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1 of DDX5 enhanced transcription from the HBV minichromosome.
2 irectly to that of the bulk, non-transcribed minichromosome.
3 protein required for replication of the SV40 minichromosome.
4 a y+ rescue element on a freely segregating minichromosome.
5 ion, but not from the additional copy of the minichromosome.
6 centromere present in the Drosophila Dp1187 minichromosome.
7 e destabilizing drugs and instability of the minichromosome.
8 ole in replication or expression of the rDNA minichromosome.
9 cription of the Tetrahymena thermophila rDNA minichromosome.
10 ciate with cellular histone proteins to form minichromosomes.
11 endogenous origins and at origins located on minichromosomes.
12 stones associated with the transcribing SV40 minichromosomes.
13 aplotypes of the two polymorphic loci on the minichromosomes.
14 DNA ends to generate functional macronuclear minichromosomes.
15 epresentation of IS elements, similar to the minichromosomes.
16 undant telomeres due to the presence of many minichromosomes.
17 iction fragments and at the ends of isolated minichromosomes.
18 cells exhibit reduced microtubule binding to minichromosomes.
19 anized into a large chromosome and 2 related minichromosomes.
20 the mitotic stability of centromere-bearing minichromosomes.
21 s, translocations, and formation of acentric minichromosomes.
23 an be suppressed by the presence of a second minichromosome, a phenomenon termed "trans-suppression."
25 omes are tethered to host histones to form a minichromosome also known as an "episome." Histones, whi
26 cription of the Tetrahymena thermophila rDNA minichromosome and are required for cell cycle-controlle
27 ired for viability, and mutations cause both minichromosome and endogenous chromosome inheritance def
31 in required for the efficient replication of minichromosomes and the transcriptional regulation of ea
32 oresis reveal that sisters of 26 kb circular minichromosomes are held together by catenation as well
33 s easily produced in bacteria, and it formed minichromosomes as HBV cccDNA episome DNA does when it w
34 used to a beta-galactosidase gene in a yeast minichromosome, as well as factors that control the chro
35 HPV origin-containing plasmids partition as minichromosomes, attributable to an association of the v
36 HBV covalently closed circular DNA (cccDNA) minichromosome, both in cultured cells in which HBV is r
41 owever, endogenous centromeres and X-derived minichromosome centromeres in vivo were replicated async
43 ue DSB could be generated in a non-essential minichromosome, Ch(16), using the Saccharomyces cerevisi
46 iotic centromeric cohesion is compromised in minichromosomes depending on their size and cannot be ma
47 n requirements at the centromere on a set of minichromosome derivatives [4], we tested the role of he
48 two de novo centromeres on Zea mays (maize) minichromosomes derived from euchromatic sites with high
55 fragment taken from the VP1 gene in the SV40 minichromosome has been measured in polyacrylamide gels
57 traps sister DNAs of circular but not linear minichromosomes implies that cohesin functions using a t
58 ed with multiple human tumors, persists as a minichromosome in the nucleus of B lymphocytes and induc
60 The 17alpha HAC vectors generated artificial minichromosomes in 32-79% of the HT1080 clones screened,
62 itro it efficiently initiates replication of minichromosomes in membrane-free DNA synthesis reactions
65 histone H3, a correlate of cohesion, in the minichromosomes in which sister chromatids separated dur
71 ive to a normal B chromosome, the progenitor minichromosome is estimated to be at least several megab
73 t minichromosomes or on host chromosomes and minichromosomes, is confirmed using chromosome conformat
75 rapamycin complex 1 (TORC1) by the increased minichromosome loss 1/ GTPase-activating proteins toward
76 nase domain and rad53 null mutants display a minichromosome loss phenotype, Rad53 is important in the
78 trains showed little difference in growth or minichromosome loss rate when compared to single deletio
80 F3 complex, results in a higher frequency of minichromosome loss, nocodazole sensitivity, and mitotic
81 elta strains exhibited a modest elevation in minichromosome loss, similar to cbh1Delta or abp1Delta s
84 emporally discrete steps: a double hexameric minichromosome maintenance (MCM) complex is first loaded
88 one mutation corresponds to a subunit of the minichromosome maintenance (MCM) complex of proteins, MC
90 The origin recognition complex, Cdc6 and the minichromosome maintenance (MCM) complex play essential
92 port the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts
93 requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin th
94 he remaining factor that is necessary as the minichromosome maintenance (MCM) complex, a cellular hel
96 hase, inhibition of chromatin loading of the minichromosome maintenance (Mcm) complex, and a reduced
102 rated for recombinant archaeal homohexameric minichromosome maintenance (MCM) complexes and their yea
108 element (DUE)-binding protein DUE-B and the minichromosome maintenance (MCM) helicase activator Cdc4
109 replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in yeas
110 to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helica
112 st human genome duplication requires loading minichromosome maintenance (MCM) helicase complexes at m
113 aromyces pombe Mcm4,6,7 complex and archaeal minichromosome maintenance (MCM) helicase from Methanoth
114 auses subunit-specific changes of sumoylated minichromosome maintenance (MCM) helicase in addition to
118 y of a replication origin and recruitment of minichromosome maintenance (MCM) helicase to that origin
121 gins requires the loading of two ring-shaped minichromosome maintenance (MCM) helicases around DNA in
122 The solved atomic structure of an archaeal minichromosome maintenance (MCM) homolog provides insigh
124 rrent models indicate that direct binding to minichromosome maintenance (MCM) plays a role, but the d
139 and Glossina, but we identified a complex of minichromosome maintenance (MCM) proteins that functiona
140 ication are licensed in G1 by recruiting the minichromosome maintenance (MCM) proteins to form a prer
141 sion yeast) as a mediator for association of minichromosome maintenance (MCM) proteins with chromatin
143 th the PBD of Plk1, we identified two of the minichromosome maintenance (MCM) proteins, Mcm2 and Mcm7
144 y involves the Cdc6-dependent loading of six minichromosome maintenance (Mcm) proteins, Mcm2-7, onto
146 s have suggested a two-step binding mode for minichromosome maintenance (MCM) proteins, with transien
151 P(4) reciprocally regulate the expression of minichromosome maintenance (MCM)-2, a protein that is an
152 the origin recognition complex (ORC) and the minichromosome maintenance (MCM)2-7 complex, the replica
153 gin recognition complex (ORC), Cdc6, and the minichromosome maintenance (MCM/P1) proteins produces a
154 leads to the assembly of double hexamers of minichromosome maintenance (Mcm2-7) at origin sites.
157 ation is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at
159 xample, the archaeal Sulfolobus solfataricus minichromosome maintenance (SsoMCM) helicase has been sh
160 soDnaG) with the replicative S. solfataricus minichromosome maintenance (SsoMCM) helicase on DNA.
161 Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in ye
165 ontaining the cell division cycle 45 (Cdc45)/minichromosome maintenance 2-7 (Mcm2-7)/Go, Ichi, Nii, a
166 egulation of RBR3-type genes, as well as the MINICHROMOSOME MAINTENANCE 2-7 gene family and PROLIFERA
167 roliferating cell nuclear antigen (PCNA) and minichromosome maintenance 4 (MCM4) proteins without cha
168 ion of PGC-1beta decreased the expression of minichromosome maintenance 4 (MCM4), which leads to a de
169 oblasts (MEFs), we show here that NCOA4 is a minichromosome maintenance 7 (MCM7)-interacting protein
170 the presence of a pathogenic variant of the minichromosome maintenance 8 gene (MCM8, c.446C>G; p.P14
172 ies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2-7, and the G
173 A1, origin recognition complex 2 (ORC2), and minichromosome maintenance complex (MCM) association wit
174 nsing mechanisms that prevent loading of the minichromosome maintenance complex (MCM2-7) onto replica
175 ion complex (ORC), Cdc6/Cdc18, Cdt1, and the minichromosome maintenance complex (Mcm2-Mcm7, or Mcm2-7
176 association of the key replication proteins minichromosome maintenance complex component (MCM7) and
177 S-phase kinase-associated protein 2 (SKP2), minichromosome maintenance complex component 4 (MCM4), a
179 between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs
180 of HPNE and PDAC cells, and correlated with minichromosome maintenance complex components (MCMs) and
182 Dpb11 stimulates DDK phosphorylation of the minichromosome maintenance complex protein Mcm4 alone an
185 eregulated cells, consistent with a role for minichromosome maintenance complex proteins in initiatio
186 Y600 to increase its association with other minichromosome maintenance complex proteins, thereby pro
187 nd Cdc6 prereplication proteins, but not the minichromosome maintenance complex, are necessary and bi
188 , Ki-67, proliferating cell nuclear antigen, minichromosome maintenance deficient 3, and phosphorylat
189 of 734 residues of this protein also called minichromosome maintenance deficient 5 (MCM5) or cell di
190 ed with G1/S cell-cycle transition including minichromosome maintenance deficient proteins, as well a
191 quence analysis of beta-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA pol
194 hese reports suggest a critical role for the minichromosome maintenance helicase complex in NK cells
197 ulator of DNA replication through effects on minichromosome maintenance helicase loading and activati
201 iginally identified as proteins required for minichromosome maintenance in Saccharomyces cerevisiae.
202 Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and l
211 n identify colorectal cancer by detection of minichromosome maintenance protein 2 (MCM2) expression i
214 lation sites in the carboxyl terminus of the minichromosome maintenance protein 3 (MCM3), a component
219 damage marker gammaH2AX is upregulated under minichromosome maintenance protein 7 (MCM7) knockdown in
220 We then used our mouse model to identify minichromosome maintenance protein 7 (MCM7), an E2F-indu
221 asmid DNA template by DNA polymerases (pol), minichromosome maintenance protein complex (Mcm), topois
223 etylation and RNR levels, maintains helicase minichromosome maintenance protein complexes (Mcm2-7) on
230 ession of E2F-5, centromere protein A and E, minichromosome maintenance proteins (MCM)-2, -3, -5, -6
231 ognition complex, and the elongation factors minichromosome maintenance proteins (MCM)2-7 and prolife
232 ication, involves the loading of six related minichromosome maintenance proteins (Mcm2-7) into prerep
234 egulated loading of the replicative helicase minichromosome maintenance proteins 2-7 (MCM2-7) onto re
236 ereplication complex that contains a Mcm2-7 (minichromosome maintenance proteins 2-7) double hexamer.
237 bers, whereas Double-parked protein/Cdt1 and minichromosome maintenance proteins are apparently essen
238 monstrate that uncontrolled DNA unwinding by minichromosome maintenance proteins upon Cdt1 overexpres
239 (origin recognition complex [ORC], Cdc6, and minichromosome maintenance proteins) causes a cell cycle
241 ber of other replication proteins, including minichromosome maintenance proteins, the origin recognit
242 group of nuclear proteins, among them MCM5 (minichromosome maintenance) and MCM3, for transcription
243 clear antigen, ribonucleotide reductase, and minichromosome maintenance) and of the retinoblastoma-re
245 ryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) complex, is loaded at each o
247 INS (go ichi ni san) complex allows the MCM (minichromosome maintenance) helicase to interact with ke
251 fi1, Dnt1 is required for rDNA silencing and minichromosome maintenance, and both Dnt1 and Net1/Cfi1
252 e-3-phosphate dehydrogenase, proteoglycan 4, minichromosome maintenance, complex component 9, high mo
254 atients identified a variant (c.71-1insG) in minichromosome maintenance-deficient 4 (MCM4) that was p
258 he transgenes would reside on an independent minichromosome, not linked to any endogenous genes; thus
260 n approach is feasible for the generation of minichromosomes of normal A chromosomes by selection of
262 we follow the catenation status of circular minichromosomes of three sizes during the Saccharomyeces
264 ranscription units, whether on two different minichromosomes or on host chromosomes and minichromosom
266 g emulsion PCR (LE-PCR) enables formation of minichromosomes preserving phase information of two poly
268 bstitutes for outer repeats on plasmid-based minichromosomes, promoting de novo CENP-A(Cnp1) and kine
269 d whether incorporation of Sir proteins into minichromosomes regulates early steps of recombinational
271 iz- cells shows that SUMO E3 is required for minichromosome segregation and thus has a positive role
272 SIZ1 and SIZ2 genes we demonstrate that the minichromosome segregation defect and dicentric minichro
273 In addition, our analysis of the plasmid minichromosome shows that T(3)-bound TR disrupts the nor
274 ichromosome segregation defect and dicentric minichromosome stabilization, both characteristic for Sm
276 l centromeres in vivo, using a budding yeast minichromosome system and temperature-sensitive mutation
280 Tetrahymena thermophila ribosomal DNA (rDNA) minichromosome that are required for origin activation.
281 nal regulatory region of the simian virus 40 minichromosome that is being transcribed in the cell is
282 the nucleus of the infected hepatocyte as a minichromosome that serves as the transcription template
283 n-Barr virus (EBV) persists as chromatinized minichromosomes that are replicated by the host replicat
285 ell lines and in larval tissues that contain minichromosomes that have structurally defined centromer
286 ts into cells, where they are assembled into minichromosomes that the cellular machinery replicates a
287 ence of the HBV genome, which forms a stable minichromosome, the covalently closed circular DNA (cccD
288 vely with origin sequences in the 21 kb rDNA minichromosome, the interaction between ORC and the non-
293 st to the hypoacetylated state of NG59, NG59 minichromosomes were hypermethylated at specific lysines
294 romatin in vivo in Saccharomyces cerevisiae, minichromosomes were isolated using an immobilized lac r
297 can be recapitulated on intracellular human minichromosomes where immunoglobulin 12- and 23-signals
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