ライフサイエンスコーパス: middle age

1 have an increased brain amyloid load at late middle age.

2 cence and their mothers during pregnancy and middle age.

3 ypically produces cerebellar degeneration in middle age.

4 or prevention of cognitive aging even before middle age.

5 reduce the risk of incident hypertension in middle age.

6 xpression changes occurring predominantly in middle age.

7 ccelerates these effects in apoE4-TR mice at middle age.

8 ly determine cardiovascular disease (CVD) by middle age.

9 es in brain structure and memory function in middle age.

10 d with specific cardiovascular phenotypes in middle age.

11 ent LV systolic and diastolic dysfunction in middle age.

12 n cardiac arrests (SCAs) occur mostly during middle age.

13 ath in those who maintain ER into and beyond middle age.

14 erozygotes, developed Parkinson signs in the middle age.

15 rted to associate with low blood pressure in middle age.

16 associated with an increased risk of CAC in middle age.

17 greatest influence on cognition may occur in middle age.

18 ased risk for subclinical atherosclerosis in middle age.

19 homeostatic set point of the synapse during middle age.

20 n older adults may hold promise for those in middle age.

21 ies are particularly pronounced in young and middle age.

22 nces for the development of COPD and ACOS by middle age.

23 urse of functional impairment and decline in middle age.

24 strategy that could reduce deaths and CVD in middle age.

25 s showing loss of one or more rhythms during middle-age.

26 he beginning of the Common Era and the Early Middle Ages.

27 Young (3-6 months) and middle-age (10-14 months) rats were trained on the five-

28 acer clearance assays in young (2-3 months), middle-aged (10-12 months), and old (18-20 months) wild-

29 nths) mice is, if anything, stronger than in middle-aged (12-14 months) mice.

30 Middle-aged (12-month old) male C57BL/6 mice.

31 tilator-associated pneumonia occurred in 103 middle-aged (14.6%), 104 old (17.0%), and 73 very old pa

32 ogress has largely been negated in young and middle-aged (25-49 years) white individuals, and America

33 Among both middle-aged (30-49 years) and older adults (50-75 years)

34 Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sit

35 arly adulthood (18 to 30 years of age) up to middle age (43 to 55 years).

36 We compared middle-aged (45-64 yr; n = 670), old (65-74 yr; n = 549)

37 BMD reduction over a 8-year follow-up of 692 middle-aged (46.7+/-12.3 yrs), low-income BACH/Bone coho

38 Young (18-49 years) and middle-aged (50-64 years) patients were 2 to 8 times mor

39 dolescent (68 days), young adult (143 days), middle-aged (551 days), and old (736 days) C57BL/6 mice

40 Participants were predominantly middle-age (64+/-11 years) women (97%).

41 Middle-aged (9-11 months) transgenic animals (both male

42 ly), virtually identical to that reported in middle-aged adult HCM patients (98% and 94%, P=0.23).

43 d obesity in a prospective cohort of Spanish middle-aged adult university graduates.

44 ptimal for infants; older children; young to middle-age adults (including pregnant women); and elderl

45 The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequ

46 ity in diabetes risk between black and white middle-aged adults after adjustment for biological, neig

47 ffness in a biracial (black-white) cohort of middle-aged adults aged 32-51 years from the semirural c

48 a hospitalizations in children and young and middle-aged adults did not vary substantially across low

49 pective, US population-based cohort study of middle-aged adults enrolled between 1987 and 1989 with o

50 In middle-aged adults free of the disease, we observed that

51 We recruited 569 healthy middle-aged adults from the Fenland Study, an ongoing po

52 rences in patient characteristics, young and middle-aged adults have 30-day readmission rates that ar

53 oung black adults in CARDIA, and 3,471 white middle-aged adults in FOS, cumulative T2D incidence was

54 This study included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In

55 e commute to work could reduce obesity among middle-aged adults in the UK.

56 The proportion of cases in middle-aged adults increased steadily from 41% (55 of 13

57 ood pressure (DBP) <90 mm Hg, in younger and middle-aged adults is increasing in prevalence.

58 e ideal aortic valve substitute in young and middle-aged adults remains unknown.

59 However, whether young and middle-aged adults share a similar risk pattern is uncer

60 Middle-aged adults show few phenotypic signs of aging ye

61 ption and should be considered for young and middle-aged adults undergoing AVR.

62 age of 20%), whereas estimates for young and middle-aged adults varied by country and were potentiall

63 inally, higher baseline amyloid burden among middle-aged adults was related to changes in vocabulary,

64 ffer a possible antigenic explanation of why middle-aged adults were highly susceptible to H1N1 virus

65 blastic Leukemia (GRAALL) show that young to middle-aged adults who receive a pediatric-intensive che

66 lthough the 10-year risk is low in young and middle-aged adults who would not be treated according to

67 not been rigorously evaluated for young and middle-aged adults with chronic low back pain.

68 tial overuse of chemotherapy among young and middle-aged adults with colon cancer.

69 Over long-term follow-up, younger and middle-aged adults with ISH had higher relative risk for

70 Among middle-aged adults, HSV-1 and CMV seropositivity were as

71 OPSCC) has been reported predominantly among middle-aged adults.

72 incident CKD in a population-based cohort of middle-aged adults.

73 erosclerosis in a population of asymptomatic middle-aged adults.

74 vated BP precedes large-artery stiffening in middle-aged adults.

75 scular disease (CVD) with ISH in younger and middle-aged adults.

76 ight in a cohort of initially normal-weight, middle-aged adults.

77 associated with increased mortality risk in middle-aged adults.

78 f HA targeted by antibodies elicited in many middle-aged adults.

79 culties with daily functioning are common in middle-aged adults.

80 on muscle metabolism, mass, and function in middle-aged adults.

81 A decreasing BMI from early to middle age and a low BMI in middle age may be positively

82 nt with AD are first detectable during early middle age and are associated with later amyloid positiv

83 Being underweight in middle age and old age carries an increased risk of deme

84 ificantly accelerated in schizophrenia up to middle age and plateaued thereafter.

85 ing degree of dendritic retraction occurs by middle age and that this can be mostly offset by pharmac

86 litude of the EPSP abruptly increases during middle age and that this enhanced EPSP is maintained int

87 Obesity in the middle aged and elderly is associated with a reduction i

88 brosis (IPF) is a progressive disease of the middle aged and elderly with a prevalence of one million

89 mposition and faecal metabolomic profiles in middle aged and elderly women.

90 Studies in middle-age and older (masters) athletes with atheroscler

91 ween 1964 and 1973 when the individuals were middle-aged and 1996 and 2015 when participants were in

92 s within the three subdivisions of the CN in middle-aged and aged rhesus macaques.

93 rum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubi

94 iated with increased risk of incident CHD in middle-aged and elderly Chinese populations.

95 Middle-aged and elderly individuals, once having diabete

96 alth in a population-based cohort of healthy middle-aged and elderly men.

97 h screening units, we consecutively followed middle-aged and elderly participants who had no chronic

98 c evaluation occur in over 3% of the general middle-aged and elderly population, but are mostly witho

99 f years lived with and without diabetes in a middle-aged and elderly population.

100 ole of these factors in a community-dwelling middle-aged and elderly population.

101 Free thyroxine levels in middle-aged and elderly subjects were positively associa

102 resonance (MR) images in community-dwelling middle-aged and elderly subjects without dementia and wi

103 portance in the prevention of weight gain in middle-aged and elderly women who are initially normal w

104 In this study of middle-aged and elderly women, neither baseline nor time

105 CC mortality in those aged 40 years or more (middle-aged and elderly).

106 ) on lifespan and neurological parameters in middle-aged and old mice.

107 ng very old patients (59% vs 76% and 74% for middle-aged and old patients, respectively; p = 0.035).

108 In total, 231 middle-aged and older adults (167 women [72.3%] and 64 m

109 All participants were middle-aged and older adults (aged >/=55 years) who rece

110 ccess to recreational facilities may benefit middle-aged and older adults by enabling them to maintai

111 et was capable of lowering blood pressure in middle-aged and older adults with elevated blood pressur

112 e development of coronary atherosclerosis in middle-aged and older adults.

113 risk has primarily been shown in studies of middle-aged and older adults.

114 values for RV measurements among principally middle-aged and older adults.

115 mination is adversely related to CVD risk in middle-aged and older adults.

116 ant, health- and well-being-related trait in middle-aged and older adults.

117 iated with increased poststroke mortality in middle-aged and older adults.

118 years compared with a dichotomous measure in middle-aged and older adults.

119 rden and cognitive decline was present among middle-aged and older adults.

120 verity of SDB in a community-based cohort of middle-aged and older adults.

121 poral trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40-94) duri

122 IADL disability occurs frequently among middle-aged and older HIV-infected adults on effective a

123 These structural changes in a group of middle-aged and older individuals may represent adaptive

124 However, we observed that middle-aged and older individuals who are carriers of th

125 Conclusions and Relevance: In middle-aged and older individuals with type 2 diabetes,

126 re associated with gray matter changes among middle-aged and older individuals.

127 duce the risk of CVD by one-third in healthy middle-aged and older men and women.

128 vascular disease (CVD) prevention in healthy middle-aged and older men and women.

129 ia thickness and the risk of incident CAD in middle-aged and older men from eastern Finland.

130 egg consumption and risk of incident T2D in middle-aged and older men from eastern Finland.

131 r disease (AD), and cognitive performance in middle-aged and older men from Eastern Finland.

132 ses in the risk of major chronic diseases in middle-aged and older men, and these associations were a

133 d with a lower risk of T2D in this cohort of middle-aged and older men.

134 riathlon are not rare; most have occurred in middle-aged and older men.

135 f ischemic stroke beyond manifest AF in this middle-aged and older population.

136 s to the variation in the number of teeth in middle-aged and older populations using a population-bas

137 ations of these findings could be limited to middle-aged and older white European populations, our re

138 ed lipoprotein measures among 23 738 healthy middle-aged and older women (median follow-up 16.4 years

139 We prospectively followed up 99,316 middle-aged and older women for 8 years from the Nurses'

140 Recruited were 328 middle-aged and older women from a community health cent

141 associated with increased hospital costs for middle-aged and older women in England across a broad ra

142 ifestyle modification is often difficult for middle-aged and older women living in the community who

143 itive benefit in reducing metabolic risks in middle-aged and older women.

144 ffecting risk of disease and mortality among middle-aged and older women.

145 substantial reduction in the risk of T2D in middle-aged and older women.

146 d importantly affects tooth loss in both the middle-aged and the older populations.

147 s decline in fitness from young adulthood to middle age, and achieving increased fitness from young a

148 integration of adult-born DGCs in adulthood, middle age, and aging enhanced memory precision.

149 Dedifferentiation began in middle age, and continued into old-old age.

150 eridemia in young adulthood, hypertension in middle age, and diabetes later.

151 od, hypertension and hypertriglyceridemia in middle age, and diabetes later; men tended to have onset

152 associated with three age groups (young age, middle age, and old age), in younger and older participa

153 y a factor of 1.5 from the Neolithic to the Middle Ages, and increased again only during the Early M

154 Younger, middle-aged, and older listeners (10 per group) with goo

155 executive function deficits were apparent in middle-age animals observed as a decrease in choice accu

156 the synaptic response to a greater extent in middle-age animals.

157 ng increased fitness from young adulthood to middle age are associated with less decline in lung heal

158 Low cardiovascular risk factor burdens in middle age are associated with lower health care costs i

159 ctional impairment and decline are common in middle age, as are transitions from impairment to indepe

160 Such measures may be useful for targeting middle-aged, asymptomatic individuals for therapeutic tr

161 ths from COPD, in China, whereas quitting at middle age (at approximately 50 years of age) substantia

162 to compare estimated biomarker slopes among middle-age bins at baseline (early, 45-54 years; mid, 55

163 cial disparity in diabetes incidence between middle-aged black and white individuals.

164 be partly related to higher urate levels in middle-aged blacks.

165 regional variations in cortical thickness in middle age can be traced to regional differences in neur

166 FECD affects approximately 5% of middle-aged Caucasians in the United States and accounts

167 atherosclerosis was highly prevalent in this middle-aged cohort, with nearly half of the participants

168 ts contradict the hypothesis that obesity in middle age could increase the risk of dementia in old ag

169 es show that dendritic losses are evident by middle age despite housing in an enriched environment an

170 Detecting brain abnormalities in middle age enables implementation of therapies to slow p

171 PLMS are highly prevalent in our middle-aged European population.

172 Case Report: A middle-aged female patient presenting with a history of

173 We hereby report a case of a middle-aged female who was subsequently diagnosed with l

174 s identified by TPI, between three groups of middle-aged females matched for age: patients with depre

175 Here, the authors report that middle-aged flies have more elongated, or 'hyper-fused'

176 d both Pythagoras and music theorists in the Middle Ages found that their tonal frequencies form simp

177 ors in a well-characterized cohort of 20,625 middle-aged French workers who were followed from the 19

178 e 80+ year olds (n = 21) than in the healthy middle-aged group (n = 18).

179 declined markedly between the young and the middle-aged group, but showed no further reduction in th

180 Obesity in middle age has been proposed to lead to dementia in old

181 Two groups of male F344 rats in late middle-age having similar learning and memory abilities

182 ously acquired resting-state fMRI data in 22 middle-aged healthy subjects.

183 Regular GFJ consumption by middle-aged, healthy postmenopausal women is beneficial

184 During Europe's Middle Ages, honey and wax became important commodities

185 ears or younger than 12 years as compared to middle-aged human subjects.

186 t appears for the first time in the adult or middle-aged individual or even later in life.

187 chronologically younger individuals than in middle age individuals, with a diminution of that effect

188 Recolonizing the gut of middle-age individuals with bacteria from young donors r

189 sms of this impaired exercise response in 20 middle-aged individuals at high risk of developing type

190 Many CVRF-free middle-aged individuals have atherosclerosis.

191 l evidence that chronic smoking in young and middle-aged individuals is associated with significant a

192 Middle-aged individuals with physician-diagnosed COPD an

193 In these middle-aged individuals, HIV infection was independently

194 udy, a community-based prospective cohort of middle-aged individuals.

195 ght to determine whether exposure to TRAP in middle age is associated with allergic sensitization, cu

196 to BP over 25 years from young adulthood to middle age is associated with incipient LV systolic and

197 evidence that resveratrol treatment in late middle age is efficacious for improving memory and mood

198 Higher cardiorespiratory fitness in middle age is strongly associated with lower health care

199 nance of a constantly intervening God in the Middle Ages lessened interest in the inherent features o

200 in favorable cardiovascular health in early middle age live a longer, healthier life free of all typ

201 offsets age-related dendritic retraction in middle-aged (MA) rats.

202 atherosclerosis was highly prevalent in this middle-aged male cohort.

203 sion in the CA1 region of the hippocampus of middle-aged male mice using a viral vector rejuvenates h

204 entially affect the host immune phenotype in middle-aged males and females.

205 A middle-aged man with non-Hodgkin lymphoma received chemo

206 Of this mostly middle-age, married, non-Hispanic white sample, 66% had

207 MI from early to middle age and a low BMI in middle age may be positively associated with ALS risk.

208 study included 150 cognitively normal, late middle-aged (mean [SD] age, 60.7 [5.8] years) adults fro

209 dy group, the disease predominantly affected middle aged men.

210 ories of lipids and lipoproteins in young to middle-age men than in older men.

211 robability of death from vascular disease in middle-aged men (35-69 years) has decreased from 22% in

212 d subclinical atherosclerosis in a cohort of middle-aged men (40 to 59 years of age), underwent carot

213 nge, and level of PA in a biracial cohort of middle-aged men and women.

214 Middle-aged men engaged in competitive or recreational l

215 countries, including a high concentration of middle-aged men with alcohol use disorders in China and

216 hickness) in an independent sample cohort of middle-aged men with subclinical cardiovascular disease

217 nd, placebo-controlled trials in unmedicated middle-aged men, one in a hyperlipidemic group (HYL grou

218 Among middle-aged men, recreational marathon training is assoc

219 and coronary artery calcium score (CACS) in middle-aged men.

220 t structural abnormalities in developing and middle age mice.

221 ic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-2

222 Conversely, loss of FGF21 function in middle-aged mice accelerated thymic aging, increased let

223 drastically improved the survival outcome of middle-aged mice during both polymicrobial sepsis and st

224 ll populations that produce interleukin-6 in middle-aged mice during systemic inflammation.

225 ducing PERK expression in the hippocampus of middle-aged mice enhances hippocampal-dependent learning

226 tion increased with advancing age, such that middle-aged mice showed much more pronounced differences

227 to 60% and improve measures of healthspan in middle-aged mice.

228 Case Report: Our case is of a middle-aged multiparous female who presented with amenor

229 raftable thymic epithelial cells (TECs) to a middle-aged or defective thymus leads to thymic growth a

230 The study included 5,269 Danish middle-aged or older twins who provided data on the numb

231 present in 10% of this predominantly female, middle-aged, overweight, and deprived population.

232 2; 95% CI, 0.8895-0.9808), especially in mid middle age (P < .001).

233 ker YKL-40 increased consistently throughout middle age (P </= .003).

234 ncreased in some individuals in mid and late middle age (P </= .02), whereas the neuroinflammation ma

235 served in some individuals as early as early middle age (P </= .05) and low Abeta42 levels were assoc

236 Towards this end, 175 late middle-aged participants (mean age 55.9 +/- 5.7 years at

237 ce of CKD in metabolically healthy young and middle-aged participants.

238 [7.6%, 6.5-8.7] of 3652 women; p=0.004) and middle-aged participants.

239 ding 850 younger patients (<50 years), 2,540 middle-aged patients (50-69 years) and 1,542 elder patie

240 Of 954 middle-aged patients (57 +/- 10 years, 63% men) with a m

241 ll predominantly affects relatively young to middle-aged patients and is associated with severe hypox

242 Is of hazard ratios included 1 for young and middle-aged patients compared with older patients for al

243 r health (CVH) on health-related outcomes in middle-aged patients is firmly established.

244 the status of perceived stress in young and middle-aged patients presenting with acute myocardial in

245 ia was higher among elderly patients: 35% in middle-aged patients versus 51% in old and very old pati

246 dardized 1-year mortality rates declined for middle-aged patients with heart failure but remained con

247 Middle-aged patients with stage I (odds ratio, 5.04; 95%

248 The risk of accelerated cognitive decline in middle-aged patients with type 2 diabetes is dependent o

249 neumonia/1,000 ventilation days) was 13.7 in middle-aged patients, 16.6 in old patients, and 13.0 in

250 endophthalmitis were higher for children and middle-aged patients, and for patients with endocarditis

251 Among young and middle-aged patients, higher stress at baseline is assoc

252 of dominant and nondominant eyes of healthy middle-aged people were similar at all spatial frequenci

253 e risk factor for ischaemic heart disease in middle-aged people with type 2 diabetes and other cardio

254 noea (OSA) syndrome have been established in middle-aged people; however, the benefits in older peopl

255 In middle-aged persons without OA, linear intrameniscal sig

256 (idiopathic) etiology, affecting mostly the middle aged population.

257 In a cross-sectional study of a middle-aged population, average LTL and short telomere l

258 and extent of subclinical atherosclerosis in middle-aged populations.

259 In young to middle-aged (predominately male) nonsmokers (n = 30) and

260 coincident with the locations of two nearby middle-aged pulsars (Geminga and PSR B0656+14).

261 , have moderate agitation, and be within the middle age range (76-82 years).

262 rontal cortex enhanced memory functions in a middle-aged rat model.

263 Sports-associated SCA in middle age represents a relatively small proportion of t

264 normal (Clinical Dementia Rating [CDR] of 0) middle-aged research volunteers (n = 169) enrolled in th

265 ics, and outcomes of SCA during sports among middle-aged residents of a large US community.

266 In middle-age, SBP in both races identified risk of inciden

267 CMH among middle-aged smokers represents an early developmental ph

268 We included 8451 middle-aged Spanish university graduates who were initia

269 ce of PTF was assessed in a cohort of 10 647 middle-aged subjects (mean age [SD], 44 [8] years; 47.2%

270 rmal PTF and to compare clinical outcomes of middle-aged subjects with and without the PTF.

271 the dominant and nondominant eyes of healthy middle-aged subjects.

272 elatively common finding in a 12-lead ECG of middle-aged subjects.

273 ctional analysis of the transient changes in middle age suggest a period of heightened metabolic acti

274 Relative to patients of middle age, the youngest patients experienced 19% (95% C

275 examining outcomes from adolescence through middle age to determine the effect on long-term cardiova

276 We included 21 079 middle-aged to elderly individuals from 29 population-ba

277 However, middle-aged to old Neil2-null mice show the accumulation

278 Forty-four middle-aged to older adults (68.45 +/- 7.73 years) perfo

279 illation (AF) in a community-based cohort of middle-aged to older men.

280 Between 2002 and 2010, we studied 465 middle-aged twins from the Vietnam Era Twin Registry who

281 We examined whether middle-aged type 2 diabetic patients show reduced white

282 t, which is a prospective cohort of Spanish, middle-aged university graduates with initial BMI <25.

283 iles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replan

284 omarkers of cancer risk in otherwise healthy middle-aged volunteers.

285 ity-based sample, comprised predominantly of middle-aged white individuals of European descent, bette

286 Participants were mostly middle-aged white men who were taking ART (70%).

287 Most patients were middle-aged white men.

288 arked increase in the all-cause mortality of middle-aged white non-Hispanic men and women in the Unit

289 e the dietary intake and food consumption of middle-aged women and their female and male adult offspr

290 , on the health and lifestyle of overweight, middle-aged women in primary care.

291 nd vascular cell adhesion molecule-1) in 524 middle-aged women in the Nurses' Health Study II.

292 d as hepatocellular injury, predominantly in middle-aged women, and, more frequently, led to death or

293 ta Rica among adult men and 10% higher among middle-aged women, despite the several times higher inco

294 yndrome is typically considered a disease of middle-aged women, it may be underdiagnosed and conseque

295 In this large prospective cohort of French middle-aged women, participants with greater flavonol, a

296 In middle-aged women, poor health can cause unhappiness.

297 the top 10 leading causes of mortality among middle-aged women.

298 autoimmune liver disease that mainly affects middle-aged women.

299 depression and incident cardiac events among middle-aged workers from the GAZEL cohort.

300 performance, and blood pressure in healthy, middle-aged working mothers.