1 acer clearance assays in young (2-3 months),
middle-aged (
10-12 months), and old (18-20 months) wild-
2 nths) mice is, if anything, stronger than in
middle-aged (
12-14 months) mice.
3 Middle-aged (
12-month old) male C57BL/6 mice.
4 tilator-associated pneumonia occurred in 103
middle-aged (
14.6%), 104 old (17.0%), and 73 very old pa
5 ogress has largely been negated in young and
middle-aged (
25-49 years) white individuals, and America
6 Among both
middle-aged (
30-49 years) and older adults (50-75 years)
7 quently caused by Enterobacteriaceae (24% in
middle-aged,
32% in old, and 43% in very old patients; p
8 Higher proportion of younger (34.9%) and
middle-aged (
36.2%) patients had multiple metastatic sit
9 We compared
middle-aged (
45-64 yr; n = 670), old (65-74 yr; n = 549)
10 BMD reduction over a 8-year follow-up of 692
middle-aged (
46.7+/-12.3 yrs), low-income BACH/Bone coho
11 ulation-based cross-sectional study of 5,193
middle-aged (
47-49 years) and elderly (71-74 years) men
12 Young (18-49 years) and
middle-aged (
50-64 years) patients were 2 to 8 times mor
13 dolescent (68 days), young adult (143 days),
middle-aged (
551 days), and old (736 days) C57BL/6 mice
14 e, chemokine, and NO2 (-/)NO3 (-) data from "
middle-aged" (
6-8 months old) C57BL/6 mice were used to
15 Middle-aged (
9-11 months) transgenic animals (both male
16 ly), virtually identical to that reported in
middle-aged adult HCM patients (98% and 94%, P=0.23).
17 d obesity in a prospective cohort of Spanish
middle-aged adult university graduates.
18 cular Health Study (CHS; 1992-2006) and 3577
middle-aged adults (mean age, 54.1+/-5.8 years) in the A
19 The potential benefits of young and
middle-aged adults adopting a diet pattern whereby adequ
20 ity in diabetes risk between black and white
middle-aged adults after adjustment for biological, neig
21 ffness in a biracial (black-white) cohort of
middle-aged adults aged 32-51 years from the semirural c
22 Best survival occurs in
middle-aged adults and in children ages <12 years, where
23 a hospitalizations in children and young and
middle-aged adults did not vary substantially across low
24 er, H1N1 viruses disproportionately affected
middle-aged adults during the 2013-2014 influenza season
25 pective, US population-based cohort study of
middle-aged adults enrolled between 1987 and 1989 with o
26 This cohort study of
middle-aged adults evaluated associations of six-year ch
27 In
middle-aged adults free of the disease, we observed that
28 We recruited 569 healthy
middle-aged adults from the Fenland Study, an ongoing po
29 rences in patient characteristics, young and
middle-aged adults have 30-day readmission rates that ar
30 oung black adults in CARDIA, and 3,471 white
middle-aged adults in FOS, cumulative T2D incidence was
31 This study included 11,715
middle-aged adults in the ARIC (Atherosclerosis Risk In
32 e commute to work could reduce obesity among
middle-aged adults in the UK.
33 The proportion of cases in
middle-aged adults increased steadily from 41% (55 of 13
34 ood pressure (DBP) <90 mm Hg, in younger and
middle-aged adults is increasing in prevalence.
35 e ideal aortic valve substitute in young and
middle-aged adults remains unknown.
36 However, whether young and
middle-aged adults share a similar risk pattern is uncer
37 Middle-aged adults show few phenotypic signs of aging ye
38 ption and should be considered for young and
middle-aged adults undergoing AVR.
39 age of 20%), whereas estimates for young and
middle-aged adults varied by country and were potentiall
40 inally, higher baseline amyloid burden among
middle-aged adults was related to changes in vocabulary,
41 ffer a possible antigenic explanation of why
middle-aged adults were highly susceptible to H1N1 virus
42 h coronary artery calcium (CAC) in young and
middle-aged adults who have a cystatin C-derived estimat
43 blastic Leukemia (GRAALL) show that young to
middle-aged adults who receive a pediatric-intensive che
44 lthough the 10-year risk is low in young and
middle-aged adults who would not be treated according to
45 not been rigorously evaluated for young and
middle-aged adults with chronic low back pain.
46 tial overuse of chemotherapy among young and
middle-aged adults with colon cancer.
47 Over long-term follow-up, younger and
middle-aged adults with ISH had higher relative risk for
48 major cause of ischemic stroke in young and
middle-aged adults, although relatively uncommon in the
49 In the young and
middle-aged adults, however, birth place had a significa
50 Among
middle-aged adults, HSV-1 and CMV seropositivity were as
51 Among
middle-aged adults, short-term (3-year) weight loss of m
52 In these
middle-aged adults, six-year cognitive decline was modes
53 mong adults, the highest CGS was obtained in
middle-aged adults, whereas young adults (ages 18-25 yea
54 erosclerosis in a population of asymptomatic
middle-aged adults.
55 vated BP precedes large-artery stiffening in
middle-aged adults.
56 scular disease (CVD) with ISH in younger and
middle-aged adults.
57 ight in a cohort of initially normal-weight,
middle-aged adults.
58 associated with increased mortality risk in
middle-aged adults.
59 f HA targeted by antibodies elicited in many
middle-aged adults.
60 ages <12 years) was comparable with those in
middle-aged adults.
61 profiles in healthy individual toddlers and
middle-aged adults.
62 ncrease risk for cardiovascular mortality in
middle-aged adults.
63 causes in a general population of young and
middle-aged adults.
64 culties with daily functioning are common in
middle-aged adults.
65 on muscle metabolism, mass, and function in
middle-aged adults.
66 OPSCC) has been reported predominantly among
middle-aged adults.
67 incident CKD in a population-based cohort of
middle-aged adults.
68 Obesity in the
middle aged and elderly is associated with a reduction i
69 brosis (IPF) is a progressive disease of the
middle aged and elderly with a prevalence of one million
70 mposition and faecal metabolomic profiles in
middle aged and elderly women.
71 ff in the youngest groups but accelerated in
middle aged and older groups.
72 ween 1964 and 1973 when the individuals were
middle-aged and 1996 and 2015 when participants were in
73 s within the three subdivisions of the CN in
middle-aged and aged rhesus macaques.
74 rum bilirubin levels and incident T2D in the
middle-aged and elderly adults; instead, direct bilirubi
75 iated with increased risk of incident CHD in
middle-aged and elderly Chinese populations.
76 d BF% (r = 0.56) with similar results in the
middle-aged and elderly groups.
77 Middle-aged and elderly individuals, once having diabete
78 alth in a population-based cohort of healthy
middle-aged and elderly men.
79 h screening units, we consecutively followed
middle-aged and elderly participants who had no chronic
80 c evaluation occur in over 3% of the general
middle-aged and elderly population, but are mostly witho
81 f years lived with and without diabetes in a
middle-aged and elderly population.
82 ole of these factors in a community-dwelling
middle-aged and elderly population.
83 Free thyroxine levels in
middle-aged and elderly subjects were positively associa
84 resonance (MR) images in community-dwelling
middle-aged and elderly subjects without dementia and wi
85 portance in the prevention of weight gain in
middle-aged and elderly women who are initially normal w
86 In this study of
middle-aged and elderly women, neither baseline nor time
87 disorders and related body-image concerns in
middle-aged and elderly women.
88 isorders, eating behavior, and body image in
middle-aged and elderly women.
89 CC mortality in those aged 40 years or more (
middle-aged and elderly).
90 ) on lifespan and neurological parameters in
middle-aged and old mice.
91 ng very old patients (59% vs 76% and 74% for
middle-aged and old patients, respectively; p = 0.035).
92 increased risk of second molar pathology in
middle-aged and older adult men.
93 In total, 231
middle-aged and older adults (167 women [72.3%] and 64 m
94 All participants were
middle-aged and older adults (aged >/=55 years) who rece
95 Young,
middle-aged and older adults (total n=136) were scanned
96 ccess to recreational facilities may benefit
middle-aged and older adults by enabling them to maintai
97 et was capable of lowering blood pressure in
middle-aged and older adults with elevated blood pressur
98 outine diet would modulate blood pressure in
middle-aged and older adults with prehypertension and hy
99 iated with incident cardiovascular events in
middle-aged and older adults without prior CVD.
100 values for RV measurements among principally
middle-aged and older adults.
101 mination is adversely related to CVD risk in
middle-aged and older adults.
102 ant, health- and well-being-related trait in
middle-aged and older adults.
103 iated with increased poststroke mortality in
middle-aged and older adults.
104 years compared with a dichotomous measure in
middle-aged and older adults.
105 rden and cognitive decline was present among
middle-aged and older adults.
106 verity of SDB in a community-based cohort of
middle-aged and older adults.
107 e development of coronary atherosclerosis in
middle-aged and older adults.
108 risk has primarily been shown in studies of
middle-aged and older adults.
109 poral trends in serum PFAS levels among 1257
middle-aged and older California women (ages 40-94) duri
110 rospective population-based cohort of 63,275
middle-aged and older Chinese subjects who provided data
111 IADL disability occurs frequently among
middle-aged and older HIV-infected adults on effective a
112 These structural changes in a group of
middle-aged and older individuals may represent adaptive
113 However, we observed that
middle-aged and older individuals who are carriers of th
114 Conclusions and Relevance: In
middle-aged and older individuals with type 2 diabetes,
115 re associated with gray matter changes among
middle-aged and older individuals.
116 duce the risk of CVD by one-third in healthy
middle-aged and older men and women.
117 vascular disease (CVD) prevention in healthy
middle-aged and older men and women.
118 ients with melanoma has been demonstrated in
middle-aged and older men compared with women, but few s
119 ia thickness and the risk of incident CAD in
middle-aged and older men from eastern Finland.
120 egg consumption and risk of incident T2D in
middle-aged and older men from eastern Finland.
121 r disease (AD), and cognitive performance in
middle-aged and older men from Eastern Finland.
122 ses in the risk of major chronic diseases in
middle-aged and older men, and these associations were a
123 d with a lower risk of T2D in this cohort of
middle-aged and older men.
124 riathlon are not rare; most have occurred in
middle-aged and older men.
125 f ischemic stroke beyond manifest AF in this
middle-aged and older population.
126 nder differences in cognitive performance in
middle-aged and older populations across Europe, we show
127 s to the variation in the number of teeth in
middle-aged and older populations using a population-bas
128 randomized trial data from a large cohort of
middle-aged and older US male physicians indicate that l
129 ations of these findings could be limited to
middle-aged and older white European populations, our re
130 ed lipoprotein measures among 23 738 healthy
middle-aged and older women (median follow-up 16.4 years
131 We prospectively followed up 99,316
middle-aged and older women for 8 years from the Nurses'
132 Recruited were 328
middle-aged and older women from a community health cent
133 associated with increased hospital costs for
middle-aged and older women in England across a broad ra
134 ifestyle modification is often difficult for
middle-aged and older women living in the community who
135 Among this sample of
middle-aged and older women, roadway proximity was assoc
136 substantial reduction in the risk of T2D in
middle-aged and older women.
137 iction by using a novel measurement scale in
middle-aged and older women.
138 ics in relation to a food-addiction scale in
middle-aged and older women.
139 FQ) predict the development of depression in
middle-aged and older women.
140 itive benefit in reducing metabolic risks in
middle-aged and older women.
141 ffecting risk of disease and mortality among
middle-aged and older women.
142 d importantly affects tooth loss in both the
middle-aged and the older populations.
143 d to visualize and segment the STh in young,
middle-aged,
and elderly participants.
144 Younger,
middle-aged,
and older listeners (10 per group) with goo
145 heterosubtypic immune responses in young and
middle-aged as well as more senior individuals.
146 Such measures may be useful for targeting
middle-aged,
asymptomatic individuals for therapeutic tr
147 cial disparity in diabetes incidence between
middle-aged black and white individuals.
148 gh (eg, increasing risk from 10% to 20% in a
middle-aged black woman with multiple risk factors).
149 We examined 15 004
middle-aged blacks and whites enrolled in the Atheroscle
150 be partly related to higher urate levels in
middle-aged blacks.
151 may be associated with the risk of T2D among
middle-aged,
but not older, women.
152 FECD affects approximately 5% of
middle-aged Caucasians in the United States and accounts
153 atherosclerosis was highly prevalent in this
middle-aged cohort, with nearly half of the participants
154 -dependent cognitive tasks, were observed in
middle-aged ES animals.
155 enic, neurotrophic, and cognitive changes in
middle-aged ES animals.
156 c, transcriptional, and cognitive effects in
middle-aged ES animals.
157 PLMS are highly prevalent in our
middle-aged European population.
158 For 5-6 mo,
middle-aged F344 rats were fed diets containing low, med
159 Case Report: A
middle-aged female patient presenting with a history of
160 We hereby report a case of a
middle-aged female who was subsequently diagnosed with l
161 s identified by TPI, between three groups of
middle-aged females matched for age: patients with depre
162 Here, the authors report that
middle-aged flies have more elongated, or 'hyper-fused'
163 ors in a well-characterized cohort of 20,625
middle-aged French workers who were followed from the 19
164 e 80+ year olds (n = 21) than in the healthy
middle-aged group (n = 18).
165 declined markedly between the young and the
middle-aged group, but showed no further reduction in th
166 ously acquired resting-state fMRI data in 22
middle-aged healthy subjects.
167 Regular GFJ consumption by
middle-aged,
healthy postmenopausal women is beneficial
168 ears or younger than 12 years as compared to
middle-aged human subjects.
169 ulthood and that the rates are comparable in
middle-aged humans and mice, suggesting that adult hippo
170 t appears for the first time in the adult or
middle-aged individual or even later in life.
171 sms of this impaired exercise response in 20
middle-aged individuals at high risk of developing type
172 Findings show that whites, women, and
middle-aged individuals had the largest increase in POD
173 Many CVRF-free
middle-aged individuals have atherosclerosis.
174 l evidence that chronic smoking in young and
middle-aged individuals is associated with significant a
175 Middle-aged individuals with physician-diagnosed COPD an
176 In these
middle-aged individuals, HIV infection was independently
177 udy, a community-based prospective cohort of
middle-aged individuals.
178 offsets age-related dendritic retraction in
middle-aged (
MA) rats.
179 atherosclerosis was highly prevalent in this
middle-aged male cohort.
180 Young and
middle-aged male F344 rats were provided 1 d of training
181 sion in the CA1 region of the hippocampus of
middle-aged male mice using a viral vector rejuvenates h
182 We conducted a prospective study of
middle-aged male twins from the Vietnam Era Twin Registr
183 For the chronic study, 10
middle-aged male volunteers were randomly assigned in a
184 entially affect the host immune phenotype in
middle-aged males and females.
185 A
middle-aged man with non-Hodgkin lymphoma received chemo
186 study included 150 cognitively normal, late
middle-aged (
mean [SD] age, 60.7 [5.8] years) adults fro
187 dy group, the disease predominantly affected
middle aged men.
188 robability of death from vascular disease in
middle-aged men (35-69 years) has decreased from 22% in
189 d subclinical atherosclerosis in a cohort of
middle-aged men (40 to 59 years of age), underwent carot
190 Participants were cognitively normal
middle-aged men (40-60 years of age) with normal sleep (
191 nge, and level of PA in a biracial cohort of
middle-aged men and women.
192 sunscreen use retards skin aging in healthy,
middle-aged men and women.
193 Middle-aged men engaged in competitive or recreational l
194 countries, including a high concentration of
middle-aged men with alcohol use disorders in China and
195 are urgent needs for complementary tools for
middle-aged men with modest PSA elevations in blood.
196 hickness) in an independent sample cohort of
middle-aged men with subclinical cardiovascular disease
197 nd, placebo-controlled trials in unmedicated
middle-aged men, one in a hyperlipidemic group (HYL grou
198 Among
middle-aged men, recreational marathon training is assoc
199 RW intake in relation to high fat intake in
middle-aged men.
200 ong-term predictor of incident AF in healthy
middle-aged men.
201 g was a predictor of AF in initially healthy
middle-aged men.
202 and coronary artery calcium score (CACS) in
middle-aged men.
203 ic insults, young C57BL/6 mice (age 3-4 mo),
middle-aged mice (age 10-12 mo), and aged mice (age 24-2
204 Conversely, loss of FGF21 function in
middle-aged mice accelerated thymic aging, increased let
205 hese studies suggested that macrophages from
middle-aged mice are more susceptible to cell death, as
206 drastically improved the survival outcome of
middle-aged mice during both polymicrobial sepsis and st
207 ll populations that produce interleukin-6 in
middle-aged mice during systemic inflammation.
208 ducing PERK expression in the hippocampus of
middle-aged mice enhances hippocampal-dependent learning
209 , resident peritoneal cells from endotoxemic
middle-aged mice exhibited reduced viability and produce
210 tion increased with advancing age, such that
middle-aged mice showed much more pronounced differences
211 ing lymphocytes from inflamed versus healthy
middle-aged mice, we found elevated numbers of T follicu
212 to 60% and improve measures of healthspan in
middle-aged mice.
213 ry and reversal learning from both young and
middle-aged mice.
214 ency leads to reduced insulin sensitivity in
middle-aged mice.
215 Case Report: Our case is of a
middle-aged multiparous female who presented with amenor
216 mproving vascular endothelial dysfunction in
middle-aged/
older adults with moderately elevated systol
217 raftable thymic epithelial cells (TECs) to a
middle-aged or defective thymus leads to thymic growth a
218 The study included 5,269 Danish
middle-aged or older twins who provided data on the numb
219 present in 10% of this predominantly female,
middle-aged,
overweight, and deprived population.
220 Towards this end, 175 late
middle-aged participants (mean age 55.9 +/- 5.7 years at
221 [7.6%, 6.5-8.7] of 3652 women; p=0.004) and
middle-aged participants.
222 ce of CKD in metabolically healthy young and
middle-aged participants.
223 ding 850 younger patients (<50 years), 2,540
middle-aged patients (50-69 years) and 1,542 elder patie
224 Of 954
middle-aged patients (57 +/- 10 years, 63% men) with a m
225 en MGD and hypercholesterolemia in young and
middle-aged patients (aged 18-54 years).
226 ll predominantly affects relatively young to
middle-aged patients and is associated with severe hypox
227 Is of hazard ratios included 1 for young and
middle-aged patients compared with older patients for al
228 periodontal diseases was higher in young and
middle-aged patients compared with patients >65 years of
229 r health (CVH) on health-related outcomes in
middle-aged patients is firmly established.
230 the status of perceived stress in young and
middle-aged patients presenting with acute myocardial in
231 ia was higher among elderly patients: 35% in
middle-aged patients versus 51% in old and very old pati
232 dardized 1-year mortality rates declined for
middle-aged patients with heart failure but remained con
233 The results suggest that young and
middle-aged patients with MGD with no history of hyperch
234 Middle-aged patients with stage I (odds ratio, 5.04; 95%
235 The risk of accelerated cognitive decline in
middle-aged patients with type 2 diabetes is dependent o
236 Thus,
middle-aged patients with type 2 diabetes show white mat
237 neumonia/1,000 ventilation days) was 13.7 in
middle-aged patients, 16.6 in old patients, and 13.0 in
238 endophthalmitis were higher for children and
middle-aged patients, and for patients with endocarditis
239 Among young and
middle-aged patients, higher stress at baseline is assoc
240 Tumors were located inferotemporally in
middle-aged patients.
241 of dominant and nondominant eyes of healthy
middle-aged people were similar at all spatial frequenci
242 e risk factor for ischaemic heart disease in
middle-aged people with type 2 diabetes and other cardio
243 noea (OSA) syndrome have been established in
middle-aged people; however, the benefits in older peopl
244 In
middle-aged persons without OA, linear intrameniscal sig
245 ral hepatitis is growing, particularly among
middle-aged persons.
246 (idiopathic) etiology, affecting mostly the
middle aged population.
247 In a cross-sectional study of a
middle-aged population, average LTL and short telomere l
248 al and non-fatal CVD events in this healthy,
middle-aged population.
249 and extent of subclinical atherosclerosis in
middle-aged populations.
250 In young to
middle-aged (
predominately male) nonsmokers (n = 30) and
251 coincident with the locations of two nearby
middle-aged pulsars (Geminga and PSR B0656+14).
252 rontal cortex enhanced memory functions in a
middle-aged rat model.
253 rats was used as a criterion for classifying
middle-aged rats as impaired and unimpaired on the task.
254 normal (Clinical Dementia Rating [CDR] of 0)
middle-aged research volunteers (n = 169) enrolled in th
255 ics, and outcomes of SCA during sports among
middle-aged residents of a large US community.
256 CMH among
middle-aged smokers represents an early developmental ph
257 We included 8451
middle-aged Spanish university graduates who were initia
258 Ninety eyes of 45 healthy
middle-aged subjects (30 males and 15 females) were incl
259 ce of PTF was assessed in a cohort of 10 647
middle-aged subjects (mean age [SD], 44 [8] years; 47.2%
260 rmal PTF and to compare clinical outcomes of
middle-aged subjects with and without the PTF.
261 the dominant and nondominant eyes of healthy
middle-aged subjects.
262 elatively common finding in a 12-lead ECG of
middle-aged subjects.
263 d 24-h dietary records (1994-1996) from 3083
middle-aged subjects.
264 We included 21 079
middle-aged to elderly individuals from 29 population-ba
265 In total, 185
middle-aged to elderly offspring of nonagenarian sibling
266 Both
middle-aged to elderly offspring of nonagenarian sibling
267 However,
middle-aged to old Neil2-null mice show the accumulation
268 Forty-four
middle-aged to older adults (68.45 +/- 7.73 years) perfo
269 Findings from
middle-aged to older adults confirm associations between
270 illation (AF) in a community-based cohort of
middle-aged to older men.
271 Between 2002 and 2010, we studied 465
middle-aged twins from the Vietnam Era Twin Registry who
272 We examined whether
middle-aged type 2 diabetic patients show reduced white
273 We investigated whether
middle-aged type 2 diabetic patients show these brain ac
274 t, which is a prospective cohort of Spanish,
middle-aged university graduates with initial BMI <25.
275 iles to pollen allergens in the young vs the
middle-aged Uzbek population were associated with replan
276 24-hour ambulatory electrocardiogram in 459
middle-aged veteran male twins.
277 In
middle-aged veteran men, combat exposure and current PTS
278 omarkers of cancer risk in otherwise healthy
middle-aged volunteers.
279 Ten
middle-aged,
weight-stable, fructose-naive monkeys were
280 ity-based sample, comprised predominantly of
middle-aged white individuals of European descent, bette
281 Participants were mostly
middle-aged white men who were taking ART (70%).
282 Most patients were
middle-aged white men.
283 arked increase in the all-cause mortality of
middle-aged white non-Hispanic men and women in the Unit
284 Protection by EE occurred in both young and
middle-aged wild-type mice.
285 an average week night) was assessed in 5,003
middle-aged women and men in 1991/1994 and 1997/1999.
286 e the dietary intake and food consumption of
middle-aged women and their female and male adult offspr
287 patterns and risk of VMSs by using data from
middle-aged women born between 1946 and 1951 in the Aust
288 , on the health and lifestyle of overweight,
middle-aged women in primary care.
289 nd vascular cell adhesion molecule-1) in 524
middle-aged women in the Nurses' Health Study II.
290 vent myocardial infarction (MI) in young and
middle-aged women is limited, and the impact of diet is
291 PA)) on global cognitive function in younger
middle-aged women relative to placebo.
292 d as hepatocellular injury, predominantly in
middle-aged women, and, more frequently, led to death or
293 ta Rica among adult men and 10% higher among
middle-aged women, despite the several times higher inco
294 yndrome is typically considered a disease of
middle-aged women, it may be underdiagnosed and conseque
295 In this large prospective cohort of French
middle-aged women, participants with greater flavonol, a
296 In
middle-aged women, poor health can cause unhappiness.
297 the top 10 leading causes of mortality among
middle-aged women.
298 autoimmune liver disease that mainly affects
middle-aged women.
299 depression and incident cardiac events among
middle-aged workers from the GAZEL cohort.
300 performance, and blood pressure in healthy,
middle-aged working mothers.