaches have not yet exceeded a few microseconds.

29 s a proton transfer lasting over hundreds of microseconds.

30 pid modifications of rhodopsin from multiple-microsecond all-atom molecular dynamics simulations.

31 Advances in computing have enabled microsecond all-atom molecular dynamics trajectories of

32 e the dynamics of this SH3-SH2 tandem, using microsecond all-atom simulations and differential scanni

33 ergy relaxation time of T1 approximately 100 microseconds and a phase-coherence time of T2 approximat

34 y observed due to its short lifetime (in the microseconds) and unique breakdown signature.

35 cs at timescales ranging from nanoseconds to microseconds, and other "jittering" motions at timescale

36 olecular-dynamics simulation time of several microseconds ( approximately 2 mus) using all-atom, expl

37 net in which long coherence times (up to 8.4 microseconds at 5 kelvin) are obtained at unusually high

38 We used microsecond atomistic molecular-dynamics (MD) simulation

39 signature that persists for several tens of microseconds, before charge recombination with NiO holes

40 Femtosecond-to-microsecond broadband transient absorption experiments a

41 s an observable folding intermediate, but no microsecond burst phase in the folding kinetics of the s

42 ionally high input precision in the range of microseconds, but not in mice.

43 periments, RBCs are stretched within tens of microseconds by a strong shear flow generated from a las

44 resolved PL imaging analyses highlighted the microsecond decay-kinetic behavior of the emission, conf

45 to the ground-state QD following a suitable microsecond delay and (2) the QD subsequently transferre

46 simulation times ranging from nanoseconds to microseconds depending on system size.

47 te through transitions that are gated by the microsecond dihedral motions of the side chain of R476 a

48 ure IR spectroelectrochemical studies in the microsecond domain are discussed.

49 obtain self-starting Q-switched pulses with microsecond duration and kilohertz repetition rates at 1

50 A new approach brought on by the advent of microsecond dwell times in single particle ICP-MS allows

51 n dispersion NMR spectroscopy, the milli- to microsecond dynamics of the HIV-1 transactivation respon

52 f the apo-form, enhancing the millisecond to microsecond dynamics of the holo-form at sites critical

53 s particularly useful for studying milli- to microsecond dynamics via NMR spectroscopy, as an isolate

54 te between relaxation (highly disordered and microsecond dynamics) and rigor (highly ordered and rigi

55 Here we probe how the crystal packing alters microsecond dynamics, using solid-state NMR measurements

56 fferent constructs, all are within range for microsecond electron transfer.

57 atomic resolution, revealed by unrestrained microsecond equilibrium molecular dynamics simulations o

58 by increasing the pulse width from 60 to 240 microseconds, even at a lower stimulation frequency of 6

59 ligand, is characterized by room temperature microsecond excited-state lifetimes.

60 Microsecond exposures produced by scanning laser destroy

61 cted RPE cells were selectively destroyed by microsecond exposures to scanning laser with 50% pattern

62 lex dynamics in many degrees of freedom, yet microsecond folding experiments provide only low-resolut

63 We find microsecond folding times, consistent with temperature j

64 his ordering is robust and persists into the microsecond folding timescale.

65 es over their intrinsic physical timescales (microseconds for microbubble dynamics and seconds to min

66 ndreds of picoseconds, but slows down to sub-microseconds in a sample with 33% PC61BM.

67 Sampling of a total of >700 microseconds in all-atom detail with explicit solvent en

68 Although slow relaxation beyond microseconds is observed in different perturbative simul

69 r temperature jump tracks the nanosecond and microsecond kinetics of unfolding and the exchange betwe

70 ed kinetic multiplicity of transitions: from microseconds-lasting flickers to minutes-long modes.

71 ctional selectivity, we carried out unbiased microsecond-length MD simulations of the human serotonin

72 of positional mutual information in multiple microsecond-length molecular dynamics (MD) simulations t

73 distance change with temporal resolution at microsecond level and structural resolution at Angstrom

74 phosphorescence with large Stokes shift and microsecond lifetime.

75 measurements reveal long-lived carriers with microsecond lifetimes in the alloyed material, which is

76 r triplet excited states, according to their microsecond lifetimes, with quantum yields of up to 58%.

77 LFP studies indicate transient species with microsecond lifetimes.

78 Combining with a number of microsecond long MD simulations, we also found that the

79 cally, we have performed several independent microsecond long molecular simulations of TAR based on o

80 Here, we simulate CypA using multiple-microsecond-long atomistic molecular dynamics in explici

81 Our microsecond-long atomistic simulations elucidate key str

82 We performed three independent microsecond-long MD simulations to evaluate the structur

83 Here, we use all-atom, microsecond-long molecular dynamics to simulate the stru

84 Here we show that in a state-of-the-art, microsecond-long simulation of the same DNA sequence, th

85 In this work, we present multi-microsecond-long simulations of fengycin interacting wit

86 Microsecond-long simulations show that the binding of th

87 Using microsecond-long simulations, we examined the open and c

88 We have analyzed microsecond-long trajectories of E1.H(+)771, a protonate

89 Examination of these interactions using microsecond-long unrestrained simulations shows that ure

90 ral angles were computed using the output of microseconds-long atomistic simulations.

91 n in torsion angle movements calculated from microseconds-long molecular-dynamics simulations, we elu

92 reducing pulse duration from milliseconds to microseconds markedly decreases the minimal pulse energy

93 The allosteric mechanism was probed by microsecond MD simulations in explicit water, complement

94 Microsecond MD simulations indicated that the BH3 domain

95 using solid-state NMR measurements and multi-microsecond MD simulations of different crystal forms of

96 Further insight was obtained from microsecond MD simulations, which revealed a large struc

97 e fingers domain of T7 RNAP according to the microsecond MD simulations.

98 ectrophoresis, site-directed mutagenesis and microsecond MD simulations.

99 namics (MD), we simulated an extended (three microseconds) MD trajectory with SAM bound to a modeled

100 Two accelerated, half microsecond, MD simulations of the system having protona

101 on the subnanosecond time scale followed by microsecond-millisecond back electron transfer from the

102 we present a method to characterize protein microsecond-millisecond dynamics based on the analysis o

103 The free form of YmoA shows collective microsecond-millisecond dynamics that can by measured by

104 tions, NMR spectroscopy, and extensive multi-microsecond molecular dynamics calculations of Pdx1 that

105 the basis of a total cumulative time of one microsecond molecular dynamics simulation.

106 We present the results of microsecond molecular dynamics simulations carried out b

107 Microsecond molecular dynamics simulations of harzianin

108 med extensively long unconstrained, all-atom microsecond molecular dynamics simulations of nucleosome

109 Microsecond molecular dynamics simulations permitted a c

110 PAM-induced allosteric mechanism revealed by microsecond molecular dynamics simulations.

111 dary structure stability utilizing extensive microsecond molecular dynamics simulations.

112 Here, we have performed a series of microsecond molecular simulations to study how the dynam

113 In this context, even microsecond molecular-dynamics simulations are not suffi

114 From microsecond molecular-dynamics simulations, we are able

115 ov modelling analysis of an aggregate of 275 microseconds molecular dynamics simulations, we reveal t

116 Extensive (more than 90 microseconds) molecular dynamics simulations complemente

117 nificant reduction in slower (millisecond to microsecond) motions compared with the homologous domain

118 nced intermediate time scale (millisecond to microsecond) motions in the mutant.

119 tions uncovered site-dependent nanosecond-to-microsecond movement of secondary and tertiary structure

120 Protein dynamics on the microsecond (mus) time scale were investigated by temper

121 ion bubble, which forms and collapses within microseconds of ablation.

122 These simulations yielded over 250 microseconds of accumulated data, which correspond to ap

123 ptors, we have carried out approximately 160 microseconds of biased molecular dynamics simulations to

124 ecular dynamics simulations spanning several microseconds of dsDNA packing inside nanometer-sized vir

125 e computer simulations (totaling hundreds of microseconds of dynamics) can identify prospective crypt

126 al backbone NH groups within the initial 140 microseconds of folding of horse cytochrome c.

127 a proton to the surrounding solution within microseconds of long-wave ultraviolet irradiation.

128 To verify this hypothesis, microseconds of molecular dynamics simulations were comp

129 The results of >16 microseconds of simulation predict that polymyxin B1 is

130 h misplaced alpha-helix content within a few microseconds of the P-drop.

131 ich is 5 orders of magnitude slower than the microsecond opening/closing ("breathing") previously obs

132 relatively long-lived (approximately tens of microseconds or more).

133 molecular dynamics (REMD) simulations on the microseconds-per-replica timescale are used to character

134 r and a slower kinetic phase, and the "slow" microsecond phase is activated.

135 In addition to a microsecond phase, we observe a slower 1.4-ms phase duri

136 al ganglion neurons (SGNs) encode sound with microsecond precision.

137 We present such a comparison of microsecond pressure and temperature jump refolding kine

138 Using a newly developed microsecond pressure-jump apparatus, we monitor the refo

139 We report the use of microsecond pulses of electric current to induce rapid c

140 Microsecond radiolytic labeling identified rearrangement

141 orce spectroscopy by optical tweezers to the microsecond range by fast sampling.

142 or the kinetics of proteins that fold in the microsecond range or faster.

143 iques of computational chemistry [e.g., long-microsecond-range, all-atom molecular dynamics (MD) simu

144 to non-native helical structure frustrating microsecond refolding.

145 more, we observe a transient response in the microsecond regime associated with slow lattice cooling,

146 ce times from few tens of nanoseconds to the microsecond regime between 2 and 3 T magnetic field and

147 d H/D exchange labeling experiments into the microsecond regime by adopting a microfluidics approach.

148 re we show a fast algorithm suitable for the microsecond region with precision closely approaching th

149 Using force spectroscopy optimized for 1-microsecond resolution, we reexamined the unfolding of i

150 Recent microsecond-resolution experiments and long duration (to

151 nt time correlation function analysis to the microsecond-resolved smFRET data obtained to determine a

152 ntrolled on the timescale of nanoseconds and microseconds respectively.

153 ved brightness and voltage sensitivity, have microsecond response times and produce no photocurrent.

154 itches, and nearly concentration-independent microsecond response times.

155 sential roles in regulation, we detected the microsecond rotational diffusion of both proteins using

156 ng protein-C (MyBP-C) and its domains on the microsecond rotational dynamics of actin, detected by ti

157 ments with polarized light, in which tens-of-microseconds rotational motions of internally labeled iC

158 MD simulations were performed at a microsecond scale and combined with Monte Carlo sampling

159 measurement of luminescence lifetimes on the microsecond scale based on variable excitation time dete

160 In recent microsecond scale molecular dynamics simulations of a co

161 Here we use microsecond-scale all-atom molecular dynamics simulation

162 -photon fluorescence microscope and achieved microsecond-scale axial scanning, thus enabling volumetr

163 ed on a dual-resolution approach, using both microsecond-scale explicit-solvent all-atom and coarse-g

164 From microsecond-scale molecular dynamics simulations and cog

165 of partial agonism, we performed comparative microsecond-scale molecular dynamics simulations startin

166 in protein kinases, we carried out multiple microsecond-scale molecular-dynamics simulations of prot

167 solution, which has reached the limit of the microsecond-scale relaxation times of biological molecul

168 0 nm in lateral dimension) and time (tens of microseconds) scales.

169 modern mass spectrometry (MS) operating with microsecond scan speeds.

170 tructure have now been identified in a multi-microsecond simulation of the same reverse micelle syste

171 ion models is analyzed in detail using multi-microsecond simulations.

172 sible regime located between millisecond and microsecond single pulse illumination.

173 We here report microsecond single-molecule FRET (smFRET) measurements o

174 neous metal and proton pathways during fast (microsecond) structural transitions remains unknown.

175 In addition, free MD simulations up to one microsecond suggest that the calculated profiles are hig

176 sive molecular dynamics simulations (several microseconds) support experimental results.

177 We show microsecond-sustained lasing, achieved by placing ultra-

178 ile observing the bead's thermal motion with microsecond temporal and nanometer spatial resolution us

179 cultures with hundreds of microelectrodes at microsecond temporal resolution.

180 or longer, biologically relevant timescales (microseconds), the need for improved computational metho

181 pin coherence persists for longer than a few microseconds, the output of the sensor contains a sharp

182 with a robust 'plateau' that extends over a microsecond; the rate constants vary by two orders of ma

183 efficiently reject laser background through microsecond time gating.

184 ved Forster resonance energy transfer in the microsecond time range of refolding.

185 lete temporal resolution over the picosecond-microsecond time range, to propose a new mechanism for t

186 populate an off-pathway kinetic trap in the microsecond time range.

187 Microfluidic mixing with microsecond time resolution and Forster resonance energy

188 perpendicular to the lipid surface on a low microsecond time scale ( approximately 2 mus), while sim

189 It forms on the microsecond time scale after light absorption by the oxi

190 3 is kinetically reactive and reacts in the microsecond time scale following a first-order kinetic l

191 ctronically excited triplet state exhibits a microsecond time scale lifetime characteristic of the Ru

192 rganic solvent: femtosecond, nanosecond, and microsecond time scale pump-probe transient absorption s

193 f milliseconds, considerably longer than the microsecond time scale suggested by previous kinetics st

194 mic features of substrates on the nanosecond-microsecond time scale that correlate with enzymatic rat

195 pering molecular dynamics simulations on the microsecond time scale to compare the stability of the d

196 asize the need to examine motions on the low microsecond time scale when probing these types of inter

197 apable of measuring pA-range currents on the microsecond time scale with a very low noise and stable

198 linking substrate dynamics on the nanosecond-microsecond time scale with large collective substrate m

199 ormation of polar hydrated layers at the sub-microsecond time scale, however with a thickness of only

200 endo and vice versa is on the nanosecond and microsecond time scale, respectively.

201 s efficiently in all systems on the nano- to microsecond time scale, through three distinct routes: r

202 r from oxidized dye to IrO2 occurring on the microsecond time scale.

203 rly 500 mus of refolding was revealed on the microsecond time scale.

204 rizing the internal dynamics of TAR over the microsecond time scale.

205 -ordered character form and disappear on the microsecond time scale.

206 d hole mobilities remain very high up to the microsecond time scale.

207 hairpin WW domain system, which folds on the microsecond time scale.

208 crofluidic mixing to observe kinetics on the microsecond time scale.

209 tection) ranging from the femtosecond to the microsecond time scale.

210 to study the folding kinetics of ACBP on the microsecond time scale.

211 ew nanoseconds, followed by its decay in the microsecond time scale.

212 easurements on the femto-, pico-, nano-, and microsecond time scales and are examined by multiwavelen

213 rge recombination on both the nanosecond and microsecond time scales in a donor-acceptor system compr

214 e infrequent and because they often occur on microsecond time scales that are not easy to access expe

215 d catalysis are much slower (millisecond and microsecond time scales).

216 etails of dynamic cantilever response at sub-microsecond time scales, higher-order eigenmodes and har

217 ules to larger pools and from femtosecond to microsecond time scales.

218 Here, we investigate the mechanism at the microsecond time- and nanometer space- scale using MD si

219 Detailed analysis of ultrafast and microsecond time-resolved excited state decays result in

220 MD simulations it becomes possible to model microsecond time-scale protein dynamics and, in particul

221 rrelation spectroscopy study, we suggest the microsecond time-scale reactions are due to intermediate

222 all-atom molecular-dynamics simulations on a microsecond time-scale starting with different NMR-deriv

223 triplet excited-state (T1) lifetimes on the microseconds time scale are simultaneously realized.

224 with an 3-5 degrees amplitude on a tens-of-microseconds time scale in one of the crystals, but not

225 S0 conversion dynamics that short-circuit a microseconds time scale triplet lifetime.

226 rved spectroscopically on the nanoseconds to microseconds time scale.

227 in CB2.Gi complex formation, we carried out microsecond-time scale molecular dynamics simulations of

228 The microsecond-time scale recombination is probably gated b

229 Here, we performed microsecond timescale all-atom molecular dynamics (MD) s

230 BSC0OL15) show predictive power in the multi-microsecond timescale and can be safely used to reproduc

231 te with reorganization of the bilayer on the microsecond timescale and persist throughout a total of

232 s substantial dynamics on the millisecond-to-microsecond timescale but autoinhibited and DNA-bound ER

233 f DNA dissociation from the nucleosome using microsecond timescale coarse-grained molecular dynamics

234 erize the rearrangements in nucleosomes on a microsecond timescale including the coupling between the

235 thermodynamic free energy cycle approach and microsecond timescale molecular dynamics simulations.

236 uilibrium growth of the nascent protein with microsecond timescale molecular dynamics trajectories.

237 Computers now allow microsecond timescale molecular-dynamics simulations, wh

238 Microsecond timescale trajectories reveal the intrinsic

239 analysis of such proteins, which fold on the microsecond timescale, apply to the millisecond or slowe

240 eptide unfolds and refolds repeatedly on the microsecond timescale, indicating that the alpha-helical

241 at the fully assembled pump is stable in the microsecond timescale.

242 conformations in solution on the millisecond-microsecond timescale.

243 ion diffusion in Gd2Ti2O7 pyrochlore, on the microsecond timescale.

244 enough to drive concerted motions on the sub-microsecond timescale.

245 ns such as lambda-repressor that fold on the microsecond timescale.

246 Unbiased microsecond-timescale all-atom molecular dynamics simula

247 Here we use microsecond-timescale Anton molecular dynamics simulatio

248 dynamics simulation, in contrast to previous microsecond-timescale conventional molecular dynamics si

249 c spines, synaptic transmission, subcellular microsecond-timescale details of AP propagation, and sim

250 Interactions with metal ions attenuate microsecond-timescale motions of the loop regions, indic

251 Microsecond-timescale simulations have calculated that t

252 To that end, we performed microsecond-timescale simulations of the A(2A) adenosine

253 d for studying irreversible reactions at sub-microsecond timescales using high-brightness X-ray facil

254 unprecedented mobility on the nanosecond to microsecond timescales, and the experimental NMR dipolar

255 erformance molecular dynamics simulations at microsecond timescales.

256 sidue-specific probes of motions on nano- to microsecond timescales.

257 representations of acoustic signals resolves microsecond timing of sounds processed by the two ears.

258 However, microsecond to millisecond dynamics measurements reveale

259 ) and by inspection of elevated R(2) values (microsecond to millisecond motions).

260 In contrast, fluctuations on the microsecond to millisecond time scale depended on the fo

261 al validation demonstrate detectable "slow" (microsecond to millisecond) conformational exchange rate

262 plicity of states in the ensemble and rapid (microsecond to millisecond) exchange between them.

263 cant increase in the scanning speed from the microsecond to nanosecond regime, which represents a maj

264 u(A)-binding cupredoxin domain, arising from microsecond to second dynamics that are quenched upon me

265 oatings to expel water and collapse within a microsecond to the nanoscale, millions of times faster t

266 f single-domain globular proteins range from microseconds to hours: the difference (11 orders of magn

267 which probes displacements over hundreds of microseconds to milliseconds, to reveal the conformation

268 ides a large dynamic range of lifetimes from microseconds to milliseconds, which allows creating larg

269 ifferent conformational states range between microseconds to milliseconds, which clearly implicate al

270 ning between these states range from several microseconds to milliseconds.

271 ally relevant information on timescales from microseconds to tens of seconds.

272 ics of materials on time scales ranging from microseconds to thousands of seconds and length scales r

273 on-based gating (in the order of hundreds of microseconds) to improve the spatiotemporal resolution b

274 of the 70S ribosome (2.1 million atoms; 1.3 microseconds) to provide this bridge for specific confor

275 odeling that provide unprecedented access to microsecond- to millisecond-timescale fluctuations of a

276 edict that unspecific interactions slow down microsecond- to millisecond-timescale protein dynamics d

277 the time-dependent structure of TRAP in the microsecond-to-millisecond "chemical exchange" time wind

278 lation with a change in dynamics on both the microsecond-to-millisecond (mus-ms) timescale and the pi

279 cal responses in U1A, they produce extensive microsecond-to-millisecond global motions throughout SNF

280 Recently, a study of the late, microsecond-to-millisecond kinetics of photointermediate

281 t to beta(1)-CBM, unbound beta(2)-CBM showed microsecond-to-millisecond motion at the base of a beta-

282 Upon binding to carbohydrate, similar microsecond-to-millisecond motion was observed in this b

283 s in conformational exchange dynamics in the microsecond-to-millisecond time regime between the diffe

284 Our results demonstrate that a microsecond-to-millisecond time scale conformational tra

285 ormational exchange processes in proteins on microsecond-to-millisecond time scales can be detected a

286 The intrinsic microsecond-to-millisecond timescale dynamics of the dsR

287 s timescales, base-pair/tertiary dynamics at microsecond-to-millisecond timescales, stacking dynamics

288 and H undergo conformational fluctuations on microsecond-to-millisecond timescales.

289 (picosecond to nanosecond) and intermediate (microsecond-to-millisecond) dynamics of U1A and SNF RRM1

290 The generated multiple microsecond trajectories consistently show that the heli

291 By subjecting microsecond trajectories of two proteins (lysozyme and a

292 tic and protic solvents using femtosecond-to-microsecond transient absorption and product analysis, i

293 A combination of picosecond and microsecond transient absorption dynamics reveals the in

294 In this work we exploit femtosecond to microsecond transient IR spectroscopy to record, in D2 O

295 fluorescence with lifetimes on the order of microseconds was observed.

296 e and absorption spectroscopy from femto- to microseconds, we provide the first experimental evidence

297 r time scale structural dynamics (nanosecond-microsecond) were the source and therefore impart the co

298 ntermediates with half-lives on the order of microseconds, which is 4-5 orders of magnitude faster th

299 er a wide time range, from subpicoseconds to microseconds with a combination of ultrafast optical ele

300 agnitude in time, from one nanosecond to ten microseconds, with a single adjustable parameter.