ライフサイエンスコーパス: milestone

1 owel disease (IBD) have reached an important milestone.

2 ilia B and approaches to advance beyond this milestone.

3 ft recipients who survived beyond the 5-year milestone.

4 f the linker has been an early technological milestone.

5 ams are now required to rate residents using milestones.

6 teriorates according to agreed-upon clinical milestones.

7 tonia, growth retardation, and delayed motor milestones.

8 olecule techniques that sought to detect its milestones.

9 linically meaningful mobility and upper limb milestones.

10 s that include both short-term and long-term milestones.

11 is is required to gauge innate developmental milestones.

12 ridines on delaying parkinsonism progression milestones.

13 n of age at milestones or the time between 2 milestones.

14 ession and progressive loss of developmental milestones.

15 represent different developmental and social milestones.

16 cal disorder and regression of developmental milestones.

17 ed with disrupted attainment of adult social milestones.

18 ions of coiled-coil cracking under load with Milestoning.

19 able decision makers to assess the following milestones: (1) a minimum of 33% reduction of CO2 emissi

20 Milestone 2 was released in December 2011.

21 dination and tracking of key global planning milestones, (2) guidance facilitating development of cou

22 Mumbai, India, reached its platinum jubilee milestone (75 years), which was celebrated with conferen

23 In celebration of this milestone, a unique Grand Rounds case is presented.

24 This review focuses on the most significant milestones achieved to date in the conformational analys

25 sion in multiple cancer types and biological milestones achieved using the available methodologies.

26 tify feeding-associated differences in motor milestone achievement in preterm infants.Our results sug

27 Pups were monitored for developmental milestone achievement, and then underwent adult behavior

28 The milestone achievements and recent results by both approa

29 ectrical properties highlighting some of the milestone achievements reported to date but also address

30 mobility and upper limb disease progression milestones across the lifespan as well as reduced risk o

31 es by a carbon-capturing microbiome is a key milestone addressed in this study that advances microbia

32 which provides criteria for defining optimal milestones, allowing short, independent, cell-constraine

33 I also provide a few milestones along Blood's 70 years of publication, includ

34 sub-states associated to distinct structural milestones along the pore, and how to control residence

35 perspective, we highlight some of the major milestones along the way to provide a historical view of

36 es of delay in attaining motor and cognitive milestones, along with learning difficulties and cerebel

37 d with advanced path sampling techniques and milestoning analysis to characterize how mRNA substrate

38 s regression models on the risk of a disease milestone and death were used.

39 cal discoveries that have brought us to this milestone and to explore other targets and immunotherapy

40 zed by regressive loss of neurodevelopmental milestones and acquired psychomotor deficits.

41 with patient numbers completing key clinical milestones and adverse events.

42 nt most commonly presents with delayed motor milestones and ankle contractures.

43 tnatal maternal environment on developmental milestones and behavioral phenotypes.

44 The research milestones and current trends of the immunosensors are r

45 ncy that results in failure to achieve motor milestones and in death or the need for mechanical venti

46 ished since the year 2000, but including the milestones and key citations of earlier work.

47 walking, pain during exercise, delayed motor milestones and learning disabilities at school.

48 and OS HR but not 9-month PFS or 6-month ORR milestones and OS HR.

49 accompanied by improvement in developmental milestones and pulmonary function.

50 The socioeconomic milestones and QOL measures were assessed by clinical ev

51 ted with a more rapid development of disease milestones and shorter survival in patients with PD.

52 elays in the expression of key developmental milestones and their diminished preference for maternal

53 We present an overview of key milestones and their significance in the understanding a

54 The patient achieved normal developmental milestones and was not taking medications.

55 rning to read is a fundamental developmental milestone, and achieving reading competency has lifelong

56 nger survival, superior achievement of motor milestones, and better motor function than in historical

57 n brain dopamine (DA) systems, developmental milestones, and later vulnerability to substance abuse i

58 ve 20 years, achieve important socioeconomic milestones, and report quality of life superior to patie

59 ognostic significance of achieving treatment milestones, and the critical importance of molecular mon

60 ession is more rapid, age-related disability milestones are identical to relapsing-onset disease.

61 To facilitate this aim, reporting milestones are now required across all internal medicine

62 ce requirements and competitive transitional milestones are substantial.

63 Future work is needed to explore how milestones are used to support residents' development an

64 (eg, nifedipine, felodipine) on parkinsonism milestones as measured by time to requiring drug treatme

65 cted, and iOCT was performed during surgical milestones, as directed by the operating surgeon.

66 rticipants, analyzing those who are past the milestone at the time of recruitment as left censored ra

67 s suggests a moderate association between OS milestones at 12 or 9 months and OS HR but not 9-month P

68 l report; observed the attainment of 7 motor milestones at 6, 12, and 18 mo of age; and conducted a c

69 order characterized by loss of developmental milestones at 9-24 months of age followed by seizures, d

70 may inform establishment of the validity of milestone-based assessment.

71 The initial milestone-based evaluations of IM residents nationally s

72 ne residents in the 2013-2014 academic year, milestone-based ratings correlated with RAES ratings but

73 I exposure were found to shift developmental milestones bidirectionally on infant speech perception t

74 patients who had died by dividing time to a milestone by disease duration.

75 d with increased median age at loss of three milestones by 2.1-2.7 years in comparison with prednison

76 ith increased median age at loss of mobility milestones by 2.1-4.4 years and upper limb milestones by

77 y milestones by 2.1-4.4 years and upper limb milestones by 2.8-8.0 years compared with treatment for

78 t 6 and 12 months with the usual cytogenetic milestones, categorization by transcript numbers was the

79 approaches customize interventions based on milestone completion and can be more effective while cos

80 re we color in some details of the lives and milestone contributions of our seven personal heroes of

81 g (Brief COPE), achievement of developmental milestones (Course of Life Questionnaire), and satisfact

82 Such findings suggest that examining early milestone differences and standardized testing results m

83 ectoderm occupying opposite poles-is a vital milestone during human embryo implantation.

84 g movements emerge in utero and show several milestones during development to independent walking.

85 ; 3: GD14.5-16.5; 4: GD0.5-16.5) aligning to milestones during human development.

86 18 years, p=0.0001) and to reach disability milestones (EDSS 4.0, 23.8 vs 15.5 years, p<0.0001; EDSS

87 ) and fill factor (FF) to 77.19%, yielding a milestone efficiency of 11%.

88 considerably with the achievement of recent milestones encompassing the identification of many loci

89 on of the Archives of Clinical Surgery was a milestone event in the ensuing rise of surgery as a spec

90 Time to all disease progression milestone events was significantly longer in patients tr

91 found impairments in postnatal developmental milestones, fewer inhibitory forebrain neurons, and defi

92 ll as civilians at both short- and long-term milestones following mild TBI.

93 An important milestone for achieving not only such skyrmion materials

94 opment of amnion-is a critical developmental milestone for early human embryogenesis and successful p

95 transplantation in primates is an important milestone for informed clinical translation.

96 ty and, if confirmed, they are going to be a milestone for instructing computational models of brain

97 ad of using cryogenic distillation, is a key milestone for molecular separations because of the multi

98 erefore, pEFS24 is an appealing and relevant milestone for patient counseling and could be a surrogat

99 ing mobile phone microscopy, achieving a new milestone for tele-medicine technologies.

100 lution of the structure of Bc28 represents a milestone for the characterization of the parasite eryth

101 clinical trials in 2013 marked an important milestone for the clinical validation of AXL as an antic

102 heory of insular zoogeography', was a recent milestone for this theme.

103 These fish lines establish an important milestone for zebrafish genetics research and should gre

104 te, patient preferences, treatment plan, and milestones for evaluating the treatment plan.

105 table professional activities and curricular milestones for fellowship training in pulmonary medicine

106 urvival and overall survival, supporting new milestones for optimal response in patients with early C

107 viors is demonstrated, representing critical milestones for the use of SiO2-based materials in future

108 Developmental milestones, general health, olfactory abilities, explora

109 in order to stay below 550 ppm by 2100 (this milestone goes up to 46% in the case of delayed policies

110 The primary clinical milestone has been completion of accrual in a phase 3 tr

111 on on current status (i.e., whether or not a milestone has passed) is collected on all potential part

112 s including ages at which some participants' milestones have already passed.

113 However in the past five years significant milestones have been achieved by X-ray crystallography a

114 Major milestones have been identified, but a precise sequence

115 utD increased the risk of reaching the first milestone (hazard ratio, 0.86; 95% CI, 0.83-0.89; P < .0

116 ation Council for Graduate Medical Education Milestones help define competent trainees and practition

117 x to mitigate climate change and meet policy milestones; however, the extent that solar energy develo

118 are followed prospectively with intermediate milestones identified as they occur.

119 s and chemical modulation, thus signifying a milestone in advancing our understanding of pluripotency

120 blished data, and it represents an important milestone in an ongoing collaborative effort to examine

121 CFTR-targeted drugs represents an important milestone in CF, perhaps revolutionizing the care of the

122 The structure of Tra1 is a key milestone in deciphering the mechanism of multiple coact

123 I IFNs are essential disease mediators is a milestone in delineating the mechanisms of lupus pathoge

124 It also represents a milestone in describing synteny between perennial ryegra

125 he appearance of the notochord represented a milestone in Deuterostome evolution.

126 veness in the target population is a crucial milestone in developing IPV-Al.

127 nals (P < 5 x 10(-8)) for age at menarche, a milestone in female pubertal development.

128 This marked a milestone in global polio eradication and was a public h

129 ntation of the blastocyst is a developmental milestone in mammalian embryonic development.

130 a single neuron, which would be an important milestone in neuroscience.

131 and the plain black-glazed ware represent a milestone in our material culture due to their aesthetic

132 ributions and collectively mark an important milestone in our understanding of both familial and spor

133 issue, Distefano et al. provide yet another milestone in our understanding of regulated necrosis as

134 A potential milestone in personalized nuclear medicine is theranosti

135 stabilization for in vivo applications is a milestone in pharmaceutical research and protein-drug de

136 etative to reproductive stages marks a major milestone in plant development.

137 cing delta-catenin mutations is an important milestone in prostate cancer metabolic adaptation by mod

138 These findings constitute an important milestone in realizing low-voltage polymer transistors f

139 ocean-ridge type topography is a significant milestone in rift evolution as it signifies the localiza

140 Persons with Disabilities (CRPD) is a major milestone in safeguarding the rights of persons with dis

141 ixtures of HS oligosaccharides, an essential milestone in the analysis of structure-function relation

142 ordable, consumer-oriented 3-D printers is a milestone in the current "maker movement," which has bee

143 n reflectivity measurements represents a key milestone in the deduction of the interfacial structure

144 Therefore, these studies represent a major milestone in the development of attenuated rVSIV, and li

145 high energy-transfer efficiency represents a milestone in the development of plasma wakefield acceler

146 e models of tinnitus; our results serve as a milestone in the development of precision medicine in th

147 adiolabeled somatostatin analogs represent a milestone in the development of theranostic compounds.

148 effect in HgTe quantum wells is considered a milestone in the discovery of topological insulators.

149 overt structural liabilities was a critical milestone in the effort to realize the full clinical pot

150 an important but almost completely forgotten milestone in the evolution of case-control studies and o

151 ation of hydraulic conductance marks a major milestone in the evolution of the herbaceous habit, not

152 Transcriptomic analysis has been a milestone in the field and has recently been enhanced by

153 )- and (S)-BINOL molecules constitutes a key milestone in the field of asymmetric catalysis.

154 This constitutes a major milestone in the field, yielding a generation of microme

155 The presented findings represent a milestone in the fields of porphyrinoid chemistry and su

156 Lister's visit is a crucial milestone in the history of medicine.

157 This result serves as a key milestone in the quest for two-electron transformations

158 A key milestone in this field will be when a universal quantum

159 ered drug delivery vehicle s is an important milestone in treating cancer.

160 cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary

161 fant feeding and time to achieve major motor milestones in a US cohort.The Upstate New York Infant De

162 Clinical milestones in ALS progression were defined by loss of in

163 has provided a unique opportunity to achieve milestones in automated image analysis.

164 Herein, we review the key historical milestones in cancer genomics since the completion of th

165 in biological samples are therefore critical milestones in diagnostics.

166 This review aims to highlight the key milestones in filaggrin research over the past 25 years,

167 establishment, Israel has achieved important milestones in health.

168 y life but the link to adverse developmental milestones in humans is unknown.

169 s (CHL) at several experimentally determined milestones in mouse primary auditory cortex (A1) develop

170 Historical milestones in neuroscience have come in diverse forms, r

171 In addition to the latest milestones in our pathway collection and curation effort

172 to this phenomenon, a brief history of major milestones in our understanding of NPQ, definitions, and

173 Our study identifies intellectual milestones in the applications of DECT in abdominal radi

174 Here, we review the important milestones in the discovery of these RTKs and their liga

175 Here we present milestones in the establishment of a new biotrophic mode

176 etter function) in the two cohorts and motor milestones in the high-dose cohort with scores in studie

177 llular composition at multiple developmental milestones in the short-tailed opossum, Monodelphis dome

178 m's Cave (Gibraltar), being one of the first milestones in the so-called "Anthropocene".

179 Intervals between milestones in the STEMI triage/transfer/treatment proces

180 This article reviews important milestones in the use of animal models to study human Sa

181 In this Review, we highlight recent milestones in these areas and some key scientific challe

182 o CD1 dams accelerated several developmental milestones independent of genotype, and induced earlier

183 molars (SPMs) is an important developmental milestone influencing caries risk and the timing of seal

184 gressive microcephaly, delayed developmental milestones, intellectual disability, and, in two out of

185 This milestone is also critical to advance our ultimate goal

186 rogress via the accomplishment of competency milestones is an important element of the Next Accredita

187 Milestoning is an approach that captures the main featur

188 To achieve this milestone, it must first be established that CLI data co

189 age of acquisition of certain developmental milestones, it did not affect our assessments of motor,

190 ecently celebrated reaching the $1000 genome milestone, making affordable DNA sequencing a reality.

191 This milestone marked the beginning of a new era in the field

192 The standardized times to milestones may well vary between different studies and p

193 Rates of decline and progress through milestones measured using the scale vary between sporadi

194 rence, -0.9; 95% CI, -1.0 to -0.8; P < .001; milestone medical knowledge 1 difference, -0.3; 95% CI,

195 We use Markovian milestoning molecular dynamics (MD) simulations on a tes

196 onitored the acquisition of 11 developmental milestones monthly by maternal report; observed the atta

197 Milestoning network analysis of E929 cracking determined

198 uals except 1 had normal cognitive and motor milestones, neuroimaging, and interictal neurological st

199 Milestones occurred at predictable proportions of the di

200 l Prize work; however, the latest efficiency milestone of 5.0% was more than 30 years ago.

201 After passing the milestone of 50% urbanisation, humanity is rapidly becom

202 By reaching the key milestone of magnetic coupling above 77 K, these results

203 Recently, the milestone of sequencing and assembling a human genome on

204 A milestone of the year was the Ebola outbreak.

205 A major milestone of this effort was the publication in Cancer R

206 ching Expanded Disability Status Scale score milestones of 4 and 6 in ever-smokers compared to never-

207 This review recounts the milestones of CD19 CAR therapy and summarizes lessons le

208 irus (HBV) DNA undetectability are important milestones of chronic hepatitis B and major treatment en

209 transcriptomes that define the developmental milestones of DE differentiation.

210 hannel blocker use and the time to important milestones of disease progression among patients with pa

211 Clinical notes were scrutinised and milestones of disease progression were compared with oth

212 itors able to recapitulate the developmental milestones of lung/thyroid development.

213 It briefly covers the milestones of qualitative changes in the field of electr

214 The milestones of the early spontaneous static compensation

215 cle at CERN will be remembered as one of the milestones of the scientific endeavor of the 21(st) cent

216 ccumulation of genetic alterations providing milestones of tumor initiation, progression, disseminati

217 merge capable of achieving the developmental milestones of young adulthood, important work remains to

218 rimate (NHP) baboon PET imaging-an important milestone on the path to human PET imaging.

219 s when estimating the distribution of age at milestones or the time between 2 milestones.

220 ose group, incremental achievements of motor milestones (p<0.0001), improvements in CHOP-INTEND motor

221 lump-sum payments (cooperative group) versus milestone payments (industry).

222 reward from antibiotic sales through prizes, milestone payments, or insurance-like models in which in

223 two assessments of motor function: the motor milestones portion of the Hammersmith Infant Neurologica

224 -up data, focusing on three key irreversible milestones: postural instability (Hoehn and Yahr 3), dem

225 For milestone projects such as Escherichia coli or Homo sapi

226 To explore milestone rate, a proposed intermediate end point for im

227 Milestone rates may be useful as a complementary tool to

228 This analysis of milestone rates suggests a moderate association between

229 Trial-level milestone ratios for milestone rates were calculated for overall response rat

230 comes and Measures: Correlations of RAES and milestone ratings by training year; correlations of medi

231 Of the 26 PGY-3 residents with milestone ratings indicating deficiencies on either of t

232 Evidence of validity of milestone ratings is needed.

233 Milestone ratings may better detect problems with profes

234 Results: Corresponding RAES ratings and milestone ratings showed progressively higher correlatio

235 red more between PGY-1 and PGY-3 years using milestone ratings than the RAES (all P values <.001).

236 alism with residents' lowest professionalism milestone ratings was 0.44 (95% CI, 0.43 to 0.45; P < .0

237 on improvement." However, when subcompetency milestone ratings were used, 861 residents (12.8%) who s

238 es: Program director ratings on the RAES and milestone ratings.

239 velopmental rating scale, with developmental milestone ratings.

240 sociations were observed between 9-month PFS milestone ratio and OS HR (R2 = 0.19; 95% CI, 0.03-0.49)

241 R2 = 0.80; 95% CI, 0.63-0.91) and 9-month OS milestone ratio and OS HR (R2 = 0.67; 95% CI, 0.49-0.82)

242 association was observed between 12-month OS milestone ratio and OS HR (R2 = 0.80; 95% CI, 0.63-0.91)

243 ression model evaluated associations between milestone ratios and hazard ratios (HRs).

244 Trial-level milestone ratios for milestone rates were calculated for

245 data and pooled data to compare trial-level milestone ratios with conventional end points.

246 revisits IMG's original aims, highlights key milestones reached by the system during the past 10 year

247 t years, charting the ideas, challenges, and milestone reactions that were essential for the progress

248 the long-term effects of glucocorticoids on milestone-related disease progression across the lifespa

249 ualification to identify key experiences and milestones relating to successful employment particularl

250 s and stringent competency-based supervision milestone requirements (ie, from direct to indirect supe

251 [0.67-0.81], and 0.74 [0.64-0.85] for the 3 milestones, respectively).

252 group than in the control group had a motor-milestone response (21 of 51 infants [41%] vs. 0 of 27 [

253 group than in the control group had a motor-milestone response (37 of 73 infants [51%] vs. 0 of 37 [

254 The primary end points were a motor-milestone response (defined according to results on the

255 cement therapy, achievement of developmental milestones, satisfaction of psychological needs, and cop

256 ucted a systematic analysis of developmental milestones, sensory abilities, and motor deficits, follo

257 series of clinically valuable translational milestones such as airway grafts and disease models.

258 ment with respect to the first developmental milestones such as synaptogenesis, dendrite formation, a

259 A milestone survival analysis was conducted to capture the

260 cine development, the synthetic vaccine is a milestone that is in stark contrast with traditional vac

261 sought to define easily identified clinical milestones that could be shown to occur at specific poin

262 In this review, we describe the milestones that have led to this era of global transcrip

263 Here, we look back on the historical milestones that have paved the way for the discovery of

264 Ages at milestones that occur prior to study entry are left cens

265 fter starting imatinib to identify molecular milestones that would predict for overall survival (OS)

266 The year 2016 will mark an important milestone - the 35th anniversary of the first reported c

267 have taken the field to its first scientific milestone; the elemental principles of neural repair in

268 vant molecular systems by a method that uses milestoning theory to combine Brownian dynamics simulati

269 ions were conducted in explicit solvent with milestoning theory, making it possible to extract kineti

270 ts with POMS take longer to reach disability milestones, they do so at a younger age than their adult

271 onitoring and tracking of the activities and milestones through dashboards and review meetings were u

272 Milestone timings were standardized as proportions of ti

273 This is a milestone to better understand their growth mechanism an

274 le stem loop motifs represents a significant milestone to the accurate prediction of RNA tertiary str

275 tion uses the newly developed ACC Curricular Milestones to provide specific, competency-based feedbac

276 growth of brain volume, and early behavioral milestones, to the third year of human postnatal life.

277 Our study constitutes a first milestone toward a plausible role of DNMT3L in the estab

278 blood vessels in vivo, which is an important milestone toward clinical translation of this approach.

279 (DRC) was reported in 2001, marking a major milestone toward polio eradication in Africa.

280 s with CF and a CF mouse model, an important milestone toward the development of a clinical rAAV cand

281 We have thus reached a critical milestone toward the development of specific antiviral t

282 induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative

283 clinical application remain, important early milestones toward translation have been met.

284 aAlO(3) and SrTiO(3) represents an important milestone towards exploiting such properties in all-oxid

285 sequently, this work represents an important milestone towards the detection of biomarkers in tissues

286 The present approach represents a first milestone towards visualizing magnetization textures of

287 These results represent major milestones towards the goal of creating a significant qu

288 This milestone was one of the key criteria prompting the Glob

289 An important milestone was reached in 2011 with the approval of the f

290 An important milestone was the creation of heterostructures based on

291 Progression to key milestones was evaluated using Kaplan-Meier and Cox regr

292 Time to fixed disability milestones was shorter than in ROMS (Expanded Disability

293 To unravel these milestones we propose a framework, tumor evolutionary di

294 In reaching this milestone, we can write a new chapter in the history of

295 and time from diagnosis to specific disease milestones were calculated to assess disease progression

296 Milestones were defined as symptom onset (functional inv

297 ent of social and psychosexual developmental milestones were related to higher subjective well-being.

298 time in the first reporting period in which milestones were used.

299 The theory presented here is a milestone work for in-depth understanding of the working

300 necessary to progress through each cellular milestone, yet the underlying transcriptional programs r