ライフサイエンスコーパス: miniature swine

1 atically isolated from lean, healthy Ossabaw miniature swine.

2 ng and smell, at rest and during exercise in miniature swine.

3 n) using L-[1-13C]Leu as a tracer in 24 male miniature swine.

4 allografts procured from healthy MHC-inbred miniature swine.

5 poiesis and provide long-term engraftment in miniature swine.

6 cs of PBSCs were determined in 2-5-month-old miniature swine.

7 ft and support host thymopoiesis in euthymic miniature swine.

8 dies of allogeneic thymic transplantation in miniature swine.

9 ng-lasting acceptance of renal allografts in miniature swine.

10 implanted in the iliac arteries of nine NIH miniature swine.

11 tal major histocompatibility complex-defined miniature swine.

12 ajor histocompatibility complex (MHC)-inbred miniature swine.

13 lpha-1,3-galactosyltransferase gene knockout miniature swine.

14 to fully MHC-mismatched renal transplants in miniature swine.

15 combined immunodeficient (NOD/SCID) mice and miniature swine.

16 eneic stem cell or spleen transplantation in miniature swine.

17 ajor histocompatibility complex (MHC)-inbred miniature swine.

18 lity complex (MHC) mismatch in thymectomized miniature swine.

19 f antibodies to non-MHC antigens in tolerant miniature swine.

20 eactivity against either standard or GalT-KO miniature swine.

21 ormed across a class I MHC barrier in inbred miniature swine.

22 es and maintains tolerance to both organs in miniature swine.

23 larized thymic lobe (VTL) transplantation in miniature swine.

24 e tissue allografts across an MHC barrier in miniature swine.

25 an intact, vascularized thymic lobe (VTL) in miniature swine.

26 nts were present in the genomic DNA of these miniature swine.

27 to six MHC-matched, minor antigen-mismatched miniature swine.

28 x (MHC)- mismatched barriers in juvenile MGH-miniature swine.

29 vascularized thymic lobe transplantation in miniature swine.

30 n both "tolerant" and "nontolerant" chimeric miniature swine.

31 thout the need for whole body irradiation in miniature swine.

32 l of chronic lung rejection using MHC-inbred miniature swine.

33 lanted beneath the renal capsule of juvenile miniature swine.

34 isease across MHC barriers in mixed chimeric miniature swine.

35 pic lung transplants (n=3) were performed in miniature swine across a major histocompatibility comple

36 leen transplantation (SpTx) was performed in miniature swine across full major histocompatibility com

37 or reactivity against: 1) human; 2) standard miniature swine; and 3) GalT-KO peripheral blood lymphoc

38 Miniature swine are likely to be suitable organ donors f

39 recipient bone marrow cells (BMC), using the miniature swine as a model.

40 ere implanted in the coronary arteries of 31 miniature swine at 28 days after creation of a fibrocell

41 immunotoxin was administered i.v. to several miniature swine at doses ranging from 0.15-0.2 mg/kg eit

42 sis of Hoechst dye-stained human, rhesus and miniature swine bone marrow cells reveals a small, disti

43 toxin provides excellent T-cell depletion in miniature swine but is associated with significant dose-

44 ismatched renal allografts can be induced in miniature swine by treatment with a short course of cycl

45 nce of class I disparate renal allografts in miniature swine can be induced by a short course of cycl

46 nce to class I-disparate renal allografts in miniature swine can be induced by a short course of cycl

47 rs for cloning, resulting in the creation of miniature swine containing mono- and biallelic mutations

48 Partially inbred miniature swine developed in this laboratory provide a u

49 Three herds of miniature swine, each homozygous for a different set of

50 1,3 galactosyltransferase knockout (GalT-KO) miniature swine enjoyed survival comparable to that of a

51 s II identical renal grafts is achievable in miniature swine following a short immunosuppressive trea

52 promised mice for one tumor cell line and in miniature swine for 1 of 2 tumor cell lines expanded for

53 copies of closely related proviruses in the miniature swine genome.

54 1,3-galactosyltransferase knockout (GalT-KO) miniature swine has eliminated anti-Gal antibodies as th

55 Miniature swine have been shown to share many relevant i

56 Studies utilizing partially inbred miniature swine have demonstrated that a short course of

57 Recent studies in young (5-7 months) miniature swine have demonstrated that the thymus is inv

58 Such animals were identified within the miniature swine herd and may further enhance the safety

59 The identification of animals in an inbred miniature swine herd that consistently fail to produce r

60 these recombinants are exogenous viruses in miniature swine; i.e., they are not present in the germ

61 lografts has been accomplished previously in miniature swine in our laboratory.

62 he family of study were not present in other miniature swine in the herd that produced humantropic PE

63 immunosuppression and used partially inbred miniature swine, in which the genetics of major histocom

64 ion between swine leukocyte Ag (SLA)-matched miniature swine, in which tolerance can be established w

65 d recombinant PERV-A/C loci in the genome of miniature swine, indicate that exogenous PERV is the pri

66 ce of class I mismatched renal allografts in miniature swine is induced by a short course of cyclospo

67 te systemic tolerance to renal allografts in miniature swine is induced in 100% of cases across a two

68 or-specific tolerance to renal allografts in miniature swine is uniformly induced across a two-haplot

69 rus transplantation in a large animal model (miniature swine) is feasible using this heterotopic mode

70 After transplantation of a miniature swine kidney, maintenance therapy comprised co

71 Miniature swine lacking Gal (Gal pigs) have been produce

72 hed against PAEC from partially inbred SLAdd miniature swine lysed only PAEC and phytohemagglutinin-s

73 We also have described a miniature swine model of fully mismatched allogeneic com

74 investigation was to establish a transgenic miniature swine model of RP using the human P23H RHO gen

75 n RHO P23H transgene in the retina creates a miniature swine model with an inheritance pattern and re

76 re, we demonstrate, in a clinically relevant miniature swine model, induction of immunologic toleranc

77 inary results show that in this well-defined miniature swine model, recombinant swine cytokine combin

78 ter transplantation of a limb allograft in a miniature swine model.

79 in fractions in different organs, we infused miniature swine (n = 8 per group) with saline, insulin a

80 C) obtained by leukapheresis from MHC-inbred miniature swine (n=6) were transplanted into baboons.

81 both major histocompatibility complex-inbred miniature swine (n=7) and human decay-accelerating facto

82 1 region was found to be invariant among MGH miniature swine of different haplotypes, despite 25 year

83 (P1 and P14) obtained from homozygous inbred miniature swine of three haplotypes (aa, cc, and dd), re

84 ed with WBI- or CPP-based therapy, and after miniature swine or hDAF kidney transplantation.

85 Kidneys harvested from miniature swine or pigs transgenic for human decay-accel

86 During our studies of autoBMT in miniature swine, performed without CsA treatment, we not

87 PCR amplification of genomic DNA from miniature swine peripheral blood lymphocytes, using prim

88 ted human cells following cocultivation with miniature swine peripheral blood mononuclear cells (PBMC

89 ogenous retrovirus taken from lymphocytes of miniature swine (PERV-MSL) has been characterized.

90 GalT-KO miniature swine produce anti-Gal antibodies and titers i

91 Miniature swine provide a genetically defined large-anim

92 Inbred miniature swine provide a large animal model in which th

93 Fifteen SLA(dd) miniature swine received 1.5 Gy whole body irradiation a

94 Five miniature swine received autologous BMC conditioned with

95 In addition, three SLA(dd) miniature swine received class I mismatched kidney with

96 Seventeen miniature swine received class-I mismatched kidneys with

97 Ten SLA(d/d) miniature swine received fully MHC-mismatched renal allo

98 jor histocompatibility complex (MHC)-defined miniature swine received haploidentical hematopoietic ce

99 Seven MGH-miniature swine received heterotopic intestinal grafts,

100 Miniature swine receiving a transplant of a class I-mism

101 T-cell chimerism predominates in miniature swine receiving hematopoietic-cell transplanta

102 Six miniature swine recipients received fully MHC-mismatched

103 by vascularized renal allografts in juvenile miniature swine recipients.

104 on of mixed chimerism across MHC barriers in miniature swine, severe graft-versus-host disease was av

105 Naive miniature swine SLA(dd) T cells were rendered hyporespon

106 NA transcript profiles in a family of inbred miniature swine (SLA(d/d) haplotype) in which individual

107 ed pigs and 6 of 17 (35%) MHC matched inbred miniature swine survived more than 100 days.

108 Sixteen Yucatan miniature swine (Sus scrofa).

109 Inbred miniature swine that are treated for 12 d with a high do

110 at transmitted HTRC PERV as well as from one miniature swine that did not transmit HTRC PERV.

111 Here we report the identification of inbred miniature swine that failed to produce human-tropic repl

112 of animals within a research herd of inbred miniature swine that lack the capacity to transmit PERV

113 human cells and were also identified in some miniature swine that lacked this ability.

114 enomic DNA libraries were generated from one miniature swine that transmitted HTRC PERV as well as fr

115 These viruses were invariably present in miniature swine that transmitted PERV to human cells and

116 Miniature swine that were tolerant of heart and/or kidne

117 Analyses of fetal and adult miniature swine tissues revealed a broad mRNA expression

118 ated whether tolerance could be generated in miniature swine to composite tissue allografts across a

119 We have used partially inbred miniature swine to determine the role of class I MHC ant

120 otransplantation were carried out in Yucatan miniature swine to explore the effects of IDN6556 on isl

121 eloped a surgical technique for spleen Tx in miniature swine to investigate its immunologic impact in

122 neys were transplanted from Gal-positive MGH miniature swine to MGH GalT-KO swine with systemic immun

123 Previous studies demonstrated that miniature swine treated with 12 days of cyclosporine (Cs

124 jor histocompatibility complex (MHC)-matched miniature swine treated with 12 days of cyclosporine.

125 ce of class I-mismatched renal allografts in miniature swine treated with 12 days of high dose Cyclsp

126 into major histocompatibility complex-inbred miniature swine treated with a 12-day course of cyclospo

127 involved in tolerance to renal allografts in miniature swine treated with a short course of calcineur

128 C class I disparate hearts transplanted into miniature swine treated with a short course of cyclospor

129 This study found a high incidence of PTLD in miniature swine undergoing allogeneic hematopoietic stem

130 Miniature swine underwent bilateral nephrectomy and clas

131 Twenty-two miniature swine underwent class I major histocompatibili

132 (1) Islet-cell isolation: miniature swine underwent either partial pancreatectomy

133 Massachusetts General Hospital miniature swine underwent occlusion of the midleft anter

134 Twelve miniature swine underwent vascularized musculoskeletal a

135 previously demonstrated T-cell depletion in miniature swine using a CRM9-based CD3-immunotoxin, pCD3

136 full MHC-mismatch barrier was established in miniature swine using a high-dose allogeneic peripheral

137 chieved in euthymic and not in thymectomized miniature swine using this treatment regimen.

138 nor-specific tolerance can be established in miniature swine, using a relatively mild, non-myeloablat

139 ning stable mixed hematopoietic chimerism in miniature swine, using MHC-matched donors and recipients

140 ogenicity of MHC alloantigens in MHC-defined miniature swine via primary and secondary MLR culture as

141 Bone marrow harvested from SLA miniature swine was T-cell depleted and injected intrava

142 m Massachusetts General Hospital MHC-defined miniature swine, we assessed immunogenicity across a ful

143 llograft induces tolerance to both organs in miniature swine, we examined the renal elements responsi

144 By using UTC from miniature swine, we previously demonstrated that despite

145 d islet-kidney (IK) transplantation model in miniature swine, we studied whether an islet-toxic tripl

146 screening negative for MHC allele SLA of MGH miniature swine were bred.

147 peripheral blood stem cell transplantation, miniature swine were conditioned with thymic irradiation

148 Miniature swine were immunized with cardiac myosin (CM)

149 Adult female miniature swine were subjected to chronic, progressive a

150 Two miniature swine were thymectomized before thymic tissue

151 Miniature swine were treated with varying doses of pCD3-

152 reported that Massachusetts General Hospital miniature swine, which had accepted class I-mismatched k

153 safety of clinical xenotransplantation from miniature swine will be most enhanced by the utilization

154 Previously, we generated inbred miniature swine with a null allele of the alpha-1,3-gala

155 pe class I disparity is uniformly induced in miniature swine with a short course of cyclosporine (CsA

156 cular response to the Multi-Link stent in 19 miniature swine with experimentally induced coronary ath

157 mestic farm pigs and between pairs of inbred miniature swine with genetically defined major histocomp

158 PBPC were mobilized from miniature swine with porcine interleukin 3 (pIL-3), porc

159 ograft vasculopathy, we immunized MHC inbred miniature swine with synthetic polymorphic peptides span

160 Tissue-engineered arteries were implanted in miniature swine, with patency documented up to 24 days b

161 t two different haplotypes of inbred Yucatan miniature swine (y/y and z/z).