ライフサイエンスコーパス: microvilli

1 (with myelin loops) and at nodal gaps (with microvilli).

2 nd the membrane corrugation (microridges and microvilli).

3 refractoriness of its 30,000 sampling units (microvilli).

4 a membrane but instead is highly enriched on microvilli.

5 lls display a unique apical membrane lacking microvilli.

6 fusion, apical membrane blebs, and disrupted microvilli.

7 s kinetically coupled to the loss of surface microvilli.

8 in the stabilization of apical cargoes into microvilli.

9 abdomere, consisting of tens of thousands of microvilli.

10 le in regions of the plasma membrane lacking microvilli.

11 layer with tightly opposed cells and apical microvilli.

12 after ABCB1a translocates to the tips of the microvilli.

13 nclusions regarding their role in intestinal microvilli.

14 growth delay but surprisingly still develop microvilli.

15 ased 8.6-fold, probably due to the growth of microvilli.

16 ssociates with NHERF2 in opossum kidney cell microvilli.

17 a dramatic increase in the number of apical microvilli.

18 related to alterations in the number of RPE microvilli.

19 of harmonin became colocalized with Cdh23 in microvilli.

20 ng with decreased canalicular and sinusoidal microvilli.

21 eptive membrane derived either from cilia or microvilli.

22 t is preceded by an elongation of RPE apical microvilli.

23 creased, largely due to increased binding to microvilli.

24 minal web and striking puncta at the tips of microvilli.

25 hat both are required for assembly of apical microvilli.

26 of kinetic Monte Carlo simulation within the microvilli.

27 bodies and disorganization of follicle cell microvilli.

28 by lateral bacterial binding to the sides of microvilli.

29 ed in hair cell stereocilia and sensory cell microvilli.

30 ovel membrane feature in the form of bundled microvilli.

31 tered length, thickness and density of their microvilli.

32 microscopy showed extensive apical membrane microvilli.

33 inds ezrin, a major actin-binding protein of microvilli.

34 n, or knock down of EBP50 results in loss of microvilli.

35 horylated-ERM proteins in Schwann cell nodal microvilli.

36 or (TCR) accumulation selectively stabilized microvilli.

37 culature into hepatocytes by endocytosis via microvilli.

38 the bonds, within the context of deformable microvilli.

39 inding protein) also bound preferentially to microvilli.

40 in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli.

41 unding sustentacular cells (SCs) with apical microvilli.

42 bsorptive surface of the tube into villi and microvilli.

43 mic F-actin deforms exocytosed membrane into microvilli.

44 d abnormal beating of cilia, blebbing of the microvilli.

45 d reduced body weight and shorten intestinal microvilli.

46 testinal enterocytes and efface brush border microvilli.

47 scaffolding protein NHERF-1 and PLCbeta2 in microvilli.

48 BL) promotes the growth of brush border (BB) microvilli.

49 is essential for localization to actin-based microvilli.

50 +)-dependent adhesion links between adjacent microvilli.

51 n in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in ac

52 Knockdown of EBP50 decreases the presence of microvilli, a phenotype that can be rescued by EBP50 re-

53 hotoreceptors and retinal pigment epithelium microvilli, a region critical for retinal function and h

54 t for deficits in apical absorption, loss of microvilli, aberrant junctions, and losses in transcellu

55 YO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disr

56 ctin network with concomitant loss of apical microvilli, an increase in actin bundles at the basal su

57 e is enriched in apical markers and displays microvilli and a primary cilium; its lumenal space is ri

58 icles that are released from the tips of IEC microvilli and accumulate in the intestinal lumen.

59 he apical marker ezrin, and disrupted apical microvilli and basal infoldings are observed in mutant m

60 cells exhibited a significant loss of apical microvilli and basal infoldings, reduced retinal adhesio

61 dling protein espin was targeted to CL4 cell microvilli and caused microvillar elongation, whereas es

62 The photoreceptors bear both microvilli and cilia and express proteins that are ortho

63 Thus, bristle and hair cells use microvilli and cross-bridges to generate the common raw

64 os depleted of Arp2/3 form apical actin-rich microvilli and electron-dense apical junctions.

65 These lesions cause destruction of the microvilli and elicit actin rearrangement to form pedest

66 ed that DMT1 was localized to both the lumen microvilli and end feet of the sustentacular cells of th

67 L. rhamnosus treatment also increased microvilli and enterocyte lengths and decreased lipid dr

68 ecialized plasma membrane structures such as microvilli and filopodia.

69 d a complex surface topography with numerous microvilli and filopodia.

70 ctor of two the amount of membrane stored in microvilli and folds.

71 e villin self-association in living cells in microvilli and in growth factor-stimulated cells in memb

72 gest that ingression drives unfolding of the microvilli and incorporation of microvillar membrane int

73 showed that FTY-P greatly reduced lymphocyte microvilli and increased cell-cell contacts in the paren

74 calizes to the tips of adherent brush border microvilli and is essential for intermicrovillar adhesio

75 n-binding site, retains specific proteins in microvilli and is necessary for microvillar biogenesis.

76 rrounded by basement membrane and had apical microvilli and junctional complexes.

77 Both kinases were enriched in microvilli and locally activated there.

78 ane matches the excess membrane contained in microvilli and membrane folds, as determined using scann

79 These sensors include actin-based microvilli and microtubule-based cilia that extend from

80 and protected the structure of cell membrane microvilli and mitochondria after cold storage preservat

81 The strength of adhesion between RPE apical microvilli and photoreceptor outer segments also decline

82 cific actins may be specialized for building microvilli and related structures.

83 are essential for the growth and function of microvilli and stereocilia.

84 well as the disappearance of ependymal cell microvilli and the development of periventricular edema.

85 ed by a change in cell shape, development of microvilli, and apical endocytosis.

86 apices of RPE cells, at the roots of the RPE microvilli, and at the base of RPE cells next to the Bru

87 covered with randomly distributed deformable microvilli, and endothelial cells are modeled as flat me

88 ad (Caudiverbera caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cilia.

89 E3), distribution of NHE3 at the base of the microvilli, and less abundant expression of Na(+)/Pi cot

90 rastructural changes, including reduction of microvilli, and marked increases in secretory vesicle fo

91 EBP50 is not necessary for mitotic cell microvilli, and PKC activation causes a rearrangement of

92 rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated act

93 pid bilayer that lead to contractions of the microvilli, and suggest that the resultant mechanical fo

94 plus the loss of apical cytoskeleton, apical microvilli, and the columnar epithelial shape of clone C

95 sence of junctional complexes/desmosomes and microvilli, and the production of membrane-associated mu

96 Ectopic expression of Cobl shortens apical microvilli, and this requires functional WH2 domains.

97 ed by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surf

98 Microvilli are actin-based protrusions found on the surf

99 Microvilli are actin-rich membrane protrusions common to

100 Because membranes of the furrow and microvilli are contiguous, we suggest that ingression dr

101 in linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and mai

102 Microvilli are found on the surface of many cell types,

103 Microvilli are membrane extensions on the apical surface

104 cal events occurring in cilia, flagella, and microvilli are of fundamental importance for the functio

105 ce microscopy of glioma cells confirmed that microvilli are present.

106 Following each bump, individual microvilli are rendered briefly (~100-200 ms) refractory

107 rhabdomere structure is disorganized and the microvilli are short and occasionally unraveled.

108 ules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretin

109 ss the lumen surface of the small intestinal microvilli as cuprous ion by Ctr1.

110 teractors confirmed by their localization to microvilli, as well as a significant class of proteins t

111 s, EBP50 is a critical factor that regulates microvilli assembly and whose activity is regulated by s

112 n vitro and in vivo rapidly depolarize their microvilli at the wound edge.

113 of the vertebrate photoreceptor cell and the microvilli-based rhabdomere of the invertebrate photorec

114 hat Cobl is localized to the basal region of microvilli both to participate in length regulation and

115 and stochastically adjusting availability of microvilli (bump production rate: sample rate), whereas

116 gh affinity (K(d) = 32 nM) and insect midgut microvilli but did not alter Cry1Ab or Cry1Ac binding lo

117 ins, suggesting they are all anchored in the microvilli but to different extents.

118 nositol 4,5-bisphosphate-binding protein) in microvilli, but only lactaderin-C2 expression reduced br

119 ASAP1 is recruited to the base of microvilli by binding the COBL domain through its SH3.

120 a accumulated at the tips of espin-elongated microvilli, by analogy to its location in stereocilia, w

121 ors, we show how adaptive sampling by 30,000 microvilli captures the temporal structure of natural co

122 0, but not E3KARP, shows rapid exchange from microvilli compared with its binding partners.

123 by the number of its photon sampling units (microvilli), constituting its light sensor (the rhabdome

124 The microvilli contain filaments that stretch into the under

125 hat the extracellular matrix ensheathing RPE microvilli contains ligands for this integrin.

126 Microvilli could act as a platform to concentrate adhesi

127 As determined in micropipette experiments, microvilli deform like an elastic spring at small forces

128 We show that cell and microvilli deformation, and hydrodynamic drag contribute

129 vitro led to increased apoptosis and reduced microvilli density and length.

130 inal uterine epithelium, including increased microvilli density and maintenance of apical cell polari

131 in-binding protein villin drives both apical microvilli disassembly in vitro and in vivo and promotes

132 olling trajectories of cells with deformable microvilli display periods of rolling interdispersed wit

133 ial arrangement of actin filaments in apical microvilli due to the loss of ezrin integrity in parieta

134 EBP50/NHERF1 in the formation of interphase microvilli, E3KARP S303D cannot.

135 r's light sensor, the rhabdomere, has 30,000 microvilli, each of which stochastically samples incomin

136 hered midbody remnants dancing across apical microvilli, encountering the centrosome, and beckoning f

137 Microvilli establishment required interaction between RA

138 Microvilli exhibited high density of antigen-presenting

139 Single microvilli extend and retract in approximately 20 s, whi

140 e microdomains such as the neck of caveolae, microvilli/filopodia and intraluminal vesicles of multiv

141 orin, which was detected within the glioma's microvilli/filopodia, indicating these structures can re

142 Air-dried gliomas revealed nodes within the microvilli/filopodia.

143 ickening, interstitial fibrin deposition and microvilli flattening or disappearance on days 14, 21 an

144 EM revealed irregular stunting of microvilli, foci of indistinct tight junctions, and area

145 Functionally this resulted in reduced microvilli formation and impaired transendothelial migra

146 , PDZK1 can provide a function necessary for microvilli formation normally provided by EBP50.

147 emokines stimulate endothelial filopodia and microvilli formation, leading to their presentation to l

148 membrane as well as augment EBP50's role in microvilli formation.

149 e associated with CXCL8-stimulated filopodia/microvilli formation; these included tropomyosin, fascin

150 ming bundle is defined by the 'bare zone', a microvilli-free sub-region of apical membrane specified

151 lifying apical surface area, we propose that microvilli function as actomyosin contractile arrays tha

152 In combination, these data show that microvilli function as vesicle-generating organelles, wh

153 Decreasing the overall deformability of the microvilli greatly reduces a simulated cell's ability to

154 For decades, enterocyte brush border microvilli have been viewed as passive cytoskeletal scaf

155 These data reveal that microvilli have distinct cytoskeletal subdomains and tha

156 ical value, suggesting that the mechanics of microvilli have evolved ideally for rolling and adhesion

157 of molecules and a realistic distribution of microvilli heights was matched to the data, and the fits

158 ssion of WT MYO5B in MYO5B-KD cells restored microvilli; however, expression of MYO5B-P660L, a MVID-a

159 photon sampling units in the cell structure (microvilli), (ii) sample size (QB waveform), (iii) laten

160 image representations, with more and faster microvilli improving encoding.

161 To test the role of microvilli in bacterial adhesion and uptake, we develope

162 Myo7b is highly enriched at the tips of microvilli in both kidney and intestinal brush borders,

163 led a substantial increase in the density of microvilli in DIO mice.

164 ing in the morphogenesis of the brush border microvilli in epithelial cells remain unknown.

165 from the nucleus in low confluence cells to microvilli in high confluence cells, and this regulates

166 bserved ablation, blunting, or distortion of microvilli in infected epithelial cells.

167 involved in the assembly and maintenance of microvilli in polarized epithelial cells.

168 mined by the same technique, and toxin bound microvilli in posterior midgut.

169 ry of sectioned larvae, predominately to the microvilli in posterior midgut.

170 cells and is crucial for the maintenance of microvilli in such cells.

171 for molecules concentrated near the tips of microvilli in the case of L-selectin, and sequestered aw

172 The microvilli in the R8 rhabdom are not aligned in a unifor

173 vity and highlight the multifaceted roles of microvilli in the spatial distribution of membrane prote

174 helial cells create tightly packed arrays of microvilli in their apical membrane, but the fate of the

175 KI mouse model, and in renal epithelial cell microvilli in vitro.

176 ts and EBP50's relocalization to the base of microvilli, including to the actin rootlet devoid of ezr

177 um had gross hyperplasia, crypt enlargement, microvilli inclusion, and abnormal epithelial permeabili

178 r, to the formation of kidney and intestinal microvilli, inner ear stereocilia, immune synapses, endo

179 mptive hair cells with numerous disorganized microvilli instead of ordered stereocilia.

180 motor also redistributes along the length of microvilli, into compartments normally occupied by Myo1a

181 Thus, the domain-specific presence of microvilli is a dynamic process requiring a localized ki

182 our results suggest that Myo1a targeting to microvilli is driven by membrane binding potential that

183 their apical membrane, but the fate of these microvilli is relatively unknown when epithelial cell po

184 lls assemble, stabilize, and organize apical microvilli is still developing, investigations of the bi

185 ved in the anchorage of membrane proteins in microvilli, is also mislocalized.

186 u could want: filament nucleation, growth of microvilli, joining of microvillar bundles into modules,

187 The epithelium exhibited apical vacuoles, microvilli, junctional complexes, and linear basement me

188 he intestinal tract build an apical array of microvilli known as the brush border.

189 environment using a tightly packed array of microvilli known as the brush border.

190 ition, morphological changes in the gut wall microvilli layer were observed.

191 ons of Fas2 expression levels impact on both microvilli length and organization, which in turn dramat

192 uction, survival, larval growth and gut wall microvilli length were observed with low AC dose (0.5% s

193 ls, we observed a reduction of espin-induced microvilli length, pointing to a potent function of twin

194 uptake and increasing intestinal, villi, and microvilli lengths.

195 ial effectors, mediates antiphagocytosis and microvilli lesions by inhibiting myosin function.

196 SEM images show distinct shedding of microvilli-like features upon treatment with LPA.

197 sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of

198 evealed that CXCL8-stimulated filopodial and microvilli-like protrusions that interacted with leukocy

199 hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair c

200 than those in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen

201 The microvilli-like structures on the surface of multicellul

202 interdigitated, actin- and Moesin-positive, microvilli-like structures wrapping the RCs.

203 erent ionic conditions, we hypothesized that microvilli may augment the mucosal barrier by providing

204 icles from microvillar tips, suggesting that microvilli may function as vesicle-generating organelles

205 Our data suggest that microvilli may participate in sperm-oocyte fusion.

206 These microvilli may play multiple roles in glioma biology, su

207 E-cadherin-dependent adhesion organizes the microvilli meshwork and ensures the proper attachment of

208 These brush layers, which consist mainly of microvilli, microridges and cilia, are important for int

209 intracellular vacuolar structures containing microvilli (microvillus inclusion bodies) in epithelial

210 zed intestinal epithelial cells with reduced microvilli ("microvillus-minus," or MVM) but retaining n

211 MVID can be diagnosed based on loss of microvilli, microvillus inclusions, and accumulation of

212 we characterize organization and dynamics of microvilli (MV) and a previously unappreciated actomyosi

213 retract from top to base of proximal tubule microvilli (MV) and Na(+) reabsorption decreases in prox

214 sease is the loss (effacement) of absorptive microvilli (MV) from the surface of small intestinal ent

215 Within brush border microvilli, Myo1a carries out a number of critical funct

216 ffects of receptor clustering on the tips of microvilli, number of adhesion molecules on the cell, an

217 This includes severe diarrhea, loss of microvilli, occurrence of microvillus inclusions, and su

218 n glycosaminoglycans along the apical midgut microvilli of Anopheles gambiae and further demonstrated

219 Moreover, at the same shear stress, microvilli of cells with higher cortical tension carried

220 syndecan-1 was expressed specifically on the microvilli of hepatocyte basal membranes, facing the spa

221 Histone H1 molecules were visualized on the microvilli of intestinal epithelial cells by immunohisto

222 been observed in association with the dense microvilli of polarized epithelia as well as the filopod

223 ing scaffolding proteins found in the apical microvilli of polarized epithelial cells.

224 n mammals, peropsin is present in the apical microvilli of retinal pigment epithelial (RPE) cells.

225 Localized in the microvilli of the absorptive epithelium, villin can bund

226 is expressed in zebrafish in both i) apical microvilli of the chemosensory cells of taste buds inclu

227 Within microvilli of the enterocyte brush border (BB), myosin-1

228 ot aligned in a uniform direction, while the microvilli of the main rhabdom show the typical crustace

229 TRP and TRPL, reside in the light-sensitive microvilli of the photoreceptor's rhabdomere.

230 Immunohistochemistry localized AgAPN2 to the microvilli of the posterior midgut.

231 microscopy to be surprisingly mobile in the microvilli of the renal proximal tubule OK cell line.

232 Alphavbeta5 localizes specifically to apical microvilli of the RPE and contributes to retinal adhesio

233 ssociated with calyceal processes, which are microvilli of unknown function surrounding the base of t

234 and PKC activation causes a rearrangement of microvilli on cells due to phosphorylation-dependent los

235 It has long been supposed that microvilli on T cells act as sensory organs to enable se

236 s an essential regulator of the structure of microvilli on the apical aspect of epithelial cells.

237 avascular taste sensation takes place at the microvilli on the apical side of taste cells after diffu

238 o the formation of a brush border containing microvilli on the apical surface.

239 d preferential binding of PFO* and ALO-D4 to microvilli on the plasma membrane; lower amounts of bind

240 ncreasing formation and elongation of stable microvilli on the surface of cultured epithelial cells.

241 d AM with a cobblestone appearance, abundant microvilli on the surface, and wide connection with the

242 ch epithelial cells regulate the presence of microvilli on their apical surface are largely unknown.

243 tinal epithelial cells without effacement of microvilli or cup-and-pedestal formation.

244 These include abnormally tall and numerous microvilli or stereocilia, ungraded stereocilia bundles,

245 known about how the concerted action of the microvilli population encodes light changes into neural

246 Stereocilia, the modified microvilli projecting from the apical surfaces of the se

247 zontally (R3, R4, R7) and vertically aligned microvilli (R1, R2, R5, R6).

248 of real-world intensity changes that reduce microvilli refractoriness, these performance gains are s

249 of this hypothesis, showing that enterocyte microvilli release unilamellar vesicles into the intesti

250 to bacterial surface charge, suggesting that microvilli resist binding of microbes by using electrost

251 U251 cells with microvilli resisted the cytolytic actions of different h

252 zed along the full length and to the base of microvilli, respectively.

253 keleton leads to slower rolling, and stiffer microvilli result in faster rolling.

254 ss to epithelial soma through densely packed microvilli rooted on the terminal web (TW) remains uncle

255 ture of cell morphology, e.g., filopodia and microvilli, serving a huge variety of functions.

256 n distinct cytoskeletal processes, including microvilli, stereocilia and filopodia.

257 nt, and for the formation and maintenance of microvilli, stereocilia, and filopodia.

258 intimate bacterial attachment, effacement of microvilli, submucosal edema, mucosal heterophile infilt

259 evealed that hepatocyte apical membrane with microvilli substantially extended into the basolateral d

260 malous diffusion and fractal organization of microvilli survey the majority of opposing surfaces with

261 by cortical tension and considers leukocyte microvilli that deform viscoelastically and form viscous

262 des an elaborate example with tightly packed microvilli that function in nutrient absorption and host

263 ctin-supported membrane protrusions known as microvilli that increases the functional capacity of the

264 The microvilli that penetrated 0.4-mum transwell chamber's p

265 cumulated in lysosomes and in espin-enlarged microvilli that resemble stereocilia.

266 nfirmed an almost complete absence of apical microvilli, the appearance of microvillus inclusions, an

267 of ezrin and actin at the tips and crypts of microvilli, the site of chlamydial attachment and entry,

268 targeted to the plasma membrane of CL4 cell microvilli, the topological equivalent of stereocilia.

269 ents that indicated ACT-5 is enriched within microvilli themselves, these results suggest a microvill

270 f stereocilia and of subsequently regressing microvilli, thus contributing to the early hair bundle s

271 the lamellipod, L-selectin is distributed on microvilli tips along the top of the lamellipodium, wher

272 locally within the apical cortex cause their microvilli to become motile over the dorsal/apical surfa

273 protrusions called 'pedestals' and disrupts microvilli to form attaching and effacing (A/E) lesions.

274 Transporting epithelial cells build apical microvilli to increase membrane surface area and enhance

275 redistribution of Npt2a from proximal tubule microvilli to intracellular compartments and lysosomes a

276 Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requ

277 regulatory process is necessary to restrict microvilli to the apical aspect of polarized epithelial

278 f NHE3, which may increase its delivery from microvilli to the intervillus clefts, perhaps for NHE3-r

279 network forms a passage from the base of the microvilli to the rough endoplasmic reticulum.

280 ized enterocytes harboring actin-rich apical microvilli undergo extensive cell remodeling to drive in

281 inesis in Drosophila embryos, a reservoir of microvilli unfolds to fuel cleavage furrow ingression.

282 from these mice localized PSGL-1 normally in microvilli, uropods, and lipid rafts.

283 COBL localizes to the base of BB microvilli via a mechanism that requires its proline-ric

284 ejuni cells adhered to the tips of host cell microvilli via intimate flagellar contacts and by latera

285 ectin concentrated on the tips of deformable microvilli was cleaved by force exerted on the L-selecti

286 tical plasma membrane-cytoskeletal linker of microvilli, was required to restrict its function to the

287 onal cell polarity; components of the apical microvilli were induced as the brush border formed durin

288 nsistent with that seen in experiments where microvilli were observed to stretch.

289 Anti-adhesive Muc1 protein and microvilli were present on the luminal epithelium of PUG

290 microdomain surrounding AFD receptive ending microvilli, where it regulates K(+) and Cl(-) levels.

291 omplexes that localize to the distal tips of microvilli, where they drive physical interactions betwe

292 usively to the membrane-surrounded region of microvilli, whereas EPI64 localizes to variable regions

293 e formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a indu

294 on of Eps8L1a leads to the formation of long microvilli, whereas its overexpression has the opposite

295 channel 4 (CLIC4) is enriched at apical RPE microvilli, which are interdigitated with the photorecep

296 e in our studies of a scaffolding protein in microvilli, which forced us to reevaluate its contributi

297 id (<10 ms) acidification originating in the microvilli, which is eliminated in mutants of PLC, and t

298 repel microbes from epithelial cells bearing microvilli, while M cells are more susceptible to microb

299 ressed in epithelial cells induced a loss of microvilli with consequent enhanced microbial binding.

300 kdown cells showed disorganized brush border microvilli with decreases in villin expression.