ライフサイエンスコーパス: midlife

1 0.16-0.64) compared with men with low CRF in midlife.

2 fitness had higher cognitive test scores at midlife.

3 ve effect of cardiorespiratory fitness as of midlife.

4 nd striatal neurons, as well as morbidity in midlife.

5 sk of hyperproliferative disease (cancer) by midlife.

6 le to costly health and social problems into midlife.

7 evaluate men with above-median PSA levels in midlife.

8 o middle adulthood and cognitive function at midlife.

9 it scores and cardiovascular disease risk at midlife.

10 ines, was associated with worse cognition in midlife.

11 with intellectual decline from childhood to midlife.

12 ed, executive function, and verbal memory in midlife.

13 gain are associated with adult body size in midlife.

14 s either before or after elective surgery in midlife.

15 Of these adults, 10.6% had FCR in midlife.

16 sess the effectiveness of dietary changes in midlife.

17 hood to middle age and cognitive function in midlife.

18 l adversity in childhood to lung function in midlife.

19 ically leading to end-stage renal disease in midlife.

20 risk factor for obesity-related disorders in midlife.

21 fspring BMI associations are maintained into midlife.

22 acetyl-aspartate/creatine (NAA/Cr) ratio, in midlife.

23 ts in humans and animals that are evident by midlife.

24 ly childhood growth with BMI in daughters at midlife.

25 reasing cardiovascular (CV) risk in women at midlife.

26 associated with better cognitive function in midlife.

27 high fat intake during both adolescence and midlife.

28 socioeconomic mobility between childhood and midlife.

29 cognitive sequelae of these risk factors in midlife.

30 al territory, and with increasing age during midlife.

31 edict more pronounced depressive symptoms in midlife.

32 ed ELS in relation to depressive symptoms in midlife.

33 father, and a sibling from childhood through midlife.

34 with other physical health problems in early midlife.

35 nd measured coronary artery calcium (CAC) in midlife.

36 es (ACEs) are associated with elevated AL in midlife.

37 Social engagement was assessed in midlife (1968) and late life (1991).

38 Maximum weight and height in midlife (40-65 years of age) were retrospectively ascert

39 in and resultant excess cholesterol that, by midlife, activates cholesterol transport from astrocytes

40 Although midlife adiposity predicts increased incidence of AD, it

41 Midlife adiposity was derived from BMI data at 50 years

42 obe white matter volumes increase throughout midlife adulthood in humans, and this aspect of aging is

43 ood psychological health are associated with midlife affective and anxiety disorders and to examine s

44 These results suggest that in midlife African American but not white women, adverse as

45 later life with cardiorespiratory fitness in midlife after adjustment for cardiovascular risk factors

46 (birth), early adulthood (age 23 years), and midlife (age 42 years).

47 sociated with RCC, whereas weight gain after midlife (age 50 years to baseline) was unrelated.

48 oved Pegboard tasks as children and again at midlife (age = 38 years).

49 In analyses of BMI during midlife (age of 50 years) among those who had never smok

50 e hypothesis that reproductive senescence in midlife, although apparent in natural-fertility, natural

51 mine whether better cognitive functioning at midlife among more physically fit individuals reflects n

52 ust negative effect on HRQOL in women during midlife, an association not explained by VMS or sleep di

53 cells with a rapid decline in population at midlife and a concomitant increase in peripheral blood b

54 oid-beta1-42 levels were already frequent in midlife and APOE genotype strongly affects the levels of

55 Midlife and concurrent cardiovascular risk factors.

56 Midlife and concurrent vascular risk factor associations

57 n ICAD prevalence and the risk factors (both midlife and concurrent) associated with its development

58 relation between habitual dietary intake at midlife and incident PAD over approximately 20 y of foll

59 of age-related volume decline in area 31, at midlife and late in life.

60 d whether low levels of social engagement in midlife and late life were associated with the risk of i

61 ritis is the most common health condition in midlife and late life, and heart disease is the leading

62 ighest quartile of social engagement at both midlife and late life, only decreased social engagement

63 Studies have linked midlife and late-life cardiovascular risk factors (CVRFs

64 [95% CI, 1.67-2.55]), whereas subjects with midlife and late-life symptoms had more than a 3-fold in

65 nile survivorship and increased mortality at midlife and near the maximum life span.

66 post-intervention surveys for this sample of midlife and older adults new to smartphone technology.

67 3.5 million individuals providing support to midlife and older adults.

68 tigated whether duration of diabetes in late midlife and poor glycaemic control were associated with

69 ation between specific sources of fat during midlife and risk of postmenopausal breast cancer.

70 s Risk in Communities (ARIC) participants in midlife and to explore associations between midlife vasc

71 ich women are at greatest stroke risk during midlife and to identify the safest formulation, dose, an

72 life and fish-oil consumption in early life, midlife, and late life with osteoporotic fracture risk.

73 ansition to adolescence, emerging adulthood, midlife, and old age.

74 -being is high in youth, falls to a nadir in midlife, and rises again in old age.

75 ly recorded ELS, but not stressful events in midlife, and the mean BDI score (average of time 1 and t

76 panics; black non-Hispanics and Hispanics at midlife, and those aged 65 and above in every racial and

77 d with a 1.5- to 2-fold increase in risk for midlife anxiety and affective disorder (P<.05), whereas

78 prospectively examined shift-work history at midlife as associated with cognitive function among olde

79 nges in memory circuitry that occur in early midlife, as a function of sex and women's reproductive s

80 Associations between midlife BMI and brain amyloid burden approached statisti

81 We find that each unit increase in midlife BMI predicts earlier onset of AD by 6.7 months (

82 Thus, higher midlife BMI was also associated with greater fibrillar a

83 Higher midlife BMI was associated with greater Braak neurofibri

84 dy aims to examine the relationships between midlife body mass index (BMI) and (1) AAO of AD (2) seve

85 Greater decline is found with higher midlife BP in whites than in African Americans.

86 erweight (25-29.9 kg/m(2) was significant at midlife but not at baseline.

87 Midlife hypertension and elevated midlife but not late-life systolic BP was associated wit

88 childhood SES affects health status through midlife but the effects may abate in late life; its effe

89 w that induction of mitochondrial fission in midlife, but not in early life, extends the health and l

90 een apoB in young adults and the presence of midlife CAC independent of baseline traditional CVD risk

91 iation between cardiorespiratory fitness and midlife cognitive functioning.

92 ntia risk by examining its associations with midlife cognitive performance and cognitive decline from

93 ects of these risk factors from childhood on midlife cognitive performance are unknown.

94 m childhood/adolescence associate with worse midlife cognitive performance independent of adulthood e

95 ood were independently associated with worse midlife cognitive performance, especially memory and lea

96 /adolescence cardiovascular risk factors and midlife cognitive performance.

97 adolescents are more risk-averse than their midlife counterparts.

98 There is an inverse association between midlife CRF and incident lung and colorectal cancer but

99 High midlife CRF is associated with lower risk of cause-speci

100 Here we report the identification of midlife crisis (mdlc; CG4973) as a gene required for the

101 This U-shaped pattern or "midlife crisis" emerges with or without use of parametri

102 ning, and TPI identified an increased BTP in midlife depressed patients, suggesting early and subtle

103 ate-life depression but poorly documented in midlife depression.

104 oes not allow the detection of subtle CVD in midlife depression.

105 subtle changes in brain vascular function in midlife depression.

106 entia was increased by approximately 20% for midlife depressive symptoms only (hazard ratio, 1.19 [95

107 eported many risk factors for poor child and midlife development (e.g., low IQ, dropping out of schoo

108 r Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health

109 se mortality over a 10-year follow-up in the Midlife Development in the United States (MIDUS) cohort

110 everyday discrimination using the 1995-2004 Midlife Development in the United States cohort study (N

111 25-74 years at baseline) from the survey of Midlife Development in the United States.

112 Midlife development of obesity, a major risk factor of i

113 Adolescent and midlife diet may play a role in colorectal carcinogenesi

114 ted with a 2- to 7-fold increase in risk for midlife disorder (P<.05).

115 Risk for midlife disorder increased significantly with the cumula

116 ibute to variations in the associations with midlife disorder.

117 ical health shows stronger associations with midlife disorders, indicating a poorer prognosis for adu

118 ychological ill health in early adulthood on midlife disorders.

119 Interventions aimed at reducing midlife disparities in physical capability should target

120 gy is required for the anti-aging effects of midlife Drp1-mediated mitochondrial fission.

121 rom demographics and the APOE genotype, only midlife dyslipidemia was associated with amyloid deposit

122 he early phase of the study corresponding to midlife, even when chronic/recurring, do not increase th

123 n early adulthood were associated with worse midlife executive function and processing speed.

124 Midlife exposure to these factors may be most important

125 cancer, exploring the influence of early and midlife exposures will further advance our understanding

126 ting Drp1-mediated mitochondrial fission, in midlife, facilitates mitophagy and improves both mitocho

127 odds (95% confidence interval, 1.01-18.2) of midlife FCR in comparison with those low in all factors.

128 l, 1.1-1.6) higher respective odds of having midlife FCR.

129 tive childhood factors and the likelihood of midlife FCR.

130 ld the key to understanding the evolution of midlife fertility loss.

131 fies how early-life exposures impact on both midlife FEV1 and FVC.

132 Associations between midlife fitness and hospitalizations for heart failure a

133 lder with high midlife fitness than with low midlife fitness in both men($7,569 vs. $12,811; p < 0.00

134 Higher midlife fitness levels seem to be associated with lower

135 articipants aged 65 years or older with high midlife fitness than with low midlife fitness in both me

136 psychiatric symptoms typically occurring in midlife, followed by unremitting progression and eventua

137 o women never on HT, those taking HT only at midlife had a 26% decreased risk (multivariate adjusted

138 of intake of several flavonoid subclasses at midlife had greater odds of healthy aging.

139 High BP in midlife has been associated with more brain atrophy late

140 rt the hypothesis that shift-work history in midlife has long-term effects on cognition in older adul

141 Dietary fat in midlife has not been associated with breast cancer risk

142 m consequences of early adult overweight for midlife health and socioeconomic attainment using prospe

143 e confounding in studies of fetal growth and midlife health outcomes.

144 ean age 60 years) from the Melbourne Women's Midlife Health Project and included 17 early (perimenopa

145 ut it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in a

146 We focused on shift work through midlife (here, ages 58-68 years) because cognitive decli

147 low intake in adolescence to high intake in midlife (HR = 0.71, 95% CI: 0.54, 0.93).

148 Midlife hypertension and elevated midlife but not late-l

149 Midlife hypertension and hyperlipidemia were associated

150 with late-life ICAD in blacks only, whereas midlife hypertension and hyperlipidemia were associated

151 2) of several variables except job score and midlife hypertension in predicting exceptional aging wit

152 Midlife hypertension was also associated with larger pla

153 k factors (eg, physical inactivity, smoking, midlife hypertension, midlife obesity, and diabetes) and

154 f an association with the disease (diabetes, midlife hypertension, midlife obesity, physical inactivi

155 ly modifiable risk factors for AD: diabetes, midlife hypertension, midlife obesity, smoking, depressi

156 relations between dietary intake of women at midlife in 1996-1997 and prevalence of physical function

157 were incrementally lower per MET achieved in midlife in men (6.8% decrease in costs per MET achieved;

158 ist actigraphy among 426 participants in the Midlife in the United States Study (31% AA; 69% EA; 61%

159 RIH2 mRNA levels significantly decrease from midlife in vastus lateralis muscles and highly correlate

160 ealth-related quality of life (HRQOL) during midlife in women when vasomotor symptoms (VMS) and sleep

161 Excess body weight during midlife, including overweight, is associated with an inc

162 ry heart disease and its progression through midlife independent of the degree of adiposity.

163 Already, before midlife, individuals who were aging more rapidly were le

164 th the hypothesis that migraine with aura in midlife is associated with late-life vascular disease in

165 These results suggest that increased BMI at midlife is associated with neuronal and/or myelin abnorm

166 st that avoidance of certain risk factors in midlife is associated with the probability of a long and

167 en and their clinicians that hysterectomy in midlife is unlikely to accelerate the CVD risk of women.

168 OSA, assessed in midlife, is independently associated with higher levels

169 e find that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and

170 Midlife may be a critical period for initiating treatmen

171 A healthy BMI at midlife may delay the onset of AD.

172 Diabetes prevention and glucose control in midlife may protect against late-life cognitive decline.

173 HT use was determined at midlife (mean age, 48.7 years) from a survey in 1964 and

174 he associations of overweight and obesity at midlife (mean age, 50 (standard deviation, 4.7) years) w

175 , and interviewed about migraine symptoms in midlife (mean age, 51 years; range, 33-65 years).

176 were to investigate the association between midlife MedDiet adherence and cognitive performance asse

177 High adiposity in midlife might increase risk for late-life brain patholog

178 nce or more per month (n = 3243), those with midlife migraine with aura (n = 361) had an increased ri

179 ogy and mortality in mammals when applied in midlife.Mitochondrial fission and fusion are important m

180 the hypothesis that high body mass index in midlife modulates the risk for dementia.

181 on-Hispanics were paralleled by increases in midlife morbidity.

182 he most dramatic decreases in early-life and midlife mortality coincided with advances in medicine; c

183 Rising midlife mortality rates of white non-Hispanics were para

184 The midlife mortality reversal was confined to white non-His

185 rs and cognitive deficits in a predominantly midlife multiethnic population-based sample.

186 a population-based cohort study of women at midlife (n = 396).

187 Midlife negative and positive aspects of close relations

188 across categories of shift-work duration at midlife (none, 1-9, 10-19, or >/=20 years).

189 f these results, gathered in a population of midlife northeast American adults, hold in the general p

190 Midlife obesity has been associated with an increased ri

191 l inactivity, smoking, midlife hypertension, midlife obesity, and diabetes) and depression.

192 the disease (diabetes, midlife hypertension, midlife obesity, physical inactivity, depression, smokin

193 tors for AD: diabetes, midlife hypertension, midlife obesity, smoking, depression, cognitive inactivi

194 ocioeconomic markers (height, education, and midlife occupation categorized as low, intermediate, and

195 15, and 26 years, for height, education, and midlife occupation, respectively.

196 was strongly associated with baseline PSA in midlife: odds ratios (95% CIs) comparing PSA in the > 90

197 These findings suggest that use of HT in midlife only may protect against cognitive impairment, w

198 ymptoms were present in 14.1% of subjects in midlife only, 9.2% in late life only, and 4.2% in both.

199 epressive symptoms were categorized as none, midlife only, late life only, or both.

200 y extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, de

201 functioning in healthy menopausal women with midlife onset of executive difficulties include modulati

202 ise to a broad spectrum of developmental and midlife-onset disorders.

203 e find DHEA to be an effective treatment for midlife-onset major and minor depression.

204 and women (n = 23) aged 45 to 65 years with midlife-onset major or minor depression participated in

205 Herein we describe Japanese siblings with a midlife-onset, slowly progressive type of cerebellar ata

206 dolescence (vs. less than daily), but not in midlife or currently, was associated with a 3.2-fold ris

207 Depressive symptoms in midlife or in late life are associated with an increased

208 The authors examined midlife outcomes of childhood bullying victimization.

209 ings The National Institute of Mental Health Midlife Outpatient Clinic in the National Institutes of

210 -up of 26.2 (standard deviation, 4.9) years, midlife overweight and obesity were not associated with

211 In conclusion, midlife overweight predicts earlier onset of AD and grea

212 associated with better cognitive function in midlife (p for trend < 0.01, for all).

213 that childhood growth and development affect midlife performance; prevention of disability and frailt

214 the shift to interventional studies from the midlife period.

215 Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality

216 to determine if a baseline PSA level during midlife predicts lethal PCa in a US population with oppo

217 otein that promotes mitochondrial fission-in midlife, prolongs Drosophila lifespan and healthspan.

218 on-based sample of individuals with NAFLD in midlife, prospectively assessed alcohol use is not assoc

219 Risk-stratified screening on the basis of midlife PSA should be considered in men age 45 to 59 yea

220 ldhood psychological ill health persists for midlife psychological health.

221 is study, we investigated the association of midlife quality of close relationships with subsequent c

222 Cognitive impairment first appeared in the midlife range (9-12 months) and coincided and correlated

223 demographics, APOE, intellectual enrichment, midlife risk factors (physical inactivity, obesity, smok

224 Understanding how midlife risk factors influence age at onset (AAO) of Alz

225 1, and 134 had 2 or more; a higher number of midlife risk factors was associated with elevated amyloi

226 ablished, controversial and novel modifiable midlife risk factors.

227 Better diet quality at midlife seems to be strongly linked to greater health an

228 ted biomechanical exposure and job strain in midlife separately and jointly predicted back and degene

229 l health and prolong lifespan, and observe a midlife shift toward a more elongated mitochondrial morp

230 Midlife smoking and diabetes were associated with increa

231 Midlife smoking and diabetes were strongly associated wi

232 No level of midlife social engagement was associated with the risk o

233 Cardiovascular risk factors in midlife (specifically elevated blood pressure, physical

234 Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins

235 development, would be positively related to midlife standing balance and chair rising, independently

236 PSA levels in midlife strongly predict future lethal PCa in a US cohor

237 he same age (12 months of age; approximately midlife), sufficiently early to influence initial cognit

238 In midlife, the prevalence of overweight was 39% and that o

239 an and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begi

240 symptoms (hot flashes, night sweats) during midlife, their etiology and risk factors are incompletel

241 ly influence outcomes in young adulthood and midlife, this long-term prospective study examines the e

242 etary factors present during adolescence and midlife to be associated with pancreatic cancer.

243 nteract with the psychosocial environment of midlife to contribute to perimenopausal depression risk.

244 ents in, ideal cardiovascular health through midlife to late life are associated with lower CVD preva

245 al and primary prevention efforts throughout midlife to late life as a potential intervention to decr

246 that increasing weight loss per decade from midlife to late life is a marker for MCI and may help id

247 life, only decreased social engagement from midlife to late life was associated with an increased ri

248 the relationship of CVHS attainment through midlife to late life with CVD prevalence and cardiovascu

249 whether such discrepancies are also seen in midlife to late life.

250 percentile of education/occupation score and midlife to late-life cognitive activity), the onset of c

251 his, Apoe-deficient mice were exercised from midlife to old age and in contrast to wild-type (Apoe-su

252 Importantly, long-term aerobic exercise from midlife to old age prevented this age-related neurovascu

253 itive performance and cognitive decline from midlife to old age, including cognitive decline trajecto

254 n (SD) rate of weight change per decade from midlife to study entry was greater for participants who

255 and coincided and correlated primarily with midlife upregulation of genes associated with cholestero

256 is 6-year longitudinal cohort study of 1,903 midlife US women (2000-2006) asked whether symptoms nega

257 me observational studies have suggested that midlife use of HT may be beneficial; however, this has n

258 rowth factors with adult BMI in daughters at midlife using quantile, linear, and logistic regression

259 be examined, highlighting the importance of midlife vascular risk factor control in the prevention o

260 midlife and to explore associations between midlife vascular risk factors and 25-year dementia incid

261 Midlife vascular risk factors are associated with increa

262 To determine if midlife vascular risk factors are associated with late-l

263 cipants without dementia and with nonmissing midlife vascular risk factors at baseline (mean age, 52

264 Place of birth, race, educational level, and midlife vascular risk factors data were collected betwee

265 Midlife vascular risk factors have been associated with

266 An increasing number of midlife vascular risk factors was significantly associat

267 In adjusted models, compared with 0 midlife vascular risk factors, the OR for elevated SUVR

268 terol, and smoking associated inversely with midlife visual and episodic memory and visuospatial asso

269 Diet quality in midlife was ascertained using the Alternative Healthy Ea

270 Diabetes in midlife was associated with a 19% greater cognitive decl

271 s having cancer at Medicare age, high CRF in midlife was associated with an adjusted 32% (HR, 0.68; 9

272 s level in metabolic equivalents achieved in midlife was associated with approximately 20% lower risk

273 Elevated body mass index in midlife was associated with elevated SUVR (odds ratio [O

274 Migraine with aura in midlife was associated with late-life prevalence of cere

275 Daily fish-oil consumption in midlife was associated with lower fracture risk in women

276 ithout an incident CV event, OSA assessed in midlife was independently associated with higher left ve

277 the AHEI-2010 (upper vs. lower quintiles) in midlife was related to 34% (95% CI, 9% to 66%; P for tre

278 cognitive function is limited, especially in midlife.We hypothesize that higher intake of these B vit

279 Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intake

280 arge differences in cognitive performance in midlife were attenuated at dementia diagnosis.

281 These healthy women in midlife were randomly assigned to receive placebo or 800

282 mance, associations with area deprivation in midlife were robust to adjustment for individual socioec

283 at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP

284 with poor outcomes in young adulthood and in midlife, were largely unrelated to satisfaction with ret

285 alance and kinetics studies performed in 190 midlife, white women.

286 Increasing evidence of associations from midlife will guide the shift to interventional studies f

287 e of optimal levels of these risk factors in midlife will reduce the burden of LV hypertrophy, and po

288 Our objective was to compare HT use in midlife with that in late life on risk of dementia among

289 examined the relation of flavonoid intake in midlife with the prevalence of healthy aging.

290 lly diverse community sample of nearly 3,300 midlife women enrolled in the longitudinal, multisite St

291 Because few midlife women participate in strength training, this mod

292 ure is an important public health problem in midlife women, especially among minority groups.

293 In midlife women, incident incontinence is mild with differ

294 urinary incontinence in a diverse cohort of midlife women, the authors analyzed the baseline and fir

295 pattern of decreasing depressive symptoms in midlife women, with higher risk before and lower risk af

296 oflavones lessened lumbar spine bone loss in midlife women.

297 rk adverse underlying vascular changes among midlife women.

298 t mass, and central adiposity experienced by midlife women.

299 ersonal semantic memory, most pronounced for midlife years.

300 As adults approaching midlife, young suicide attempters were significantly mor