ライフサイエンスコーパス: microtubule dynamics

1 pecific but is more responsive to changes in microtubule dynamics.

2 The TUBB mutations also have an impact on microtubule dynamics.

3 Bs end-tracking behavior and their effect on microtubule dynamics.

4 overexpressed gene (TOG) domains to modulate microtubule dynamics.

5 -tubulin assembly and maintenance to support microtubule dynamics.

6 growth retardation syndrome and function in microtubule dynamics.

7 alpha-tubulin 4 and shows aberrant cortical microtubule dynamics.

8 1 mutant is hypersensitive to alterations in microtubule dynamics.

9 lecular basis of the roles of p150(glued) in microtubule dynamics.

10 deling of the cytoskeleton including altered microtubule dynamics.

11 sregulating DP-EB1 interactions and altering microtubule dynamics.

12 implicated in regulating several aspects of microtubule dynamics.

13 unbound M1 or M87 mutant spastins increased microtubule dynamics.

14 cently found to bind microtubules and affect microtubule dynamics.

15 tabilizing protein whose depletion increases microtubule dynamics.

16 ha/beta-tubulin heterodimers is critical for microtubule dynamics.

17 can be rapidly modulated to control cellular microtubule dynamics.

18 erging as interesting mechanisms to regulate microtubule dynamics.

19 vasive procedure that may interfere with the microtubule dynamics.

20 nd function of the pronucleus by fine-tuning microtubule dynamics.

21 These proteins are crucial regulators of microtubule dynamics.

22 ts its antiproliferative action by dampening microtubule dynamics.

23 eleases the FH2 domain to modulate actin and microtubule dynamics.

24 telet production, particularly by regulating microtubule dynamics.

25 ol of the subcellular cytoskeleton including microtubule dynamics.

26 microtubule-based stepping and regulation of microtubule dynamics.

27 ibuted significantly to our understanding of microtubule dynamics.

28 e chromatin spring in response to changes in microtubule dynamics.

29 signaling node that controls both actin and microtubule dynamics.

30 ends in the form of comet tails and regulate microtubule dynamics.

31 the pericentric chromatin upon reduction of microtubule dynamics.

32 e, and define a target for the modulation of microtubule dynamics.

33 ffect through a previously unknown effect on microtubule dynamics.

34 way and by promoting interference of MP with microtubule dynamics.

35 ve been recently identified as regulators of microtubule dynamics.

36 nt to the pericentric chromatin, rather than microtubule dynamics.

37 racting proteins (termed +TIPs) that control microtubule dynamics.

38 alignment via spatial control of kinetochore-microtubule dynamics.

39 1 and ClipCG12 act cooperatively to regulate microtubule dynamics.

40 ed protein type-2 (MAP-2) modulates neuronal microtubule dynamics.

41 via phosphorylation of c-Src to modulate YSL microtubule dynamics.

42 boxypeptidase important in the regulation of microtubule dynamics.

43 pendent association of factors that modulate microtubule dynamics.

44 crotubules, revealing how the CPC influences microtubule dynamics.

45 totic spindle assembly through regulation of microtubule dynamics.

46 g pseudopod extension, which also depends on microtubule dynamics.

47 aintained by IFT and by intrinsic and active microtubule dynamics.

48 llowing the detection of spatial patterns of microtubule dynamics.

49 ospinal neurons to coordinate ER shaping and microtubule dynamics.

50 ng cardiac myocyte karyokinesis by affecting microtubule dynamics.

51 molecular motor mechanochemistry in cellular microtubule dynamics.

52 re subset of kinesins are also able to alter microtubule dynamics.

53 d stabilize microtubules, thereby regulating microtubule dynamics.

54 anding how tubulin isoform composition tunes microtubule dynamics.

55 MAP2c also may regulate processes other than microtubule dynamics.

56 ells, forming pools that fundamentally drive microtubule dynamics.

57 portant for the regulatory roles of MAP2c in microtubule dynamics.

58 y of cancers due to their ability to perturb microtubule dynamics.

59 known, as is the effect of this interplay on microtubule dynamics.

60 tion as network hubs to coordinate actin and microtubule dynamics.

61 ns-acting GTP into a computational model for microtubule dynamics.

62 diversity is exploited to modulate intrinsic microtubule dynamics.

63 dent of its previously studied regulation of microtubule dynamics.

64 8 protein, Kif18B, in the control of mitotic microtubule dynamics.

65 ue platform for novel approaches to studying microtubule dynamics.

66 role in controlling organelle transport and microtubule dynamics.

67 edback mechanism that couples furrowing with microtubule dynamics.

68 ed to neuronal axons, binds to and regulates microtubule dynamics.

69 e coordination between furrow ingression and microtubule dynamics.

70 nal complex whose activity is fundamental to microtubule dynamics.

71 ty light to spatially and temporally control microtubule dynamics.

72 nomenon regulated by molecules that modulate microtubule dynamics [3-6], as well as by limiting cytop

73 ion deficit could be related to cardiac cell microtubule dynamics alterations.

74 rstanding of how cellular effectors modulate microtubule dynamics, analysis of the relationship betwe

75 ling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclea

76 ng hypomyelination phenotypes showed altered microtubule dynamics and acted through a dominant toxic

77 llular NKCC1 trafficking by interfering with microtubule dynamics and associated motor proteins.

78 nto the microtubule network where they alter microtubule dynamics and can reduce kinesin localization

79 paired units and were sufficient to promote microtubule dynamics and EB1 comet formation.

80 uble mutants indicated that F-actin enhances microtubule dynamics and enables reorientation.

81 small G-protein implicated as a regulator of microtubule dynamics and folding.

82 cells in vitro However, our understanding of microtubule dynamics and functions in vivo, in different

83 etyrosination of alpha-tubulin is crucial to microtubule dynamics and functions, and defects have bee

84 rowing plus-ends of microtubules to regulate microtubule dynamics and functions.

85 Increased microtubule dynamics and global neuronal stabilization w

86 Interestingly, one of the compounds alters microtubule dynamics and increases microtubule density i

87 s suggest that the combination of disrupting microtubule dynamics and inhibiting complex I, either by

88 ERG affects several parameters of microtubule dynamics and inhibits effective drug-target

89 ommonly found in tumor stromal cells, affect microtubule dynamics and interphase cell polarity.

90 bule-associated phosphoprotein tau regulates microtubule dynamics and is involved in neurodegenerativ

91 igated the role of RSK2 in the regulation of microtubule dynamics and its potential implication in ca

92 eacetylating alpha-tubulin, which suppresses microtubule dynamics and leads to cell cycle arrest and

93 These +TIPs control microtubule dynamics and microtubule interactions with o

94 ulations reveals a direct effect of Myo10 on microtubule dynamics and microtubule-cortex interactions

95 functions as a mitotic kinase necessary for microtubule dynamics and mitosis.

96 Isoforms of MAP1S have been implicated in microtubule dynamics and mitotic abnormalities and mitot

97 ty, as shown using drugs that interfere with microtubule dynamics and myosin II activity.

98 -responsive scaffold protein AKAP9 regulates microtubule dynamics and nucleation at the Golgi.

99 undwork for a more complete understanding of microtubule dynamics and of the viscoelastic properties

100 tive and inactive conformations and roles in microtubule dynamics and organelle transport is not well

101 xonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone

102 tein that plays a central role in regulating microtubule dynamics and organization.

103 , we propose the first inclusive model where microtubule dynamics and phragmoplast asymmetry are cons

104 We conclude that regulation of microtubule dynamics and polarity in response to JNK sig

105 Microtubule dynamics and polarity stem from the polymeri

106 kinetics of nuclear migration and determine microtubule dynamics and polarity.

107 show that B1 regulates indirectly endogenous microtubule dynamics and stability while its loss leads

108 lead to the fine-tuning of the regulation of microtubule dynamics and stability.

109 port of SCG10, which is necessary for proper microtubule dynamics and subsequent axon extension.

110 Thus, we examined microtubule dynamics and synaptic density in primary cor

111 Cdk1 and Ipl1/Aurora cooperatively modulate microtubule dynamics and that Ipl1/Aurora-dependent phos

112 atforms for essential proteins that regulate microtubule dynamics and their interactions with cellula

113 In this review, we discuss how microtubule dynamics and their rotational movement drive

114 e investigated direct effects of profilin on microtubule dynamics and whether ALS-linked mutations in

115 inked mutations in PFN1 may perturb cellular microtubule dynamics and/or the coordination between the

116 Centromere positioning, microtubule dynamics, and bipolar spindle formation can

117 How growth, microtubule dynamics, and cell-cycle progression are coo

118 ver, chimera levels fluctuate in response to microtubule dynamics, and disruption of microtubules lea

119 evere impairment of spindle pole separation, microtubule dynamics, and genome integrity.

120 However, whether Cdk1 has sole control over microtubule dynamics, and how CPC-microtubule associatio

121 participate in signaling cascades, modulate microtubule dynamics, and preferentially inhibit kinesin

122 XPO5 suppression reduces miR-122, increases microtubule dynamics, and results in tumor development a

123 r mitotic arrest in conditions of suppressed microtubule dynamics, and the duration of mitotic arrest

124 Furthermore, anaphase Stu2-dependent microtubule dynamics are critical for separation of long

125 Microtubule dynamics are critically important for plant

126 Microtubule dynamics are essential throughout mitosis to

127 Microtubule dynamics are regulated by plus-end tracking

128 tachronic cilia beating, whereas cytoplasmic microtubule dynamics are required for local coordination

129 Intact microtubules and microtubule dynamics are required for RRV trafficking to

130 Microtubule dynamics are thought to play an important ro

131 Small molecule inhibitors of microtubule dynamics are widely used as cell biology res

132 u functions, which include the regulation of microtubules dynamics, are dependent on its phosphorylat

133 ings highlight the regulation of cytoplasmic microtubule dynamics as a role of the IFT54 protein beyo

134 und that the B1-KD cells exhibited increased microtubule dynamics as compared with parental A549 cell

135 ubule-severing enzyme complex that regulates microtubule dynamics as well as ciliary functions.

136 This interaction is functionally relevant to microtubule dynamics, as mouse embryonic fibroblasts der

137 ges of these labels to visualize and analyze microtubule dynamics at any given time.

138 have suggested that AKAP350 is important for microtubule dynamics at both locations, but how this sca

139 gs suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo.

140 COMA/CENP-H/I kinetochore complex regulates microtubule dynamics at kinetochores.

141 Mechanisms controlling microtubule dynamics at the cell cortex play a crucial r

142 Microtubule dynamics at the growth cone are mediated by

143 Changes in microtubule dynamics at the metaphase-anaphase transitio

144 g cell morphology, likely through regulating microtubule dynamics at the posterior end of the cell.

145 ry useful genetic tool to record intrabundle microtubule dynamics at the subdiffraction level.

146 r data support the notion that by decreasing microtubule dynamics, ATIP3 controls the ability of micr

147 The observed adverse effects on microtubule dynamics, axonal transport, endoplasmic reti

148 th microtubules, resulting in an increase in microtubule dynamics because of the activation of tubuli

149 he spindle poles, where it regulates mitotic microtubule dynamics, bipolar spindle formation, and sub

150 axonal growth requires alterations in axonal microtubule dynamics, but the signalling mechanisms invo

151 term mitochondria distribution to short-term microtubule dynamics by attenuating microtubule dynamics

152 p150(Glued) alters microtubule dynamics by binding both to microtubules and

153 at dynein plays a primary role in regulating microtubule dynamics by destabilizing microtubules.

154 describe a computational approach to analyze microtubule dynamics by detecting growing microtubule pl

155 acilitating mechanisms such as regulation of microtubule dynamics by diffusible gradients, spatially

156 ubulin; the other holds that stathmin alters microtubule dynamics by directly destabilizing growing m

157 s suggest that the coordination of actin and microtubule dynamics by FHDC1 is required for normal Gol

158 TACC3 promotes axon outgrowth and regulates microtubule dynamics by increasing microtubule plus end

159 esults demonstrate that phosphoregulation of microtubule dynamics by MNB/DYRK1a is critical for dendr

160 ylation of Sli15/INCENP promotes preanaphase microtubule dynamics by preventing chromosomal passenger

161 nt phosphorylation of Sli15/INCENP modulates microtubule dynamics by preventing CPC binding to the pr

162 EB1 and EB3 together can regulate microtubule dynamics by promoting microtubule growth and

163 Thus, increased microtubule dynamics can delay short-term injury-induced

164 l chromatin-chromatin tethers, together with microtubule dynamics, can mobilize the genome in respons

165 lular processes, including the regulation of microtubule dynamics, cell migration, and intracellular

166 es and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration.

167 ing dynamic micropatterns, and modulation of microtubule dynamics, confirmed that centrosome repositi

168 otubule regulation and suggests that altered microtubule dynamics contribute to CFEOM1 pathogenesis.

169 that an unidentified factor that depends on microtubule dynamics destabilizes position of the centro

170 Current models for microtubule dynamics do not account for GDP-to-GTP excha

171 rtant player in the regulation of centrosome/microtubule dynamics during mitosis and found to be dere

172 with chTOG required for spindle assembly and microtubule dynamics during mitotic cell division.

173 at tao and par-1 act in a pathway to control microtubule dynamics during neural development.

174 ver, little is known about the regulation of microtubule dynamics during synaptic development and fun

175 mediates the fidelity of MII by maintaining microtubule dynamics during the rapid formation of the M

176 , GAR22beta interacted with the regulator of microtubule dynamics end-binding protein 1 (EB1) via a n

177 reenter active translation, suggesting that microtubule dynamics exert tight yet reversible control

178 Microtubule dynamics facilitate neurite growth and estab

179 cell signaling, cytoskeletal transport, and microtubule dynamics for axon growth and guidance.

180 To follow microtubule dynamics for hours without triggering photom

181 tubule depolymerases, which tightly regulate microtubule dynamics for many cellular processes.

182 axonal growth and regeneration by promoting microtubule dynamics for reorganization at the neuronal

183 R+ cells to assess the effects on individual microtubule dynamics for RNA interference-mediated deple

184 Extraction and computational analysis of microtubule dynamics from EB3-GFP time-lapse image seque

185 include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and c

186 which likely resulted from the impairment of microtubule dynamics, Golgi organization, and the ubiqui

187 ation of microtubules by testing the role of microtubule dynamics, gradients of regulators, and retro

188 Investigating midzone microtubule dynamics has been difficult in part because

189 However, inhibition of microtubule dynamics has no effect on BDNF/TrkB motility

190 bona fide nucleation factors also regulating microtubule dynamics have challenged this notion.

191 studying mitochondrial, membrane, Golgi, and microtubule dynamics in cells and calcium activity in ne

192 Microtubule dynamics in cells are regulated by associate

193 ctivates kinesin-1's function of controlling microtubule dynamics in cells, demonstrating that these

194 However, profilin also influences microtubule dynamics in cells, which may be mediated in

195 tive approach to study spatial regulation of microtubule dynamics in cells.

196 0 chaperone complex may function to increase microtubule dynamics in Chlamydomonas cells.

197 ical regulator of mitosis and could modulate microtubule dynamics in chromosome segregation.

198 However, the mechanisms regulating microtubule dynamics in dendrites and spines remain uncl

199 Concomitant with stabilization, microtubule dynamics in dendrites increased.

200 ndent role of ERI complexes in modulation of microtubule dynamics in differentiated keratinocytes.

201 ins that have a conserved role in regulating microtubule dynamics in diverse cell types.

202 at high density, enabling video recording of microtubule dynamics in interphase and mitotic cells.

203 F1A is a key regulator in the fine tuning of microtubule dynamics in interphase cells and proper Golg

204 nvestigating spatial and temporal control of microtubule dynamics in live cells is critical to unders

205 Using this method, we demonstrated imaging microtubule dynamics in living cells with a time resolut

206 rosome biogenesis in progenitor cells and in microtubule dynamics in migrating neurons.

207 Interestingly, the Bim1-Bik1 complex affects microtubule dynamics in much the same way as Bim1 alone.

208 This fact together with a key role of microtubule dynamics in neurite outgrowth led to the con

209 Regulation of microtubule dynamics in neurons is critical, as defects

210 Microtubule dynamics in neurons play critical roles in p

211 ncoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse

212 er, we found that the severity of defects in microtubule dynamics in spr1 eb1b mutant hypocotyl cells

213 To study this process, we reconstituted microtubule dynamics in the absence and presence of the

214 ivation and F-actin remodeling and decreased microtubule dynamics in the AIS.

215 inks transport of SCG10 to the regulation of microtubule dynamics in the axon growth cone and enhance

216 idence suggests that regulators of actin and microtubule dynamics in the growth cone might serve as a

217 pha-tubulin isoforms indicative of increased microtubule dynamics in the hippocampus of naive Sprague

218 of how microtubule-associated proteins tune microtubule dynamics in trans, we have yet to understand

219 ly tagged end-binding proteins have revealed microtubule dynamics in vitro and in non-mammalian model

220 Here, we reconstituted microtubule dynamics in vitro to investigate the influen

221 To test its potential role as a modulator of microtubule dynamics in vitro, an engineered homodimeric

222 a stable kinesin-5 dimer and reconstituting microtubule dynamics in vitro, we demonstrate that kines

223 Our approach allows measurement of microtubule dynamics in vivo and ex vivo in peripheral n

224 new data indicating these activities enhance microtubule dynamics in vivo via repair or removal of al

225 iation in vitro and causes severe defects in microtubule dynamics in vivo.

226 rmly support a structural plasticity view of microtubule dynamics in which microtubule lattice confor

227 ng, we show that EFA-6 inhibits regrowth via microtubule dynamics, independent of its Arf GEF activit

228 Eribulin mesilate is a non-taxane microtubule dynamics inhibitor with a novel mode of acti

229 ster chromatids to the spindle and transduce microtubule dynamics into chromosome movement.

230 Microtubule dynamics involves the polymerization and dep

231 The precise regulation of microtubule dynamics is essential during cell division.

232 Proper regulation of microtubule dynamics is essential for cell functions and

233 Indeed, the regulation of microtubule dynamics is essential to the integrity and f

234 The spatial and temporal control of microtubule dynamics is fundamentally important for prop

235 Our study shows that proper control of microtubule dynamics is important for axon elongation in

236 G protein dynamics and their contribution to microtubule dynamics is important for understanding the

237 owever, the mechanism by which they regulate microtubule dynamics is not well understood.

238 Microtubule dynamics is regulated by plus end-tracking p

239 In cells, microtubule dynamics is regulated by stabilizing and des

240 Coordinated actin microfilament and microtubule dynamics is required for salivary gland deve

241 To fully understand how +TIPs regulate microtubule dynamics, it is essential to know the intrin

242 ecent work studying effects of kinesin-8s on microtubule dynamics, it remains unclear whether the kin

243 ds and has seemingly antagonistic effects on microtubule dynamics: it induces catastrophes, and it in

244 Although PAK1 regulates cytoskeleton and microtubule dynamics, its role in controlling the functi

245 l suggests that kinesin-8-induced effects on microtubule dynamics, kinetochore attachment stability,

246 -like motor proteins that directly attenuate microtubule dynamics make key contributions to this cont

247 Growing evidence suggests that altered microtubule dynamics may also underlie or contribute to

248 ltiple defects in focal adhesion remodeling, microtubule dynamics, mechanotransduction, proliferation

249 Thus increased microtubule dynamics might serve as a general indicator

250 Actin and microtubule dynamics must be precisely coordinated durin

251 The alterations in microtubule dynamics observed in the presence of mutated

252 Interestingly, the timescale of microtubule dynamics occurs in seconds, and the timescal

253 e that Aurora A kinase regulates kinetochore-microtubule dynamics of metaphase chromosomes, and we id

254 , whether this modification alters intrinsic microtubule dynamics or affects extrinsic associations w

255 as been to trigger cell killing by targeting microtubule dynamics or spindle assembly.

256 served protein involved in the regulation of microtubule dynamics orchestrates NLRP3 inflammasome act

257 independently regulate specific and distinct microtubule dynamics parameters in endothelial cells to

258 Although it is known that microtubule dynamics play a role in varicosity formation

259 CUL7 depletion results in altered microtubule dynamics, prometaphase arrest, tetraploidy,

260 e, including regulators of microfilament and microtubule dynamics, protein interactions, and enzymati

261 nsistent with kinesin-8s being regulators of microtubule dynamics rather than cargo transporters.

262 le plus end-tracking proteins, in specifying microtubule dynamics required for directional tip growth

263 hase, facilitating spatiotemporal control of microtubule dynamics required for proper metaphase centr

264 e generally attributed to the suppression of microtubule dynamics resulting in defects in cell divisi

265 ct as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome co

266 pounds cellular growth arrest phenotypes and microtubule dynamics suggest that the antiproliferative

267 The DYT4 mutation had no impact on microtubule dynamics suggesting a distinct mechanism of

268 Current in vitro optical studies of microtubule dynamics tend to rely on fluorescent labelin

269 Schizosaccharomyces pombe, depend on astral microtubule dynamics that drag the nucleus through the z

270 Although degranulation depends crucially on microtubule dynamics, the molecular machinery that coupl

271 enotypes are consequences of their effect on microtubule dynamics, their well-established motor activ

272 These motors have complex effects on microtubule dynamics: they destabilize growing microtubu

273 tor (BDNF)-TrkB complexes and also regulates microtubule dynamics through a separable, non-motor micr

274 hese results indicate that the regulation of microtubule dynamics through KLP10A plays a critical rol

275 ting proteins (Rho GAPs), controls actin and microtubule dynamics through negative regulation of Rac.

276 ting attachment stability, Aurora B controls microtubule dynamics through phosphorylation of the Ndc8

277 rough its extracellular domain and regulates microtubule dynamics through RUVBL proteins at its intra

278 iwaki and Goshima reconstitute all phases of microtubule dynamics through the inclusion of five key r

279 is pathway, Rac1 serves as a hub to modulate microtubule dynamics through two different routes: 1) ph

280 ort-term microtubule dynamics by attenuating microtubule dynamics, thus enhancing the mitochondria-mi

281 l division requires that kinetochores couple microtubule dynamics to chromosome movement.

282 How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microt

283 ommodate the changing tension resulting from microtubule dynamics to maintain a stable metaphase spin

284 FoxM1 altered microtubule dynamics to protect tumor cells from paclita

285 ow that Plk1 activity suppresses kinetochore-microtubule dynamics to stabilize initial attachments in

286 , thereby enabling accurate control over the microtubule dynamics to treat various pathologies.

287 HDAC6 might function as a MAP that regulates microtubule dynamics under certain conditions.

288 Our study establishes a mechanism governing microtubule dynamics via the separase-dependent activati

289 , dendrite stabilization was suppressed when microtubule dynamics was dampened, which was achieved by

290 r chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeab

291 Using computational modeling of microtubule dynamics, we show that these mechanisms coul

292 Microtubule-bound mutant M1 decreased microtubule dynamics, whereas unbound M1 or M87 mutant s

293 y and chromosome segregation rely on precise microtubule dynamics, which are governed in part by the

294 cal nucleus depends on a critical balance of microtubule dynamics, which is regulated by the chromati

295 (Glued) in nonpolarized cells does not alter microtubule dynamics, while depletion of p150(Glued) in

296 underscoring an additional cause of altered microtubule dynamics with impact on neuronal function an

297 associated protein, thereby coupling spindle microtubule dynamics with kinetochore capture.

298 dynein-NCAM180 interaction, or dampening of microtubule dynamics with low dose nocodazole all result

299 or low concentrations of drugs that suppress microtubule dynamics without affecting the amount of mic

300 it is an open question how tau can regulate microtubule dynamics without impeding microtubule-depend