ライフサイエンスコーパス: microsomal

1 This is the first structure of a eukaryotic microsomal 14DM that acts on sterol biosynthesis, and it

2 ral, mutagenicity was higher with S9 hepatic microsomal activation.

3 g that 4-oxo-atRA formation is mediated by a microsomal alcohol dehydrogenase.

4 tentially, a better choice than caffeine for microsomal and cell studies due to its reported lack of

5 were investigated using human in vitro liver microsomal and cytosolic bioassays.

6 xhibited favorable in vitro ADME properties (microsomal and hepatocyte stability, MDCK permeability,

7 Preliminary human liver microsomal and in vivo rodent studies demonstrated that

8 reconstitution experiments showed that both microsomal and mitochondrial WT CYP2C8 efficiently catal

9 nthesized standards, we identified the major microsomal and plasma metabolites of 230 as products of

10 d had favorable ADME properties but had poor microsomal and plasma stability.

11 tabolites were detectable after gull and rat microsomal assay incubation with solutions 3 or 4, and s

12 lamino)phenyl)propanoates in a MCF-7 CYP26A1 microsomal assay is described.

13 tial metabolites of TBECH were identified in microsomal assays of both the TBECH mixture and beta-TBE

14 The microsomal assays revealed that C.sativa seeds have very

15 In vitro microsomal assays suggested that compounds (R)-1 and (S)

16 cubation period of solution 1 in gull or rat microsomal assays, there was no significant (p > 0.05) d

17 entatus) and adult male Wister-Han rat liver microsomal assays.

18 , respectively) and compared them with human microsomal b(5) (Cyb5A) and b(5)R (Cyb5R3).

19 e interactions between the soluble domain of microsomal b5 and the catalytic domain of the bifunction

20 In order to design a green microsomal bioreactor on suitably identified carbon elec

21 s probably due to the known accessibility of microsomal carboxylase to water, which reprotonates the

22 l structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P45

23 e brain/free plasma >/= 1 in rat and reduced microsomal clearance along with the ability to increase

24 cterium tuberculosis (Mtb), high mouse liver microsomal clearance, and low aqueous solubility.

25 GPR119 receptor with low unbound human liver microsomal clearance.

26 SRFR1 is localized in both a cytoplasmic microsomal compartment and in the nucleus.

27 that Mi-1.2 and SlSERK1 colocalize only in a microsomal complex.

28 o acid sequence diversity than their type A (microsomal) counterparts, as exemplified by the type B p

29 first structure of full-length rabbit ferric microsomal cytb5 (16 kDa), incorporated in two different

30 Microsomal cytochrome b5 (cytb5) is a membrane-bound pro

31 Human microsomal cytochrome P450 (CYP) 2E1 is widely known for

32 se (POR) is essential for the functioning of microsomal cytochrome P450 (P450) monooxygenases and hem

33 om drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequentia

34 yt b(5)) is one of the key components in the microsomal cytochrome P450 monooxygenase system.

35 CYPOR) is essential for electron donation to microsomal cytochrome P450-mediated monooxygenation in s

36 f multi-walled carbon-nanotubes (MWCNTs) and microsomal cytochrome P4501A2 (msCYP1A2) on a graphite s

37 Evaluation of the microsomal cytochrome-P450 (CYP) enzymes revealed signif

38 ges in the structural studies of full-length microsomal cytochrome-P450 and cytochrome-b5 by solid-st

39 tb5 interaction epitope recognized by ferric microsomal cytP450 (56 kDa).

40 e by hmoDCs, and enhances their stability to microsomal degradation.

41 s are limited by poor solubilities and rapid microsomal degradations.

42 Twelve full-length genes coding for microsomal Delta12 fatty acid desaturases (FADs) from th

43 tional proteoliposomes, reconstituted from a microsomal detergent extract, lost their activity when m

44 ke accompanied by an increased resistance to microsomal digestion.

45 erved in the crystallographic dimers of some microsomal drug-metabolizing cytochromes P450.

46 , and their subsequent hydrolysis by sEH and microsomal EH.

47 Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that co

48 HO-1 (heme oxygenase-1) is an inducible microsomal enzyme that catalyzes the degradation of pro-

49 Heme oxygenase-1 (HO-1) is a microsomal enzyme with antioxidant, antiapoptotic, and i

50 The microsomal epoxide hydrolase (mEH) plays a significant r

51 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical

52 ncreased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95%

53 However, rat microsomal ER provides a statistically significant, and

54 R was associated with increased levels of ER/microsomal (ER/M) associated alphaS monomers and aggrega

55 CYP3A4 inhibition, hERG inhibition, and rat microsomal extraction ratio (ER).

56 In microsomal extracts, mPGES-1 protein was barely detectab

57 t in both species; in a phylogenetic tree of microsomal FAD enzymes, FADX and FADY formed a unique cl

58 P450 (CYP)-specific bioactivity of the liver microsomal film on the catalytically superior, stable HP

59 ctroactive surface coverage and stability of microsomal films were greater on highly surface defectiv

60 s share a kinetic mechanism with the hepatic microsomal flavin monooxygenases and bacterial Baeyer-Vi

61 A microsomal fraction containing recombinant LaPT1 prenyla

62 We also found that the TH microsomal fraction content decreases after inhibition o

63 ATP7B, isolated with the microsomal fraction of cell homogenates, accounts for 10

64 radation was simulated in vitro by using the microsomal fraction of JAWS II cells, followed by liquid

65 specific prenyltransferase activity from the microsomal fraction of peanut hairy roots.

66 The presence of PKD protein in the microsomal fraction was demonstrated by Western blotting

67 a cells, with decreased association with the microsomal fraction, whereas a phospho-mimic mutant, TH1

68 This microsomal fraction-derived resveratrol 4-dimethylallyl

69 Fluorescence imaging and microsomal fractionation studies revealed that SAUR63:GF

70 , this protein predominantly associates with microsomal fractions isolated from bovine retinal pigmen

71 more, in vitro assays of acyltransferases in microsomal fractions prepared from developing seeds of s

72 G6PT transport is the rate-limiting step in microsomal G6P metabolism, this may explain why the trea

73 ls for antioxidant enzymes (lactoperoxidase, microsomal glutathione S-transferase 2 and 3, glutathion

74 level is directly correlated to the level of microsomal GPAT enzymatic activity in seeds.

75 erfamily but is likely to be present also in microsomal GST-1 based on sequence similarity.

76 tro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeabi

77 can be metabolically degraded, using a model microsomal in vitro assay (Wistar-Han rats liver microso

78 e concentrations increased over the 0-60 min microsomal incubation period.

79 Rat liver microsomal incubations from eight test compounds were an

80 Microsomal incubations using NADPH concentrations below

81 inhibitor was subjected to a series of liver microsomal incubations, which generated a number of meta

82 efflux, but it was rapidly cleared in liver microsomal incubations.

83 to 130% of the parent compound added to the microsomal incubations.

84 efficacy, it formed reactive metabolites in microsomal incubations.

85 nd 5-136 were formed atropselectively in all microsomal incubations; however, the direction and exten

86 The participation of the microsomal isoform (CYB5A) in N-reduction could be exclu

87 Higher microsomal levels of 7-ethoxycoumarin-O-deethylase activ

88 Most derivatives strongly inhibited in vitro microsomal lipid and LDL peroxidation, exhibiting potent

89 by significant increases in small intestinal microsomal lovastatin-hydroxylase activity and systemic

90 tion is typically catalyzed by an LPAT2 from microsomal LPAT class A that has high specificity for C1

91 ntly increases VLDL lipidation in hepatocyte microsomal lumina, and also VLDL secretion into the plas

92 Rat liver microsomal lysoplasmalogenase was solubilized with octyl

93 Microsomal (m) prostaglandin (PG) E(2) synthase (S)-1 ca

94 dant in Arabidopsis tissues and present in a microsomal membrane fraction.

95 d mobilized Ca(2+) stored in sperm (and from microsomal membrane preparations).

96 mental measurements of PLB in detergents and microsomal membrane.

97 Topology mapping in microsomal membranes also indicates that TM1 does not in

98 sicle formation assays involve incubation of microsomal membranes and purified COPII proteins with nu

99 ly labeled and unlabeled RTA bind both to ER microsomal membranes and to negatively charged liposomes

100 ption/translation systems in the presence of microsomal membranes and with detergent phase separation

101 the nature of RPE65 interactions with native microsomal membranes by using extraction and phase separ

102 logically relevant P450-P450 interactions in microsomal membranes continues to grow.

103 Microsomal membranes from immature peanut seeds were sol

104 pable of acylating monoacylglycerol from the microsomal membranes of developing peanut cotyledons.

105 Third, detergent extracts from microsomal membranes prepared from transgenic lines were

106 and the specific binding of [(3)H]LTD(4) to microsomal membranes were fully inhibited.

107 acum) and Arabidopsis (Arabidopsis thaliana) microsomal membranes were studied here with an in vitro

108 ation of human CYP3A4, CYP3A5, and CYP2E1 in microsomal membranes.

109 proteins Bik, Bim, Noxa, Bmf, and Puma into microsomal membranes.

110 f a light-emitting ruthenium metallopolymer, microsomal metabolic enzymes, and DNA to detect potentia

111 ethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable

112 following oral dosing at 4 x 30 mg/kg, with microsomal metabolic stability data suggesting that this

113 hat improved the human/rodent correlation in microsomal metabolic stability.

114 -TB while retaining low toxicity with higher microsomal, metabolic, and plasma stability.

115 ing low cytotoxicity, increased stability to microsomal metabolism, and also revealed striking enanti

116 nly limitation currently being their rate of microsomal metabolism.

117 Here, we identify the microsomal metabolite and describe synthesized analogues

118 on immunoblottings performed with cytosolic, microsomal, mitochondrial, and nuclear proteins from rat

119 Rates of microsomal NA bioactivation and the effects of an anti-C

120 tivated by cyanide, and is distinct from the microsomal NOD activity.

121 largely controlled by the activities of the microsomal omega-6 and omega-3 fatty acid desaturases, F

122 Although some human microsomal P450 enzymes can instead accept the second el

123 e (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, l

124 ccurs throughout the cell, as expected for a microsomal P450, but CYP4G16 localizes to the periphery

125 ed cell-wall methylesterification levels and microsomal pectin methyltransferase activity.

126 methylesterification, coupled with decreased microsomal pectin methyltransferase activity.

127 versions were also localized to cytosol and microsomal pellets.

128 EP3 and microsomal PG synthase type 1 play a role in decreasing

129 ase, highlights the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE2 signaling in hypertension

130 Microglial cyclooxygenase-2, microsomal PGE synthase, and PGE2 expression were increa

131 id shear via the sequential up-regulation of microsomal PGE synthase-1 (mPGES-1) and L-PGDS.

132 cytofluorescence, we detected both COX-2 and microsomal PGE synthase-1 (mPGES-1) but not COX-1 in the

133 Microsomal PGE synthase-1 (mPGES-1) is an inducible enzy

134 LPS exposure induced expression of microsomal PGE synthase-1 (mPGES-1), a key enzyme in PGE

135 ) production primarily through inhibition of microsomal PGE synthase-1 (mPGES-1), not COX-2.

136 d WT mice have increased levels of COX-2 and microsomal PGE synthase-1 (mPGES-1).

137 IL-6 coinduced Cox-2 and microsomal PGE synthase-1, and inhibited the expression

138 king the critical terminal synthetic enzyme, microsomal PGE(2) synthase (mPGES)-1.

139 or-kappaB-dependent thromboxane synthase and microsomal PGE(2) synthase was down-regulated by seleniu

140 d the development of disease in mice lacking microsomal PGE(2) synthase-1 (mPGES1), which converts CO

141 n-related increase in a COX-2-linked enzyme, microsomal PGE(2) synthase-1, and the PGE(2)R, EP2.

142 nerated by dust mite priming of mice lacking microsomal PGE2 synthase (ptges(-/-) mice), shows a simi

143 landin E2 (PGE2) through inducible COX-2 and microsomal PGE2 synthase 1 (mPGES-1) (1).

144 s of prostaglandin E2 (PGE2)-forming enzymes microsomal PGE2 synthase 1 (mPGES1) and COX2.

145 Microsomal PGE2 synthase, PGE2, and its receptors (EP1,

146 The main source of inducible PGE2, microsomal PGE2 synthase-1 (mPGES-1), has emerged as an

147 We demonstrate that microsomal PGE2 synthase-1 null mice develop a remarkabl

148 because mice lacking the genes encoding the microsomal PGE2 synthase-1 or the EP2 receptor were prot

149 o 4 hrs; whereas the increased expression of microsomal PGES (mPGES)-1 and a myeloid cell transcripti

150 We found that microsomal PGES1 (mPGES1), mPGES2, and cytosolic PGES (c

151 Microsomal PGES1 may be a potential target to prevent or

152 amagnetic microparticles bearing recombinant microsomal phase I cytochrome P450 or phase II conjugati

153 This is explained by an increase in microsomal phospholipids containing polyunsaturated fatt

154 three parent compounds was dependent on the microsomal preparation used and followed the rank order

155 heptachlor epoxide differed depending on the microsomal preparation.

156 lically stable in both human and mouse liver microsomal preparations and has a plasma t(1/2) of 50 h

157 ation studies and analysis of nascent XyG in microsomal preparations demonstrated that this glycosylh

158 Microsomal preparations from leaves of these mutants sho

159 Microsomal preparations from Pichia cells expressing AtG

160 ere confirmed with in vitro assays utilizing microsomal preparations from yeast overexpressing the re

161 chiral and formed enantioselectively by all microsomal preparations investigated.

162 lites showed considerable differences across microsomal preparations obtained from different species.

163 in yeast and characterized biochemically in microsomal preparations of the cells.

164 oxidation of PCB 51 and PCB 102 by different microsomal preparations results in the formation of chir

165 The corresponding microsomal preparations were equally effective at mediat

166 t that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E2 synthase-1 system may un

167 Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is

168 By contrast, deletion of microsomal prostaglandin E synthase 1 (mPGES-1) confers

169 Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice

170 Microsomal prostaglandin E synthase 1 (mPGES-1) is a key

171 Microsomal prostaglandin E synthase 1 (mPGES-1) is an al

172 namely IL-1 type I receptor (IL-1RI), COX-2, microsomal prostaglandin E synthase 1 (mPGES-1), and EP

173 of the enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1).

174 A2 (cPLA(2)), cyclooxygenase 2 (COX-2), and microsomal prostaglandin E synthase 1 (mPGES1).

175 An x-ray study indicated that microsomal prostaglandin E synthase type 2 (mPGES2) is a

176 neuroblastoma tumors express high levels of microsomal prostaglandin E synthase-1 (mPGES-1) and elev

177 y consisting of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) by a yet

178 Microsomal prostaglandin E synthase-1 (mPGES-1) in myelo

179 more, injection of a virus vector expressing microsomal prostaglandin E synthase-1 (mPGES-1) into the

180 Microsomal prostaglandin E synthase-1 (mPGES-1) is a key

181 Microsomal prostaglandin E synthase-1 (mPGES-1) is a rat

182 vious studies in rats have demonstrated that microsomal prostaglandin E synthase-1 (mPGES-1) is induc

183 itions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an

184 e associated with altered PGE(2) metabolism, microsomal prostaglandin E synthase-1 (mPGES-1), prostag

185 he expression of cyclooxygenase 2 (COX2) and microsomal prostaglandin E synthase-1 (mPGES-1), which a

186 duces the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and reduces 15-hyd

187 Inhibiting COX-2 or microsomal prostaglandin E synthase-1 suppressed the 6-O

188 e downstream of COX-1 that synthesizes PgE2 (microsomal prostaglandin E synthase-1) depends criticall

189 Cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1, key components of

190 age aggrecanase, and of cyclooxygenase-2 and microsomal prostaglandin E synthase-1, key enzymes in th

191 Microsomal prostaglandin E(2) synthase-1 (mPGES-1), enco

192 Microsomal prostaglandin E2 synthase (mPGES)-1 is respon

193 Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is

194 Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-l

195 crophages followed by sustained elevation in microsomal prostaglandin synthase 1 (mPGES-1) expression

196 d astrocytes, LPS strongly induced COX-2 and microsomal prostaglandin-E(2) (PGE(2)) synthase-1, media

197 o 96 pmol/mg protein in liver and intestinal microsomal protein digests.

198 with the ability to use as low as 0.25mug of microsomal protein per assay.

199 level in human liver, kidney, and intestinal microsomal protein was determined by extrapolation from

200 Isolated microsomal proteins appeared to also be involved in the

201 cal inhibitors, substantially attenuated the microsomal reaction.

202 Piperidine-derived analogues showing minimal microsomal reactive metabolite formation were discovered

203 The microsomal retinol dehydrogenase (RDH11) and cytosolic s

204 in vivo pharmacokinetic studies and in vitro microsomal/S9 stability studies, and the results generat

205 ere the real product ions of DRM detected in microsomal samples from IDA, SWATH, and MS(All) methods,

206 hree independent approaches: an experimental microsomal Sec61 translocon assay, a biophysical (spectr

207 not block the translocation of a full-length microsomal secretory protein and was cleaved as part of

208 vigera var. pulcherrima (CpuLPAT2a) encoding microsomal, seed-specific class A LPAT2s and a cDNA from

209 igera var. pulcherrima (CpuLPATB) encoding a microsomal, seed-specific LPAT from the bacterial-type c

210 organelle clustering into a two-dimensional microsomal spread and 2) identification of TGN and post-

211 The log D values, plasma stabilities, and microsomal stabilities of selected compounds were found

212 he 18 compounds further assessed showed high microsomal stabilities, although in the acute infection

213 splayed low off-target activity (>500x), and microsomal stability (T(1/2) > 30 min).

214 suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to

215 An empirical approach to improve the microsomal stability and CYP inhibition profile of lead

216 l)-3,5-dimethy lisoxazole (31) has excellent microsomal stability and good oral pharmacokinetics in r

217 xazepine 1, an EP2 antagonist possessing low microsomal stability and potent CYP3A4 inhibition.

218 od-stage growth with improved solubility and microsomal stability and reduced hERG binding.

219 This substitution also increased the microsomal stability and the free fraction of compounds

220 studies, driven primarily by in vitro liver microsomal stability assessment, identified compound 10b

221 Addressing P2X7 affinity and liver microsomal stability issues encountered with this templa

222 that further optimization of solubility and microsomal stability of the series could provide a stron

223 ther with its improved chemical, plasma, and microsomal stability relative to compound 2 (apogossypol

224 Microsomal stability studies demonstrated that 14 was mo

225 ere complemented with in vitro human and rat microsomal stability studies.

226 ibitor compound 3, a strategy to improve the microsomal stability was pursued resulting in the identi

227 It had good microsomal stability when incubated with rat and human l

228 ssessed desirable properties in terms of its microsomal stability, and CYP and hERG inhibition, along

229 for CCR1 over other CCR-family members, high microsomal stability, and good pharmacokinetics in mice.

230 lectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.

231 Structure-property relationships including microsomal stability, cell permeability, and in vivo pha

232 1 and 75 displayed excellent microsomal stability, intrinsic clearance, and hepatic e

233 several optimization cycles, we improved the microsomal stability, potency, and kinase selectivity.

234 e properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brai

235 ovement of both the water solubility and the microsomal stability.

236 against W2 and TM90-C2B as well as improved microsomal stability.

237 feration, solubility, CYP450 inhibition, and microsomal stability.

238 ties, including high solubility and moderate microsomal stability.

239 istance, low cytotoxicity, and high in vitro microsomal stability.

240 boptimal physicochemical properties and poor microsomal stability.

241 and TM90-C2B, as well as the improvement of microsomal stability.

242 the EP2 receptor and significantly improved microsomal stability.

243 idant, anti-inflammatory, and anti-apoptotic microsomal stress protein, migrates to the nucleus in a

244 Mouse and human microsomal studies of analogue 2b show it to have excell

245 Moreover, microsomal studies showed convenient metabolic stability

246 pids that have been transferred to the ER by microsomal TG transfer protein (MTP), inducing ER stress

247 Both lomitapide, a microsomal transfer protein inhibitor (MTPI), and mipome

248 In addition, we established a microsomal translation/translocation/O-mannosylation sys

249 ing or genetic or pharmacologic reduction in microsomal triglyceride transfer protein (MTP) activity,

250 hylomicron and HDL pathways are dependent on microsomal triglyceride transfer protein (MTP) and ATP-b

251 lesterol absorption pathways and the role of microsomal triglyceride transfer protein (MTP) and ATP-b

252 Using a microsomal triglyceride transfer protein (MTP) inhibitor

253 The use of microsomal triglyceride transfer protein (MTP) inhibitor

254 Microsomal triglyceride transfer protein (MTP) is a key

255 Microsomal triglyceride transfer protein (MTP) is a targ

256 Microsomal triglyceride transfer protein (MTP) is a uniq

257 Furthermore, these mice had higher microsomal triglyceride transfer protein (MTP) mRNA and

258 Microsomal triglyceride transfer protein (MTP) plays a k

259 Here we demonstrate that microsomal triglyceride transfer protein (MTP), a protei

260 We have shown previously that Clock, microsomal triglyceride transfer protein (MTP), and noct

261 n of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well

262 lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can cont

263 Microsomal triglyceride transfer protein (MTP), essentia

264 Here, we investigated the role of microsomal triglyceride transfer protein (MTP), required

265 The microsomal triglyceride transfer protein (MTP), the prod

266 ipid metabolism due to genetic deficiency in microsomal triglyceride transfer protein (MTP).

267 rough genetic or pharmacologic inhibition of microsomal triglyceride transfer protein (Mttp) causes h

268 Impaired expression of microsomal triglyceride transfer protein (MTTP) contribu

269 Silymarin inhibited microsomal triglyceride transfer protein activity, apoli

270 Both microsomal triglyceride transfer protein and apolipoprot

271 and/or vit genes, the orthologs of mammalian microsomal triglyceride transfer protein and apolipoprot

272 ry-low-density lipoprotein (VLDL) synthesis (microsomal triglyceride transfer protein and apolipoprot

273 activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcr

274 ates transcription and activity of placental microsomal triglyceride transfer protein as well as expr

275 ol and mitigates atherosclerosis by reducing microsomal triglyceride transfer protein expression and

276 hibits triglyceride secretion and intestinal microsomal triglyceride transfer protein expression in v

277 ed lipoprotein production by down-regulating microsomal triglyceride transfer protein expression.

278 Lipid-lowering was induced by microsomal triglyceride transfer protein gene inactivati

279 reversed by conditional inactivation of the microsomal triglyceride transfer protein gene, were plac

280 Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceride transfer protein in the intestin

281 A microsomal triglyceride transfer protein inhibitor and a

282 med to assess the efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomit

283 second-generation antisense oligonucleotide, microsomal triglyceride transfer protein inhibitors that

284 at physiological levels increased intestinal microsomal triglyceride transfer protein levels and acti

285 l mediates the transcriptional regulation of microsomal triglyceride transfer protein via hepatic nuc

286 /-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more li

287 in part by transcriptional effects on apoB, microsomal triglyceride transfer protein, and lipogenic

288 ydrogenase 1A1, and catalase, as well as the microsomal triglyceride transfer protein, involved in re

289 Furthermore, we identified microsomal triglyceride transfer protein, which we show

290 ed cellular apoB stability via activation of microsomal triglyceride transfer protein.

291 posttranscriptional effects on the LDLR and microsomal triglyceride transfer protein.

292 decreased expression of Mttp and its product microsomal triglyceride transfer protein.

293 was normalized by inactivating the gene for microsomal triglyceride transfer protein.

294 er conditional knockout of the gene encoding microsomal triglyceride transfer protein.

295 On the other hand, microsomal triglycerol transfer protein (MTP) activity a

296 acterized by pathognomonic anti-liver kidney microsomal type 1 (LKM-1) showing a remarkable antigen-s

297 Finally, we showed that microsomal vesicles isolated from mammalian cells contai

298 tivity in sealed wild type and Rft1-depleted microsomal vesicles when the activity was assessed by th

299 d abrogates (35)S-PC(2) uptake into S. pombe microsomal vesicles.

300 bited substrate-specific reductions in liver microsomal vitamin E-omega-hydroxylase activity ranging