ライフサイエンスコーパス: mindin

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1 re, neutrophils directly bind to immobilized mindin, and mindin matrix mediates neutrophil migration

2 Moreover, mindin binds directly to bacteria and their components a

3 Mindin comprises an N-terminal F-spondin (FS) domain and

4 Mindin(-/-) DCs had reduced expression of Rac1/2 and imp

5 xpression restored the priming capability of Mindin(-/-) DCs.

6 influenza virus particles directly and that mindin-deficient macrophages exhibited impaired activati

7 ed ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to

8 We found that intranasal infection of mindin-deficient mice by influenza virus resulted in dra

9 ontrast, lungs from intratracheally infected mindin-deficient mice contained similar influenza virus

10 MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N Cd151 (-

11 rt we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutroph

12 The mindin FS domain therefore represents a new integrin lig

13 trated that the extracellular matrix protein mindin functions as a pattern recognition molecule for b

14 Additionally, mindin functions as a pattern recognition molecule for i

15 Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively

16 In this study, we examined the role of mindin in influenza virus infection.

17 n serves as a novel ligand for integrins and mindin-integrin interactions are critical for inflammato

18 These results suggest that mindin-integrin interactions play a key role in regulati

19 We showed that mindin interacted with influenza virus particles directl

20 The adhesion of neutrophils to mindin is blocked by anti-integrin alpha4, anti-integrin

21 Thus, mindin is essential in the initiation of the innate immu

22 Given the known function of mindin, its early expression in the diseased GBM could r

23 rins exhibit enhanced binding to immobilized mindin matrix and the increased binding can be blocked b

24 ils directly bind to immobilized mindin, and mindin matrix mediates neutrophil migration in vitro.

25 Furthermore, we show that DC adhesion to mindin matrix was blocked by antibodies to alpha4, alpha

26 cking beta1 integrin had reduced adhesion to mindin matrix, decreased expression of Rac1/2 and impair

27 o influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influ

28 Mindin(-/-) mice displayed defective CD4+ T-cell priming

29 Together, these results demonstrate that mindin plays an essential role in the host innate immune

30 dual interactions, the FS and TSR domains of mindin promote activation of both adaptive and innate im

31 We further showed that mindin recognizes lipopolysaccharide (LPS) through its T

32 e show that the extracellular matrix protein mindin regulates the expression of Rho GTPases in DCs.

33 In contrast, mindin/RG-1 expression in other normal tissues is signif

34 human antibody, 19G9, was generated against mindin/RG-1 protein and was shown to accumulate at high

35 Mindin/RG-1 protein expression is maintained in >80% of

36 alysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissue

37 Our results suggest that mindin serves as a novel ligand for integrins and mindin

38 re, intranasal administration of recombinant mindin significantly enhanced the clearance of influenza

39 Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have

40 Mindin (spondin-2) is an extracellular matrix protein of

41 Interestingly, mindin was also detected in urinary samples of FVB/N Cd1

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