ライフサイエンスコーパス: midline

1 , uniting the neural fold tips in the dorsal midline.

2 towards or away from the cells lying at the midline.

3 e and a loss of the desmosomal intercellular midline.

4 to explain the guidance of all axons at the midline.

5 ich fail to condense appropriately along the midline.

6 hrough a defect in the occipital bone in the midline.

7 mp in hypogastric region on the left side of midline.

8 gle 30 degrees contralateral to the animal's midline.

9 l interneurons (CINs), whose axons cross the midline.

10 al interneurons (CINs) whose axons cross the midline.

11 o an enrichment of emc expression at the D/V midline.

12 de at frontal and central sites at the scalp midline.

13 path with high net speed towards the dorsal midline.

14 Collected brains were bisected down the midline.

15 ptors (Aplr, APJ) for their migration to the midline.

16 the hands uncrossed or crossed over the body midline.

17 ns through Robo3 and helps steer them to the midline.

18 projected abnormally at angles away from the midline.

19 ain the expression of four-jointed along the midline.

20 ed by several cues secreted from the ventral midline.

21 eflect overlapping receptive fields near the midline.

22 KPS, age at diagnosis, and NER crossing the midline.

23 t for a period after that object crosses the midline.

24 then migrated tangentially into the ventral midline.

25 tiation, as they failed to reach the ventral midline.

26 and enhancing; however, it was still in the midline.

27 ment direction is mirror-reversed across the midline.

28 plate (FP), a glial structure occupying the midline.

29 patterned head-like outgrowths containing a midline.

30 underlying neural circuits along the ventral midline.

31 2 depending on the distance from the ventral midline.

32 ough upregulation of the E3 ubiquitin-ligase midline-1 (MID1), which binds to and deactivates the cat

33 xpected removal was higher for patients with midlines (6.90 per 1000 VAD days) than for PICCs (2.89 p

34 There was a membrane covered, midline, abdominal wall defect at the base of the umbili

35 ting in many more axons failing to cross the midline, although mutations in mud alone have little eff

36 s on high levels of myosin along the ventral midline, although the basis for this localization is unc

37 When a tracked object crosses the midline, an inversion in CDA polarity revealed the dropp

38 kers were separated by 15 degrees around the midline and 30 degrees at more lateral locations.

39 forces for reaches to targets either side of midline and a minimal grip force for midline movements.

40 eurons had unbranched axons that crossed the midline and ascended rostrally in the contralateral whit

41 ial vessels, angioblasts migrate towards the midline and coalesce underneath the notochord.

42 xons of the PrV barrelette neurons cross the midline and confer the whisker-related patterning to the

43 language-specific activity, particularly in midline and contralateral cortical regions, is an upregu

44 t, resulting in widening of the neural plate midline and defective neural tube closure.

45 /-) mice, many vertebrae are split along the midline and fused across the anterior-posterior axis, su

46 representation in the cortex and cerebellum (midline and hemispheric) before acquisition of baseline

47 highlight a network centred on the cortical midline and hippocampus that allows us to make prospecti

48 ised mouse tongue at 7T demonstrated similar midline and lateral crossing fiber patterns, whereas his

49 patic, retrocecal, intraperitoneal abdominal midline and left side in situs inversus or intestinal ma

50 atial perception, with a linear mapping near midline and more complex relations at lateral locations.

51 EGFR is activated in the ventral midline and neurogenic ectoderm by the Spitz ligand, whi

52 tal proliferative compartments: ventricular, midline and parenchymal.

53 wer was suppressed for IC sources in central midline and parietal regions, whereas mean beta band pow

54 tion, it receives dense projections from the midline and posterior intralaminar thalamus, and moderat

55 e responsiveness of commissural axons at the midline and raise the possibility that nuclear signaling

56 the cranial neural folds to move toward the midline and results in NTD.

57 ation abilities were least accurate near the midline and showed an improvement in performance at more

58 tive and repellent cues leading axons to the midline and then directing them to the contralateral hem

59 There were 231 midlines and 97 PICCs inserted into 64 patients (39 male

60 colorectal cancer), axons cross the ventral midline, and many turn to grow longitudinally on the con

61 Parietal, midline, and prefrontal, but not primary cortical areas,

62 typic transition on their way to the ventral midline, and that this transition is driven in response

63 ation: a polarized AP axis, the pre-existing midline, and the dorsal-ventral median plane.

64 ve protein signals to approach and cross the midline, and then are thought to switch to repulsive cue

65 by axon fibers that grow across the ventral midline, and then away on the other side to their target

66 two regions of the fronto-striatal circuit: midline anterior cingulate cortex (ACC) and left dorsal

67 lateral positions in each hemispace, and the midline area represented by either their overlap or a se

68 while FMSR selectivity was focused near the midline at sound levels near threshold and expanded cons

69 s required for migration of axons across the midline at the CC, and that their absence results direct

70 optic stalk (OS), and cross the diencephalon midline at the optic chiasm en route to their brain targ

71 results in the hindbrain show that the major midline attractant, Netrin1, is not required for midline

72 deleted in colorectal cancer (DCC)-mediated midline attraction to Netrin-1, but without binding eith

73 in Colorectal Cancer (DCC) receptor promotes midline axon crossing by signaling locally in response t

74 After crossing the midline, axons are thought to lose their responsiveness

75 t as a bilateral structure, then crosses the midline between P6 and P12, and subsequently bends to ad

76 erve cord neurons do not respect the ventral midline boundary and cross over to the contralateral axo

77 omatosensory cortex without any infection of midline brain regions, indicating the virus can move by

78 of the brain are coordinated by a series of midline-bridging neuronal commissures whose development

79 tants endocardial progenitors migrate to the midline but fail to assemble into a cardiac cone and do

80 ral axons to reach and cross the spinal cord midline by antagonizing Robo1/2-mediated repulsion from

81 Crossing of the midline by callosal axons relies on a proper midline env

82 t VZ-derived Ntn1 directs CAs to the ventral midline by its local actions.

83 emc expression at the midline can be eliminated when D/V patterning is disrupt

84 NUT midline carcinoma (NMC) is a rare but highly aggressive

85 NUT midline carcinoma (NMC) is an aggressive type of squamou

86 NUT midline carcinoma (NMC), a subtype of squamous cell canc

87 atic mistargeting of active chromatin in NUT midline carcinoma (NMC), we have identified protein inte

88 in the treatment of the genetically defined midline carcinoma and hematopoietic malignancies.

89 ered that BRD4 is hyperphosphorylated in NUT midline carcinoma and identified CDK9 as a potential kin

90 ently repressed by BRD4-NUT, a driver of NUT midline carcinoma.

91 Midline catheters and ultrasonography-guided peripheral

92 ariety of smaller connections from posterior midline, caudal posterior parietal, and extrastriate are

93 the zippering point at the embryonic dorsal midline causes far-reaching, rapid separation of the ele

94 However, mutant mice did have a large midline cavity originating from the embryonic forebrain

95 Analysis of Drosophila CNS midline cell development provides a useful system for st

96 pment of the anterior mesendoderm, node, and midline cell populations responsible for establishment o

97 pectedly, we find that Robo2 is expressed in midline cells during the early stages of commissural axo

98 ruction suggests that contractile mesodermal midline cells existed in bilaterian ancestors.

99 In this study, FAIRE-seq on FACS-purified midline cells was performed and the midline FAIRE data w

100 The midline central gray of the pons and nucleus incertus re

101 s, dorsal striatum and ventral striatum, and midline cerebellar vermis and subgenual cingulate cortex

102 uding shorter snout, expansion of the facial midline, cleft lip, extensive exencephaly, and microphth

103 ation of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patt

104 VBW myofibroblasts in orchestrating ventral midline closure by mediating the response to the TGFbeta

105 s a situation in some embryos whereby dorsal midline closure is incomplete.

106 find that Pvr mutants have defects in dorsal midline closure with incomplete amnioserosa internalizat

107 These cells, which reside in the suture midline, contribute directly to injury repair and skelet

108 be is formed by the migration and subsequent midline convergence of two bilateral heart fields.

109 ect reinstatement effects within a posterior midline core memory retrieval network during all phases

110 volved in processing emotion or salience and midline cortical regions that may mediate top-down regul

111 CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex,

112 No midline craniofacial anomaly was seen.

113 variants defines the most frequent cause of midline craniosynostosis and has implications for the ge

114 t near BMP2 that is strongly associated with midline craniosynostosis explained nearly all the phenot

115 between two gene variants that rarely cause midline craniosynostosis on their own make the developme

116 so coexpressed on commissural axons prior to midline crossing and can mediate precrossing semaphorin-

117 dings show that DCC is a master regulator of midline crossing and development of white-matter project

118 h on responsiveness to Wnt attraction during midline crossing and turn anteriorly only after exiting

119 a Brn3b(Cre) knock-in allele reduced axonal midline crossing at the optic chiasm and optic tract fas

120 pression of Robo2 can rescue robo2-dependent midline crossing defects non-cell autonomously.

121 obo axon guidance pathway to target neuronal midline crossing defects selectively to particular regio

122 as an axon guidance molecule that regulates midline crossing in the CNS.

123 overlap in representation is reduced if the midline crossing is unpredictable.

124 ckground EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpu

125 As expected, Sox11 treatment caused robust midline crossing of CST axons into previously denervated

126 Partial midline crossing of the PrV axons, in a conditional Robo

127 An ephrinB2a mutant can rescue midline crossing when serotonergic signaling is blocked.

128 also required for Robo2's ability to promote midline crossing, in both gain-of-function and rescue as

129 anism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to

130 ent pathway that acts in parallel to promote midline crossing.

131 tral nervous system and regulation of axonal midline crossing.

132 ine attractant, Netrin1, is not required for midline crossing.

133 serotonin in the setting of hypoxia restored midline crossing.

134 serotonin levels, leading to a reduction in midline crossing.

135 repulsion by Semaphorin3B and Slits controls midline crossing.

136 urning of commissural axons before or during midline crossing.

137 the raphe neurons extend projections toward midline-crossing axons and that when serotonergic signal

138 is protein in Emx1 knockout mice rescues the midline-crossing phenotype.

139 who experienced blunt trauma with resultant midline CS tenderness and/or neurologic deficits and wer

140 ogenic progenitor cells does not manifest in midline defects.

141 tem development, commissural axons cross the midline despite the presence of repellant ligands.

142 F signaling steers cardiomyocytes toward the midline during cardiac fusion.

143 commissural neuron axon guidance to the CNS midline during development.

144 cebo-dependent sustained increase of frontal midline EEG theta (4-7 Hz) power and frontoposterior the

145 A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog (

146 Midline enhancer fragments with a midline FAIRE peak ten

147 k whole-embryo FAIRE peak overlap with known midline enhancers and provide a useful predictive tool f

148 to be near midline-expressed genes, whereas midline enhancers without a midline FAIRE peak were ofte

149 ogous auditory nuclei, on either side of the midline, enhances the precision of sound localization.

150 midline by callosal axons relies on a proper midline environment that harbors guidepost cells emittin

151 of acrophase, bathyphase, amplitude, and the midline estimating statistic of rhythm were used to eval

152 el due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers.

153 a midline FAIRE peak were often distant from midline-expressed genes and unlikely to drive midline tr

154 ts with a midline FAIRE peak tend to be near midline-expressed genes, whereas midline enhancers witho

155 antagonizing Robo1/2-mediated repulsion from midline-expressed Slits and potentiating deleted in colo

156 ared a large dataset of fragments that drive midline expression in vivo with the FAIRE data.

157 Mllt10 knockout mutants (Mllt10-KO) exhibit midline facial cleft.

158 purified midline cells was performed and the midline FAIRE data were compared with whole-embryo FAIRE

159 ind that regions of the genome with a strong midline FAIRE peak and weak whole-embryo FAIRE peak over

160 Midline enhancer fragments with a midline FAIRE peak tend to be near midline-expressed gen

161 d genes, whereas midline enhancers without a midline FAIRE peak were often distant from midline-expre

162 roglia morphology over 28 days following rat midline fluid percussion injury (mFPI) as a first step i

163 ripe of two or three cells along the ventral midline, followed by progressive expansions into more la

164 sing from maxillary prominences, fuse at the midline, forming the hard and soft palate.

165 icting trajectories moved towards the visual midline from the other eye.

166 jacent cortex in the superior frontal gyrus (midline frontal cortex).

167 onstrated that a node within MDC, located in midline frontal cortex, becomes active during the early

168 cies, non-PTSD soldiers showed activation of midline frontal regions associated with fear regulation

169 on tensor imaging and increase resting-state midline frontal theta activity.

170 ty showed a shift from anterior to posterior midline functional coupling in the naturalistic conditio

171 these defects were accompanied by failure of midline fusion within the developing annulus fibrosis of

172 d Notch, play key roles in controlling early midline gene expression.

173 noncrossing axons flanking large tangles of midline glial processes.

174 The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbo

175 ir absence results directly or indirectly in midline gliosis, increased Slit2, and complete CC agenes

176 dies identify a parallel pathway controlling midline guidance in Drosophila and highlight a novel rol

177 Netrin-1 (Ntn1) emanating from the ventral midline has been thought to act as a long-range diffusib

178 rst extracted separately on each side of the midline in brainstem nuclei that project to the ICs.

179 can account for persistent attraction to the midline in hypomorphs.

180 he rounded fluctuant mass was present in the midline in occipital region covered with alopecic skin w

181 However, CAs still grow towards the midline in the absence of the floor plate (FP), a glial

182 ntral nerve cord, many axons still cross the midline in the absence of the Netrin genes (NetA and Net

183 itro and project ipsilaterally at the chiasm midline in vivo, and Plexin-A1 and Nr-CAM expression in

184 ects in commissural axon trajectories at the midline intermediate target.

185 red with normative data despite crossing the midline into the blind hemifield in 11 of 12 eyes.

186 migratory and part of their movement to the midline is independent of the ectoderm.

187 e abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133).

188 A standardized procedure of closing the midline laparotomy by using a "small steps" technique of

189 The standardized procedure of closing the midline laparotomy by using a "small steps" technique of

190 All patients had a midline laparotomy in an emergency setting.

191 romuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic ane

192 ective surgery, it is well documented that a midline laparotomy should be closed with a slowly absorb

193 dure (both elective and emergency) through a midline laparotomy were divided into 2 groups.

194 scheduled for any gastrointestinal emergency midline laparotomy were included until October 2015.

195 ents were included if they were operated via midline laparotomy, and had an abdominal aortic aneurysm

196 rtality compared with operations requiring a midline laparotomy.

197 ent the object before the object crosses the midline, leading to a period in which the object is repr

198 derive from the rostral diencephalic ventral midline, lie above the prechordal mesendoderm and expres

199 syndrome, including intestinal malrotation, midline liver with left-sided gallbladder and an interru

200 rocecal ascending, intraperitoneal abdominal midline localised.

201 Second, we detect no midline localization of Slit during brain development.

202 rosine phosphatase 69D (RPTP69D) and loss of midline-localized Slit inhibit formation of specific axo

203 Schema retrieval was associated with midline, medial-temporal, and parietal processing.

204 ve endoderm development and impedes node and midline morphogenesis in part due to severe disturbances

205 grip force was minimal, appropriate for the midline movement, and not the average of the large grip

206 side of midline and a minimal grip force for midline movements.

207 ression in the organizer and along the axial midline, neural tube closure defects (NTDs) arose and do

208 anscranial magnetic stimulation of a frontal midline node of the cingulo-opercular MDC affected learn

209 equencing of 291 parent-offspring trios with midline NSC revealed 15 probands with heterozygous damag

210 experience on synaptic transmission from the midline nuclei of the thalamus (mThal) to the NAc have y

211 ogenitors were specified at the pre-existing midline of regenerating fragments, even when this locati

212 ed in the avascular region around the dorsal midline of the developing midbrain.

213 The primitive streak marks the midline of the future embryo.

214 d, the CM fascicles from the two sides cross midline on dorsal surface and continue as sling/oblique

215 ease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HI

216 ease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HI

217 ials with two targets located either side of midline, participants initially reached straight ahead.

218 re observed crossing the ventral floor plate midline perpendicularly at about 20 microns/h and in a m

219 Midline primordium expression of the rhomboid gene is de

220 specify germ layer fate in two basal tailbud midline progenitor populations.

221 Midline progenitors can be transfated from notochord to

222 oderm lineage, the anterior mesendoderm, and midline progenitors.

223 distinct phases of movement relative to the midline: rapid convergence, little convergence and sligh

224 e early-stage PGCs randomly migrating in the midline region of human embryos before initiation of the

225 inically significant inattention centered on midline regions of the DMN in both MEG and fMRI, boostin

226 BOLD signal in medial temporal and posterior midline regions were correlated when encoding and rehear

227 axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorti

228 The Slit protein is a major midline repellent for central nervous system (CNS) axons

229 lit-UC) that cannot be cleaved revealed that midline repulsion is still present but longitudinal axon

230 ess (comm), an antagonist of Slit-Roundabout midline repulsion, through an unknown mechanism.

231 l animals commissural axons rarely cross the midline, resulting in a strongly enhanced phenotype rela

232 tations contributing to common non-syndromic midline (sagittal and metopic) craniosynostosis, we perf

233 Significant radiologic predictors included midline shift (OR, 6.8; 95% CI, 3.4-13.8), depressed sku

234 Fifty-one percent of patients had midline shift on head CT at coma onset and 43 (51%) pati

235 eft parietal intracranial hemorrhage without midline shift or hydrocephalus.

236 revealed a worsening subdural hematoma with midline shift, a single dose of factor VIII inhibitor by

237 Lower GCS score, midline shift, depressed skull fracture, and epidural he

238 duce a square cell grid in the presence of a midline signal provided by the EGF receptor ligand Spitz

239 ved lymph sacs, vessels of lumbar and dorsal midline skin form via assembly of non-Tie2-lineage cells

240 nsiveness to Netrin1 and become sensitive to midline Slit-Robo repulsion.

241 ls are transferred to the central complex, a midline-spanning brain area involved in locomotor contro

242 This proposal was based on small, midline stab SCI.

243 transition (EMT) at a morphologically stable midline structure, the primitive streak (PS).

244 ads to desmosomal remodeling and loss of the midline structure.

245 We therefore suggest that posterior midline structures aid consolidation by reinstating and

246 ted to activity along anterior and posterior midline structures and angular gyrus.

247 t only to functional changes within cortical midline structures involved in self-referential processe

248 that achieve alignment of dorsal and ventral midline structures remain a poorly understood aspect of

249 it2 at the glial wedge and indusium griseum, midline structures required for CC formation.

250 t processing of associative memory traces in midline structures that are involved in later memory ret

251 osely associated to a distributed network of midline structures that modulate hippocampal theta activ

252 egions, as well as in anterior and posterior midline structures that were also engaged during later m

253 P is reciprocally interconnected mainly with midline structures, including the MnR/DRC, nucleus incer

254 ty between several frontostriatal seeds, and midline subcallosal cortex and left paracingulate gyrus

255 NT Growing evidence suggest that the ventral midline thalamic nuclei (reuniens and rhomboid) might pl

256 n both lateral entorhinal cortex and ventral midline thalamic nuclei of neonatal rats.

257 nucleus reuniens (Re) is the largest of the midline thalamic nuclei.

258 spatial working memory (SWM) and the ventral midline thalamic reuniens and rhomboid nuclei (Re/Rh) ha

259 s is mediated by the nucleus reuniens of the midline thalamus (RE).

260 s and rhomboid (Re/Rh) nuclei of the ventral midline thalamus abolished only the SWM-specific activit

261 (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are reciprocally connected with the hip

262 s provides electrophysiological evidence for midline thalamus as a site of complex information integr

263 These data highlight midline thalamus as an important node integrating multip

264 tinct roles of entorhinal cortex and ventral midline thalamus for the functional development of prefr

265 re, we show that the nucleus reuniens of the midline thalamus gates mPFC control of VTA DA neuron fir

266 Midline thalamus is implicated in linking visceral and e

267 We found that responses of single neurons in midline thalamus to sensory cues are increased when asso

268 nterior cingulate cortex, nucleus accumbens, midline thalamus, and amygdala (nucleus accumbens: r = 0

269 the thalamus (PVT), a nucleus of the dorsal midline thalamus, in this interaction.

270 entricular thalamus, a nucleus of the dorsal midline thalamus, is integral to this behavioral competi

271 The nucleus reuniens (Re), a nucleus of the midline thalamus, is part of a cognitive network includi

272 on by directed interactions with the ventral midline thalamus.

273 behaviours, such as the ventral striatum and midline thalamus.

274 organizing center from stem cells at the old midline that directs head patterning and outgrowth.

275 pression in the rostral diencephalon ventral midline, the alobar phenotype is caused by downregulatio

276 onmental relationships between event-related midline theta oscillations, RTV, and ADHD.

277 acing it within the larger class of "frontal midline theta" cognitive control signals.

278 nsight into the local computation of frontal midline theta, and have implications for reinforcement l

279 support to a continuous allocation model of midline tissue formation in zebrafish, and provide an em

280 al endoderm, raising the question of whether midline tissues also arise from basal posterior progenit

281 r plasticity, these cells never give rise to midline tissues of the notochord, floor plate and dorsal

282 2(+) callosal axons also failed to cross the midline to form the corpus callosum.

283 fusion of the paired palatal shelves at the midline to separate the oral cavity from the nasal cavit

284 m (CNS)-organizing activity from the ventral midline to the neurogenic ectoderm.

285 ormalities, particularly evident in anterior midline tracts, although these changes might be, at leas

286 idline-expressed genes and unlikely to drive midline transcription in vivo.

287 terior lateral plate mesoderm to the ventral midline, undergoing a mesenchymal-to-epithelial transiti

288 Ectopic midline vascularisation in endothelial Nrp1 and Vegfa(18

289 NER crossing the midline was the only morphologic feature of NER associat

290 ly, the neurogenic ectoderm, not the ventral midline, was found to be the dominant source of EGF patt

291 or lateral plate mesoderm and migrate to the midline where they coalesce to form the cardiac tube.

292 n the early embryo fold directly towards the midline, where they meet and fuse to create the primitiv

293 ved plexin A2 (PlxnA2) for navigation at the midline, whereas a cis-interaction between PlxnA2 and Se

294 dorsal VZ highly disrupts CA guidance to the midline, whereas the deletion from the FP has little imp

295 e to decode target positions on the vertical midline, which cannot be achieved using standard N2pc me

296 ce of netrin1 directing axons to the ventral midline, while local VZ-supplied netrin1 is required for

297 em cell niche that centers around the dorsal midline with high expression of neural crest genes, plur

298 nation performance in and around the frontal midline, with a decline at more eccentric locations.

299 lts of the PRImary Mesh Closure of Abdominal Midline Wounds trial, a multicenter double blind randomi

300 ue by mutant hemocytes coupled with impaired midline zippering of mutant epithelium creates a situati