ライフサイエンスコーパス: migrating cell

1 and exocytic membrane flow at the front of a migrating cell.

2 ransitions between blebs and lamellipodia in migrating cells.

3 otide exchange factor at the leading edge of migrating cells.

4 d for relocalization of DMIB to the front of migrating cells.

5 nitial fuzzy pattern into a compact group of migrating cells.

6 ll protrusions and retract trailing edges of migrating cells.

7 polarity, membrane dynamics, and the rate of migrating cells.

8 dients and to permit direct visualization of migrating cells.

9 ed tails and higher directional stability of migrating cells.

10 wn about the role of Lgl in cell polarity in migrating cells.

11 regulate polarization, speed, and turning of migrating cells.

12 he direction, efficiency, and persistence of migrating cells.

13 the extreme leading edge of lamellipodia of migrating cells.

14 o force-bearing sites at the leading edge of migrating cells.

15 s are transported toward cell protrusions in migrating cells.

16 paxillin and focal adhesion kinase (FAK) in migrating cells.

17 heir intended substrates at leading edges of migrating cells.

18 that governs protrusion-retraction cycles in migrating cells.

19 finding, PhdI located to the leading edge in migrating cells.

20 bling or sliding FAs at the trailing edge of migrating cells.

21 ws and dictates the initial direction of the migrating cells.

22 ocal adhesions mediates their disassembly in migrating cells.

23 2/3, and Myosin-I linker) family proteins in migrating cells.

24 nd overlaps with ARF6 at the leading edge of migrating cells.

25 h colocalize with FAK at the lamellipodia of migrating cells.

26 he direction of actin flow on the surface of migrating cells.

27 embly and disassembly in the lamellipodia of migrating cells.

28 atrix-degradative activity to the surface of migrating cells.

29 ation of lamellipodia at the leading edge of migrating cells.

30 e and are restricted to the basal surface in migrating cells.

31 bution, caspase 8 is recruited to lamella of migrating cells.

32 n complexes maintain front-rear asymmetry in migrating cells.

33 d in the formation of head-to-tail arrays of migrating cells.

34 e distinct distribution of these isoforms in migrating cells.

35 show isoform-specific front-back polarity in migrating cells.

36 al for the establishment of cell polarity in migrating cells.

37 eal activation of PKA at the leading edge of migrating cells.

38 to contribute to the protrusive activity of migrating cells.

39 ted its translocation to the leading edge of migrating cells.

40 gression, which may reduce the population of migrating cells.

41 etween the cytoskeleton and the substrate in migrating cells.

42 ve feedback signal necessary for polarity in migrating cells.

43 redistribution of the actin cytoskeleton in migrating cells.

44 filamentous actin bundles along the base of migrating cells.

45 ons and cell-matrix adhesions at the rear of migrating cells.

46 romote Rac activation at the leading edge of migrating cells.

47 TGalpha6 protein levels are increased in the migrating cells.

48 was found in cloche and scl(mo), possibly in migrating cells.

49 ator of F-actin functional specialization in migrating cells.

50 ation of a microtubule-associated protein in migrating cells.

51 matically relocalized to the leading edge of migrating cells.

52 actin polymerization at the leading edge of migrating cells.

53 is spatially and temporally regulated inside migrating cells.

54 ures for real-time observation of individual migrating cells.

55 icits mechanical behavior similar to that of migrating cells.

56 filament nucleation and cell shape change in migrating cells.

57 GM1, to stabilize MTs in the leading edge of migrating cells.

58 of the model for lamellipodial protrusion in migrating cells.

59 ellipodial protrusion at the leading edge of migrating cells.

60 ribution of mitochondria to the periphery of migrating cells.

61 cytoskeletal systems in the leading edge of migrating cells.

62 and the inactive, phosphorylated AC (pAC) in migrating cells.

63 thrin-coated pits and at the leading edge of migrating cells.

64 phrin signaling acting positively to pattern migrating cells.

65 nts that drive plasma membrane protrusion in migrating cells.

66 events at the leading edge of directionally migrating cells.

67 o macroscopic tracks created in scaffolds by migrating cells.

68 er alignment of contractile stress fibers in migrating cells.

69 n of Rab13 by DENND2B at the leading edge of migrating cells.

70 sive actin-based structures in spreading and migrating cells.

71 chemokine-dependent strategies used to guide migrating cells.

72 and dynamic cell-shape changes performed by migrating cells.

73 tiffness, but does not increase the speed of migrating cells.

74 re important for locomotion in many types of migrating cells.

75 ation and to provide directional guidance to migrating cells.

76 ments that protrude from the leading edge of migrating cells.

77 rear Cdc42-GTP distribution in directionally migrating cells.

78 native ways of extending the leading edge of migrating cells.

79 of ATX, which redistributes to the front of migrating cells.

80 geometry to predict where blebs will form in migrating cells.

81 adients that provide directional signals for migrating cells.

82 ng cells with a morphology characteristic of migrating cells.

83 e adhesion protein and filopodia dynamics in migrating cells.

84 that extended into the collagen matrix with migrating cells.

85 activated both in the front and the rear of migrating cells.

86 and myosin II light chain/actin filaments in migrating cells.

87 and phagocytic cups and the leading edge of migrating cells.

88 d basic machinery, neurons differ from other migrating cells.

89 -bearing proteins present in lamellipodia of migrating cells.

90 ansport Ca-calmodulin to the leading edge of migrating cells.

91 ctin cytoskeleton and focal adhesion (FA) in migrating cells.

92 r, a region corresponding to the lamellum of migrating cells.

93 e formation of lamellipodia and filopodia in migrating cells.

94 measured by increased distance and speed of migrating cells.

95 nocytes was composed largely of pre-existing migrating cells (555.6 +/- 38.1/mm(2)) and to a lesser e

96 (EFs) are able to influence the direction of migrating cells, a process commonly referred to as elect

97 In the leading edge of migrating cells, a subset of microtubules exhibits net g

98 In migrating cells actin remodeling is tightly regulated an

99 In migrating cells, actin polymerization promotes protrusio

100 MT1-MMP was directed to the leading edge of migrating cells along micropatterned fibronectin stripes

101 ike protrusions found at the leading edge of migrating cells and are believed to play a role in direc

102 orm protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 s

103 een the nucleus and the leading edge in many migrating cells and contributes to directional migration

104 enriched in adhesions at the leading edge of migrating cells and depletion of beta2-adaptin by RNAi i

105 diates polarity in several systems including migrating cells and early embryos, which involve reorien

106 on of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the sur

107 cells reactivate from dormancy more than non-migrating cells and exhibit differential migration-react

108 etworks within lamellipodia and filopodia of migrating cells and in actin comet tails.

109 oning and cell polarization were impaired in migrating cells and in cells plated on micropatterned su

110 ed in focal adhesions at the leading edge of migrating cells and inhibition or knockdown of Kir4.2 ca

111 p1 protein is present at the leading edge of migrating cells and interacts directly with cytoskeletal

112 ized distribution toward the leading edge in migrating cells and is clearly distinct from the Myo5a o

113 adients are generated at the leading edge of migrating cells and provide additional insight into the

114 contacts the leader TVC, then 'encases' both migrating cells and provides the inputs maintaining lead

115 n of 'sticky fingers' at the leading edge of migrating cells and show that an MIT complex drives thes

116 ccumulate at the leading edge of a number of migrating cells and that PI3Ks and PTEN associate with t

117 ositioning is an initial polarizing event in migrating cells and that the positions of the nucleus an

118 nces investigating the nature of polarity in migrating cells and the pathways that establish it.

119 egarding the localization of PCP proteins in migrating cells and their impact on the cell biology of

120 ctant stimulation and at the leading edge of migrating cells and this localization is dependent on PI

121 genous CIP4 localized to the leading edge of migrating cells and to invadopodia in cells invading gel

122 DdVASP localizes to the leading edge in migrating cells and to the tips of filopodia.

123 lized compartment-specific PKA activation in migrating cells and used it to reveal that adhesion-medi

124 iosynthetic exocytic pathway is polarized in migrating cells and whether polarized exocytosis promote

125 ZEB expression measurements in collectively migrating cells) and explains the lack of observed mesen

126 results show that motor neurons are actively migrating cells, and are normally trapped in a static po

127 three GTPases are activated at the front of migrating cells, and biochemical evidence suggests that

128 nonmuscle myosin IIA (NMIIA) to the front of migrating cells, and depletion of NMIIA by RNAi disrupts

129 a occurs specifically at the leading edge of migrating cells, and induces the interaction of adenomat

130 filopodia and regulate adhesion dynamics in migrating cells, and its expression is correlated with p

131 n of PKL and beta-PIX to the leading edge of migrating cells, and knockdown of Vav2 results in a decr

132 ically interact at the centrosomal region of migrating cells, and PKC-mediated phosphorylation on Thr

133 ration indirectly by exposing plasminogen to migrating cells, and second, fibrin selectively disrupts

134 possibility that in other contexts in which migrating cells appear to breach tissue barriers, they a

135 2D, or 3D environments, we hypothesize that migrating cells are also able to sense the dimension of

136 by which microtubules control FA turnover in migrating cells are beginning to emerge.

137 actin filament array at the leading edge of migrating cells are interdependent and coupled, but the

138 in ciliary axonemes, neuronal processes, and migrating cells are marked by alpha-tubulin acetylation

139 a major reason for treatment failure: these migrating cells are not eliminated in surgical resection

140 rom the extracellular fluid by CCR2-positive migrating cells as they cross the BBB, resulting in decr

141 3 and the upregulation of MCT4 expression in migrating cells at the edge of the wound.

142 move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through

143 Migrating cells between the graft and the lesion express

144 , mammalian homolog of Diaphanous (mDia), in migrating cells, but factors responsible for localized s

145 MLCK is highly active in the lamella of migrating cells, but not at the retracting tail.

146 and migrating cells reacted to pgp 9.5, and migrating cells, but not the cell clusters, reacted to t

147 unction are regulated at the leading edge of migrating cells by a balance of kinase and phosphatase a

148 indicate that Lgl1 regulates the polarity of migrating cells by controlling the assembly state of NMI

149 by two-photon microscopy and by phenotyping migrating cells by flow cytometry.

150 el regulatory mechanism of NMII in polarized migrating cells by identifying a key molecular determina

151 ymmetric distribution of mitochondria within migrating cells by interfering with mitochondrial fusion

152 complex translocates to the leading edge of migrating cells by membrane trafficking that requires th

153 We found that the nucleus in an isolated migrating cell can move forward without any trailing-edg

154 reveal that the type of protrusion formed by migrating cells can be dynamically controlled independen

155 Migrating cells can sustain a relatively constant direct

156 In migrating cells, CARMIL2 is important for cell polarity,

157 suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source th

158 d that myosin IIA skewed toward the front of migrating cells, coincident with actin assembly at the l

159 The leading edge of migrating cells contains rapidly translocating activated

160 :6HP formed in the photoreceptors, and these migrating cells could help modulate the inflammation.

161 In migrating cells, cytosolic Ca(2+) pool and Ca(2+) pulses

162 Guidance of individually migrating cells depends critically on subcellularly loca

163 osome orientation toward the leading edge of migrating cells depends on dynein and microtubules (MTs)

164 In migrating cells, depletion of clathrin or Dab2 and ARH i

165 ycling compartment has specific functions in migrating cells discrete from early and recycling endoso

166 eveloping cerebellar white matter, where the migrating cells dispersed widely before entering the int

167 These migrating cells do not contribute to venous or lymphatic

168 These migrating cells do not replace the entire microglial poo

169 fected, although a decrease in the number of migrating cells does occur after CSF obstruction.

170 ctyostelium, TORC2 functions at the front of migrating cells downstream of the Ras protein RasC, cont

171 been suggested to be spatially regulated in migrating cells due to its ability to control signaling

172 d pseudopod extension at the leading edge of migrating cells during chemotaxis.

173 Most studies have focused on migrating cells equipped with an existing polarity befor

174 turbations, which revealed that individually migrating cells exhibit diminished chemosensitivity.

175 Migrating cells exhibit distinct motility modes and can

176 , which extends from the leading edge of the migrating cell, exploring the cell's neighborhood.

177 Migrating cells extend protrusions, probing the surround

178 In migrating cells, external signals polarize the microtubu

179 actin also localized to the leading front of migrating cells, F-actin polymerization was unstable, an

180 In migrating cells, feedback loops can amplify stochastic f

181 MLC was redistributed to the leading edge of migrating cells following 6 hours of strain on collagen

182 1 (NHE1), which is necessary at the front of migrating cells for polarity and directional motility.

183 in cell transport and delivery that captures migrating cells from the circulating flow.

184 like actin protrusion at the leading edge of migrating cells, functions as a sensor of the local envi

185 osphere labeling with BrdU, we determined if migrating cells had gone through the S-phase of the cell

186 n, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH

187 This analysis revealed that non-radially migrating cells have a complex pattern of extending and

188 In particular, migrating cells have been shown to sense substrate stiff

189 ominantly accumulates at the leading edge of migrating cells; however, the pathways that link the act

190 an extensive catalog of genes that act in a migrating cell, identify unique molecular functions invo

191 nalyze the co-flux of adhesion components in migrating cells imaged using total internal reflection f

192 the varying nanotopology experienced by the migrating cell in vivo.

193 and high-dynamic-range time-lapse imaging of migrating cells in complex three-dimensional microenviro

194 rity pathway coordinates the polarity of non-migrating cells in epithelial sheets and is required for

195 The majority of migrating cells in ischemic rats had a neuronal phenotyp

196 g process and nuclear translocation, and the migrating cells in the CC showed both modes.

197 t both attractive and repulsive responses in migrating cells in the central and peripheral nervous sy

198 We also track migrating cells in the developing zebrafish embryo, demo

199 ly CCL4, significantly reduced the number of migrating cells in vitro, indicating their role in the i

200 Addition of DAN reduces the speed of migrating cells in vivo and in vitro, respectively.

201 nal information regarding the role of CaD in migrating cells in vivo.

202 , and phosphocofilin at the leading edges of migrating cells, in wound-healing assays.

203 adless Myo10 in regions of proliferating and migrating cells, including the embryonic ventricular zon

204 auses loss of vinculin in focal adhesions of migrating cells, increased cell adhesion and impeded rea

205 wth factor-independent and reorient randomly migrating cells inside the sheet when boundary cells beg

206 In migrating cells, integrin-based focal adhesions (FAs) as

207 The migrating cell is highly polarized with complex regulato

208 Front-rear polarity of migrating cells is determined by local activation of a s

209 On rigid surfaces, the cytoskeleton of migrating cells is polarized, but tissue matrix is norma

210 nals from these chemokines are integrated by migrating cells is poorly understood.

211 Actin in migrating cells is regulated by Rho GTPases.

212 ly (adhesion turnover) in the protrusions of migrating cells is regulated by unclear mechanisms.

213 at MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, wh

214 In migrating cells, it has been shown that the locations of

215 the disassembly of adhesive cell contacts at migrating cells' lagging ends, immunohistochemical analy

216 results in decreased expression of Cxcr4 in migrating cells, leading to a premature burst of granule

217 We also show that migrating cells leave behind ACA-containing vesicles, li

218 GAP and actin motor protein, in collectively migrating cells led to altered organization of the actin

219 re dynamic constructs at the leading edge of migrating cells, linking them to the extracellular matri

220 Collectively migrating cells maintain group polarity and interpret ex

221 tribution in response to strain in confluent migrating cells may explain the matrix dependence of the

222 The actin machinery in migrating cells may tune the number of filaments at the

223 In live migrating cells, membrane-associated PKA activity was hi

224 ha5beta1-fn adhesions located at the edge of migrating cell monolayers while also increasing alpha5be

225 A migrating cell must establish front-to-back polarity in

226 metazoan development and metastatic cancer, migrating cells must carry out a detailed, complex progr

227 In migrating cells, myosin contraction provides the driving

228 Migrating cells need to overcome physical constraints fr

229 a cells with significantly larger numbers of migrating cells observed in overexpressing clones compar

230 Migrating cells of Myxococcus xanthus (MX) in the early

231 Migrating cells often exhibit signal relay, a process in

232 al alterations that reduce the dependence of migrating cells on adhesion-contraction force coupling.

233 onditioned medium and reduced the numbers of migrating cells on injured explants.

234 volution of the strain energy exerted by the migrating cells on their substrate is quasi-periodic and

235 ify enhancing factors, measure the effect of migrating cells on underlying extracellular matrix (ECM)

236 r direct observation of H2O2 accumulation in migrating cells or protrusions.

237 with the lipophilic dye DiI shows that late-migrating cells, originating from the trunk neural tube

238 In contrast to randomly migrating cells, PDGF-induced membrane protrusions have

239 In migrating cells, phosphorylated alpha4 accumulated along

240 study was to assess our hypothesis that the migrating cell population included chondrogenic progenit

241 he correlations observed experimentally in a migrating cell population.

242 retrieval of the distinct migrating and non-migrating cell populations for further analysis.

243 Migrating cells possess intracellular gradients of activ

244 zeta complex by Cdc42 at the leading edge of migrating cells promotes both the localized association

245 h caspase 8 is recruited to the lamella of a migrating cell, promoting cell migration independent of

246 At the leading edge of migrating cells, protrusion of the lamellipodium is driv

247 Cell clusters and migrating cells reacted to pgp 9.5, and migrating cells,

248 Migrating cells reorganize their actin and microtubule c

249 tail, but it has been unclear how individual migrating cells respond to Reelin.

250 electron microscopy (TEM) demonstrated that migrating cells retain neuronal structures for signal tr

251 Profiling of migrating cells revealed a possible SCF/c-Kit paracrine

252 In randomly migrating cells, RhoA activity is concentrated in a shar

253 d by an overall increase in the speed of the migrating cell sheet.

254 Our results indicate that migrating cells show patterns of local matrix deformatio

255 lipodia, which, in contrast to nonexpressing migrating cells, stained for pAC.

256 s controlled by the small GTPase Rho in fast migrating cells such as leukocytes.

257 The integrin alpha9beta1 is expressed on migrating cells, such as leukocytes, and binds to multip

258 directional persistence and polarization in migrating cells, suggesting a coordination between PKL/V

259 assume distinct subcellular distribution in migrating cells suggests that discrete spatiotemporal re

260 In migrating cells, syntaxin clusters polarize to the leadi

261 flects formation of clusters of coordinately migrating cells that are generated further away from the

262 increasingly larger clusters of coordinately migrating cells that move faster with enhanced alignment

263 In migrating cells, the actin filament nucleation activity

264 rane protein, present at the leading edge of migrating cells, the expression of which in normal tissu

265 and adaptation of leading-edge machinery in migrating cells, the invasion of one cell into another d

266 In migrating cells, the majority of PhdB was found at the l

267 ion of focal contacts at the leading edge of migrating cells, the mechanisms and signaling pathways r

268 tracking and quantifying FAK and paxillin in migrating cells, the normalized FAK/Paxillin fluorescenc

269 In migrating cells, the relative importance of myosin II co

270 this invasive migration, acting both in the migrating cells themselves and in the non-migratory pola

271 the same region, and is not expressed in the migrating cells themselves.

272 tegrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of

273 ocalize p130Cas to nascent adhesive sites in migrating cells thereby leading to the activation of Rac

274 also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and

275 fic information that precedes the arrival of migrating cells, thus priming the node for a more effect

276 ocytes into inflammatory tissue requires the migrating cell to overcome mechanical forces produced by

277 pithelial migration describes the ability of migrating cells to cross epithelial tissues and occurs d

278 erse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons

279 Thus, PGI2 may act as a "brake" on migrating cells to facilitate cell-cell contact and fusi

280 d adherens junction proteins at the front of migrating cells to locally activate Rac1 in response to

281 hosphorylated Rabaptin-5 toward the front of migrating cells to promote delivery of alphavbeta3 to th

282 One month later, OECs formed an apparent migrating cell tract continuously extending from the inj

283 are interdependent and suggest that distinct migrating cell types can coordinately influence each oth

284 Migrating cells typically form filopodia that extend fro

285 tin turnover in lamellipodia and lamellae of migrating cells, using quantitative Fluorescent Speckle

286 We propose that migrating cells utilize dscam to remodel the developing

287 es to cellular polarization in directionally migrating cells via effects on Rho GTPase activity.

288 In spreading and migrating cells we find local periodic contractions of l

289 tanding of actomyosin function in individual migrating cells, we know little about the mechanisms by

290 nitor cytoskeletal and signaling dynamics in migrating cells, we show that peripheral F-actin bundles

291 serially imaged by confocal microscopy, and migrating cells were evaluated for chondrogenic progenit

292 Migrating cells were highly clonogenic and multipotent a

293 orylated CaD is found at the leading edge of migrating cells where dynamic actin filament remodeling

294 se and tensin homolog (Pten) accumulation in migrating cells, whereas Pten overexpression slows ENS p

295 ntains a repulsive activity for tangentially migrating cells, whereas the cerebral cortex contains an

296 in distinct clusters at the leading edge of migrating cells, whereas unphosphorylated alpha4 and pax

297 olocalizes with actin at the leading edge of migrating cells, wherein active actin polymerization and

298 induced mislocalized activation of Cdc42 in migrating cells, which coincided with a displacement of

299 ndito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are ess

300 D44 functions to provide directional cues to migrating cells without affecting the motility apparatus