ライフサイエンスコーパス: microsomal triglyceride transfer protein

1 f the enzymes prolyl 4-hydroxylase (P4H) and microsomal triglyceride transfer protein.

2 o LDL, and was greater than its affinity for microsomal triglyceride transfer protein.

3 ells were incubated with an inhibitor of the microsomal triglyceride transfer protein.

4 ed cellular apoB stability via activation of microsomal triglyceride transfer protein.

5 decreased expression of Mttp and its product microsomal triglyceride transfer protein.

6 posttranscriptional effects on the LDLR and microsomal triglyceride transfer protein.

7 was normalized by inactivating the gene for microsomal triglyceride transfer protein.

8 er conditional knockout of the gene encoding microsomal triglyceride transfer protein.

9 including apolipoprotein B (apoB), apoE, and microsomal triglyceride transfer protein.

10 al apoB synthetic rate, and abundance of the microsomal triglyceride transfer protein 97-kDa subunit

11 Finally, mRNA levels of the large subunit of microsomal triglyceride transfer protein, a required com

12 /-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more li

13 tion both in vivo and in vitro, inhibits the microsomal triglyceride transfer protein activity as wel

14 Silymarin inhibited microsomal triglyceride transfer protein activity, apoli

15 nhibition of cholesteryl-ester synthesis and microsomal triglyceride transfer-protein activity.

16 ylase alpha(2)beta(2)-tetramer (P4H) and the microsomal triglyceride transfer protein alphabeta-dimer

17 Microsomal triglyceride transfer protein also transfers

18 Both microsomal triglyceride transfer protein and apolipoprot

19 and/or vit genes, the orthologs of mammalian microsomal triglyceride transfer protein and apolipoprot

20 ry-low-density lipoprotein (VLDL) synthesis (microsomal triglyceride transfer protein and apolipoprot

21 id absorption in the small intestine, namely microsomal triglyceride transfer protein and apolipoprot

22 osis by enhancing proteasomal degradation of microsomal triglyceride transfer protein and can be part

23 ApoB-independent pathways do not require microsomal triglyceride transfer protein and involve eff

24 activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcr

25 ts that block VLDL assembly: an inhibitor of microsomal triglyceride transfer protein and siRNA direc

26 a conditional allele for Mttp (the gene for microsomal triglyceride transfer protein) and the induci

27 in part by transcriptional effects on apoB, microsomal triglyceride transfer protein, and lipogenic

28 lipoprotein lipase and reduced expression of microsomal triglyceride transfer protein, apolipoprotein

29 Thus, microsomal triglyceride transfer protein appears to cont

30 The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed i

31 ates transcription and activity of placental microsomal triglyceride transfer protein as well as expr

32 a stable lipoprotein structure by inhibiting microsomal triglyceride transfer protein attenuates the

33 duce cytosolic Hsp70 or with an inhibitor of microsomal triglyceride transfer protein; both treatment

34 monensin, cycloheximide, and an inhibitor of microsomal triglyceride transfer protein but remains unc

35 Inhibition of the microsomal triglyceride transfer protein by BMS-201038 r

36 with lipid is thought to be promoted by the microsomal triglyceride transfer protein complex.

37 Until recently it was assumed that microsomal triglyceride transfer protein-dependent apoli

38 The evidence indicates that microsomal triglyceride transfer protein does not play a

39 Microsomal triglyceride transfer protein emerged as a ph

40 ol and mitigates atherosclerosis by reducing microsomal triglyceride transfer protein expression and

41 ons, plasma apoB-containing lipoproteins and microsomal triglyceride transfer protein expression exhi

42 hibits triglyceride secretion and intestinal microsomal triglyceride transfer protein expression in v

43 ts length, its requirement for lipidation or microsomal triglyceride transfer protein expression.

44 with coactivators and corepressors modulate microsomal triglyceride transfer protein expression.

45 ed lipoprotein production by down-regulating microsomal triglyceride transfer protein expression.

46 Lipid-lowering was induced by microsomal triglyceride transfer protein gene inactivati

47 reversed by conditional inactivation of the microsomal triglyceride transfer protein gene, were plac

48 ssion of genes encoding apolipoprotein B and microsomal triglyceride transfer protein, (ii) an increa

49 been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein

50 summarizes recent advances about the role of microsomal triglyceride transfer protein in plasma and t

51 Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceride transfer protein in the intestin

52 id levels of BMS-201038, an inhibitor of the microsomal triglyceride transfer protein, in six patient

53 The effects of microsomal triglyceride transfer protein inhibition were

54 A microsomal triglyceride transfer protein inhibitor and a

55 duce apoB degradation, but the addition of a microsomal triglyceride transfer protein inhibitor led t

56 med to assess the efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomit

57 Furthermore, addition of either the microsomal triglyceride transfer protein inhibitor or tr

58 Upon omitting fatty acids from, or adding a microsomal triglyceride transfer protein inhibitor to, c

59 When HepG2 cells were incubated with a microsomal triglyceride transfer protein inhibitor, the

60 us expression systems, as well as the use of microsomal triglyceride transfer protein inhibitors in h

61 second-generation antisense oligonucleotide, microsomal triglyceride transfer protein inhibitors that

62 ay is induced by oleic acid, is repressed by microsomal triglyceride transfer protein inhibitors, and

63 ydrogenase 1A1, and catalase, as well as the microsomal triglyceride transfer protein, involved in re

64 Microsomal triglyceride transfer protein is a target to

65 The microsomal triglyceride transfer protein is necessary fo

66 Microsomal triglyceride transfer protein is regulated at

67 poprotein secretion (e.g., in heart-specific microsomal triglyceride transfer protein knockout mice)

68 The intracellular concentration of the microsomal triglyceride transfer protein large subunit (

69 Conventional knockout of the microsomal triglyceride transfer protein large subunit (

70 at physiological levels increased intestinal microsomal triglyceride transfer protein levels and acti

71 Inhibition of the microsomal triglyceride transfer protein may be effectiv

72 In a previous model we suggested that microsomal triglyceride transfer protein might play a st

73 Reductions in microsomal triglyceride transfer protein mRNA and activi

74 Triglyceride levels as well as microsomal triglyceride transfer protein mRNA and activi

75 Lower microsomal triglyceride transfer protein mRNA levels wer

76 ted by either 6 mM OA or 20% Intralipid, but microsomal triglyceride transfer protein mRNA was signif

77 ve expression of 7alpha-hydroxylase mRNA and microsomal triglyceride transfer protein mRNA, a gene pr

78 ing or genetic or pharmacologic reduction in microsomal triglyceride transfer protein (MTP) activity,

79 Moreover, intestinal microsomal triglyceride transfer protein (MTP) activity,

80 Recent studies indicate that microsomal triglyceride transfer protein (MTP) and apoli

81 strated protein-protein interactions between microsomal triglyceride transfer protein (MTP) and apoli

82 Expression of human microsomal triglyceride transfer protein (MTP) and apoli

83 hylomicron and HDL pathways are dependent on microsomal triglyceride transfer protein (MTP) and ATP-b

84 lesterol absorption pathways and the role of microsomal triglyceride transfer protein (MTP) and ATP-b

85 by inhibiting lipid transfer mediated by the microsomal triglyceride transfer protein (MTP) and is pr

86 Although microsomal triglyceride transfer protein (MTP) and newly

87 f a complex between apolipoprotein (apo)B, a microsomal triglyceride transfer protein (MTP) and prote

88 Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are essen

89 ApoB and the microsomal triglyceride transfer protein (MTP) are essen

90 Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are essen

91 Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are known

92 Microsomal triglyceride transfer protein (MTP) catalyzes

93 A deficiency in microsomal triglyceride transfer protein (MTP) causes th

94 However, it is now clear that microsomal triglyceride transfer protein (MTP) exists in

95 oth the apolipoprotein B (apoB) gene and the microsomal triglyceride transfer protein (MTP) gene is r

96 Microsomal triglyceride transfer protein (MTP) has been

97 VLDL production is facilitated by microsomal triglyceride transfer protein (MTP) in a rate

98 We also investigated the role of the microsomal triglyceride transfer protein (MTP) in the as

99 Recently, we generated mice lacking microsomal triglyceride transfer protein (MTP) in the li

100 of biarylamide-substituted diaminoindanes as microsomal triglyceride transfer protein (MTP) inhibitor

101 Using a microsomal triglyceride transfer protein (MTP) inhibitor

102 ation across the endoplasmic reticulum by an microsomal triglyceride transfer protein (MTP) inhibitor

103 The use of microsomal triglyceride transfer protein (MTP) inhibitor

104 A microsomal triglyceride transfer protein (MTP) inhibitor

105 h accumulate triglycerides when treated with microsomal triglyceride transfer protein (MTP) inhibitor

106 The microsomal triglyceride transfer protein (MTP) is a hete

107 Microsomal triglyceride transfer protein (MTP) is a key

108 Microsomal triglyceride transfer protein (MTP) is a targ

109 Microsomal triglyceride transfer protein (MTP) is a uniq

110 Microsomal triglyceride transfer protein (MTP) is an end

111 Microsomal triglyceride transfer protein (MTP) is essent

112 The microsomal triglyceride transfer protein (MTP) is requir

113 h lipid synthesis, proteasomal activity, and microsomal triglyceride transfer protein (MTP) lipid-tra

114 Furthermore, these mice had higher microsomal triglyceride transfer protein (MTP) mRNA and

115 ty lipoprotein (VLDL) secretion and elevated microsomal triglyceride transfer protein (MTP) mRNA and

116 Microsomal triglyceride transfer protein (MTP) plays a c

117 Microsomal triglyceride transfer protein (MTP) plays a k

118 The first involves transfer of lipid by the microsomal triglyceride transfer protein (MTP) to apoB d

119 Microsomal triglyceride transfer protein (MTP) transfers

120 Although very small amounts of microsomal triglyceride transfer protein (MTP) were asso

121 eins, increased cellular lipids, and reduced microsomal triglyceride transfer protein (MTP) without d

122 Microsomal triglyceride transfer protein (MTP), a chaper

123 Since both B17 and microsomal triglyceride transfer protein (MTP), a critic

124 Microsomal triglyceride transfer protein (MTP), a hetero

125 Here we demonstrate that microsomal triglyceride transfer protein (MTP), a protei

126 Here we show that microsomal triglyceride transfer protein (MTP), a protei

127 Microsomal triglyceride transfer protein (MTP), an endop

128 Microsomal triglyceride transfer protein (MTP), an endop

129 We have shown previously that Clock, microsomal triglyceride transfer protein (MTP), and noct

130 n of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well

131 lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can cont

132 Due to the absence of microsomal triglyceride transfer protein (MTP), Chinese

133 teinemia, a disease caused by defects in the microsomal triglyceride transfer protein (MTP), do not p

134 Microsomal triglyceride transfer protein (MTP), essentia

135 Here, we investigated the role of microsomal triglyceride transfer protein (MTP), required

136 The microsomal triglyceride transfer protein (MTP), the prod

137 d lipidated apoB forms despite their lack of microsomal triglyceride transfer protein (MTP), which me

138 Whereas L35 cells do not express microsomal triglyceride transfer protein (MTP), which re

139 s observed in Chinese hamster ovary cells, a microsomal triglyceride transfer protein (MTP)-negative

140 asma, is caused by mutations in the gene for microsomal triglyceride transfer protein (MTP).

141 an cells requires the presence of functional microsomal triglyceride transfer protein (MTP).

142 ipid metabolism due to genetic deficiency in microsomal triglyceride transfer protein (MTP).

143 de, lipids in defined forms, chaperones, and microsomal triglyceride transfer protein (MTP).

144 VLDL assembly in the liver is catalyzed by microsomal triglyceride transfer protein (MTP).

145 assembly of which is critically dependent on microsomal triglyceride transfer protein (MTP).

146 pocket" without a structural requirement for microsomal triglyceride transfer protein (MTP).

147 horin II/I, apolipoprotein B (apoB), and the microsomal triglyceride transfer protein (MTP).

148 S cells with and without coexpression of the microsomal triglyceride transfer protein (MTP).

149 he endoplasmic reticulum-localized cofactor, microsomal triglyceride transfer protein (MTP).

150 ith a betaD-like amphipathic beta sheet from microsomal triglyceride transfer protein (MTP).

151 defect can be overcome by coexpression with microsomal triglyceride transfer protein (MTP); moreover

152 Western blots with a microsomal triglyceride transfer protein) (MTP)-specific

153 rough genetic or pharmacologic inhibition of microsomal triglyceride transfer protein (Mttp) causes h

154 Impaired expression of microsomal triglyceride transfer protein (MTTP) contribu

155 eractions of apolipoprotein B (apoB) and the microsomal triglyceride transfer protein (Mttp).

156 It has been shown that microsomal triglyceride transfer protein plays a key rol

157 l mediates the transcriptional regulation of microsomal triglyceride transfer protein via hepatic nuc

158 low density lipoprotein receptor) as well as microsomal triglyceride transfer protein were elevated a

159 Furthermore, we identified microsomal triglyceride transfer protein, which we show

160 These cells do not express microsomal triglyceride transfer protein yet secrete apo