ライフサイエンスコーパス: might

1 ogies, highlight new gene drive designs that might achieve better outcomes, and explain why we need o

2 Therefore, our study supports that 38u might act as a potent and specific AEP inhibitor useful

3 In conclusion, FER rs4957796 might act as a prognostic variable for survival in patie

4 revious observations, we suggest that CENP-F might act as a transporter of mitochondria and other cel

5 These results indicate that distinct MMPs might act as molecular switches for specific types of LT

6 e same phenotypes, suggesting that MKK4/MKK5 might act upstream of MPK6 in this pathway.

7 Our hypothesis is that immunosuppressives might affect airway integrity.

8 to assess anastomotic perfusion, and its use might affect the incidence of anastomotic leaks.

9 ibition antibody responses, and consequently might affect vaccine effectiveness.

10 onsidering its positive predictive value, it might allow to make a considerable number of oral challe

11 tion-related cost concerns prior to donation might allow transplant centers to target financial suppo

12 cannabinoid is not rewarding in rodents and might also account for individual differences in the hed

13 sibility that autophagy and polyploidization might also affect the antigenicity of cancer cells by al

14 ons to prime CPK28 for Ca(2+) activation and might also allow CPK28 to remain active when Ca(2+) leve

15 behavioural variant frontotemporal dementia might also be associated with altered energy expenditure

16 It might also be beneficial for other spectroscopy approach

17 -righting, SR), suggesting that other miRNAs might also be involved in behavioral control.

18 l that antioxidative peptides from rice bran might also be produced in the gastrointestinal tract of

19 tional processes and positive selection, but might also be shaped by negative selection.

20 ternatively, ecological or neutral processes might also drive correlated evolution.

21 th chronic mucocutaneous candidiasis disease might also have viral or intracellular pathogen infectio

22 ng the overrepresentation of a mutant allele might also play a role in other autosomal-recessive diso

23 chronic hepatitis B virus (HBV)infection but might also signify occult HBV infection.

24 suggests that facilitation of NMDAR function might ameliorate CIAS.

25 e currently tested in clinical trials, STAT3 might be a candidate for molecular targeted therapies of

26 and caspase-4/11-mediated inflammation, TcpB might be a candidate target for developing drugs against

27 t in cardiac enhancers, suggesting that this might be a common mechanism underlying synergy in the co

28 hat accompanies juvenile psoriatic arthritis might be a distinct disease that is particularly severe

29 We wondered whether bilateral activation might be a general coping strategy that is independent o

30 The formation of urate hydroperoxide might be a key event in vascular inflammation, where the

31 c development of auditory brainstem circuits might be a major underlying cause of the auditory proces

32 by the Elbe River is negligible, while there might be a maximum input of 12 g/yr via the Baltic Sea.

33 Collectively, our study indicated that CD44 might be a novel target of DACH1 in breast carcinoma.

34 he data in this study suggest that myricetin might be a potential drug candidate for the treatment of

35 Our study indicates that miR-96 might be a potential target for therapy of pediatric SE.

36 This suggests that Myr might be a potential therapeutic agent for the treatment

37 ple signaling pathways and suggest that Gab2 might be a powerful therapeutic target for HCC.

38 rine screening of different drug classes and might be a promising alternative to conventional procedu

39 i-cancer drugs, and ATRA-PLLA microparticles might be a promising targeted drug for HCC therapy as PL

40 n patients with preserved renal function and might be a reasonable alternative to warfarin for stroke

41 cts of ethanol, and pretreatment of caffeine might be a strategy to counter the hypnotic effects of e

42 oth receptors with STAT3 signaling inhibitor might be a therapeutic approach for the treatment of GBM

43 ans, and our limited data indicate that this might be a useful strategy for filovirus vaccines as wel

44 cting molecular features of a metastasis and might be a useful tool for future clinical applications,

45 Data demonstrated that ASP might be a valuable functional ingredient to create a re

46 kade of interleukin-23 via inhibition of p19 might be a viable therapeutic approach in Crohn's diseas

47 The Sino-Nasal Outcome Test score might be able to predict more severe reactions and merit

48 findings support the idea that bipolar cells might be able to synapse with reintroduced photoreceptor

49 Each of these steps might be addressed algorithmically using various compute

50 molecular signatures within macrophages that might be affected by Trpc3 expression requires an altern

51 Thus, SPHK2 might be an attractive new target for the treatment of f

52 Our results suggest that Foxp1 might be an attractive therapeutic target for HD.

53 ocking antibody 1 year after discontinuation might be an early indicator of a protolerogenic mechanis

54 Thus, Dyrk1A might be an ideal therapeutic target for Alzheimer's dis

55 C, suggesting that the NGS-based ctDNA assay might be an optional method to monitor EGFR-TKI resistan

56 that use of angiotensin II receptor blockers might be associated with a lesser risk of acute pancreat

57 n predicted that increased disease detection might be associated with a transient increase in colposc

58 em is completed by additional functions that might be assumed by non-orthologous genes in different s

59 RI, and that perihaematomal vasogenic oedema might be attributable to microglial activation, iron dep

60 TrkC diverse functions might be attributed to the hypothetical non-coding RNAs

61 the calculation of other cationic attributes might be based on similar principles.

62 This restraint might be because of the poor proliferative capacity of a

63 of a physiologic gastrointestinal microbiota might be beneficial for this condition.

64 er biomarker, AMF secretion into body fluids might be closely related to metastases formation.

65 y L1 at a low rate; the utility of avibactam might be compromised by mutations that increase this dea

66 Selective use of screening for CAC might be considered in individuals with risk factors in

67 tile organic compound tracers in a city that might be considered representative for Central Europe an

68 In conclusion, the SYNTAX score might be considered useful in interventional cardiology.

69 ecent behavioral evidence suggests that this might be coupled with perception.

70 tion of the small F508del-CFTR subpopulation might be crucial for CF therapy development.

71 x of the molecule; the receptor-binding mode might be different from that of retroviruses.

72 of European ancestry, suggesting that there might be different genetic factors affecting susceptibil

73 results suggest that asthma pathophysiology might be differentially associated with hypertension in

74 cts in maintaining whole-body energy balance might be early events that contribute to weight gain and

75 uggest that, although female euglossine bees might be effective at moving pollen within populations,

76 ehaviors, such as overeating or drug taking, might be especially prone to relapse following treatment

77 This difference might be explained by structural preservation after crus

78 The majority of protected areas ( 80%) might be exposed to high rates of climate displacement t

79 tention- and stopping-related processes that might be implemented by divergent neural networks.

80 results of neural stem cell transplantation might be improved by accommodating the protracted develo

81 ling and intuitive as personalized nutrition might be in the current era in which data-intensive biom

82 development of periodontitis in young adults might be increased by combining periodontal information,

83 This pathway might be induced to resolve intestinal inflammation in p

84 hus, polymorphism in certain plant NLR genes might be influenced by competing environmental stresses.

85 ty oscillations are coupled and the coupling might be instrumental in temporally aligning the initiat

86 ach a consensus regarding how these outcomes might be integrated into enhancing clinical care.

87 While this feature might be interpreted as a clue for another significant (

88 ts move us towards understanding how the PAG might be intricately involved in human responses to thre

89 ling key biological processes where lincRNAs might be involved during parasite development.

90 These findings suggest that 3-HIB and FGF21 might be involved in protein-mediated insulin resistance

91 w cells leading to a mosaic in aged tissues, might be involved in the development of chronic subclini

92 BACKGROUND & AIMS: Epigenetic mechanisms might be involved in the regulation of liver enzyme leve

93 ly localized in CE cells, suggesting that it might be involved.

94 nd involved allergens and that such patterns might be more biologically and clinically relevant.

95 suggests that the ecosystem in such settings might be more conducive for intrafacility transmission e

96 scopically, indicating that SPECT/CT imaging might be more sensitive than the macroscopic arthritis s

97 Here, we consider reasons why germ plasm might be neither a direct target of selection nor causal

98 ata suggest that suppressing the PAK pathway might be of therapeutic benefit in this type of melanoma

99 ying nonmutational wtp53 inactivation, which might be of therapeutic relevance.

100 the chemotherapeutic treatment of cancer and might be overcome by inhibition of the transporter.

101 ems often start in early childhood, and this might be particularly important in Africa, where the inc

102 en sex work policy and HIV among sex workers might be partly moderated by the effectiveness and fairn

103 BACKGROUND & AIMS: It might be possible to manipulate the intestinal microbiot

104 exists in the literature that transformation might be prevented altogether, based on the choice of th

105 In conclusion, blood-derived miRNAs might be promising biomarkers for SZ diagnosis.

106 blood-brain barrier dysfunction in psychosis might be relevant to many aspects of disrupted neuronal

107 This novel mechanism might be specific to the maintenance of gaze direction a

108 e to treatment suggests that the effect seen might be sustained, but this needs to be confirmed at th

109 (Abeta), tau, or alpha-synuclein (alphaSyn) might be the major deleterious species for neuronal func

110 n in subthreshold voltage-activated currents might be the mechanism underlying defective repetitive f

111 Dietary AGEs and AGE-forming sugars might be the missing link, a hypothesis supported by a n

112 nesses studied, and the severity of flooding might be the reason for some, but not all, of the differ

113 on amino acid 186 between H3N8 and H3N2 CIVs might be the result of adaptive changes acquired during

114 in protein transport, loss of this function might be the trigger for the resultant cellular events t

115 o highlight endogenous coping responses that might be therapeutically bolstered to treat PD.

116 olic homeostasis, we hypothesized that there might be thermogenic lipokines that activate BAT in resp

117 no quantitative models to study how biofilm might be transferred into sterile tissue/implant materia

118 rty of activated beige/brite adipocytes that might be under epigenetic control.

119 in HC, suggesting that these two biomarkers might be used to detect at risk individuals.

120 These might be used to monitor disease progression and identif

121 However, such therapies might be used to supplement conventional therapies and h

122 This information might be useful as a prognostic aid for individual patie

123 Therefore, it might be useful as first-line monotherapy for adults wit

124 NTERPRETATION: To enhance OPV commitment, it might be useful to consider a multifactorial approach th

125 s of Gd-DTPA transport across these barriers might be useful to estimate local DOX concentrations in

126 hese shortcomings, the human imiquimod model might be useful to investigate early pathogenic events a

127 Oral biotherapy with TLR4 ligands might be useful to potentiate oral tolerance to haptens

128 growth applied strategy (GRAS), business as might be usual and sustainable European development goal

129 survey suggesting that one-third of patients might be willing to donate at imminent death, we estimat

130 Thus, inhibition of Clks might become a novel anticancer strategy, leading to a s

131 Electrical impedance tomography-derived maps might become clinically feasible and relevant, being sim

132 Tibetan alpine grasslands where P limitation might become more widespread relative to N as temperatur

133 Nursing science might benefit from deeper involvement in engineering res

134 udies are warranted to identify patients who might benefit from this therapy.

135 colonies in coculture with PC3 cells, which might boost tumor stem-like properties.

136 lar adsorbent recirculating system treatment might bridge to liver recovery or liver transplantation.

137 ible lentiviral-mediated ChR2 overexpression might cause cytotoxicity in NRVM cultures, which could b

138 s can occur, especially in severe forms that might cause substantial morbidity and even mortality, pa

139 e resulting data regarding how HIV infection might change the balance of commensal bacteria in the gu

140 we hypothesized that freely or wrapped FKRP might circulate as an extracellular glycosyltransferase,

141 chnologies, provides perspective on what one might consider a practical contribution, and hints at di

142 non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to direct the ATPase SMARCA5.

143 issues further suggest that phloem and xylem might contribute to the de novo biosynthesis of JA after

144 aspects of the neonatal immune system which might contribute to the development of early life wheezi

145 gammadelta T cells might contribute to the development of hypertension in h

146 In endothelial cells, this phenomenon might contribute to vascular disease.

147 ylation of Akt after 2 h of hypoxic exposure might deactivate RNA-binding protein BRF1, hence resulti

148 IAC(187)), known to block binding to CX3CR1, might decrease disease.

149 intenance of gaze direction across blinks or might depend on a more general oculomotor recalibration

150 modules of at least some classes of viruses might descend from primordial selfish genetic elements,

151 lucidation of the means by which the protein might dictate an alternative oxo position.

152 Those different strategies might differentially involve attention- and stopping-rel

153 Future studies might elucidate how brain diseases change this modular a

154 cine signals into adaptive immune responses, might enable development of age-specific vaccine formula

155 ying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; ho

156 ffect on vaccine potency, or, conversely, it might establish a temporary state that limits the initia

157 Alternatively, task representations might even be enhanced to overcome the previous task.

158 This result, suggests that C. minutus might exclude C. flamarioni from areas with softer soils

159 ically in their detection principle and thus might exhibit limitations for a specific application.

160 This might explain a breakdown of the DMN in many neurologica

161 more factors than simply charismatic species might explain attractiveness of protected areas, and cal

162 altered colorectal stem cell dynamics, which might explain the chemopreventive action of this drug in

163 various agents is poorly understood, but it might explain the differential responsiveness of patient

164 amate neurons produces aversive effects that might explain why cannabinoid is not rewarding in rodent

165 on of mutated allele burden, and ruxolitinib might extend survival of patients with higher-risk myelo

166 Future interventions might focus on preserving exercise capacity.

167 PSI-enriched domains in cyanobacteria might foreshadow the partitioning of PSI into stromal la

168 This indicates that Pum proteins might form collaborative networks with FMRP and possibly

169 dying physical, cognitive, and social health might further clarify the prognostic role of aging.

170 Antidiabetic therapies might further improve outcomes in patients with heart fa

171 Further, human clinical studies suggest it might have a causal role in these diseases.

172 Therefore, lifestyle modification might have a positive effect in the treatment of GERD in

173 The development of analytical alternatives might have advantages such as greater efficiency, more r

174 crepancies in the literature concerning GpsB might have arisen from accumulation of unidentified supp

175 : 7.90 million-9.59 million) life years that might have been achieved if South Africa had moved swift

176 suggesting that deregulating these pathways might have dramatic consequences for human health.

177 of the moon's semi-diurnal gravimetric tides might have driven the patients' bipolar cycles, by perio

178 d confocal microscopy reveal that rust fungi might have evolved multiple effectors that target chloro

179 nscription and discuss how these differences might have important implications for the functional con

180 indicates that subjects with celiac disease might have increased intestinal permeability in early li

181 hanisms of interaction and molecular control might have made the initial pathways to prebiotic system

182 ks involving desiccated soils and vegetation might have played a role in driving the heat extreme.

183 Maternal supplementation with fish oil might have prophylactic potential for long-term preventi

184 Human-specific regulatory circuitry of DLX5 might help explain certain aspects of preeclampsia.

185 motoneuronal contributions to eye movements might help in designing drug therapies for human eye mov

186 les (EVs) may represent novel effectors that might help to elucidate disease-specific pathways in met

187 t predators conferred by their high toxicity might help to explain why calling has not yet disappeare

188 These findings might help to explain why TNF blockade improves lung fun

189 detect these patterns in digital social data might help us identify populations at heightened risk of

190 ples of other extra-axial skull tumours that might histologically mimic meningioma variants.

191 record of ancient infections whose analysis might illuminate mechanisms of viral extinction.

192 l activation and asked whether their absence might impact in vivo alloresponses using a severe acute

193 -care testing (POCT) for respiratory viruses might improve clinical care by reducing unnecessary anti

194 ecently, regimens have become available that might improve HCW acceptance and compliance with LTBI tr

195 itive strain from eye movements over decades might in susceptible individuals lead to optic neuropath

196 ation and divergence, and some of the themes might include descendants of ancestral segments.

197 or-prey interactions, for example, predators might increase capture success because of specialization

198 ild polioviruses had been eradicated, but it might increase the cost of OPV withdrawal.

199 heterozygote individuals disturbs sleep and might increase the risk for developing mood disorders.

200 Longstanding diabetes might increase the risk of acute rejections.

201 soil C models and suggest that elevated CO2 might increase turnover rates of new soil C.

202 As a result, we hypothesized that RRV might induce changes in the cytoskeleton at both early a

203 olar androgen therapy [BAT]) in this setting might induce tumour responses.

204 ng pathways by which a fall in oxygen levels might initiate Type I cell activation.

205 ops and transmembrane segments of hERG1 that might interact with Rg3.

206 of HSC specification with vessel patterning might involve modulatory regulatory factors such as R-sp

207 the striatoentopeduncular/nigral projections might lead to increased intensity and duration of D1-sti

208 of PDE10A in the striatopallidal projections might lead to increased intensity and duration of D2-inh

209 ors that promote more severe viral illnesses might lead to new strategies for the prevention of viral

210 s I, B7-H3, PD-L1, and PD-L2, molecules that might limit NK cell function.

211 The findings suggest that humans might literally 'listen to their heart' to guide their a

212 ure of the fusion of two heavy-quark baryons might manifest itself.

213 the two broadest criteria by which listeners might meaningfully compare violins.

214 results provide a first insight into how we might measure the genotoxic and cytotoxic effect of plas

215 ets of Galphat-S-ir neurons, suggesting they might mediate non-visual modulation by light in many sys

216 and highlight that transcriptional enhancers might modulate the release of paused RNAPII via 3D chrom

217 We propose that miR-26a delivery might not be a viable therapeutic strategy due to the po

218 the procedure has inherent complications and might not be available for all patients.

219 lateral, in TN patients the DPPS of the face might not be horizontally symmetric as in pain-free indi

220 ed because extrapolations from adult studies might not be implementable.

221 aring numerosities and (2) a sense of number might not be innate.

222 Such distributional changes might not be rescued by dispersal in space or time (as s

223 of mAbs, where some of the individual peaks might not be well resolved.

224 rate that even though the direction of force might not follow the flow of energy, the positive radiat

225 diagnostic tests by promoting research that might not have otherwise been feasible with conventional

226 posed candidate Zika virus vaccines might or might not succeed in raising safe, effective, and durabl

227 rogrammes focused on biomedical determinants might not sufficiently enhance child cognition, and that

228 n might produce autoinducers, whereas others might not.

229 tes of TDP-43-associated hippocampal atrophy might occur at least 10 years before death.

230 shrub, and similar impacts on native species might occur in its invasive range, or in areas with simi

231 engue viruses, an analogous unwanted outcome might occur with some Zika virus vaccine designs.

232 of metastatic disease, and its manipulation might offer a new possibility for diminishing bone metas

233 Newly proposed candidate Zika virus vaccines might or might not succeed in raising safe, effective, a

234 ray ionization (PSI) technique coupled to MS might overcome these steps by direct analysis of complex

235 hile the male preponderant prevalence of ASD might partially be explained by sex differences in clini

236 presenting symptoms among patients with NETs might permit more tailored assessment and management tha

237 ed and actual outcome of another's decisions-might play a crucial role in processing social informati

238 The results indicate that LRX proteins might play a role in cell wall-plasma membrane communica

239 h individual changes in a variety of species might play a role over evolutionary timescales.

240 This might point to a ceiling effect for enteral protein inta

241 We hypothesized that these patients might possess other defects in filaggrin expression and

242 d schema for a randomised phase 3 trial that might potentially answer this question definitively.

243 In the cortex, focal lesion changes might precede diffuse atrophy with cortical thinning.

244 t some of the isogenic cells in a population might produce autoinducers, whereas others might not.

245 nabis use disorder, and (3) whether cannabis might produce lasting changes in the brain that increase

246 reasonable approach for urine screening and might produce negative results in as few as 3 h, with no

247 We considered that tumor-associated T cells might promote malignancy via distinct mechanisms used by

248 cted at month 12, suggesting that this genus might protect against the later development of AD.

249 This demonstrates that this strategy might prove useful for next generation sequencing.

250 (18)F-FET PET might provide additional information beyond the tumor ex

251 criteria, non-interventional studies (NISs) might provide additional information to guide management

252 of emtricitabine and tenofovir alafenamide, might provide an advantage to patients.

253 g straight from the light scatter suspension might provide dramatic improvement in times to a result.

254 ults suggest that group hunting in predators might provide more suitable conditions for the evolution

255 searching for proteins that bind 3',5'-cAMP might provide new insight into this question.

256 cination against group B Streptococcus (GBS) might provide protection against invasive GBS disease in

257 Replacing Nemo through gene therapy might provide therapeutic benefits.

258 l of optimal policing to explore how society might reasonably resolve the tension between these two o

259 n n-3 long-chain polyunsaturated fatty acid, might reduce the risk of bronchopulmonary dysplasia, but

260 milk and avoidance of bovine-origin products might reduce the risk of necrotising enterocolitis, but

261 e growing season), the large-scale component might reflect co-variability of sea ice and tundra produ

262 , but the substantial phenotypic differences might reflect fundamental differences in the pathogenesi

263 he Golgi of hair cells, suggesting that Tomt might regulate the trafficking of other MET components t

264 tal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which highe

265 Goji berries therefore might represent a more potent source of macular pigments

266 QOL compared with that for chemotherapy, and might represent a new first-line standard of care for PD

267 ression of HIFs, specific inhibition of HIFs might represent a new powerful treatment strategy.

268 CT-P10 might represent a new therapeutic option for advanced-st

269 resulting in viral attenuation in vivo This might represent an adaptation of pH1N1 virus to humans.

270 phrenia in high-risk, developmental studies, might represent early manifestations of genetic liabilit

271 eutrophil-associated inflammasome activation might represent interacting pathways in patients with SA

272 a protist belonging to the phylum Perkinsea might represent the third most common infectious disease

273 Finally, novel therapies that might restore homeostasis in the GI tract during GVHD ar

274 f specific diabetes phenotypes and genotypes might result in more specific and tailored management of

275 5-21], and these Argentine-breeding swallows might retain ancestral patterns, breeding in Argentina b

276 These results might reveal generic mechanisms of plasticity in cogniti

277 and newly discovered classes of riboswitches might reveal subgroups of RNAs that respond to different

278 Shutdown of this translation mechanism might selectively impact viral protein synthesis, sugges

279 ndogenous CircPVT1, suggesting that CircPVT1 might selectively modulate let-7 activity and hence expr

280 cells from the enteric nervous system (ENS) might serve as a source of cells for treatment of neurog

281 her these features of PDACs with dMMR or MSI might serve as prognostic factors.

282 Rivaroxaban, an oral factor Xa inhibitor, might simplify treatment compared with fondaparinux beca

283 n, we proposed that proline-directed kinases might specifically initiate the activation of CDK4.

284 Those lesions might stabilize intermediate receptor conformations alon

285 n of active Rags for mTORC1 recruitment, and might suggest an unconventional mechanism for Rag GEF ac

286 The induced magnetic moment at 60 T might suggest that only one subset of magnetic moments h

287 sed catalysts is more diverse than precedent might suggest.

288 n atoms, and we propose an architecture that might take advantage of this.

289 tribution, and hints at directions the field might take in the future.

290 phthalmologic education in diabetic programs might take up patients' propensity for SDM.

291 -P and PSP than in PD and MSA-C patients and might therefore be of interest for differential diagnosi

292 Psychological therapies might therefore have beneficial effects on disease activ

293 f IL-22 in IL-22/IL-17-producing T cells and might thus impact the T-cell responses in asthma.

294 erns of missed general practice appointments might thus provide a risk marker for vulnerability and p

295 Accordingly, "contempt" might transcend traditional conceptual levels in social

296 That sex-biased exposure might translate to sex-specific adverse outcomes such as

297 yet known whether or how sensory stimulation might trigger abnormal sensory processing at the circuit

298 ata alone, especially in a young population, might underestimate disease risk.

299 d during TCR triggering, and that the T cell might use its force-generation machinery to probe the me

300 gous pathways in bacterial microcompartments might yield significant benefits for pathway flux, as we