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1 by forced expression of a deacetylated CTTN mimetic.
2 of inhibitor has emerged that lacks the RGD-mimetic.
3 of superoxide dismutase 1 (SOD1) or an SOD1 mimetic.
4 th low oxygen and cobalt chloride, a hypoxia mimetic.
5 ting concentrations of agonist and G protein mimetic.
6 istate 13-acetate (PMA), which acts as a DAG mimetic.
7 presence of a superoxide dismutase/catalase mimetic.
8 haride capsule, hydrolyzed a peptide antigen mimetic.
9 an help guide the design of a simpler Klotho mimetic.
10 g cells from the lethal effects of UV and UV mimetics.
11 5-nonyloxytryptamine and vinorelbine as PSA mimetics.
12 E1 efficiently hydrolyzes acyl-CoA substrate mimetics.
13 er normal degradation when expressed as SUMO mimetics.
14 c restriction and act as caloric restriction mimetics.
15 ind fatty acids are considered as fatty acid mimetics.
16 red resistance to BCL-2 family-targeting BH3 mimetics.
21 but not in Sirt3(-/-) mice, whereas an SOD2 mimetic, (2-[2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylami
23 for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functi
24 e, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallizatio
25 e anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix fo
26 antidiabetic drug metformin or with the AMP mimetic 5-aminoimidazole-4-carboxamide ribonucleotide in
28 y the small molecule Bcl-2 homology domain 3 mimetic, A-1331852, or Bcl-xL-specific small interfering
29 h host neuronal proteins, and these anti-GAS mimetic Abs are associated with autoimmune diseases of t
31 % bromine content has shown novel peroxidase mimetic activity toward 3,3',5,5'-tetramethylbenzidine (
32 ium-gold nanozyme shows excellent peroxidase mimetic activity with O-phenylenediamine in the presence
34 these molecular events, a reconstructed ivy-mimetic adhesive composite was developed by integrating
35 pressed after treatment with the adiponectin mimetic AdipoRon, which were associated with increased i
37 d highlight the therapeutic potential of Shh mimetics against CNS complications associated with HIV i
38 eltaN-expressing mice and exposed to hypoxia-mimetic agent cobalt chloride exhibited less apoptosis a
39 inhibited by Tempol (a superoxide dismutase-mimetic agent) and by glyburide (an inhibitor of potassi
40 o the design of the first serum stable TSP-1 mimetic agonist peptide able to trigger selective progra
41 mately led us to engineer a minimized hINSL5 mimetic agonist that retains native hINSL5-like RXFP4 af
44 uced by SFA palmitate, we found that the AMP-mimetic AMPK activator 5-aminoimidazole-4-carboxamide-1-
45 asitism risk is challenging: cuckoo eggs are mimetic and adult cuckoos are secretive and resemble haw
46 find that bidirectional transitions between mimetic and cryptic coloration are unexpectedly frequent
47 rtib, a styryl-benzyl sulfone, acts as a RAS-mimetic and interacts with the RBDs of RAF kinases, resu
48 l hydrophobic peptides that act as substrate mimetics and compete in the luciferase aggregation suppr
49 arrier proteins (ACPs) loaded with substrate mimetics and cross-linkers to visualize and trap interac
50 L, or Mcl-1 recapitulated the effects of BH3 mimetics and enhanced the effects of gamitrinib-TPP.
54 ALL cultures were both more sensitive to BH3 mimetics and more uniform in their response than establi
55 ed to the development of calorie restriction mimetics and other pharmacological interventions capable
56 a novel in vivo screening platform for mucin mimetics and other strategies to treat diseases of the o
57 field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-gr
58 hydrolytic activity of 18B7 against peptide mimetics and show that 18B7 is able to hydrolyze an olig
59 P1 and XIAP in MC38 and YAMC cells, and Smac-mimetics and TNF-related weak inducer of apoptosis incre
60 ccommodate the faster reacting water-soluble mimetics and to more closely duplicate in vivo condition
61 f the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailabilit
65 s of the interaction of CsgB with a membrane-mimetic anionic surfactant as well as with lipopolysacch
66 id) of the natural ligands; however, the RGD-mimetic antagonists for alphaIIbbeta3 have been shown to
71 tides (SAHPs) designed as apolipoprotein A-I mimetics are known to bind to class B scavenger receptor
74 here will facilitate the generation of pArg mimetics as highly potent inhibitors of the enzymes that
75 , using JR-FL SOSIP.664, a native Env trimer mimetic, as a sorting probe to isolate monoclonal Abs (M
76 al of Affimers, a recent example of antibody mimetics, as suitable bioreceptors for the detection of
77 Here we design and synthesize oligomannose mimetics, based on the unique chemical structure of a re
83 can be circumvented with small-molecule CD4 mimetics (CD4mc) that are able to transition Env into th
84 both flow cytometry and mass cytometry in a mimetic cell mixture and human peripheral blood mononucl
85 snake species to demonstrate that shifts to mimetic coloration in nonvenomous snakes are highly corr
87 d mitochondrial activator of caspases (Smac)-mimetic compound LCL161 or recombinant TNF-like weak ind
89 The consequences of the binding of the CD4-mimetic compound to the HIV-1 envelope glycoproteins dep
92 of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-alpha
93 c factors that influence the activity of CD4-mimetic compounds can help to improve their potency and
94 dition to their direct antiviral effect, CD4-mimetic compounds dramatically enhance the HIV-1-neutral
98 Used as components of microbicides, the CD4-mimetic compounds might increase the protective efficacy
101 comprehensively surveyed the efficacy of BH3 mimetic compounds, identifying potent and specific MCL-1
103 of their structural resemblance, fatty acid mimetics constitute a family of bioactive compounds show
105 uses axon degeneration and suggest that Bclw-mimetics could provide effective therapy to prevent CIPN
107 genic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each
108 repertoire of lipids versus bicelle bilayer mimetics currently employed in solid-state nuclear magne
109 reviously reported the discovery of a CXCL12-mimetic cyclic peptide (2) as a selective CXCR4 antagoni
111 both facilitate delivery of the heptaketide mimetic deep into the PT active site and anchor one end
112 that the anti-inflammatory effect of fasting-mimetic diets may be mediated, in part, through SIRT3-di
113 pment of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushere
115 (ROL; a PDE4 inhibitor) and Bt2cAMP (a cAMP mimetic) drive caspase-dependent resolution of neutrophi
118 ensive hitchhiking of linked variants on the mimetic dsx haplotype that occurred at the origin of mim
120 olution NMR and EPR spectroscopy in membrane-mimetic environments, consists of a helix-turn-helix arc
121 synthetic superoxide dismutase and catalase mimetic EUK-134 also ablated the effects of hypoxia on B
122 uman-antibody transgenic animals with a lead mimetic evokes nAbs with specificities approaching those
123 ing forskolin or the glucagon-like peptide 1 mimetic Exendin-4, inhibits the shuttling of MondoA and
124 ylic-polyuridylic acid (poly A:U) is a dsRNA mimetic explored empirically in cancer immunotherapy a l
127 d platinum nanoparticles (Pt NPs) as oxidase mimetics for effectively catalyzing the oxidation of 3,3
128 HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate regeneration after injury
129 ith the small-molecule, superoxide dismutase mimetic (GC4419; 0.25 mumol/L) significantly mitigated t
134 However, previous studies using membrane mimetics have not identified any notable difference in t
135 ereas the filaments from the cMyBP-C phospho-mimetic hearts showed a strong tendency toward disorder.
137 pressing and in situ polymerization, "nacre-mimetic" hydroxyapatite/poly(methyl methacrylate) (PMMA)
138 is binding interaction using heparan sulfate mimetics, identify an important sulfate modification, an
139 tion, requiring a systematic approach to Env mimetic immunogen design and evaluation of elicited resp
140 fford a view of a polyketide "atom-replaced" mimetic in a NR-PKS active site that could prove general
141 y demonstrates the efficacy of a novel FGF21 mimetic in hamsters, but reveals attenuated effects in t
142 thened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood brain barrier (BBB) an
144 llographic application of "atom replacement" mimetics in which isoxazole rings linked by thioethers m
145 Nucleopeptides are promising nucleic acid mimetics in which the peptide backbone bears nucleobases
147 rexpression of a Ser166-Mdm2 phosphorylation mimetic increased EC migration, increased Mdm2 to FoxO1
150 will discuss the discovery of these non-RGD-mimetic inhibitors and the progress that has been made i
151 ted that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate
152 The self-assembly of peptides and peptide mimetics into supramolecular polymers has been establish
153 tematically evaluates targets for fatty acid mimetics, investigates their common structural character
155 chemical structure analysis and to produce a mimetic Kdo-lipid A domain AlmG substrate to that synthe
156 oduce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma
158 rehensive functional screen of a human miRNA mimetic library in a cell-based assay for invasion by th
159 which emerged from screening an alpha-helix mimetic library, stimulate the immune response, act by a
160 report several new classes of acetyl-lysine mimetic ligands ranging from mM to low micromolar affini
162 cordingly, the anchoring of GAD65 to exosome-mimetic liposomes strongly boosted antigen presentation
163 e W69A/S115W mutant bound to the CD4 peptide mimetic M48U1 and Fab of anti-cluster A antibody N60-i3
164 nogen by cross-linking of gp140 with the CD4-mimetic M64U1 elicited an earlier increase of binding an
165 pment of low-molecular-weight, synthetic BH3 mimetics ("magic bullets") to disrupt the protein-protei
166 -crystalline cubic phase (LCP) is a membrane-mimetic material useful for the stabilization and struct
168 ults indicate that birinapant and other Smac mimetics may have efficacy in treating HBV infection and
169 previously described highly mobile membrane mimetic membrane in combination with a conventional lipi
170 ty analysis with both highly mobile membrane mimetic membranes and conventional lipid bilayer molecul
171 so, increased mass addition to Gram-positive mimetic membranes from AMP disruption corresponded with
172 guest encapsulation behavior in a new enzyme-mimetic metal-ligand host and provides the first observa
173 regimen containing Env cross-linked to a CD4-mimetic miniprotein (gp140-M64U1) in rhesus macaques.
175 on-haem iron was investigated in an in vitro mimetic model of the digestive tract using specific chem
176 activity and synthetic tractability with RGD-mimetic molecules, along with the issues relating to pha
177 atch up with the hosts with a newly acquired mimetic morph, host polymorphism should be maintained th
179 Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b identified a critical role of
180 aspartate (HD) domain (D311A), and a phospho-mimetic mutation (T592E), abrogated the inhibitory activ
181 re targets of DNA-PKcs and show that phospho-mimetic mutations at these residues significantly inhibi
182 and pre-active state and, in complex with Gs-mimetic nanobody, between more and less active ternary c
185 ight be of relevance for the action of GLP-1 mimetics now widely used in the treatment of diabetes.
186 les, called non-saccharide glycosaminoglycan mimetics (NSGMs), as direct allosteric plasmin inhibitor
188 rdingly, the combination of THZ1 and the BH3 mimetic obatoclax improves lymphoma growth control in a
189 te whether the beneficial effects of a novel mimetic of FGF21 in the LD state are a consequence of in
191 the efficacy of birinapant, a small-molecule mimetic of the apoptotic regulator SMAC, against a diver
192 o and in vivo efficacy of SPX-101, a peptide mimetic of the natural regulation of ENaC activity by sh
193 We generated a membrane-permeable peptide mimetic of the PTPsigma wedge domain that binds to PTPsi
195 s of NagZ with the substrate, products and a mimetic of the transient oxocarbenium species, which wer
197 ance spectroscopy with (15)N-labeled peptide mimetics of cryptococcal polysaccharide antigen (Ag).
198 identify improved small molecule functional mimetics of H2-RLX with selective, full agonist or posit
200 substituents function as peroxide-destroying mimetics of the antioxidant selenoenzyme glutathione per
204 the origin of a species adapted to the local mimetic pattern and characterised by morphologically dis
205 fers from purifying selection acting on each mimetic pattern, indicates that predator knowledge, inte
207 ession and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using ma
209 was developed, being the first one based on mimetic peptide and screen-printed carbon electrode, aim
210 ide proof of concept for the use of Cavbeta2 mimetic peptide as a novel therapeutic tool for the impr
211 Using these data we have designed a BCL-3 mimetic peptide based on a region of the ANK1 of BCL-3 t
212 onal antibody E06 or with apolipoprotein A-I mimetic peptide D-4F, capturing OxPAPC in atherosclerosi
213 inds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphoryl
216 asis of this mechanism, we developed a novel mimetic peptide that, through targeting of Cavbeta2, cor
217 tion, we developed a small 5 amino acid apoE mimetic peptide(CN-105) that mimics the polar face of th
218 ped based on the immobilization of the PRF+1 mimetic peptide, as recognition biological element, on t
219 age of Cx43 HC function by TAT-Gap19, a Cx43 mimetic peptide, significantly upregulated the expressio
220 trophic factor (CNTF) small-molecule peptide mimetic, Peptide 021 (P021), rescued developmental delay
221 show how the self-assembly of short collagen-mimetic peptides (CMPs) can enable the fabrication of sy
229 for suicidality, such as ebselen (a lithium mimetic), piracetam (a nootropic), chlorogenic acid (a p
231 ehavioral and physical response to the dsRNA mimetic poly I:C is dependent on signaling via MyD88 whe
232 rats challenged with virus or with the viral mimetic polyinosinic:polycytidylic acid (poly I:C).
233 induced by maternal treatment with the viral mimetic polyriboinosinic-polyribocytidylic acid in middl
234 y, these catalytic nanomaterials with enzyme-mimetic properties have found new biomedical application
235 Using small molecule inhibitors, phospho-mimetic proteins, tamoxifen-sensitive and tamoxifen-resi
238 s indicates that sensitivity of cells to BH3 mimetics reflects the identity of the anti-apoptotic pro
239 vestigate the evolution of fangs, venom, and mimetic relationships in reef fishes from the tribe Nemo
240 ence via the formation of a diverse array of mimetic relationships that provide protective (Batesian
241 Furthermore a mutant DD with the phospho-mimetic residue Asp at this position is impaired in both
248 4-benzoxazepine backbone, an N-acetyl-lysine mimetic scaffold that led to the recent development of t
249 Our data unravel the organization of tmTNF-mimetic scTNF ligands capable of robustly activating TNF
252 e cross-linking with a 3-kDa CD4 miniprotein mimetic, serving to block ligation of gp140 on CD4(+) T
254 numata Positive FDS imposed by predators on mimetic signals favors the fixation of the most abundant
255 nsitization by cotreatment with a miR-139-5p mimetic.Significance: The microRNA described in this stu
259 -expression of either wild type or a phospho-mimetic stathmin mutant (4E) made defective in tubulin b
260 phospho-deficient [Su(H)(S269A)] and phospho-mimetic [Su(H)(S269D)] variants: the latter displayed re
263 se findings suggest that combination of SMAC mimetics such as birinapant plus radiation may be partic
265 CD4-Ig, a fusion of CD4-Ig with a small CCR5-mimetic sulfopeptide, binds avidly and cooperatively to
267 ty of a size-adaptable phospholipid membrane-mimetic system for solution NMR studies of membrane prot
268 commonly acknowledged as an optimal membrane mimetic system that provides control over size, composit
272 om aflatoxin biosynthesis with a heptaketide mimetic tethered to a stably modified 4'-phosphopantethe
274 hat receptor-binding scFvs or small antibody mimetics that have no agonist activity on their own can
275 ligands consisting of two identical oxytocin-mimetics that induce a three order magnitude boost in G-
276 eering have led to the emergence of antibody mimetics that offer the high affinity and specificity as
277 he design of peptides, proteins, and peptide mimetics that predictably and efficiently reach the inte
278 EGF domains of L-selectin bound to a fucose mimetic; that is, a terminal mannose on an N-glycan atta
279 titative analytical technique by employing a mimetic tissue model previously shown to be applicable f
280 oll-like receptor 3 (TLR3) agonist used as a mimetic to study viral infection, has been shown to elic
281 Here, we describe the design of soluble GPCR mimetics to study the details of the interplay between G
282 to selectively evaluate the efficacy of SMAC mimetic treatment in CRC patients with caspase-8 deficie
284 chondria-derived activator of caspase (SMAC) mimetic treatment induced massive cell death and led to
285 we investigated the effectiveness of a BDNF-mimetic treatment with 7,8-dihydroxyflavone at alleviati
286 plasma (PRP) treated with the thromboxane A2 mimetic U46619, collagen and thrombin in presence/absenc
288 clinical success of the BCL-2-selective BH3-mimetic venetoclax in patients with poor prognosis chron
289 tion of BCL-2 has been achieved with the BH3 mimetic venetoclax, anti-tumor efficacy is limited by co
291 ary of oligopyridylamide based alpha-helical mimetics was designed to target the central alpha-helix
292 has recently been employed as an acetylation mimetic, we conducted a series of studies to evaluate it
294 HARI, in complex with a UbcH7 Ub thioester mimetic which reveals the molecular basis for the specif
295 I with the UbcH7 Ub thioester intermediate mimetic, which reveals that HHARI binds this E2 Ub in
296 ctions with monoclonal antibodies or peptide mimetics, which cause hypoalbuminemia, biliary loss of a
298 proteins use synthetically produced heparin mimetics with defined structure or short heparin fragmen
299 analysis showed that the combination of BH3 mimetics with either SPHK1 inhibition or S1P receptor 2
300 g sites, and the development of carbohydrate mimetics with improved binding is therefore of interest.
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